343-346
| Substituted 1,2-Dihydrophthalazines: Potent, Selective, and Noncompetitive Inhibitors of the AMPA Receptor
Jeffrey C. Pelletier,
David P. Hesson,
Kenneth A. Jones, and
Anna-Maria Costa
[Full Article -
PDF] |
347-349
| (2S,3S,5R)-2-(3,5-Difluorophenyl)-3,5- dimethyl-2-morpholinol: A Novel Antidepressant Agent and Selective Inhibitor of Norepinephrine Uptake
James L. Kelley,
David L. Musso,
G. Evan Boswell,
Francis E. Soroko, and
Barrett R. Cooper
[Full Article -
PDF] |
350-352
| Two New Criteria for Choosing Sample Size in Combinatorial Chemistry
Peng-Liang Zhao,
Robert B. Nachbar,
James A. Bolognese, and
Kevin Chapman
[Full Article -
PDF] |
353-358
| Potent, Cell Active, Non-Thiol Tetrapeptide Inhibitors of Farnesyltransferase
John T. Hunt,
Ving G. Lee,
Katerina Leftheris,
Bernd Seizinger,
Joan Carboni,
John Mabus,
Carol Ricca,
Ning Yan, and
Veeraswamy Manne
[Full Article -
PDF] |
359-370
| Synthesis and Quantitative Structure-Activity Relationship of a Novel Series of Small Conductance Ca2+-Activated K+ Channel Blockers Related to Dequalinium
Dimitrios Galanakis,
Carole A. Davis,
C. Robin Ganellin, and
Philip M. Dunn
[Full Article -
PDF] |
371-379
| 2-Carbomethoxy-3-(diarylmethoxy)-1 H,5H-tropane Analogs: Synthesis and Inhibition of Binding at the Dopamine Transporter and Comparison with Piperazines of the GBR Series
Peter C. Meltzer,
Anna Y. Liang, and
Bertha K. Madras
[Full Article -
PDF] |
380-387
| A Comparative Molecular Field Analysis Study of N-Benzylpiperidines as Acetylcholinesterase Inhibitors
Weida Tong,
Elizabeth R. Collantes,
Yu Chen, and
William J. Welsh
[Full Article -
PDF] |
388-391
| A Study of the Active Site of Influenza Virus Sialidase: An Approach to the Rational Design of Novel Anti-influenza Drugs
Mark von Itzstein,
Jeffrey C. Dyason,
Stuart W. Oliver,
Hume F. White,
Wen-Yang Wu,
Gaik B. Kok, and
Michael S. Pegg
[Full Article -
PDF] |
392-397
| A Novel, Picomolar Inhibitor of Human Immunodeficiency Virus Type 1 Protease
Hing L. Sham,
Chen Zhao,
Kent D. Stewart,
David A. Betebenner,
Shuqun Lin,
Chang H. Park,
Xiang-P. Kong,
William Rosenbrook, Jr.,
Thomas Herrin,
Darold Madigan,
Suthida Vasavanonda,
Nicholas Lyons,
Akhter Molla,
Ayda Saldivar,
Kennan C. Marsh,
Edith McDonald,
Norman E. Wideburg,
Jon F. Denissen,
Terrel Robins,
Dale J. Kempf,
Jacob J. Plattner, and
Daniel W. Norbeck
[Full Article -
PDF] |
398-406
| Tetrahydrobenzothiophenone Derivatives as a Novel Class of Adenosine Receptor Antagonists
A. Michiel van Rhee,
Suhaib M. Siddiqi,
Neli Melman,
Dan Shi,
William L. Padgett,
John W. Daly, and
Kenneth A. Jacobson
[Full Article -
PDF] |
407-423
| Syntheses and Conformational Analyses of Glutamate Analogs: 2-(2-Carboxy-3-substituted-cyclopropyl)glycines as Useful Probes for Excitatory Amino Acid Receptors
Keiko Shimamoto and
Yasufumi Ohfune
[Full Article -
PDF] |
424-431
| Drug Delivery Systems: Water Soluble Taxol 2'-Poly(ethylene glycol) Ester Prodrugs-Design and in Vivo Effectiveness
Richard B. Greenwald,
Carl W. Gilbert,
Annapurna Pendri,
Charles D. Conover,
Jing Xia, and
Anthony Martinez
[Full Article -
PDF] |
432-435
| Characterizations of the Unusual Dissociation Properties of Melanotropin Peptides from the Melanocortin Receptor, hMC1R
Carrie Haskell-Luevano,
Hiroto Miwa,
Chris Dickinson,
Mac E. Hadley,
Victor J. Hruby,
Tadataka Yamada, and
Ira Gantz
[Full Article -
PDF] |
436-445
| Studies on 6-Aminoquinolones: Synthesis and Antibacterial Evaluation of 6-Amino-8-methylquinolones
Violetta Cecchetti,
Arnaldo Fravolini,
Maria Cristina Lorenzini,
Oriana Tabarrini,
Patrizia Terni, and
Tao Xin
[Full Article -
PDF] |
446-457
| The Chemistry of Pseudomonic Acid. Synthesis and Antibacterial Activity of a Series of 5-Alkyl, 5-Alkenyl, and 5-Heterosubstituted Oxazoles
Pamela Brown,
David T. Davies,
Peter J. O'Hanlon, and
Jennifer M. Wilson
[Full Article -
PDF] |
458-470
| Indium(III) and Gallium(III) Complexes of Bis(aminoethanethiol) Ligands with Different Denticities: Stabilities, Molecular Modeling, and in Vivo Behavior
Yizhen Sun,
Carolyn J. Anderson,
Tammy S. Pajeau,
David E. Reichert,
Robert D. Hancock,
Ramunas J. Motekaitis,
Arthur E. Martell, and
Michael J. Welch
[Full Article -
PDF] |
471-479
| Structure-Activity Analysis of Anandamide Analogs: Relationship to a Cannabinoid Pharmacophore
Brian F. Thomas,
Irma B. Adams,
S. Wayne Mascarella,
Billy R. Martin, and
Raj K. Razdan
[Full Article -
PDF] |
480-486
| Investigation of (Oxodioxolenyl)methyl Carbamates as Nonchiral Bioreversible Prodrug Moieties for Chiral Amines
Jose Alexander,
Dilbir S. Bindra,
Joan D. Glass,
Marie A. Holahan,
Mara L. Renyer,
Gerald S. Rork,
Gary R. Sitko,
Maria T. Stranieri,
Raymond F. Stupienski,
Hemalata Veerapanane, and
Jacquelynn J. Cook
[Full Article -
PDF] |
487-493
| Design, Synthesis, and Structure-Activity Relationship Studies of Novel 1-[(1-Acyl-4-piperidyl)methyl]-1H-2-methylimidazo[4,5-c]pyridine Derivatives as Potent, Orally Active Platelet-Activating Factor Antagonists
Elena Carceller,
Manuel Merlos,
Marta Giral,
Dolors Balsa,
Julián García-Rafanell, and
Javier Forn
[Full Article -
PDF] |
494-502
| Dual Metalloprotease Inhibitors. 6. Incorporation of Bicyclic and Substituted Monocyclic Azepinones as Dipeptide Surrogates in Angiotensin-Converting Enzyme/Neutral Endopeptidase Inhibitors
Jeffrey A. Robl,
Maria P. Cimarusti,
Ligaya M. Simpkins,
Baerbel Brown,
Denis E. Ryono,
J. Eileen Bird,
Magdi M. Asaad,
Thomas R. Schaeffer, and
Nick C. Trippodo
[Full Article -
PDF] |
503-507
| Metal-Chelating Inhibitors of a Zinc Finger Protein HIV-EP1. Remarkable Potentiation of Inhibitory Activity by Introduction of SH Groups
Mikako Fujita,
Masami Otsuka, and
Yukio Sugiura
[Full Article -
PDF] |
508-514
| Correlation of Anti-HIV Potency with Lipophilicity in a Series of Cosalane Analogs Having Normal Alkenyl and Phosphodiester Chains as Cholestane Replacements
Robert F. Keyes,
W. Marek Golebiewski, and
Mark Cushman
[Full Article -
PDF] |
515-521
| Neuroactive Polyamine Wasp Toxins: Nuclear Magnetic Resonance Spectroscopic Analysis of the Protolytic Properties of Philanthotoxin-343
Jerzy W. Jaroszewski,
Lisa Matzen,
Bente Fr lund, and
Povl Krogsgaard-Larsen
[Full Article -
PDF] |
522-530
| 2-Sulfonyl-4-chloroanilino Moiety: A Potent Pharmacophore for the Anti-Human Immunodeficiency Virus Type 1 Activity of Pyrrolyl Aryl Sulfones
Marino Artico,
Romano Silvestri,
Silvio Massa,
Anna G. Loi,
Simona Corrias,
Giovanna Piras, and
Paolo La Colla
[Full Article -
PDF] |
531-537
| Cross-Linking and Sequence Specific Alkylation of DNA by Aziridinylquinones. 1. Quinone Methides
Stephen P. Mayalarp,
Rob H. J. Hargreaves,
John Butler,
C. Caroline O'Hare, and
John A. Hartley
[Full Article -
PDF] |
538-542
| Synthesis and Antiviral Activity of 2'-Deoxy-4'-thio Purine Nucleosides
Nanine A. Van Draanen,
George A. Freeman,
Steven A. Short,
Robert Harvey,
Robert Jansen,
George Szczech, and
George W. Koszalka
[Full Article -
PDF] |
543-548
| N-Substituted Analogs of 2 -Carbomethoxy-3-(4'-iodophenyl)tropane (-CIT) with Selective Affinity to Dopamine or Serotonin Transporters in Rat Forebrain
John L. Neumeyer,
Gilles Tamagnan,
Shaoyin Wang,
Yigong Gao,
Richard A. Milius,
Nora S. Kula, and
Ross J. Baldessarini
[Full Article -
PDF] |
549-555
| 8,9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: A Potent Full Dopamine D1 Agonist Containing a Rigid -Phenyldopamine Pharmacophore
Debasis Ghosh,
Scott E. Snyder,
Val J. Watts,
Richard B. Mailman, and
David E. Nichols
[Full Article -
PDF] |
556-561
| Approaches to Short-Acting Neuromuscular Blocking Agents: Nonsymmetrical Bis-tetrahydroisoquinolinium Mono- and Diesters
Nirmal C. Dhar,
Robert B. Maehr,
Luke A. Masterson,
John M. Midgley,
John B. Stenlake, and
William B. Wastila
[Full Article -
PDF] |
562-569
| Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity. 1. Optimization of the Agonist "Trigger"
Christopher J. Aquino,
Duncan R. Armour,
Judd M. Berman,
Larry S. Birkemo,
Robin A. E. Carr,
Dallas K. Croom,
Milana Dezube,
Robert W. Dougherty, Jr.,
Gregory N. Ervin,
Mary K. Grizzle,
Julie E. Head,
Gavin C. Hirst,
Michael K. James,
Michael F. Johnson,
Laurence J. Miller,
Kennedy L. Queen,
Thomas J. Rimele,
David N. Smith, and
Elizabeth E. Sugg
[Full Article -
PDF] |
570-581
| Synthesis and Structure-Activity Relationships of N-Propyl-N-(4-pyridinyl)-1H-indol-1-amine (Besipirdine) and Related Analogs as Potential Therapeutic Agents for Alzheimer's Disease
Joseph T. Klein,
Larry Davis,
Gordon E. Olsen,
George S. Wong,
Francis P. Huger,
Craig P. Smith,
Wayne W. Petko,
Michael Cornfeldt,
Jeffrey C. Wilker,
R. D. Blitzer,
E. Landau,
V. Haroutunian,
Lawrence L. Martin, and
Richard C. Effland
[Full Article - PDF] |
582-587
| Substituted (Pyrroloamino)pyridines: Potential Agents for the Treatment of Alzheimer's Disease
Larry Davis,
Gordon E. Olsen,
Joseph T. Klein,
Kevin J. Kapples,
Francis P. Huger,
Craig P. Smith,
Wayne W. Petko,
Michael Cornfeldt, and
Richard C. Effland
[Full Article - PDF] |
588-595
| Ionophore Properties of Monensin Derivatives Studied on Human Erythrocytes by 23Na NMR and K+ and H+ Potentiometry: Relationship with Antimicrobial and Antimalarial Activities
Mohamed Rochdi,
Anne-Marie Delort,
Jacques Guyot,
Martine Sancelme,
Sylvie Gibot,
Jean-Gabriel Gourcy,
Gérard Dauphin,
Catherine Gumila,
Henri Vial, and
Georges Jeminet
[Full Article - PDF] |
596-604
| 2-[(2-Aminobenzyl)sulfinyl]-1-(2-pyridyl)-1,4,5,6-tetrahydrocyclopent[d]imidazoles as a Novel Class of Gastric H+/K+-ATPase Inhibitors
Masaki Yamada,
Takeshi Yura,
Masamichi Morimoto,
Tsunehiro Harada,
Koichiro Yamada,
Yasushi Honma,
Mine Kinoshita, and
Masaki Sugiura
[Full Article - PDF] |
605-608
| Antitumor Activity of the R- and S-Enantiomers of RS-2-[[Hydroxy[[2-[(octadecyloxy)methyl]tetrahydrofuran-2-yl]methoxy]phosphinyl]oxy]-N,N,N-trimethylethylaminium Hydroxide Inner Salt
William J. Houlihan,
Kapa Prasad,
Russell Underwood, and
Oljan Repi
, Paul G. Munder
[Full Article - PDF] |
609-613
| Aminoacetyl Moiety as a Potential Surrogate for Diacylhydrazine Group of SC-51089, a Potent PGE2 Antagonist, and Its Analogs
E. Ann Hallinan,
Timothy J. Hagen,
Sofya Tsymbalov,
Robert K. Husa,
Albert C. Lee,
Awilda Stapelfeld, and
Michael A. Savage
[Full Article - PDF] |
614-618
| Analogues of 10-Deazaaminopterin and 5-Alkyl-5,10-dideazaaminopterin with the 4-Substituted 1-Naphthoyl Group in the Place of 4-Substituted Benzoyl
James R. Piper,
Balakrishnan Ramamurthy,
Cheryl A. Johnson,
Glenys M. Otter, and
Francis M. Sirotnak
[Full Article - PDF] |
619-622
| Design, Synthesis, and Biological Activity of a Potent Inhibitor of the Neuropeptidase N-Acetylated -Linked Acidic Dipeptidase
Paul F. Jackson,
Derek C. Cole,
Barbara S. Slusher,
Susan L. Stetz,
Laurie E. Ross,
Bruce A. Donzanti, and
Diane Amy Trainor
[Full Article - PDF] |
623-623
| Ketenes Thomas T. Tidwell. John Wiley & Sons, Inc., New York. 1995. xv + 665 pp. 16.5 × 24.5 cm. ISBN 0-471-57580-1. $69.95.
Richard E. Mewshaw
[Full Article - PDF] |
623-623
| Books of Interest
[Full Article - PDF] |
623-623
| [Full Article - PDF] |
624-624
|
Bo enna Golankiewicz,
Piotr Januszczyk,
Satoru Ikeda,
Jan Balzarini, and
Erik De Clercq
[Full Article - PDF] |