Journal of Medicinal Chemistry
Volume 39, Issue 12 (June 7, 1996)
Copyright © 1996 American Chemical Society

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2281-2284

2-Phenyl-4-quinolinecarboxamides: A Novel Class of Potent and Selective Non-Peptide Competitive Antagonists for the Human Neurokinin-3 Receptor Giuseppe A. M. Giardina, Henry M. Sarau, Carlo Farina, Andrew D. Medhurst, Mario Grugni, James J. Foley, Luca F. Raveglia, Dulcie B. Schmidt, Roberto Rigolio, Marco Vassallo, Vittorio Vecchietti, and Douglas W. P. Hay [Full Article - PDF]

2285-2292

4-(Phenylamino)pyrrolopyrimidines: Potent and Selective, ATP Site Directed Inhibitors of the EGF-Receptor Protein Tyrosine Kinase Peter M. Traxler, Pascal Furet, Helmut Mett, Elisabeth Buchdunger, Thomas Meyer, and Nicholas Lydon [Full Article - PDF]

2293-2301

Synthesis and Biological Activities of Flavonoid Derivatives as A3 Adenosine Receptor Antagonists Yishai Karton, Ji-long Jiang, Xiao-duo Ji, Neli Melman, Mark E. Olah, Gary L. Stiles, and Kenneth A. Jacobson [Full Article - PDF]

2302-2312

Structural and Stereoelectronic Requirements for the Inhibition of Mammalian 2,3-Oxidosqualene Cyclase by Substituted Isoquinoline Derivatives Martine M. Barth, Jean L. Binet, Didier M. Thomas, Daniel C. de Fornel, Soth Samreth, Francis J. Schuber, and Patrice P. Renaut [Full Article - PDF]

2313-2330

Synthesis and Structure-Activity Relationships of 2-Substituted D-Tryptophan-Containing Peptidic Endothelin Receptor Antagonists: Importance of the C-2 Substituent of the D-Tryptophan Residue for Endothelin A and B Receptor Subtype Selectivity Takehiro Fukami, Takeru Yamakawa, Kenji Niiyama, Hisaki Kojima, Yuuka Amano, Fuyuko Kanda, Satoshi Ozaki, Takahiro Fukuroda, Masaki Ihara, Mitsuo Yano, and Kiyofumi Ishikawa [Full Article - PDF]

2331-2338

Ryanodine Action at Calcium Release Channels. 1. Importance of Hydroxyl Substituents Phillip R. Jefferies, Todd A. Blumenkopf, Peter J. Gengo, Loretta C. Cole, and John E. Casida [Full Article - PDF]

2339-2346

Ryanodine Action at Calcium Release Channels. 2. Relation to Substituents of the Cyclohexane Ring Phillip R. Jefferies, Peter J. Gengo, Michael J. Watson, and John E. Casida [Full Article - PDF]

2347-2353

Aristeromycin-5'-carboxaldehyde: A Potent Inhibitor of S-Adenosyl- L-homocysteine Hydrolase Siming Liu, Chong-sheng Yuan, and Ronald T. Borchardt [Full Article - PDF]

2354-2366

Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. Synthesis and Pharmacological Activity of (±)-2-Dodecyl--phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5-acetamide and Structurally Related Tetrazole Amide Derivatives Patrick M. O'Brien, Drago R. Sliskovic, Joseph A. Picard, Helen T. Lee, Claude F. Purchase, II, Bruce D. Roth, Andrew D. White, Maureen Anderson, Sandra Bak Mueller, Thomas Bocan, Richard Bousley, Katherine L. Hamelehle, Reynold Homan, Peter Lee, Brian R. Krause, J. F. Reindel, Richard L. Stanfield, and Daniel Turluck [Full Article - PDF]

2367-2378

Mapping the Aspartic Acid Binding Site of Escherichia coli Asparagine Synthetase B Using Substrate Analogs Ian B. Parr, Susan K. Boehlein, Anthony B. Dribben, Sheldon M. Schuster, and Nigel G. J. Richards [Full Article - PDF]

2379-2391

New Prolyl Endopeptidase Inhibitors: In Vitro and in Vivo Activities of Azabicyclo[2.2.2]octane, Azabicyclo[2.2.1]heptane, and Perhydroindole Derivatives Bernard Portevin, Alain Benoist, Georges Rémond, Yolande Hervé, Michel Vincent, Jean Lepagnol, and Guillaume De Nanteuil [Full Article - PDF]

2392-2399

New Neplanocin Analogues. 6. Synthesis and Potent Antiviral Activity of 6'-Homoneplanocin A Satoshi Shuto, Takumi Obara, Yasuyoshi Saito, Graciela Andrei, Robert Snoeck, Erik De Clercq, and Akira Matsuda [Full Article - PDF]

2400-2410

Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors Suvit Thaisrivongs, Musiri N. Janakiraman, Kong-Teck Chong, Paul K. Tomich, Lester A. Dolak, Steve R. Turner, Joseph W. Strohbach, Janet C. Lynn, Miao-Miao Horng, Roger R. Hinshaw, and Keith D. Watenpaugh [Full Article - PDF]

2411-2421

Retinoic Acid Receptor ,-Selective Ligands: Synthesis and Biological Activity of 6-Substituted 2-Naphthoic Acid Retinoids Kuo-Long Yu, Patrick Spinazze, Jacek Ostrowski, Stephen J. Currier, Edward J. Pack, Laura Hammer, Thor Roalsvig, Jomary A. Honeyman, David R. Tortolani, Peter R. Reczek, Muzammil M. Mansuri, and John E. Starrett, Jr. [Full Article - PDF]

2422-2426

Chemical Synthesis of Benzamide Adenine Dinucleotide: Inhibition of Inosine Monophosphate Dehydrogenase (Types I and II) Andrzej Zatorski, Kyoichi A. Watanabe, Stephen F. Carr, Barry M. Goldstein, and Krzysztof W. Pankiewicz [Full Article - PDF]

2427-2431

Synthesis and Potent Anti-HIV-1 Activity of Novel 6-Benzyluracil Analogues of 1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine Krzysztof Danel, Erik Larsen, Erik B. Pedersen, Bent F. Vestergaard, and Claus Nielsen [Full Article - PDF]

2432-2432

The Toxic Action of Marine and Terrestrial Alkaloids Edited by Murray S. Blum. Alaken, Inc., Fort Collins, CO. 1995. vi + 327 pp. 16 × 23.5 cm. ISBN 1-880293-04-8. $89.95. Staff [Full Article - PDF]

2432-2432

Mechanistic Bioinorganic Chemistry Edited by H. Holden Thorp and Vincent L. Pecoraro. Advances in Chemistry Series 246. American Chemical Society, Washington, D.C. 1995. xii + 505 pp. 15 × 23.5 cm. ISBN 0-8412-3062-5. $109.95. J. A. Cowan [Full Article - PDF]

2432-2433

Organic Synthesis Highlights II Edited by Herbert Waldmann. VCH, Weinheim and New York. 1995. ix + 407 pp. 17.5 × 24.5 cm. ISBN 3-527-29200-4. $98.00. Richard E. Mewshaw [Full Article - PDF]

2433-2433

Books of Interest [Full Article - PDF]

2433-2433

[Full Article - PDF]

2434-2434

Indium(III) and Gallium(III) Complexes of Bis(aminoethanethiol) Ligands with Different Denticities: Stabilities, Molecular Modeling, and in Vivo Behavior Yizhen Sun, Carolyn J. Anderson, Tammy S. Pajeau, David E. Reichert, Robert D. Hancock, Ramunas J. Motekaitis, Arthur E. Martell, and Michael J. Welch [Full Article - PDF]