1345-1348
| 2-Substituted Piperazines as Constrained Amino Acids. Application to the Synthesis of Potent, Non Carboxylic Acid Inhibitors of Farnesyltransferase
Theresa M. Williams,
Terrence M. Ciccarone,
Suzanne C. MacTough,
Rhonda L. Bock,
Michael W. Conner,
Joseph P. Davide,
Kelly Hamilton,
Kenneth S. Koblan,
Nancy E. Kohl,
Astrid M. Kral,
Scott D. Mosser,
Charles A. Omer,
David L. Pompliano,
Elaine Rands,
Michael D. Schaber,
Daksha Shah,
Francine R. Wilson,
Jackson B. Gibbs,
Samuel L. Graham,
George D. Hartman,
Allen I. Oliff, and
Robert L. Smith
[Full Article -
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1349-1351
| Active Site Directed Inhibition of Estrone Sulfatase by Nonsteroidal Coumarin Sulfamates
L. W. Lawrence Woo,
Atul Purohit,
Michael J. Reed, and
Barry V. L. Potter
[Full Article -
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1352-1356
| Geranylgeranyl Diphosphate-Based Inhibitors of Post-Translational Geranylgeranylation of Cellular Proteins
Marco Macchia,
Nicoletta Jannitti,
Gianbattista Gervasi, and
Romano Danesi
[Full Article -
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1357-1360
| Ligand Interactions with E-Selectin. Identification of a New Binding Site for Recognition of N-Acyl Aromatic Glucosamine Substituents of Sialyl Lewis X
John Y. Ramphal,
Mariann Hiroshige,
Boliang Lou,
John J. Gaudino,
Masaji Hayashi,
Shiow Meei Chen,
Lin C. Chiang,
Federico C. A. Gaeta, and
Shawn A. DeFrees
[Full Article -
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1361-1371
| Somatostatin Receptor-Binding Peptides Labeled with Technetium-99m: Chemistry and Initial Biological Studies
Daniel A. Pearson,
John Lister-James,
William J. McBride,
David M. Wilson,
Lawrence J. Martel,
Edgar R. Civitello,
John E. Taylor,
Brian R. Moyer, and
Richard T. Dean
[Full Article -
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1372-1382
| Thrombus Imaging Using Technetium-99m-Labeled High-Potency GPIIb/IIIa Receptor Antagonists. Chemistry and Initial Biological Studies
Daniel A. Pearson,
John Lister-James,
William J. McBride,
David M. Wilson,
Lawrence J. Martel,
Edgar R. Civitello, and
Richard T. Dean
[Full Article -
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1383-1395
| Antitumor Agents. 163. Three-Dimensional Quantitative Structure-Activity Relationship Study of 4'-O-Demethylepipodophyllotoxin Analogs Using the Modified CoMFA/q2-GRS Approach
Sung Jin Cho,
Alexander Tropsha,
Matthew Suffness,
Yung-Chi Cheng, and
Kuo-Hsiung Lee
[Full Article -
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1396-1402
| Antitumor Agents. 164. Podophenazine, 2'',3''-Dichloropodophenazine, Benzopodophenazine, and Their 4 -p-Nitroaniline Derivatives as Novel DNA Topoisomerase II Inhibitors
Sung Jin Cho,
Yoshiki Kashiwada,
Kenneth F. Bastow,
Yung-Chi Cheng, and
Kuo-Hsiung Lee
[Full Article -
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1403-1412
| Nucleoside Analogs. 14. The Synthesis and Antitumor Activity in Mice of Molecular Combinations of 5-Fluorouracil and N-(2-Chloroethyl)-N-nitrosourea Moieties Separated by a Three-Carbon Chain
R. Stanley McElhinney,
Joan E. McCormick,
Mike C. Bibby,
John A. Double,
Marco Radacic, and
Patrick Dumont
[Full Article -
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1413-1422
| The Squalestatins: Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in Vivo Evaluation of C3-Modified Analogues
Panayiotis A. Procopiou,
Brian Cox,
Barrie E. Kirk,
Michael G. Lester,
Alun D. McCarthy,
Meenu Sareen,
Peter J. Sharratt,
Michael A. Snowden,
Stephen J. Spooner,
Nigel S. Watson, and
Julia Widdowson
[Full Article -
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1423-1432
| Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) Inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as Potent Inhibitors of ACAT
Peter C. Astles,
Michael J. Ashton,
Andrew W. Bridge,
Neil V. Harris,
Terrance W. Hart,
David P. Parrott,
Barry Porter,
David Riddell,
Christopher Smith, and
Robert J. Williams
[Full Article -
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1433-1437
| Synthesis and Hypolipidemic Activities of Novel 2-[4-[(Diethoxyphosphoryl)methyl]phenyl]quinazolines and 4(3H)-Quinazolinones
Yasuhisa Kurogi,
Yasuhide Inoue,
Kazuhiko Tsutsumi,
Shizuo Nakamura,
Kazushi Nagao,
Hiroki Yoshitsugu, and
Yoshihiko Tsuda
[Full Article -
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1438-1446
| 2,4-Diamino-5-deaza-6-Substituted Pyrido[2,3-d]pyrimidine Antifolates as Potent and Selective Nonclassical Inhibitors of Dihydrofolate Reductases
Aleem Gangjee,
Anil Vasudevan,
Sherry F. Queener, and
Roy L. Kisliuk
[Full Article -
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1447-1451
| Synthesis and Cytotoxicity of 1,2-Disubstituted Naphth[2,3-d]imidazole-4,9-diones and Related Compounds
Sheng-Chu Kuo,
Toshiro Ibuka,
Li-Jiau Huang,
Jin-Cherng Lien,
Shyue-Ren Yean,
Shung-Chieh Huang,
Daniel Lednicer,
Susan Morris-Natschke, and
Kuo-Hsiung Lee
[Full Article -
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1452-1462
| Synthesis and DNA Interactions of Benzimidazole Dications Which Have Activity against Opportunistic Infections
Richard L. Lombardy,
Farial A. Tanious,
Kishore Ramachandran,
Richard R. Tidwell, and
W. David Wilson
[Full Article -
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1463-1471
| N6,C8-Disubstituted Adenosine Derivatives as Partial Agonists for Adenosine A1 Receptors
Harlof Roelen,
Nora Veldman,
Anthony L. Spek,
Jacobien von Frijtag Drabbe Künzel,
Ron A. A. Mathôt, and
Ad P. IJzerman
[Full Article -
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1472-1484
| Bradykinin Receptor Antagonists Containing N-Substituted Amino Acids: In Vitro and in Vivo B2 and B1 Receptor Antagonist Activity
Val S. Goodfellow,
Manoj V. Marathe,
Karen G. Kuhlman,
Timothy D. Fitzpatrick,
David Cuadrado,
Wendy Hanson,
John S. Zuzack,
Sherman E. Ross,
Maciej Wieczorek,
Michael Burkard, and
Eric T. Whalley
[Full Article -
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1485-1493
| trans-2-Aryl-N,N-dipropylcyclopropylamines: Synthesis and Interactions with 5-HT1A Receptors
Jerk Vallgårda,
Ulf Appelberg,
Lars-Erik Arvidsson,
Stephan Hjorth,
Björn E. Svensson, and
Uli Hacksell
[Full Article -
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1494-1508
| Influence of Glutathione on the Oxidation of 1-Methyl-6-hydroxy- 1,2,3,4-tetrahydro--carboline: Chemistry of Potential Relevance to the Addictive and Neurodegenerative Consequences of Ethanol Abuse
Qing-Ping Han and
Glenn Dryhurst
[Full Article -
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1509-1513
| Synthesis and Evaluation of N-(Phenylacetyl)trifluoromethanesulfonamides as Anticonvulsant Agents
Patrick T. Flaherty,
Thomas D. Greenwood,
Amy L. Manheim, and
James F. Wolfe
[Full Article -
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1514-1520
| A Structure-Activity Relationship Study of Novel Phenylacetamides Which Are Sodium Channel Blockers
Ioannis Roufos,
Sheryl Hays, and
Roy D. Schwarz
[Full Article -
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1521-1530
| Evolutionary Optimization in Quantitative Structure-Activity Relationship: An Application of Genetic Neural Networks
Sung-Sau So and
Martin Karplus
[Full Article -
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1531-1539
| A Possible Involvement of Solvent-Induced Interactions in Drug Design
Hongwu Wang and
Arieh Ben-Naim
[Full Article -
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1540-1544
| Synthesis and Evaluation of a Boronated Nitroimidazole for Boron Neutron Capture Therapy
David H. Swenson,
Brenda H. Laster, and
Robert L. Metzger
[Full Article -
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1545-1548
| Synthesis and Evaluation of the Antiproliferative Effects of 1-O-Hexadecyl-2-O- methyl-3-O-(2'-acetamido-2'-deoxy--D-glucopyranosyl)-sn-glycerol and 1-O-Hexadecyl-2-O-methyl-3-O-(2'-amino-2'-deoxy--D-glucopyranosyl)-sn-glycerol on Epithelial Cancer Cell Growth
Ravi Kumar Erukulla,
Xi Zhou,
Pranati Samadder,
Gilbert Arthur, and
Robert Bittman
[Full Article -
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1549-1554
| Inhibition of Human Glutathione Reductase by 10-Arylisoalloxazines: Crystallographic, Kinetic, and Electrochemical Studies
Annette Schönleben-Janas,
Peer Kirsch,
Peer R. E. Mittl,
R. Heiner Schirmer, and
R. Luise Krauth-Siegel
[Full Article -
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1555-1559
| NMR and Molecular Modeling Study of the Conformations of Taxol 2'-Acetate in Chloroform and Aqueous Dimethyl Sulfoxide Solutions
Howard J. Williams,
Guillermo Moyna, and
A. I. Scott
, Charles S. Swindell,
Lisa E. Chirlian,
Julia M. Heerding, and
David K. Williams
[Full Article -
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1560-1563
| Synthesis and Ligand Binding of h6-(2-Carbomethoxy-3-phenyltropane) Transition Metal Complexes
Blake Aronson,
Jennifer L. Enmon,
Sari Izenwasser,
Jonathan L. Katz,
Shreekrishna V. Kelkar,
Lubin Luo,
Steven P. Nolan, and
Mark L. Trudell
[Full Article -
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1564-1564
| The Year's Drug News. Therapeutic Targets. 1995 Edition Edited by J. R. Prous. J. R. Prous Scientific Publishers, Barcellona, Spain, and Philadelphia, PA. 1995. xxv + 743 pp. 22 × 28 cm. ISBN 84-8124-090-7. $250.00.
Staff
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1564-1565
| Container Molecules and their Guests By Donald J. Cram and Jane M. Cram. The Royal Society of Chemistry. London. xiv + 224 pp. 16 × 24 cm. 1994. ISBN 0-85186-972-6.  49.50.
George W. Gokel
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1565-1565
| Biomolecular NMR Spectroscopy Jeremy N. S. Evans. Oxford University Press. New York. 1994. xvi + 444 pp. 19 × 25 cm. ISBN 0-19-854767-6. $85.00.
Rickey P. Hicks
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1565-1566
| Molecular Biology and Biotechnology. A Comprehensive Desk Reference Edited by Robert A. Meyers. VCH Publishers. New York. 1995. xxxviii + 1034 pp. 21.5 × 27.5 cm. ISBN 1-56081-925-1. $59.95.
John Wm. Ferkany
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1566-1567
| Dictionary of Organic Compounds. Sixth Edition Editorial Board: J. I. G. Cadogan, S. V. Levy, G. Pattenden, R. A. Raphael, and C. W. Rees. Chapman & Hall, London. 1995. 21 × 29 cm. Volumes 1-6. A-Z. xxiii + 6515 pp. Volume 7. Name Index. 914 pp. Volume 8. Molecular Formula Index. 799 pp. Volume 9. CAS Registry Number Index. 825 pp. ISBN 0-412-54090-8 (Nine Volume Set). 3250.00. The Organic Chemist's Desk Reference. A Companion Volume to the Dictionary of Organic Compounds, Sixth Edition. By. R. H. Rhodes. Chapman & Hall, London. 1995. vii + 170 pp. 19 × 25 cm. ISBN 0-412-54100-9 (pbk). 12.99. 0-412-64410-X (hb).
Staff
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1567-1567
| Second Supplements to the Second Edition of Rodd's Chemistry of Carbon Compounds. Volume III: Aromatic Compounds. Part B: Benzoquinones and Related Compounds: Derivatives of Mononuclear Benzenoid Hydrocarbons with Nuclear Substituents Attached through an Element other than the Non-Metals in Groups VI and VII of the Periodic Table; Part C: Nuclear-substituted Benzenoid Hydrocarbons with more than One Nitrogen Atom on a Substituent Group; Part D (partial): Monobenzenoid and Phenolic Aralkyl Compounds, their Derivatives and Oxidation Products: Depsides, Tannins, Lignans, Lignin and Humic Acid (Chapter 12 in this volume) Edited by M. Sainsbury. Elsevier, Amsterdam. 1995. xiv + 368 pp. 15.5 × 23 cm. ISBN 0-444-82242-9. $211.75.
Staff
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1567-1567
| Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds. Supplement to Volume IV. Heterocyclic Compounds. Part I. Six-Membered Heterocyclic Compounds with Two-Hetero-Atoms from Group V of the Periodic Table: the Pyridazine and Pyrimidine Groups. Part J. Six-Membered Heterocyclic Compounds with Two-Hetero-Atoms from Group V of the Periodic Table: the Pyrazine Group, Phenoxazine, Phenothiazine, Phenazine and Sulphur Dyes. Six-Membered Heterocyclic Compounds with Three or More Hetero-Atoms Edited by Martin F. Ansell. Elsevier, Amsterdam. 1995. xvii + 302 pp. 17 × 23 cm. ISBN 0-444-82260-7. $197.00.
Staff
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1567-1568
| Principles of Medicinal Chemistry, 4th Edition Edited by William O. Foye, Thomas L. Lemke, and David A. Williams. Williams and Wilkins, Philadelphia, PA. 1995. xii + 995 pp. 22 × 28.5 cm. ISBN 0-683-03323-9. $70.00.
Manfred E. Wolff
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1568-1568
| Understanding Medications. What the Label Doesn't Tell You By Alfred Burger. American Chemical Society, Washington, D.C. 1995. xiv + 206 pp. 16 × 23.5 cm. ISBN 0-8412-3210-5 (hc). $39.95. ISBN 0-8412-3246-6 (pbk). $19.95.
Carl Kaiser
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1568-1569
| Reviews in Computational Chemistry. Volume 5 Edited by Kenny B. Lipkowitz and Donald B. Boyd. VCH Publishers. New York. 1994. xxi + 458 pp. 16.5 × 24 cm. ISBN 1-56081-658-9. $110.00.
Lemont B. Kier
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1569-1569
| Drug Discovery-a pharmacists story By Ivan Östholm. Swedish Pharmaceutical Press, Stockholm, Sweden. 1995. 215 pp. 15.5 × 22 cm. ISBN 91-86274-62-7. SEK 200.00.
Staff
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1569-1569
| Carbohydrate Building Blocks By Mikael Bols. John Wiley & Sons, Inc., New York. 1995. ix + 182 pp. 16 × 23.5 cm. ISBN 0-471-13339-6. $39.95.
Janice R. Sufrin
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1569-1570
| Books of Interest
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