1013-1015
| N-Terminus Urea-Substituted Chemotactic Peptides: New Potent Agonists and Antagonists toward the Neutrophil fMLF Receptor
John D. Higgins, III,
Gary J. Bridger,
Claudia K. Derian,
Michael J. Beblavy,
Pedro E. Hernandez,
Forrest E. Gaul,
Michael J. Abrams,
Marilyn C. Pike, and
Howard F. Solomon
[Full Article -
PDF] |
1016-1017
| Betulinic Acid and Dihydrobetulinic Acid Derivatives as Potent Anti-HIV Agents
Yoshiki Kashiwada,
Fumio Hashimoto,
L. Mark Cosentino,
Chin-Ho Chen,
Patricia E. Garrett, and
Kuo-Hsiung Lee
[Full Article -
PDF] |
1018-1020
| Carbohydrates in an Acidic Multivalent Assembly: Nanomolar P-Selectin Inhibitors
Wayne Spevak,
Carrol Foxall,
Deborah H. Charych,
Falguni Dasgupta, and
Jon O. Nagy
[Full Article -
PDF] |
1021-1027
| 4'-O-[2-(2-Fluoromalonyl)]-L-tyrosine: A Phosphotyrosyl Mimic for the Preparation of Signal Transduction Inhibitory Peptides
Terrence R. Burke, Jr.,
Bin Ye,
Miki Akamatsu,
Harry Ford, Jr.,
Xinjian Yan,
Hemanta K. Kole,
Gert Wolf,
Steven E. Shoelson, and
Peter P. Roller
[Full Article -
PDF] |
1028-1032
| Structure-Activity Relationship for Antineoplastic Imidazoacridinones: Synthesis and Antileukemic Activity in Vivo
Wieslaw M. Cholody,
Barbara Horowska,
Jolanta Paradziej-Lukowicz,
Sante Martelli, and
Jerzy Konopa
[Full Article -
PDF] |
1033-1038
| Time-Dependent Inactivation of Aromatase by 6-Alkylandrosta-1,4-diene-3,17-diones. Effects of Length and Configuration of the 6-Alkyl Group
Mitsuteru Numazawa,
Mariko Oshibe,
Satoshi Yamaguchi, and
Mii Tachibana
[Full Article -
PDF] |
1039-1048
| 2,4-Diarylpyrrolidine-3-carboxylic Acids-Potent ETA Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722
Martin Winn,
Thomas W. von Geldern,
Terry J. Opgenorth,
Hwan-Soo Jae,
Andrew S. Tasker,
Steven A. Boyd,
Jeffrey A. Kester,
Robert A. Mantei,
Radhika Bal,
Bryan K. Sorensen,
Jinshyun R. Wu-Wong,
William J. Chiou,
Douglas B. Dixon,
Eugene I. Novosad,
Lisa Hernandez, and
Kennan C. Marsh
[Full Article -
PDF] |
1049-1055
| Bisindolylmaleimides Linked to DNA Minor Groove Binding Lexitropsins: Synthesis, Inhibitory Activity against Topoisomerase I, and Biological Evaluation
Guojian Xie,
Rajan Gupta,
Kevin Atchison, and
J. William Lown
[Full Article -
PDF] |
1056-1068
| Betulinic Acid Derivatives: A New Class of Human Immunodeficiency Virus Type 1 Specific Inhibitors with a New Mode of Action
Michel Evers,
Christèle Poujade,
Françoise Soler,
Yves Ribeill,
Claude James,
Yves Lelièvre,
Jean-Christophe Gueguen,
Daniel Reisdorf,
Isabelle Morize,
Rudi Pauwels,
Erik De Clercq,
Yvette Hénin,
Anne Bousseau,
Jean-François Mayaux,
Jean-Bernard Le Pecq, and
Norbert Dereu
[Full Article -
PDF] |
1069-1083
| Betulinic Acid Derivatives: A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1 Entry
Françoise Soler,
Christèle Poujade,
Michel Evers,
Jean-Christophe Carry,
Yvette Hénin,
Anne Bousseau,
Thierry Huet,
Rudi Pauwels,
Erik De Clercq,
Jean-François Mayaux,
Jean-Bernard Le Pecq, and
Norbert Dereu
[Full Article -
PDF] |
1084-1094
| Hypoxia-Selective Antitumor Agents. 12. Nitrobenzyl Quaternary Salts as Bioreductive Prodrugs of the Alkylating Agent Mechlorethamine
Moana Tercel,
William R. Wilson,
Robert F. Anderson, and
William A. Denny
[Full Article -
PDF] |
1095-1099
| Toward a Novel Metal-Based Chemotherapy against Tropical Diseases. 2. Synthesis and Antimalarial Activity in Vitro and in Vivo of New Ruthenium- and Rhodium-Chloroquine Complexes
Roberto A. Sánchez-Delgado,
Maribel Navarro,
Hilda Pérez, and
Julio A. Urbina
[Full Article -
PDF] |
1100-1105
| New Mustard Prodrugs for Antibody-Directed Enzyme Prodrug Therapy: Alternatives to the Amide Link
Robert I. Dowell,
Caroline J. Springer,
David H. Davies,
Elizabeth M. Hadley,
Philip J. Burke,
F. Thomas Boyle,
Roger G. Melton,
Thomas A. Connors,
David C. Blakey, and
Anthony B. Mauger
[Full Article -
PDF] |
1106-1111
| Studies on the Mechanism of Phosphatidylinositol 3-Kinase Inhibition by Wortmannin and Related Analogs
Bryan H. Norman,
Chuan Shih,
John E. Toth,
James E. Ray,
Jeffrey A. Dodge,
Doug W. Johnson,
Pamela G. Rutherford,
Richard M. Schultz,
John F. Worzalla, and
Chris J. Vlahos
[Full Article -
PDF] |
1112-1124
| Nonpeptidic Inhibitors of Human Neutrophil Elastase. 7. Design, Synthesis, and in Vitro Activity of a Series of Pyridopyrimidine Trifluoromethyl Ketones
Philip D. Edwards,
Donald W. Andisik,
Anne M. Strimpler,
Bruce Gomes, and
Paul A. Tuthill
[Full Article -
PDF] |
1125-1129
| 8-[4-[2-(1,2,3,4-Tetrahydroisoquinolinyl)]butyl]-8-azaspiro[4.5]decane-7,9-dione: A New 5-HT1A Receptor Ligand with the Same Activity Profile as Buspirone
Jerzy L. Mokrosz,
Anna Dere -Weso ek,
Ewa Tatarczyska,
Beata Duszyska,
Andrzej J. Bojarski,
Maria J. Mokrosz, and
Ewa Chojnacka-Wójcik
[Full Article -
PDF] |
1130-1135
| Synthesis and Biological Evaluation of 1',2'-Seconucleo-5'-phosphonates
Saibaba Racha,
Chandra Vargeese,
Purushotham Vemishetti,
Hussein I. El-Subbagh,
Elie Abushanab, and
Raymond P. Panzica
[Full Article -
PDF] |
1136-1141
| Design, Synthesis, and Biological Activities of Cyclic Lactam Peptide Analogues of Dynorphin A(1-11)-NH2
Feng-Di T. Lung,
Nathan Collins,
Dagmar Stropova,
Peg Davis,
Henry I. Yamamura,
Frank Porreca, and
Victor J. Hruby
[Full Article -
PDF] |
1142-1147
| Antagonistic Properties of Centrally Truncated Analogs of [D-Trp32]NPY
A. Balasubramaniam,
M. Ujhelyi,
M. Borchers,
Y. Huang,
W. Zhai,
Y. Zhou,
M. Johnson,
S. Sheriff, and
J. E. Fischer
[Full Article -
PDF] |
1148-1156
| Nitric Oxide-Releasing Polymers Containing the [N(O)NO]- Group
Daniel J. Smith,
Debashish Chakravarthy,
Sharon Pulfer,
Maia L. Simmons,
Joseph A. Hrabie,
Michael L. Citro,
Joseph E. Saavedra,
Keith M. Davies,
Thomas C. Hutsell,
Daniel L. Mooradian,
Stephen R. Hanson, and
Larry K. Keefer
[Full Article -
PDF] |
1157-1163
| Novel Carbamates as Potent Histamine H3 Receptor Antagonists with High in Vitro and Oral in Vivo Activity
Holger Stark,
Katja Purand,
Xavier Ligneau,
Agnès Rouleau,
Jean-Michel Arrang,
Monique Garbarg,
Jean-Charles Schwartz, and
Walter Schunack
[Full Article -
PDF] |
1164-1171
| Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives: Potent and Selective A2A Adenosine Antagonists
Pier Giovanni Baraldi,
Barbara Cacciari,
Giampiero Spalluto,
Maria José Pineda de las Infantas y Villatoro,
Cristina Zocchi,
Silvio Dionisotti, and
Ennio Ongini
[Full Article -
PDF] |
1172-1188
| Structure-Activity Relationships of a Series of Substituted Benzamides: Potent D2/5-HT2 Antagonists and 5-HT1a Agonists as Neuroleptic Agents
Mark H. Norman,
Greg C. Rigdon,
William R. Hall, and
Frank Navas III
[Full Article -
PDF] |
1189-1189
| Peptide-Based Drug Design: Controlling Transport and Metabolism Editors: Michael D. Taylor and Gordon L. Amidon. American Chemical Society, Washington, D.C. 1995. xviii + 567 pp. 18.5 × 26 cm. ISBN 0-8412-3058-7. $99.95.
Richard S. Pottorf
[Full Article -
PDF] |
1189-1190
| Exploring QSAR: Hydrophobic, Electronic, and Steric Constants C. Hansch, A. Leo, and D. Hoekman. American Chemical Society, Washington, DC. 1995. Xix + 348 pp. 22 × 28.5 cm. Exploring QSAR: Fundamentals and Applications in Chemistry and Biology. C. Hansch and A. Leo. American Chemical Society, Washington, DC. 1995. Xvii + 557 pp. 18.5 × 26 cm. ISBN 0-8412-2993-7 (set). $99.95 (set).
Yvonne Connolly Martin
[Full Article -
PDF] |
1190-1190
| Heterocyclic Compounds. Isoquinolines. Volume 38. Part 3 Edited by Gary M. Coppola and Herbert F. Schuster. John Wiley & Sons, Inc., New York. 1995. xi + 552 pp. 16 × 24 cm. ISBN 0-471-62853-7. $225.00.
Stephen T. Ross
[Full Article -
PDF] |
1190-1191
| Angiotensin II Receptors Volume 1. Molecular Biology, Biochemistry, and Clinical Perspectives Edited by Robert R. Ruffolo, Jr. CRC Press, Boca Raton, FL. 1994. 170 pp. 16 × 24 cm. ISBN 0-8493-8380-3. $99.50; Volume 2. Medicinal Chemistry. 1994. 225 pp. 16 × 24 cm. ISBN 0-8493-8545-3. $99.50.
David J. Carini
[Full Article -
PDF] |
1191-1191
| Books of Interest
[Full Article -
PDF] |
1191-1191
| [Full Article -
PDF] |
1192-1192
| 4-Aza-3-oxo-5 -androst-1-ene-17 -N-arylcarboxamides as Dual Inhibitors of Human Type 1 and Type 2 Steroid 5-Reductases. Dramatic Effect of N-Aryl Substituents on Type 1 and Type 2 5-Reductase Inhibitory Potency
Raman K. Bakshi,
Gary H. Rasmusson,
Gool F. Patel,
Ralph T. Mosley,
Benedict Chang,
Kenneth Ellsworth,
Georgianna S. Harris, and
Richard L. Tolman
[Full Article -
PDF] |