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ONLINEISSN:1347-5223
PRINTISSN:0009-2363
CHEMICAL & PHARMACEUTICAL BULLETIN
Vol. 49 (2001) , No. 2


Regular Articles

Formulation Design of Ointment Base Suitable for Healing of Lesions in Treatment of Bedsores129
Masato SHIGEYAMA, Toyoaki OHGAYA, Hirofumi TAKEUCHI, Tomoaki HINO and Yoshiaki KAWASHIMA
Release Date: 2002/03/29
[Abstract] [PDF (76K)

Preparation of Rapidly Disintegrating Tablet Using New Types of Microcrystalline Cellulose (PH-M Series) and Low Substituted-Hydroxypropylcellulose or Spherical Sugar Granules by Direct Compression Method134
Tatsuya ISHIKAWA, Baku MUKAI, Shuji SHIRAISHI, Naoki UTOGUCHI, Makiko FUJI, Mitsuo MATSUMOTO and Yoshiteru WATANABE
Release Date: 2002/03/29
[Abstract] [PDF (68K)

Melt Pelletization of a Hygroscopic Drug in a High Shear Mixer. Part 3.1) Effects of Binder Variation140
Regine THIES and Peter KLEINEBUDDE
Release Date: 2002/03/29
[Abstract] [PDF (91K)

A Prodrug of NMDA/Glycine Site Antagonist, L-703, 717, with Improved BBB Permeability: 4-Acetoxy Derivative and Its Positron-Emitter Labeled Analog147
Terushi HARADAHIRA, Ming-Rong ZHANG, Jun MAEDA, Takashi OKAUCHI, Takayo KIDA, Kouichi KAWABE, Sigeki SASAKI, Tetsuya SUHARA and Kazutoshi SUZUKI
Release Date: 2002/03/29
[Abstract] [PDF (132K)

Studies on the Constituents of the Leaves of Morus alba L.151
Kayo DOI, Takashi KOJIMA, Mitsuko MAKINO, Yumiko KIMURA and Yasuo FUJIMOTO
Release Date: 2002/03/29
[Abstract] [PDF (53K)

Analgesic Components of Saposhnikovia Root (Saposhnikovia divaricata)154
Emi OKUYAMA, Tetsuya HASEGAWA, Takamitsu MATSUSHITA, Haruhiro FUJIMOTO, Masami ISHIBASHI and Mikio YAMAZAKI
Release Date: 2002/03/29
[Abstract] [PDF (136K)

Six New Withanolide-Type Steroids from the Leaves of Solanum cilistum161
Xing-Hua ZHU, Jun ANDO, Masanao TAKAGI, Tsuyoshi IKEDA and Toshihiro NOHARA
Release Date: 2002/03/29
[Abstract] [PDF (59K)

Analysis of Electron Spin Resonance Spectra of Alkyl Spin Labels in Excised Guinea Pig Dorsal Skin, Its Stratum Corneum, Delipidized Skin and Stratum Corneum Model Lipid Liposomes165
Shuji KITAGAWA and Ai IKARASHI
Release Date: 2002/03/29
[Abstract] [PDF (51K)

Preparation of a Novel Aggregate Like Sugar-Ball Micelle Composed of Poly(methylglutamate) and Poly(ethyleneglycol) Modified by Lactose and Its Molecular Recognition by Lectin169
Akiko TOYOTAMA, Shin-ichi KUGIMIYA, Junpei YAMANAKA and Masakatsu YONESE
Release Date: 2002/03/29
[Abstract] [PDF (60K)

New Antifungal 1, 2, 4-Triazoles with Difluoro(substituted sulfonyl)methyl Moiety173
Hiromichi ETO, Yasushi KANEKO, Sunao TAKEDA, Minoru TOKIZAWA, Susumu SATO, Kouiti YOSHIDA, Setsuo NAMIKI, Masaki OGAWA, Kazuki MAEBASHI, Kazuya ISHIDA, Masaru MATSUMOTO and Takemitsu ASAOKA
Release Date: 2002/03/29
[Abstract] [PDF (139K)

Triterpenes and Lignans from Artemisia caruifolia and Their Cytotoxic Effects on Meth-A and LLC Tumor Cell Lines183
Chao-mei MA, Norio NAKAMURA, Byung Sun MIN and Masao HATTORI
Release Date: 2002/03/29
[Abstract] [PDF (63K)

Phosphodiesterase 4 Isoenzyme Inhibitory Activity of 3-Phenylxanthines and 4-Phenyl[i]condensed-purines188
Hirokazu SUZUKI, Hiroyuki SAWANISHI, Kenji YAMAMOTO, Koichi YOKOGAWA and Ken-ichi MIYAMOTO
Release Date: 2002/03/29
[Abstract] [PDF (54K)

Mechanistic Studies on the Biomimetic Reduction of Tetrahydroxynaphthalene, a Key Intermediate in Melanin Biosynthesis1)192
Koji ICHINOSE, Yutaka EBIZUKA and Ushio SANKAWA
Release Date: 2002/03/29
[Abstract] [PDF (73K)

Geranylgeranyl Diphosphate Synthase from Scoparia dulcis and Croton sublyratus. Plastid Localization and Conversion to a Farnesyl Diphosphate Synthase by Mutagenesis197
Worapan SITTHITHAWORN, Naoe KOJIMA, Ekapop VIROONCHATAPAN, Dae-Yeon SUH, Naoko IWANAMI, Toshimitsu HAYASHI, Masaaki NOJI, Kazuki SAITO, Yasuo NIWA and Ushio SANKAWA
Release Date: 2002/03/29
[Abstract] [PDF (159K)

Compositional Analysis of Copoly (DL-Lactic/Glycolic Acid) (PLGA) by Pyrolysis-Gas Chromatography/Mass Spectrometry Combined with One-step Thermally Assisted Hydrolysis and Methylation in the Presence of Tetramethylammonium Hydroxide203
Koji URAKAMI, Atsuya HIGASHI, Kazuichi UMEMOTO, Masayuki GODO, Chuichi WATANABE and Keiji HASHIMOTO
Release Date: 2002/03/29
[Abstract] [PDF (48K)

Asymmetric Synthesis of a 3-Acyltetronic Acid Derivative, RK-682, and Formation of Its Calcium Salt during Silica Gel Column Chromatography206
Mikiko SODEOKA, Ruriko SAMPE, Sachiko KOJIMA, Yoshiyasu BABA, Naoko MORISAKI and Yuichi HASHIMOTO
Release Date: 2002/03/29
[Abstract] [PDF (93K)

Radical Cyclization in Heterocycle Synthesis. 12.1) Sulfanyl Radical Addition-Addition-Cyclization (SRAAC) of Unbranched Diynes and Its Application to the Synthesis of A-Ring Fragment of 1α, 25-Dihydroxyvitamin D3213
Okiko MIYATA, Emi NAKAJIMA and Takeaki NAITO
Release Date: 2002/03/29
[Abstract] [PDF (143K)

Antioxidative and 5-Lipoxygenase Inhibiting Activities of Novel Bis(4-hydroxy-2, 3, 5-trimethylphenoxy)alkyl Derivatives225
Takashi HIRANO, Nobuhide KAWASAKI, Hideki MIYATAKA, Mayumi NISHIKI and Toshio SATOH
Release Date: 2002/03/29
[Abstract] [PDF (86K)


Notes

Pharmacokinetics of Acetaminophen from Rapidly Disintegrating Compressed Tablet Prepared Using Microcrystalline Cellulose (PH-M-06) and Spherical Sugar Granules230
Tatsuya ISHIKAWA, Naoya KOIZUMI, Baku MUKAI, Naoki UTOGUCHI, Makiko FUJII, Mitsuo MATSUMOTO, Hisashi ENDO, Shoichi SHIROTAKE and Yoshiteru WATANABE
Release Date: 2002/03/29
[Abstract] [PDF (50K)

An Efficient Synthesis of N-tert-Butoxycarbonyl-O-cyclohexyl-L-tyrosine233
Yasuhiro NISHIYAMA, Sou ISHIZUKA, Suguru SHIKAMA and Keisuke KURITA
Release Date: 2002/03/29
[Abstract] [PDF (45K)

Caffeic Acid Phenethyl Ester (CAPE): Synthesis and X-Ray Crystallographic Analysis236
Sopheak SON, Emil B. LOBKOWSKY and Betty A. LEWIS
Release Date: 2002/03/29
[Abstract] [PDF (56K)

Latifolosides I and J, Two New Triterpenoid Saponins from the Bark of Ilex latifolia239
Jing HUANG, Xu WANG, Yukio OGIHARA, Noriko SHIMIZU, Tadahiro TAKEDA and Toshiyuki AKIYAMA
Release Date: 2002/03/29
[Abstract] [PDF (52K)

Vibsane-type Diterpenes from Taiwanese Viburnum odoratissimum242
Miwa KUBO, Ih-Sheng CHEN and Yoshiyasu FUKUYAMA
Release Date: 2002/03/29
[Abstract] [PDF (58K)

Triterpene Glycosides from the Cultures of Phytolacca americana246
Hironobu TAKAHASHI, Yuki NAMIKAWA, Masami TANAKA and Yoshiyasu FUKUYAMA
Release Date: 2002/03/29
[Abstract] [PDF (53K)



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