Journal of Medicinal Chemistry
Volume 39, Issue 4 (February 16, 1996)
Copyright © 1996 American Chemical Society

Click  [Full Article - PDF] to display or print the full article page image in PDF.

811-813

Bis(31/31'){[Cys31,Trp32,Nva34]NPY- (31-36)}: A Specific NPY Y-1 Receptor Antagonist A. Balasubramaniam, W. Zhai, S. Sheriff, Z. Tao, W. T. Chance, J. E. Fischer, P. Eden, and J. Taylor [Full Article - PDF]

814-816

(2S,4S)-2-Amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic Acid: A Potent and Selective Antagonist for Metabotropic Glutamate Receptors Negatively Linked to Adenylate Cyclase Camille G. Wermuth, André Mann, Angèle Schoenfelder, Rebecca A. Wright, Bryan G. Johnson, J. Paul Burnett, Nancy G. Mayne, and Darryle D. Schoepp [Full Article - PDF]

817-825

Novel 3-Pyridyl Ethers with Subnanomolar Affinity for Central Neuronal Nicotinic Acetylcholine Receptors Melwyn A. Abreo, Nan-Horng Lin, David S. Garvey, David E. Gunn, Ann-Marie Hettinger, James T. Wasicak, Patricia A. Pavlik, Yvonne C. Martin, Diana L. Donnelly-Roberts, David J. Anderson, James P. Sullivan, Michael Williams, Stephen P. Arneric, and Mark W. Holladay [Full Article - PDF]

826-833

In Vivo Biodistribution, Pharmacokinetic Parameters, and Brain Uptake of 5-Halo-6-methoxy(or ethoxy)-5,6-dihydro-3'-azido-3'-deoxythymidine Diastereomers as Potential Prodrugs of 3'-Azido-3'-deoxythymidine Lili Wang, Kevin W. Morin, Rakesh Kumar, Majid Cheraghali, Kathryn G. Todd, Glen B. Baker, Edward E. Knaus, and Leonard I. Wiebe [Full Article - PDF]

834-841

Tetrahydronaphthalenes: Influence of Heterocyclic Substituents on Inhibition of Steroidogenic Enzymes P450 arom and P450 17 Gerald A. Wächter, Rolf W. Hartmann, Tom Sergejew, Gertrud L. Grün, and Dorothea Ledergerber [Full Article - PDF]

842-849

Controlled Modification of Acidity in Cholecystokinin B Receptor Antagonists: N-(1,4-Benzodiazepin-3-yl)-N '-[3-(tetrazol-5-ylamino)phenyl]ureas José L. Castro, Richard G. Ball, Howard B. Broughton, Michael G. N. Russell, Denise Rathbone, Alan P. Watt, Raymond Baker, Kerry L. Chapman, Alan E. Fletcher, Smita Patel, Alison J. Smith, George R. Marshall, Wayne Ryecroft, and Victor G. Matassa [Full Article - PDF]

850-859

Comparative Molecular Field Analysis-Based Prediction of Drug Affinities at Recombinant D1A Dopamine Receptors Mi-Youn Kim Brusniak, Robert S. Pearlman, Kim A. Neve, and Richard E. Wilcox [Full Article - PDF]

860-872

Synthesis, Biological Evaluation, and Quantitative Receptor Docking Simulations of 2-[(Acylamino)ethyl]-1,4-benzodiazepines as Novel Tifluadom-like Ligands with High Affinity and Selectivity for -Opioid Receptors Andrea Cappelli, Maurizio Anzini, Salvatore Vomero, M. Cristina Menziani, Pier G. De Benedetti, Massimo Sbacchi, Geoffrey D. Clarke, and Laura Mennuni [Full Article - PDF]

873-880

Synthesis of Non-nucleoside Analogs of Toyocamycin, Sangivamycin, and Thiosangivamycin: Influence of Various 7-Substituents on Antiviral Activity Thomas E. Renau, Linda L. Wotring, John C. Drach, and Leroy B. Townsend [Full Article - PDF]

881-891

Structure-Activity Relationships among 2-Substituted 5,6-Dichloro-, 4,6-Dichloro-, and 4,5-Dichloro-1-[(2-hydroxyethoxy)methyl]- and -1-[(1,3-dihydroxy-2-propoxy)methyl]benzimidazoles Sunita Saluja, Ruiming Zou, John C. Drach, and Leroy B. Townsend [Full Article - PDF]

892-903

High-Affinity Inhibitors of Dihydrofolate Reductase: Antimicrobial and Anticancer Activities of 7,8-Dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with Small Molecular Size Lee F. Kuyper, David P. Baccanari, Michael L. Jones, Robert N. Hunter, Robert L. Tansik, Suzanne S. Joyner, Christine M. Boytos, Sharon K. Rudolph, Vince Knick, H. Robert Wilson, J. Marc Caddell, Henry S. Friedman, John C. W. Comley, and Jeremy N. Stables [Full Article - PDF]

904-917

Structure-Based Design of Lipophilic Quinazoline Inhibitors of Thymidylate Synthase Terence R. Jones, Michael D. Varney, Stephen E. Webber, Kathleen K. Lewis, Gifford P. Marzoni, Cindy L. Palmer, Vinit Kathardekar, Katharine M. Welsh, Stephanie Webber, David A. Matthews, Krzysztof Appelt, Ward W. Smith, Cheryl A. Janson, J. E. Villafranca, Russell J. Bacquet, Eleanor F. Howland, Carol L. J. Booth, Steven M. Herrmann, Robert W. Ward, Jennifer White, Ellen W. Moomaw, Charlotte A. Bartlett, and Cathy A. Morse [Full Article - PDF]

918-928

Tyrosine Kinase Inhibitors. 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor Gordon W. Rewcastle, Brian D. Palmer, Alexander J. Bridges, H. D. Hollis Showalter, Li Sun, James Nelson, Amy McMichael, Alan J. Kraker, David W. Fry, and William A. Denny [Full Article - PDF]

929-936

Highly Selective Bradykinin Agonists and Antagonists with Replacement of Proline Residues by N-Methyl-D- and L-phenylalanine Siegmund Reissmann, Carola Schwuchow, Lydia Seyfarth, Luis Felipe Pineda De Castro, Claus Liebmann, Inge Paegelow, Heinz Werner, and John M. Stewart [Full Article - PDF]

937-948

3- and 4-Substituted 4H-Pyrido[4,3-e]-1,2,4-thiadiazine 1,1-Dioxides as Potassium Channel Openers: Synthesis, Pharmacological Evaluation, and Structure-Activity Relationships Pascal de Tullio, Bernard Pirotte, Philippe Lebrun, Jeanine Fontaine, Léon Dupont, Marie-Hélène Antoine, Raogo Ouedraogo, Smail Khelili, Carine Maggetto, Bernard Masereel, Ousmane Diouf, Tchao Podona, and Jacques Delarge [Full Article - PDF]

949-956

Guanine, Pyrazolo[3,4-d]pyrimidine, and Triazolo[4,5-d]pyrimidine (8-Azaguanine) Phosphonate Acyclic Derivatives as Inhibitors of Purine Nucleoside Phosphorylase Lilia M. Beauchamp, Joel V. Tuttle, Martha E. Rodriguez, and Marcos L. Sznaidman [Full Article - PDF]

957-967

Azole Endothelin Antagonists. 1. A Receptor Model Explains an Unusual Structure-Activity Profile Thomas W. von Geldern, Charles Hutchins, Jeffrey A. Kester, Jinshyun R. Wu-Wong, William Chiou, Douglas B. Dixon, and Terry J. Opgenorth [Full Article - PDF]

968-981

Azole Endothelin Antagonists. 2. Structure-Activity Studies Thomas W. von Geldern, Jeffrey A. Kester, Radhika Bal, Jinshyun R. Wu-Wong, William Chiou, Douglas B. Dixon, and Terry J. Opgenorth [Full Article - PDF]

982-991

Azole Endothelin Antagonists. 3. Using log P as a Tool To Improve Absorption Thomas W. von Geldern, Daniel J. Hoffman, Jeffrey A. Kester, Hugh N. Nellans, Brian D. Dayton, Samuel V. Calzadilla, Kennan C. Marsh, Lisa Hernandez, William Chiou, Douglas B. Dixon, Jinshyun R. Wu-Wong, and Terry J. Opgenorth [Full Article - PDF]

992-998

Substituted 2,5'-Bi-1H-benzimidazoles: Topoisomerase I Inhibition and Cytotoxicity Jung Sun Kim, Barbara Gatto, Chiang Yu, Angela Liu, Leroy F. Liu, and Edmond J. LaVoie [Full Article - PDF]

999-1004

Homologs of Idoxifene: Variation of Estrogen Receptor Binding and Calmodulin Antagonism with Chain Length Ian R. Hardcastle, Martin G. Rowlands, Rachel M. Grimshaw, John Houghton, and Michael Jarman , Andrew Sharff and Stephen Neidle [Full Article - PDF]

1005-1008

Selectively Cytotoxic Diterpenes from Euphorbia poisonii Majekodunmi O. Fatope, Lu Zeng, Joseph E. Ohayaga, Guoen Shi, and Jerry L. McLaughlin [Full Article - PDF]

1009-1009

Synthesis and Applications of Isotopically Labelled Compounds 1994. Proceedings of the Fifth International Symposium, Strasbourg France, 20-24 June, 1994 Edited by J. Allen and R. Voges. John Wiley & Sons, New York. 1995. xxix + 935 pp. 15.5 × 23.5 cm. ISBN 0-471-95143-9. $199.95. Crist N. Filer [Full Article - PDF]

1009-1009

Oxidative Stress, Lipoproteins and Cardiovascular Dysfunction. Portland Press Research Monograph VII Edited by C. Rice-Evans and K. R. Bruckdorfer. Portland Press Ltd., London. 1995. xvi + 184 p. 15.5 × 23.5 cm. ISBN 1-85587-045-3. $96.00. Staff [Full Article - PDF]

1009-1010

Biochemistry of Redox Reactions By B. Testa. Academic Press, New York. 1995. xviii + 471 pp. 19.4 × 26.2 cm. ISBN 0-12-685391-6. $75.00. Neal Castagnoli, Jr. [Full Article - PDF]

1010-1010

The Logic of Chemical Synthesis By E. J. Corey and Xue-Min Cheng. John Wiley & Sons, Inc., New York. 1995. 436 pp. 18 × 25 cm. ISBN 0-471-11594-0. $24.95 (pbk). Robert S. Coleman [Full Article - PDF]

1010-1011

Fundamentals of Enzyme Kinetics. Revised Edition By Athel Cornish-Bowden. Portland Press, London. 1995. xiii + 343 pp. 17.5 cm × 24.5 cm. ISBN 1-85578-072-0. $29.00. Ariane Marolewski [Full Article - PDF]

1011-1011

New Perspectives in Drug Design Edited by P. M. Dean, G. Jolles, and C. G. Newton. Academic Press Inc., San Diego, CA. 1995. xiv + 321 pp. 15.5 × 23.5 cm. ISBN 0-12-208070-x. $50.00. Manfred E. Wolff [Full Article - PDF]

1011-1011

Biochemistry of Cell Membranes. A Compendium of Selected Topics Edited by S. Papa and J. M. Tager. Birkhauser Verlag, Basel, Switzerland. 1995. viii + 365 pp. 16 × 24 cm. ISBN 3-7643-5056-3. $149.00. Staff [Full Article - PDF]

1011-1012

The Golden Helix. Inside Biotech Ventures By Arthur Kornberg. University Science Books, Sausalito, CA. 1995. xi + 287 pp. 16 × 24 cm. ISBN 0-935702-32-6. $28.50. Staff [Full Article - PDF]

1012-1012

Diazo Chemistry By Heinrich Zollinger. VCH Verlagsgesellschaft mbH, Weinheim, Germany. I. Aromatic and Heteroaromatic Compounds. 1994. xiii + 453 pp. 17.5 × 24.5 cm. ISBN 3-527-29213-6. DM 198.00; II. Aliphatic, Inorganic and Organometallic Compounds. 1995. xvi + 522 pp. 17.5 × 24.5 cm. ISBN 3-527-29222-5. DM 174.00. Set ISBN 3-527-29328-0. DM 348.00. Staff [Full Article - PDF]