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Modern Molecular Approaches to Drug Design and Discovery Iwao Ojima pp 2–3 DOI: 10.1021/ar700158c |
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The Chemical Versatility of Natural-Product Assembly Lines Christopher T. Walsh pp 4–10 DOI: 10.1021/ar7000414 |
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Inhibitors of FabI, an Enzyme Drug Target in the Bacterial Fatty Acid Biosynthesis Pathway Hao Lu and Peter J. Tonge pp 11–20 DOI: 10.1021/ar700156e |
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Epothilones as Lead Structures for the Synthesis-Based Discovery of New Chemotypes for Microtubule Stabilization Fabian Feyen, Frédéric Cachoux, Jürg Gertsch, Markus Wartmann and Karl-Heinz Altmann pp 21–31 DOI: 10.1021/ar700157x |
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Discovery and Combinatorial Synthesis of Fungal Metabolites Beauveriolides, Novel Antiatherosclerotic Agents Hiroshi Tomoda and Takayuki Doi pp 32–39 DOI: 10.1021/ar700117b |
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Function-Oriented Synthesis, Step Economy, and Drug Design Paul A. Wender, Vishal A. Verma, Thomas J. Paxton and Thomas H. Pillow pp 40–49 DOI: 10.1021/ar700155p |
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Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection F. George Njoroge, Kevin X. Chen, Neng-Yang Shih and John J. Piwinski pp 50–59 DOI: 10.1021/ar700109k |
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Functionalized Carbon Nanotubes in Drug Design and Discovery Maurizio Prato, Kostas Kostarelos and Alberto Bianco pp 60–68 DOI: 10.1021/ar700089b |
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Hybrid Molecules with a Dual Mode of Action: Dream or Reality? Bernard Meunier pp 69–77 DOI: 10.1021/ar7000843 |
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Design of HIV Protease Inhibitors Targeting Protein Backbone: An Effective Strategy for Combating Drug Resistance Arun K. Ghosh, Bruno D. Chapsal, Irene T. Weber and Hiroaki Mitsuya pp 78–86 DOI: 10.1021/ar7001232 |
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Targeting Mitochondria Adam T. Hoye, Jennifer E. Davoren and Peter WipfMitchell P. FinkValerian E. Kagan pp 87–97 DOI: 10.1021/ar700135m |
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Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs Ravi V. J. Chari pp 98–107 DOI: 10.1021/ar700108g |
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Guided Molecular Missiles for Tumor-Targeting Chemotherapy—Case Studies Using the Second-Generation Taxoids as Warheads Iwao Ojima pp 108–119 DOI: 10.1021/ar700093f |
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Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases Philip S. Low, Walter A. Henne and Derek D. Doorneweerd pp 120–129 DOI: 10.1021/ar7000815 |
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Complex Target SELEX Steven M. Shamah, Judith M. Healy and Sharon T. Cload pp 130–138 DOI: 10.1021/ar700142z |
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Evaluating Drug Efficacy and Toxicology in Three Dimensions: Using Synthetic Extracellular Matrices in Drug Discovery Glenn D. Prestwich pp 139–148 DOI: 10.1021/ar7000827 |
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Density Functionals with Broad Applicability in Chemistry Yan Zhao and Donald G. Truhlar pp 157–167 DOI: 10.1021/ar700111a |
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Optical Detection of DNA and Proteins with Cationic Polythiophenes Hoang-A. Ho, Ahmed Najari and Mario Leclerc pp 168–178 DOI: 10.1021/ar700115t |
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Nanoscaling Laws of Magnetic Nanoparticles and Their Applicabilities in Biomedical Sciences Young-wook Jun, Jung-wook Seo and Jinwoo Cheon pp 179–189 DOI: 10.1021/ar700121f |
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Polychromophoric Metal Complexes for Generating the Bioregulatory Agent Nitric Oxide by Single- and Two-Photon Excitation Peter C. Ford pp 190–200 DOI: 10.1021/ar700128y |
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Modularly Designed Transition Metal PNP and PCP Pincer Complexes based on Aminophosphines: Synthesis and Catalytic Applications David Benito-Garagorri and Karl Kirchner pp 201–213 DOI: 10.1021/ar700129q |
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Characterization of Enzyme Motions by Solution NMR Relaxation Dispersion J. Patrick Loria, Rebecca B. Berlow and Eric D. Watt pp 214–221 DOI: 10.1021/ar700132n |
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Metal−Organic Cooperative Catalysis in C−H and C−C Bond Activation and Its Concurrent Recovery Young Jun Park, Jung-Woo Park and Chul-Ho Jun pp 222–234 DOI: 10.1021/ar700133y |
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Photophysics of Individual Single-Walled Carbon Nanotubes Lisa J. Carlson and Todd D. Krauss pp 235–243 DOI: 10.1021/ar700136v |
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Ordered Macroporous Bimetallic Nanostructures: Design, Characterization, and Applications Lehui Lu and Alexander Eychmüller pp 244–253 DOI: 10.1021/ar700143w |
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Two and Three-Dimensional Pattern Recognition of Organized Surfaces by Specific Antibodies Lia Addadi, Noa Rubin, Luana Scheffer and Roy Ziblat pp 254–264 DOI: 10.1021/ar700153u |
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Structural Diversity in Expanded Porphyrins Rajneesh Misra and Tavarekere K. Chandrashekar pp 265–279 DOI: 10.1021/ar700091k |
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Supramolecular Control of Reactivity in the Solid State: From Templates to Ladderanes to Metal−Organic Frameworks Leonard R. MacGillivray, Giannis S. Papaefstathiou, Tomislav Friščić, Tamara D. Hamilton, Dejan-Krešimir Bučar, Qianli Chu, Dushyant B. Varshney and Ivan G. Georgiev pp 280–291 DOI: 10.1021/ar700145r |
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Enamides and Enecarbamates as Nucleophiles in Stereoselective C–C and C–N Bond-Forming Reactions Ryosuke Matsubara and Shu̅ Kobayashi pp 292–301 DOI: 10.1021/ar700098d |
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Efficient Total Synthesis of Novel Bioactive Microbial Metabolites Toshiaki Sunazuka, Tomoyasu Hirose and Satoshi O̅mura pp 302–314 DOI: 10.1021/ar6000044 |
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Enzymatic Hydrogelation of Small Molecules Zhimou Yang, Gaolin Liang and Bing Xu pp 315–326 DOI: 10.1021/ar7001914 |
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Enantioselective Cross-Coupling of Anhydrides with Organozinc Reagents: The Controlled Formation of Carbon−Carbon Bonds through the Nucleophilic Interception of Metalacycles Jeffrey B. Johnson and Tomislav Rovis pp 327–338 DOI: 10.1021/ar700176t |
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Dynamics of the Photoexcited Electron at the Chromophore–Semiconductor Interface Oleg V. Prezhdo, Walter R. Duncan and Victor V. Prezhdo pp 339–348 DOI: 10.1021/ar700122b |
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Copper, Silver, and Gold Complexes in Hydrosilylation Reactions Silvia Díez-González and Steven P. Nolan pp 349–358 DOI: 10.1021/ar7001655 |
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Contacting Organic Molecules by Soft Methods: Towards Molecule-Based Electronic Devices Hossam Haick and David Cahen pp 359–366 DOI: 10.1021/ar700099n |
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Molecular Structure, Symmetry, and Shape as Design Elements in the Fabrication of Molecular Crystals for Second Harmonic Generation and the Role of Molecules-in-Materials T. P. Radhakrishnan pp 367–376 DOI: 10.1021/ar7002072 |
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Emerging Rules for Subunit-Based, Multiantigenic, Multistage Chemically Synthesized Vaccines Manuel E. Patarroyo and Manuel A. Patarroyo pp 377–386 DOI: 10.1021/ar700120t |
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The Reaction of Singlet Oxygen with Enecarbamates: A Mechanistic Playground for Investigating Chemoselectivity, Stereoselectivity, and Vibratioselectivity of Photooxidations J. Sivaguru, Marissa R. Solomon, Thomas Poon, Steffen Jockusch, Sara G. Bosio, Waldemar Adam and Nicholas J. Turro pp 387–400 DOI: 10.1021/ar7001254 |
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Electrophilic Coordination Catalysis: A Summary of Previous Thought and a New Angle of Analysis Ronald J. T. Houk, Arthur Monzingo and Eric V. Anslyn pp 401–410 DOI: 10.1021/ar700127n |
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Controlling Transport and Chemical Functionality of Magnetic Nanoparticles Andrew H. Latham and Mary Elizabeth Williams pp 411–420 DOI: 10.1021/ar700183b |
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Surface Structure at the Ionic Liquid−Electrified Metal Interface Steven Baldelli pp 421–431 DOI: 10.1021/ar700185h |
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Amide I Two-Dimensional Infrared Spectroscopy of Proteins Ziad Ganim, Hoi Sung Chung, Adam W. Smith, Lauren P. DeFlores, Kevin C. Jones and Andrei Tokmakoff pp 432–441 DOI: 10.1021/ar700188n |
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Probing Invisible, Low-Populated States of Protein Molecules by Relaxation Dispersion NMR Spectroscopy: An Application to Protein Folding Dmitry M. Korzhnev and Lewis E. Kay pp 442–451 DOI: 10.1021/ar700189y |
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Ab Initio Determination of Dark Structures in Radiationless Transitions for Aromatic Carbonyl Compounds Wei-Hai Fang pp 452–457 DOI: 10.1021/ar700205f |
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Reversible in Situ Catalyst Formation Jason P. Hallett, Pamela Pollet, Charles L. Liotta and Charles A. Eckert pp 458–467 DOI: 10.1021/ar700106a |
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Laser Flash Photolysis Generation of High-Valent Transition Metal−Oxo Species: Insights from Kinetic Studies in Real Time Rui Zhang and Martin Newcomb pp 468–477 DOI: 10.1021/ar700175k |
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Porous Manganese Oxide Octahedral Molecular Sieves and Octahedral Layered Materials Steven L. Suib pp 479–487 DOI: 10.1021/ar7001667 |
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The Liquid–Liquid Interface as a Medium To Generate Nanocrystalline Films of Inorganic Materials C. N. R. Rao and K. P. Kalyanikutty pp 489–499 DOI: 10.1021/ar700192d |
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Redox Tuning over Almost 1 V in a Structurally Conserved Active Site: Lessons from Fe-Containing Superoxide Dismutase Anne-Frances Miller pp 501–510 DOI: 10.1021/ar700237u |
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Nanographenes as Active Components of Single-Molecule Electronics and How a Scanning Tunneling Microscope Puts Them To Work Klaus Müllen and Jürgen P. Rabe pp 511–520 DOI: 10.1021/ar7001446 |
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Chiral Metallocycles: Rational Synthesis and Novel Applications Suk Joong Lee and Wenbin Lin pp 521–537 DOI: 10.1021/ar700216n |
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Phosphate Binding Energy and Catalysis by Small and Large Molecules Janet R. Morrow, Tina L. Amyes and John P. Richard pp 539–548 DOI: 10.1021/ar7002013 |
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Using Chemistry and Microfluidics To Understand the Spatial Dynamics of Complex Biological Networks Christian J. Kastrup, Matthew K. Runyon, Elena M. Lucchetta, Jessica M. Price and Rustem F. Ismagilov pp 549–558 DOI: 10.1021/ar700174g |
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A Link between Reactivity and Local Structure in Acid Catalysis on Zeolites Aditya Bhan and Enrique Iglesia pp 559–567 DOI: 10.1021/ar700181t |
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Theoretical Thermodynamics for Large Molecules: Walking the Thin Line between Accuracy and Computational Cost Tobias Schwabe and Stefan Grimme pp 569–579 DOI: 10.1021/ar700208h |
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Chiral Diphosphine and Monodentate Phosphorus Ligands on a Spiro Scaffold for Transition-Metal-Catalyzed Asymmetric Reactions Jian-Hua Xie and Qi-Lin Zhou pp 581–593 DOI: 10.1021/ar700137z |
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Conformational Polymorphism in Organic Crystals Ashwini Nangia pp 595–604 DOI: 10.1021/ar700203k |
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Quantum Mechanical Computations and Spectroscopy: From Small Rigid Molecules in the Gas Phase to Large Flexible Molecules in Solution Vincenzo Barone, Roberto Improta and Nadia Rega pp 605–616 DOI: 10.1021/ar7002144 |
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Subunit Architecture of Intact Protein Complexes from Mass Spectrometry and Homology Modeling Thomas Taverner, Helena Hernández, Michal Sharon, Brandon T. Ruotolo, Dijana Matak-Vinković, Damien Devos, Robert B. Russell and Carol V. Robinson pp 617–627 DOI: 10.1021/ar700218q |
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Microwave-Assisted Organic Synthesis and Transformations using Benign Reaction Media Vivek Polshettiwar and Rajender S. Varma pp 629–639 DOI: 10.1021/ar700238s |
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Fresh Look at Electron-Transfer Mechanisms via the Donor/Acceptor Bindings in the Critical Encounter Complex Sergiy V. Rosokha and Jay K. Kochi pp 641–653 DOI: 10.1021/ar700256a |
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Bifunctional Asymmetric Catalysis: Cooperative Lewis Acid/Base Systems Daniel H. Paull, Ciby J. Abraham, Michael T. Scerba, Ethan Alden-Danforth and Thomas Lectka pp 655–663 DOI: 10.1021/ar700261a |
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Electron Holography for the Study of Magnetic Nanomaterials John Meurig Thomas, Edward T. Simpson, Takeshi Kasama and Rafal E. Dunin-Borkowski pp 665–674 DOI: 10.1021/ar700225v |
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Evolution of the Petasis−Ferrier Union/Rearrangement Tactic: Construction of Architecturally Complex Natural Products Possessing the Ubiquitous cis-2,6-Substituted Tetrahydropyran Structural Element Amos B. Smith, III, Richard J. Fox and Thomas M. Razler pp 675–687 DOI: 10.1021/ar700234r |
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Computational Enzymatic Catalysis Maria J. Ramos and Pedro A. Fernandes pp 689–698 DOI: 10.1021/ar7001045 |
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Fast Electrochemistry of Conductive Polymer Nanotubes: Synthesis, Mechanism, and Application Seung Il Cho and Sang Bok Lee pp 699–707 DOI: 10.1021/ar7002094 |
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Exploiting Nanospace for Asymmetric Catalysis: Confinement of Immobilized, Single-Site Chiral Catalysts Enhances Enantioselectivity John Meurig Thomas and Robert Raja pp 708–720 DOI: 10.1021/ar700217y |
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The Interface Energetics of Self-Assembled Monolayers on Metals Georg Heimel, Lorenz Romaner, Egbert Zojer and Jean-Luc Bredas pp 721–729 DOI: 10.1021/ar700284q |
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Protein Control of True, Gated, and Coupled Electron Transfer Reactions Victor L. Davidson pp 730–738 DOI: 10.1021/ar700252c |
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Integration or Segregation: How Do Molecules Behave at Oil/Water Interfaces? F. G. Moore and G. L. Richmond pp 739–748 DOI: 10.1021/ar7002732 |
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A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery Jordan J. Green, Robert Langer and Daniel G. Anderson pp 749–759 DOI: 10.1021/ar7002336 |
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A Universal Approach to Solvation Modeling Christopher J. Cramer and Donald G. Truhlar pp 760–768 DOI: 10.1021/ar800019z |
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Crops: A Green Approach toward Self-Assembled Soft Materials Praveen Kumar Vemula and George John pp 769–782 DOI: 10.1021/ar7002682 |
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Polymerization in the Gas Phase, in Clusters, and on Nanoparticle Surfaces M. Samy El-Shall pp 783–792 DOI: 10.1021/ar7001396 |
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Interstrand DNA Cross-Links Induced by α,β-Unsaturated Aldehydes Derived from Lipid Peroxidation and Environmental Sources Michael P. Stone, Young-Jin Cho, Hai Huang, Hye-Young Kim, Ivan D. Kozekov, Albena Kozekova, Hao Wang, Irina G. Minko, R. Stephen Lloyd, Thomas M. Harris and Carmelo J. Rizzo pp 793–804 DOI: 10.1021/ar700246x |
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Fluorogenic Polydiacetylene Supramolecules: Immobilization, Micropatterning, and Application to Label-Free Chemosensors Dong June Ahn and Jong-Man Kim pp 805–816 DOI: 10.1021/ar7002489 |
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α-Trifluoromethylated Carbanion Synthons Kenji Uneyama, Toshimasa Katagiri and Hideki Amii pp 817–829 DOI: 10.1021/ar7002573 |
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An Advance on Exploring N-tert-Butanesulfinyl Imines in Asymmetric Synthesis of Chiral Amines Guo-Qiang Lin, Ming-Hua Xu, Yu-Wu Zhong and Xing-Wen Sun pp 831–840 DOI: 10.1021/ar7002623 |
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Metallocenyl Dendrimers and Their Applications in Molecular Electronics, Sensing, and Catalysis Didier Astruc, Cátia Ornelas and Jaime Ruiz pp 841–856 DOI: 10.1021/ar8000074 |
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Iridium Terpyridine Complexes as Functional Assembling Units in Arrays for the Conversion of Light Energy Lucia Flamigni, Jean-Paul Collin and Jean-Pierre Sauvage pp 857–871 DOI: 10.1021/ar700282n |
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Roaming Atoms and Radicals: A New Mechanism in Molecular Dissociation Arthur G. Suits pp 873–881 DOI: 10.1021/ar8000734 |
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Tandem Reactions for Streamlining Synthesis: Enantio- and Diastereoselective One-Pot Generation of Functionalized Epoxy Alcohols Mahmud M. Hussain and Patrick J. Walsh pp 883–893 DOI: 10.1021/ar800006h |
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Reactivity of Surface Alkoxy Species on Acidic Zeolite Catalysts Wei Wang and Michael Hunger pp 895–904 DOI: 10.1021/ar700210f |
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Electronic Structure and Reactivity of Three-Coordinate Iron Complexes Patrick L. Holland pp 905–914 DOI: 10.1021/ar700267b |
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Elucidating the Thermal, Chemical, and Mechanical Mechanisms of Ultraviolet Ablation in Poly(methyl methacrylate) via Molecular Dynamics Simulations Patrick F. Conforti, Manish Prasad and Barbara J. Garrison pp 915–924 DOI: 10.1021/ar700278y |
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The Mechanism of the Ketene−Imine (Staudinger) Reaction in Its Centennial: Still an Unsolved Problem? Fernando P. Cossío, Ana Arrieta and Miguel A. Sierra pp 925–936 DOI: 10.1021/ar800033j |
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Ylide-Initiated Michael Addition−Cyclization Reactions beyond Cyclopropanes Xiu-Li Sun and Yong Tang pp 937–948 DOI: 10.1021/ar800108z |
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Gold Supported on Thin Oxide Films: From Single Atoms to Nanoparticles Thomas Risse, Shamil Shaikhutdinov, Niklas Nilius, Martin Sterrer and Hans-Joachim Freund pp 949–956 DOI: 10.1021/ar800078m |
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Unraveling Water’s Entropic Mysteries: A Unified View of Nonpolar, Polar, and Ionic Hydration Dor Ben-Amotz and Robin Underwood pp 957–967 DOI: 10.1021/ar7001478 |
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Controlled Oxidation of Hydrocarbons by the Membrane-Bound Methane Monooxygenase: The Case for a Tricopper Cluster Sunney I. Chan and Steve S.-F. Yu pp 969–979 DOI: 10.1021/ar700277n |
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Dynamical Resonances in the Fluorine Atom Reaction with the Hydrogen Molecule Xueming Yang and Dong H. Zhang pp 981–989 DOI: 10.1021/ar700258g |
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Mechanistic Insights into Phosphoprotein-Binding FHA Domains Xiangyang Liang and Steven R. Van Doren pp 991–999 DOI: 10.1021/ar700148u |
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Using Singlet Oxygen to Synthesize Polyoxygenated Natural Products from Furans Tamsyn Montagnon, Maria Tofi and Georgios Vassilikogiannakis pp 1001–1011 DOI: 10.1021/ar800023v |
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Direct Functionalization of Nitrogen Heterocycles via Rh-Catalyzed C−H Bond Activation Jared C. Lewis, Robert G. Bergman and Jonathan A. Ellman pp 1013–1025 DOI: 10.1021/ar800042p |
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Catalytic Strategies of Self-Cleaving Ribozymes Jesse C. Cochrane and Scott A. Strobel pp 1027–1035 DOI: 10.1021/ar800050c |
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Contrasting Disease and Nondisease Protein Aggregation by Molecular Simulation Nicolas Lux Fawzi, Eng-Hui Yap, Yuka Okabe, Kevin L. Kohlstedt, Scott P. Brown and Teresa Head-Gordon pp 1037–1047 DOI: 10.1021/ar800062k |
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A New Generation of Sensors Based on Extraordinary Optical Transmission Reuven Gordon, David Sinton, Karen L. Kavanagh and Alexandre G. Brolo pp 1049–1057 DOI: 10.1021/ar800074d |
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2-Nitroglycals as Powerful Glycosyl Donors: Application in the Synthesis of Biologically Important Molecules Richard R. Schmidt and Yashwant D. Vankar pp 1059–1073 DOI: 10.1021/ar7002495 |
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Oxidatively Generated Damage to the Guanine Moiety of DNA: Mechanistic Aspects and Formation in Cells Jean Cadet, Thierry Douki and Jean-Luc Ravanat pp 1075–1083 DOI: 10.1021/ar700245e |
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Advanced Polymer Design and Synthesis Klaus MüllenTimothy M. Swager pp 1085–1085 DOI: 10.1021/ar800180w |
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All-Conjugated Block Copolymers Ullrich Scherf, Andrea Gutacker and Nils Koenen pp 1086–1097 DOI: 10.1021/ar7002539 |
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Monolayers and Multilayers of Conjugated Polymers as Nanosized Electronic Components Gianni Zotti and Barbara VercelliAnna Berlin pp 1098–1109 DOI: 10.1021/ar8000102 |
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Poly(2,7-carbazole)s: Structure−Property Relationships Nicolas Blouin and Mario Leclerc pp 1110–1119 DOI: 10.1021/ar800057k |
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Precision Control of Radical Polymerization via Transition Metal Catalysis: From Dormant Species to Designed Catalysts for Precision Functional Polymers Makoto Ouchi, Takaya Terashima and Mitsuo Sawamoto pp 1120–1132 DOI: 10.1021/ar800063t |
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Toward Living Radical Polymerization Graeme Moad, Ezio Rizzardo and San H. Thang pp 1133–1142 DOI: 10.1021/ar800075n |
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Ring-Opening Polymerization of Cyclic Esters by Cyclodextrins Akira Harada, Motofumi Osaki, Yoshinori Takashima and Hiroyasu Yamaguchi pp 1143–1152 DOI: 10.1021/ar800079v |
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Rational Approach to Polymer-Supported Catalysts: Synergy between Catalytic Reaction Mechanism and Polymer Design Nandita Madhavan, Christopher W. Jones and Marcus Weck pp 1153–1165 DOI: 10.1021/ar800081y |
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Single- and Double-Stranded Helical Polymers: Synthesis, Structures, and Functions Eiji Yashima, Katsuhiro Maeda and Yoshio Furusho pp 1166–1180 DOI: 10.1021/ar800091w |
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Iptycenes in the Design of High Performance Polymers Timothy M. Swager pp 1181–1189 DOI: 10.1021/ar800107v |
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Oil-in-Oil Emulsions: A Unique Tool for the Formation of Polymer Nanoparticles Markus Klapper, Svetlin Nenov, Robert Haschick, Kevin Müller and Klaus Müllen pp 1190–1201 DOI: 10.1021/ar8001206 |
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Advances in Molecular Design and Synthesis of Regioregular Polythiophenes Itaru Osaka and Richard D. McCullough pp 1202–1214 DOI: 10.1021/ar800130s |
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Single-Crystal-to-Single-Crystal Topochemical Polymerizations by Design Joseph W. Lauher, Frank W. Fowler and Nancy S. Goroff pp 1215–1229 DOI: 10.1021/ar8001427 |
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Peptidomimetics Yun-Dong Wu and Sam Gellman pp 1231–1232 DOI: 10.1021/ar800216e |
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Ceragenins: Cholic Acid-Based Mimics of Antimicrobial Peptides Xin-Zhong Lai, Yanshu Feng, Jacob Pollard, Judy N. Chin, Michael J. Rybak, Robert Bucki, Raquel F. Epand, Richard M. Epand and Paul B. Savage pp 1233–1240 DOI: 10.1021/ar700270t |
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The Practice of Ring Constraint in Peptidomimetics Using Bicyclic and Polycyclic Amino Acids Stephen Hanessian and Luciana Auzzas pp 1241–1251 DOI: 10.1021/ar8000052 |
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Peptidomimetic Therapeutic Agents Targeting the Protease Enzyme of the Human Immunodeficiency Virus and Hepatitis C Virus Youla S. Tsantrizos pp 1252–1263 DOI: 10.1021/ar8000519 |
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Design of Small-Molecule Peptidic and Nonpeptidic Smac Mimetics Haiying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Dongguang Qian, Jianfeng Lu, Su Qiu, Longchuan Bai, Yuefeng Peng, Qian Cai and Shaomeng Wang pp 1264–1277 DOI: 10.1021/ar8000553 |
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β-Hairpin Peptidomimetics: Design, Structures and Biological Activities John A. Robinson pp 1278–1288 DOI: 10.1021/ar700259k |
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A Hydrogen Bond Surrogate Approach for Stabilization of Short Peptide Sequences in α-Helical Conformation Anupam Patgiri, Andrea L. Jochim and Paramjit S. Arora pp 1289–1300 DOI: 10.1021/ar700264k |
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Protein Design with l- and d-α-Amino Acid Structures as the Alphabet Susheel Durani pp 1301–1308 DOI: 10.1021/ar700265t |
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Peptide and Protein Mimetics Inhibiting Amyloid β-Peptide Aggregation Tsuyoshi Takahashi and Hisakazu Mihara pp 1309–1318 DOI: 10.1021/ar8000475 |
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Exploring β-Sheet Structure and Interactions with Chemical Model Systems James S. Nowick pp 1319–1330 DOI: 10.1021/ar800064f |
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N-Methylation of Peptides: A New Perspective in Medicinal Chemistry Jayanta Chatterjee, Chaim Gilon, Amnon Hoffman and Horst Kessler pp 1331–1342 DOI: 10.1021/ar8000603 |
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Peptide Mimics by Linear Arylamides: A Structural and Functional Diversity Test Zhan-Ting Li, Jun-Li Hou and Chuang Li pp 1343–1353 DOI: 10.1021/ar700219m |
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Artificial β-Barrels Naomi Sakai, Jiri Mareda and Stefan Matile pp 1354–1365 DOI: 10.1021/ar700229r |
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β-Peptidic Peptidomimetics Dieter Seebach and James Gardiner pp 1366–1375 DOI: 10.1021/ar700263g |
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Hollow Crescents, Helices, and Macrocycles from Enforced Folding and Folding-Assisted Macrocyclization Bing Gong pp 1376–1386 DOI: 10.1021/ar700266f |
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Shape-Programmable Macromolecules Christian E. Schafmeister, Zachary Z. Brown and Sharad Gupta pp 1387–1398 DOI: 10.1021/ar700283y |
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Foldamers with Heterogeneous Backbones W. Seth Horne and Samuel H. Gellman pp 1399–1408 DOI: 10.1021/ar800009n |
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Biomimicry of Surfactant Protein C Nathan J. Brown, Jan Johansson and Annelise E. Barron pp 1409–1417 DOI: 10.1021/ar800058t |
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Theoretical Analysis of Secondary Structures of β-Peptides Yun-Dong Wu, Wei Han, De-Ping Wang, Yi Gao and Yi-Lei Zhao pp 1418–1427 DOI: 10.1021/ar800070b |
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α-Aminoxy Acids: New Possibilities from Foldamers to Anion Receptors and Channels Xiang Li, Yun-Dong Wu and Dan Yang pp 1428–1438 DOI: 10.1021/ar8001393 |
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Cross Coupling Stephen L. Buchwald pp 1439–1439 DOI: 10.1021/ar8001798 |
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Well-Defined N-Heterocyclic Carbenes−Palladium(II) Precatalysts for Cross-Coupling Reactions Nicolas Marion and Steven P. Nolan pp 1440–1449 DOI: 10.1021/ar800020y |
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Copper/Amino Acid Catalyzed Cross-Couplings of Aryl and Vinyl Halides with Nucleophiles Dawei Ma and Qian Cai pp 1450–1460 DOI: 10.1021/ar8000298 |
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Palladium-Catalyzed Suzuki−Miyaura Cross-Coupling Reactions Employing Dialkylbiaryl Phosphine Ligands Ruben Martin and Stephen L. Buchwald pp 1461–1473 DOI: 10.1021/ar800036s |
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Recent Advances in Efficient and Selective Synthesis of Di-, Tri-, and Tetrasubstituted Alkenes via Pd-Catalyzed Alkenylation−Carbonyl Olefination Synergy Ei-ichi Negishi, Zhihong Huang, Guangwei Wang, Swathi Mohan, Chao Wang and Hatsuhiko Hattori pp 1474–1485 DOI: 10.1021/ar800038e |
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Palladium-Catalyzed Cross-Coupling Reactions of Organosilanols and Their Salts: Practical Alternatives to Boron- and Tin-Based Methods Scott E. Denmark and Christopher S. Regens pp 1486–1499 DOI: 10.1021/ar800037p |
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The Promise and Challenge of Iron-Catalyzed Cross Coupling Benjamin D. Sherry and Alois Fürstner pp 1500–1511 DOI: 10.1021/ar800039x |
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Catalytic Sequential Reactions Involving Palladacycle-Directed Aryl Coupling Steps Marta Catellani, Elena Motti and Nicola Della Ca’ pp 1512–1522 DOI: 10.1021/ar800040u |
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Surveying Sterically Demanding N-Heterocyclic Carbene Ligands with Restricted Flexibility for Palladium-catalyzed Cross-Coupling Reactions Sebastian Würtz and Frank Glorius pp 1523–1533 DOI: 10.1021/ar8000876 |
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Evolution of a Fourth Generation Catalyst for the Amination and Thioetherification of Aryl Halides John F. Hartwig pp 1534–1544 DOI: 10.1021/ar800098p |
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Cross-Coupling Reaction of Alkyl Halides with Grignard Reagents Catalyzed by Ni, Pd, or Cu Complexes with π-Carbon Ligand(s) Jun Terao and Nobuaki Kambe pp 1545–1554 DOI: 10.1021/ar800138a |
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The Development of Versatile Methods for Palladium-Catalyzed Coupling Reactions of Aryl Electrophiles through the Use of P(t-Bu)3 and PCy3 as Ligands Gregory C. Fu pp 1555–1564 DOI: 10.1021/ar800148f |
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Nanoscience Teri W. OdomMarie-Paule Pileni pp 1565–1565 DOI: 10.1021/ar800253n |
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Nanoskiving: A New Method To Produce Arrays of Nanostructures Qiaobing Xu, Robert M. Rioux, Michael D. Dickey and George M. Whitesides pp 1566–1577 DOI: 10.1021/ar700194y |
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Noble Metals on the Nanoscale: Optical and Photothermal Properties and Some Applications in Imaging, Sensing, Biology, and Medicine Prashant K. Jain, Xiaohua Huang, Ivan H. El-Sayed and Mostafa A. El-Sayed pp 1578–1586 DOI: 10.1021/ar7002804 |
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Gold Nanocages: Synthesis, Properties, and Applications Sara E. Skrabalak, Jingyi Chen, Yugang Sun, Xianmao Lu, Leslie Au, Claire M. Cobley and Younan Xia pp 1587–1595 DOI: 10.1021/ar800018v |
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One-Dimensional Self-Assembly of Planar π-Conjugated Molecules: Adaptable Building Blocks for Organic Nanodevices Ling Zang, Yanke Che and Jeffrey S. Moore pp 1596–1608 DOI: 10.1021/ar800030w |
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Superlattice Nanowire Pattern Transfer (SNAP) James R. Heath pp 1609–1617 DOI: 10.1021/ar800015y |
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Heteroligated Supramolecular Coordination Complexes Formed via the Halide-Induced Ligand Rearrangement Reaction Christopher G. Oliveri, Pirmin A. Ulmann, Michael J. Wiester and Chad A. Mirkin pp 1618–1629 DOI: 10.1021/ar800025w |
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Synergistically Integrated Nanoparticles as Multimodal Probes for Nanobiotechnology Jinwoo Cheon and Jae-Hyun Lee pp 1630–1640 DOI: 10.1021/ar800045c |
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Induced Helical Backbone Conformations of Self-Organizable Dendronized Polymers Jonathan G. Rudick and Virgil Percec pp 1641–1652 DOI: 10.1021/ar800086w |
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Controlled Plasmonic Nanostructures for Surface-Enhanced Spectroscopy and Sensing Jon P. Camden, Jon A. Dieringer, Jing Zhao and Richard P. Van Duyne pp 1653–1661 DOI: 10.1021/ar800041s |
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Langmuir−Blodgettry of Nanocrystals and Nanowires Andrea R. Tao, Jiaxing Huang and Peidong Yang pp 1662–1673 DOI: 10.1021/ar8000525 |
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Molecular Self-Assembly into One-Dimensional Nanostructures Liam C. Palmer and Samuel I. Stupp pp 1674–1684 DOI: 10.1021/ar8000926 |
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The Pursuit of a Scalable Nanofabrication Platform for Use in Material and Life Science Applications Stephanie E. A. Gratton, Stuart S. Williams, Mary E. Napier, Patrick D. Pohlhaus, Zhilian Zhou, Kenton B. Wiles, Benjamin W. Maynor, Clifton Shen, Tove Olafsen, Edward T. Samulski and Joseph M. DeSimone pp 1685–1695 DOI: 10.1021/ar8000348 |
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Colloidal Chemical Synthesis and Formation Kinetics of Uniformly Sized Nanocrystals of Metals, Oxides, and Chalcogenides Soon Gu Kwon and Taeghwan Hyeon pp 1696–1709 DOI: 10.1021/ar8000537 |
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Methods for Describing the Electromagnetic Properties of Silver and Gold Nanoparticles Jing Zhao, Anatoliy O. Pinchuk, Jeffrey M. McMahon, Shuzhou Li, Logan K. Ausman, Ariel L. Atkinson and George C. Schatz pp 1710–1720 DOI: 10.1021/ar800028j |
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Gold Nanoparticles in Biology: Beyond Toxicity to Cellular Imaging Catherine J. Murphy, Anand M. Gole, John W. Stone, Patrick N. Sisco, Alaaldin M. Alkilany, Edie C. Goldsmith and Sarah C. Baxter pp 1721–1730 DOI: 10.1021/ar800035u |
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Molecular Electronic Devices Based on Single-Walled Carbon Nanotube Electrodes Alina K. Feldman, Michael L. Steigerwald, Xuefeng Guo and Colin Nuckolls pp 1731–1741 DOI: 10.1021/ar8000266 |
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Noble Metal Nanocrystals: Plasmon Electron Transfer Photochemistry and Single-Molecule Raman Spectroscopy Louis Brus pp 1742–1749 DOI: 10.1021/ar800121r |
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Kinetic and Thermodynamic Approaches for the Efficient Formation of Mechanical Bonds William R. Dichtel, Ognjen Š. Miljanić, Wenyu Zhang, Jason M. Spruell, Kaushik Patel, Ivan Aprahamian, James R. Heath and J. Fraser Stoddart pp 1750–1761 DOI: 10.1021/ar800067h |
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Pyramids: A Platform for Designing Multifunctional Plasmonic Particles Jeunghoon Lee, Warefta Hasan, Christopher L. Stender and Teri W. Odom pp 1762–1771 DOI: 10.1021/ar800126p |
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Functional Molecules and Assemblies in Controlled Environments: Formation and Measurements Paul S. Weiss pp 1772–1781 DOI: 10.1021/ar8001443 |
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The Reticular Chemistry Structure Resource (RCSR) Database of, and Symbols for, Crystal Nets Michael O’Keeffe, Maxim A. Peskov, Stuart J. Ramsden and Omar M. Yaghi pp 1782–1789 DOI: 10.1021/ar800124u |
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Laser Fabrication and Spectroscopy of Organic Nanoparticles T. Asahi, T. Sugiyama and H. Masuhara pp 1790–1798 DOI: 10.1021/ar800125s |
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Supracrystals of Inorganic Nanocrystals: An Open Challenge for New Physical Properties M. P. Pileni pp 1799–1809 DOI: 10.1021/ar800082q |
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New Aspects of Carrier Multiplication in Semiconductor Nanocrystals John A. McGuire, Jin Joo, Jeffrey M. Pietryga, Richard D. Schaller and Victor I. Klimov pp 1810–1819 DOI: 10.1021/ar800112v |
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Nanocrystal Plasma Polymerization: From Colloidal Nanocrystals to Inorganic Architectures Ludovico Cademartiri, Arya Ghadimi and Geoffrey A. Ozin pp 1820–1830 DOI: 10.1021/ar800158d |
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Composite Layer-by-Layer (LBL) Assembly with Inorganic Nanoparticles and Nanowires Sudhanshu Srivastava and Nicholas A. Kotov pp 1831–1841 DOI: 10.1021/ar8001377 |
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Nanoshell-Enabled Photothermal Cancer Therapy: Impending Clinical Impact Surbhi Lal, Susan E. Clare and Naomi J. Halas pp 1842–1851 DOI: 10.1021/ar800150g |