625-656
| Nonpeptide Angiotensin II Receptor Antagonists: The Next Generation in Antihypertensive Therapy
Ruth R. Wexler,
William J. Greenlee,
John D. Irvin,
Michael R. Goldberg,
Kristine Prendergast,
Ronald D. Smith, and
Pieter B. M. W. M. Timmermans
[Full Article -
PDF] |
657-660
|  -Phosphonosulfonic Acids: Potent and Selective Inhibitors of Squalene Synthase
David R. Magnin,
Scott A. Biller,
Ying Chen,
John K. Dickson, Jr.,
Olga M. Fryszman,
R. Michael Lawrence,
Janette V. H. Logan,
Ellen S. Sieber-McMaster,
Richard B. Sulsky,
Sarah C. Traeger,
Dolly C. Hsieh,
Shih-Jung Lan,
J. Kent Rinehart,
Thomas W. Harrity,
Kern G. Jolibois,
Lori K. Kunselman,
Lois C. Rich,
Dorothy A. Slusarchyk, and
Carl P. Ciosek, Jr.
[Full Article -
PDF] |
661-664
| Orally Active Squalene Synthase Inhibitors: Bis((acyloxy)alkyl) Prodrugs of the -Phosphonosulfonic Acid Moiety
John K. Dickson, Jr.,
Scott A. Biller,
David R. Magnin,
Edward W. Petrillo, Jr.,
John W. Hillyer,
Dolly C. Hsieh,
Shih-Jung Lan,
J. Kent Rinehart,
Richard E. Gregg,
Thomas W. Harrity,
Kern G. Jolibois,
Stephen S. Kalinowski,
Lori K. Kunselman,
Kasim A. Mookhtiar, and
Carl P. Ciosek, Jr.
[Full Article -
PDF] |
665-668
| The Structure-Activity Relationship between Peroxisome Proliferator-Activated Receptor  Agonism and the Antihyperglycemic Activity of Thiazolidinediones
Timothy M. Willson,
Jeffery E. Cobb,
David J. Cowan,
Robert W. Wiethe,
Itzela D. Correa,
Shimoga R. Prakash,
Kelli D. Beck,
Linda B. Moore,
Steven A. Kliewer, and
Jürgen M. Lehmann
[Full Article -
PDF] |
669-672
| 2-Iminopiperidine and Other 2-Iminoazaheterocycles as Potent Inhibitors of Human Nitric Oxide Synthase Isoforms
William M. Moore,
R. Keith Webber,
Kam F. Fok,
Gina M. Jerome,
Jane R. Connor,
Pamela T. Manning,
Pamela S. Wyatt,
Thomas P. Misko,
Foe S. Tjoeng, and
Mark G. Currie
[Full Article -
PDF] |
673-679
| Synthesis and Antibacterial Activity of U-100592 and U-100766, Two Oxazolidinone Antibacterial Agents for the Potential Treatment of Multidrug-Resistant Gram-Positive Bacterial Infections
Steven J. Brickner,
Douglas K. Hutchinson,
Michael R. Barbachyn,
Peter R. Manninen,
Debra A. Ulanowicz,
Stuart A. Garmon,
Kevin C. Grega,
Susan K. Hendges,
Dana S. Toops,
Charles W. Ford, and
Gary E. Zurenko
[Full Article -
PDF] |
680-685
| Identification of a Novel Oxazolidinone (U-100480) with Potent Antimycobacterial Activity
Michael R. Barbachyn,
Douglas K. Hutchinson,
Steven J. Brickner,
Michael H. Cynamon,
James O. Kilburn,
Sally P. Klemens,
Suzanne E. Glickman,
Kevin C. Grega,
Susan K. Hendges,
Dana S. Toops,
Charles W. Ford, and
Gary E. Zurenko
[Full Article -
PDF] |
686-694
| Slow-Binding Inhibition of -Aminobutyric Acid Aminotransferase by Hydrazine Analogues
Eric S. Lightcap and
Richard B. Silverman
[Full Article -
PDF] |
695-704
| Quinazoline Antifolates Thymidylate Synthase Inhibitors: Lipophilic Analogues with Modification to the C2-Methyl Substituent
Laurent F. Hennequin,
F. Thomas Boyle,
J. Michael Wardleworth,
Peter R. Marsham,
Rosemary Kimbell, and
Ann L. Jackman
[Full Article -
PDF] |
705-712
| An Approach to Rapid Estimation of Relative Binding Affinities of Enzyme Inhibitors: Application to Peptidomimetic Inhibitors of the Human Immunodeficiency Virus Type 1 Protease
Vellarkad N. Viswanadhan,
M. Rami Reddy,
Alexander Wlodawer,
Michael D. Varney, and
John N. Weinstein
[Full Article -
PDF] |
713-719
| Water Soluble Inhibitors of Topoisomerase I: Quaternary Salt Derivatives of Camptothecin
Karen Lackey,
Daniel D. Sternbach,
Dallas K. Croom,
David L. Emerson,
Michael G. Evans,
Peter L. Leitner,
Michael J. Luzzio,
Gordon McIntyre,
Alain Vuong,
Julie Yates, and
Jeffrey M. Besterman
[Full Article -
PDF] |
720-728
| In Vivo Activity and Hydrophobicity of Cytostatic Aziridinyl Quinones
Ed E. Moret,
Mark de Boer,
Hans W. Hilbers,
Jan P. Tollenaere,
Lambert H. M. Janssen,
Joost J. M. Holthuis,
Reinoud J. Driebergen,
Willem Verboom, and
David N. Reinhoudt
[Full Article -
PDF] |
729-735
| Structure-Activity Relationships of the Quinolone Antibacterials against Mycobacteria: Effect of Structural Changes at N-1 and C-7
Thomas E. Renau,
Joseph P. Sanchez,
Jeffrey W. Gage,
Julie A. Dever,
Martin A. Shapiro,
Stephen J. Gracheck, and
John M. Domagala
[Full Article -
PDF] |
736-748
| 3-Aryl-1,2-diacetamidopropane Derivatives as Novel and Potent NK-1 Receptor Antagonists
Philip A. Hipskind,
J. Jeffry Howbert,
Robert F. Bruns,
Steven S. Y. Cho,
Thomas A. Crowell,
Mark M. Foreman,
Donald R. Gehlert,
Smriti Iyengar,
Kirk W. Johnson,
Joseph H. Krushinski,
Dominic L. Li,
Karen L. Lobb,
Norman R. Mason,
Brian S. Muehl,
James A. Nixon,
Lee A. Phebus,
Domenico Regoli,
Rosa M. Simmons,
Penny G. Threlkeld,
Diane C. Waters, and
Bruce D. Gitter
[Full Article -
PDF] |
749-756
| Structure-Activity Relationship Studies of Novel 4-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine Analogs: Synthesis and Biological Evaluation at the Dopamine and Serotonin Transporter Sites
Aloke K. Dutta,
Cen Xu, and
Maarten E. A. Reith
[Full Article -
PDF] |
757-772
| Structure-Activity Relationships of a New Family of Steroidal Aromatase Inhibitors. 1. Synthesis and Evaluation of a Series of Analogs Related to 19-[(Methylthio)methyl]androstenedione (RU54115)
Dominique Lesuisse,
Jean-François Gourvest,
Ouafae Benslimane,
Frank Canu,
Christine Delaisi,
Bernard Doucet,
Catherine Hartmann,
Jean-Michel Lefrançois,
Bernadette Tric,
Daniel Mansuy,
Daniel Philibert, and
Georges Teutsch
[Full Article -
PDF] |
773-780
| Design and Synthesis of 1-Aminocycloalkane-1-carboxylic Acid-Substituted Deltorphin Analogues: Unique  and  Opioid Activity in Modified Peptides
Angela Breveglieri,
Remo Guerrini,
Severo Salvadori,
Clementina Bianchi,
Sharon D. Bryant,
Martti Attila, and
Lawrence H. Lazarus
[Full Article -
PDF] |
781-788
| Interactions of Flavonoids and Other Phytochemicals with Adenosine Receptors
Xiao-duo Ji,
Neli Melman, and
Kenneth A. Jacobson
[Full Article -
PDF] |
789-795
| Synthesis and Anti-Herpes Virus Activity of 2'-Deoxy-4'-thiopyrimidine Nucleosides
S. George Rahim,
Naimisha Trivedi,
Mirjana V. Bogunovic-Batchelor,
George W. Hardy,
Gail Mills,
John W. T. Selway,
Wendy Snowden,
Edward Littler,
Paul L. Coe,
Ivan Basnak,
Robert F. Whale, and
Richard T. Walker
[Full Article -
PDF] |
796-801
| Antitumor 2-(Aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines
Krishnamurthy Shyam,
Philip G. Penketh,
Regina H. Loomis,
William C. Rose, and
Alan C. Sartorelli
[Full Article -
PDF] |
802-806
| Novel N6-(Substituted-phenylcarbamoyl)adenosine-5'-uronamides as Potent Agonists for A3 Adenosine Receptors
Pier Giovanni Baraldi,
Barbara Cacciari,
Giampiero Spalluto,
Xiao-duo Ji,
Mark E. Olah,
Gary Stiles,
Silvio Dionisotti,
Cristina Zocchi,
Ennio Ongini, and
Kenneth A. Jacobson
[Full Article -
PDF] |
807-807
| Taxol®: Science and Applications Edited by Matthew Suffness. CRC Press, Boca Raton, FL. 1995. 426 pp. 18.5 × 26 cm. ISBN 0-8493-8382-X. $129.95.
Iwao Ojima
[Full Article -
PDF] |
807-808
| Cancer Chemotherapeutic Agents William O. Foye, Editor. American Chemical Society, Washington, D.C. 1995. xx + 698 pp. 18.5 × 26 cm. ISBN 0-8412-2920-1. $149.95.
Robert W. Brueggemeier
[Full Article -
PDF] |
808-808
| Percutaneous Penetration Enhancers Edited by Eric W. Smith and Howard I. Maibach. CRC Press, New York. 1995. 500 pp. 16.5 × 24 cm. ISBN 0-8493-2605-2. $125.00.
Mark Chasin
[Full Article -
PDF] |
808-809
| CNS Neurotransmitters and Neuromodulators Glutamate Edited by Trevor W. Stone. CRC Press, Boca Raton, FL. 1995. 380 pp. 18.5 × 26 cm. ISBN 0-8493-7631-9. $159.95.
John Wm. Ferkany
[Full Article -
PDF] |
809-809
| Endothelin Receptors. From the Gene to the Human Edited by Robert R. Ruffolo, Jr. CRC Press Inc., Boca Raton, FL. 1995. 285 pp. 16 × 24 cm. ISBN 0-8493-5938-4. $169.95.
Wayne L. Cody
[Full Article -
PDF] |
809-809
| Antibiotics. A Multidisciplinary Approach By Giancarlo Lancini, Francesco Parenti, and Gian Gualberto Gallo. Plenum Press, New York. 1995. ix + 278 pp. 15.5 × 23.5 cm. ISBN 0-306-44924-2. $59.50.
Richard L. Elliott
[Full Article -
PDF] |
809-810
| Annual Reports in Medicinal Chemistry. Volume 30 Editor-in-Chief: James A. Bristol. Academic Press, Inc., San Diego, CA. 1995. xi + 387 pp. 17 × 25 cm. ISBN 0-12-040530-X. $70.00 (pbk).
Staff
[Full Article -
PDF] |