2435-2437
| (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D4 Antagonist
Ruth E. TenBrink,
Carol L. Bergh,
J. Neil Duncan,
Douglas W. Harris,
R. M. Huff,
Robert A. Lahti,
Charles F. Lawson,
Barry S. Lutzke,
Iain J. Martin,
Susan A. Rees,
Siusaidh K. Schlachter,
John C. Sih, and
Martin W. Smith
[Full Article -
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2438-2440
| First Examples of Peptidomimetic Inhibitors of Interleukin-1 Converting Enzyme
Roland E. Dolle,
Catherine P. Prouty,
C. V. C. Prasad,
Ewell Cook,
Ashis Saha,
Tina Morgan Ross,
Joseph M. Salvino,
Carla T. Helaszek, and
Mark A. Ator
[Full Article -
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2441-2448
| Synthesis of Potent Cyclic Hexapeptide NK-1 Antagonists. Use of a Minilibrary in Transforming a Peptidal Somatostatin Receptor Ligand into an NK-1 Receptor Ligand via a Polyvalent Peptidomimetic
Ralph Hirschmann,
Wenqing Yao,
Margaret A. Cascieri,
Catherine D. Strader,
Laurie Maechler,
Maria A. Cichy-Knight,
John Hynes, Jr.,
Rachel D. van Rijn,
Paul A. Sprengeler, and
Amos B. Smith, III
[Full Article -
PDF] |
2449-2455
| Topographical Amino Acid Substitution in Position 10 of Glucagon Leads to Antagonists/Partial Agonists with Greater Binding Differences
Bassem Y. Azizeh,
Mark D. Shenderovich,
Dev Trivedi,
Guigen Li,
Noel S. Sturm, and
Victor J. Hruby
[Full Article -
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2456-2460
| Effects of Modifications of Residues in Position 3 of Dynorphin A(1-11)-NH2 on  Receptor Selectivity and Potency
Feng-Di T. Lung,
J.-P. Meyer,
Bih-Show Lou,
Li Xiang,
Guigen Li,
Peg Davis,
Irene A. De Leon,
Henry I. Yamamura,
Frank Porreca, and
Victor J. Hruby
[Full Article -
PDF] |
2461-2471
| Metabolically Programmed Polyamine Analogue Antidiarrheals
Raymond J. Bergeron,
Guo Wei Yao,
Hua Yao,
William R. Weimar,
Charles A. Sninsky,
Brian Raisler,
Yang Feng,
Qianhong Wu, and
Fenglan Gao
[Full Article -
PDF] |
2472-2481
| Antiretroviral Agents as Inhibitors of both Human Immunodeficiency Virus Type 1 Integrase and Protease
Abhijit Mazumder,
Shaomeng Wang,
Nouri Neamati,
Marc Nicklaus,
Sanjay Sunder,
Julie Chen,
George W. A. Milne,
William G. Rice,
Terrence R. Burke, Jr., and
Yves Pommier
[Full Article -
PDF] |
2482-2491
| Chiral Pyrrolo[2,3-d]pyrimidine and Pyrimido[4,5-b]indole Derivatives: Structure-Activity Relationships of Potent, Highly Stereoselective A1-Adenosine Receptor Antagonists
Christa E. Müller,
Uli Geis,
Bettina Grahner,
Wolfgang Lanzner, and
Kurt Eger
[Full Article -
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2492-2498
| Structural Differences between the Free and Bound States of the DNA-Bisintercalating Peptide YSPTSPSY
Abdesslem Khiat,
Martin Lamoureux, and
Yvan Boulanger
[Full Article -
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2499-2507
| Synthesis and X-ray Crystal Structure of trans,cis-[Pt(OAc)2I2(en)]: A Novel Type of Cisplatin Analog That Can Be Photolyzed by Visible Light to DNA-Binding and Cytotoxic Species in Vitro
Nicole A. Kratochwil,
Manfred Zabel,
Klaus-Jürgen Range, and
Patrick J. Bednarski
[Full Article -
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2508-2517
| Hypoxia-Selective Antitumor Agents. 13. Effects of Acridine Substitution on the Hypoxia-Selective Cytotoxicity and Metabolic Reduction of the Bis-bioreductive Agent Nitracrine N-Oxide
Ho H. Lee,
William R. Wilson,
Dianne M. Ferry,
Pierre van Zijl,
Susan M. Pullen, and
William A. Denny
[Full Article -
PDF] |
2518-2528
| Hypoxia-Selective Antitumor Agents. 14. Synthesis and Hypoxic Cell Cytotoxicity of Regioisomers of the Hypoxia-Selective Cytotoxin 5-[N,N-Bis(2-chloroethyl)amino]-2,4-dinitrobenzamide
Brian D. Palmer,
William R. Wilson,
Robert F. Anderson,
Maruta Boyd, and
William A. Denny
[Full Article -
PDF] |
2529-2535
| Synthesis and Biological Evaluation of New Imidazole, Pyrimidine, and Purine Derivatives and Analogs as Inhibitors of Xanthine Oxidase
Giuliana Biagi,
Alberto Costantini,
Luca Costantino,
Irene Giorgi,
Oreste Livi,
Piergiorgio Pecorari,
Marcella Rinaldi, and
Valerio Scartoni
[Full Article -
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2536-2540
| Synthesis and Biological Evaluation of N -(4-Amino-4-deoxy-10-methylpteroyl)-DL-4,4-difluoroornithine
Takashi Tsukamoto,
William H. Haile,
John J. McGuire, and
James K. Coward
[Full Article -
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2541-2553
| Molecular Modeling and Site-Directed Mutagenesis Studies of a Phorbol Ester-Binding Site in Protein Kinase C
Shaomeng Wang,
Marcelo G. Kazanietz,
Peter M. Blumberg,
Victor E. Marquez, and
G. W. A. Milne
[Full Article -
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2554-2558
| Synthesis of 3-Aryl-8-azabicyclo[3.2.1]octanes with High Binding Affinities and Selectivities for the Serotonin Transporter Site
Huw M. L. Davies,
Lisa A. Kuhn,
Craig Thornley,
Julius J. Matasi,
Tammy Sexton, and
Steven R. Childers
[Full Article -
PDF] |
2559-2570
| Novel 3,7-Diheterabicyclo[3.3.1]nonanes That Possess Predominant Class III Antiarrhythmic Activity in 1-4 Day Post Infarction Dog Models: X-ray Diffraction Analysis of 3-[4-(1H-Imidazol-1-yl)benzoyl]-7-isopropyl-3,7-diazabicyclo[3.3.1]nonane Dihydroperchlorate
Gregory L. Garrison,
K. Darrell Berlin,
Benjamin J. Scherlag,
Ralph Lazzara,
Eugene Patterson,
Tamas Fazekas,
Subbiah Sangiah,
Chun-Lin Chen,
F. D. Schubot, and
Dick van der Helm
[Full Article -
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2571-2578
| 4-[4-[(2-Hydroxybenzoyl)amino]phenyl]butyric Acid as a Novel Oral Delivery Agent for Recombinant Human Growth Hormone
Andrea Leone-Bay,
Koc-Kan Ho,
Rajesh Agarwal,
Robert A. Baughman,
Kiran Chaudhary,
Frenel DeMorin,
Lise Genoble,
Campbell McInnes,
Christine Lercara,
Sam Milstein,
Doris O'Toole,
Donald Sarubbi,
Bruce Variano, and
Duncan R. Paton
[Full Article -
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2579-2585
| Esters and Amides of 6-(Chloromethyl)-2-oxo-2H-1-benzopyran-3-carboxylic Acid as Inhibitors of -Chymotrypsin: Significance of the "Aromatic" Nature of the Novel Ester-Type Coumarin for Strong Inhibitory Activity
Lionel Pochet,
Caroline Doucet,
Marc Schynts,
Nicole Thierry,
Nicole Boggetto,
Bernard Pirotte,
Kai Y. Jiang,
Bernard Masereel,
Pascal de Tullio,
Jacques Delarge, and
Michèle Reboud-Ravaux
[Full Article -
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2586-2593
| Synthesis and Biological Activity of 3- and 5-Amino Derivatives of Pyridine-2-carboxaldehyde Thiosemicarbazone
Mao-Chin Liu,
Tai-Shun Lin,
Joseph G. Cory,
Ann H. Cory, and
Alan C. Sartorelli
[Full Article -
PDF] |
2594-2608
| Design of Orally Active Dual Inhibitors of Neutral Endopeptidase and Angiotensin-Converting Enzyme with Long Duration of Action
Marie-Claude Fournie-Zaluski,
Pascale Coric,
Vincent Thery,
Walter Gonzalez,
Hervé Meudal,
Serge Turcaud,
Jean-Baptiste Michel, and
Bernard P. Roques
[Full Article -
PDF] |
2609-2614
| Alkyl and Alkoxyethyl Antineoplastic Phospholipids
Maria Koufaki,
Vanessa Polychroniou,
Theodora Calogeropoulou,
Andrew Tsotinis,
Markus Drees,
Heiner H. Fiebig,
Sophie LeClerc,
Hans R. Hendriks, and
Alexandros Makriyannis
[Full Article -
PDF] |
2615-2620
| Carbocyclic Nucleosides as Inhibitors of Human Tumor Necrosis Factor- Production: Effects of the Stereoisomers of (3-Hydroxycyclopentyl)adenines
David R. Borcherding,
Norton P. Peet,
H. Randall Munson,
Hao Zhang,
Paul F. Hoffman,
Terry L. Bowlin, and
Carl K. Edwards, III
[Full Article -
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2621-2624
| Thermodynamic Aspects of Hydrophobicity and the Blood-Brain Barrier Permeability Studied with a Gel Filtration Chromatography
Junko Kai,
Katsuhiko Nakamura,
Takashi Masuda,
Ikuo Ueda, and
Hideaki Fujiwara
[Full Article - PDF] |
2625-2625
| Aspartic Proteinases. Physiology and Pathology. By M. Fusek and V. Vetvicka. CRC Press, Inc., Boca Raton, FL. 1995. xii + 308 pp. 16 × 24 cm. ISBN 0-8493-7660-2. $179.95.
Suvit Thaisrivongs
[Full Article - PDF] |
2625-2626
| Cardiovascular Regulation Edited by David Jordan and Janice Marshall. Portland Press, London. 1995. ix + 159 pp. 19 × 25 cm. ISBN 1-85578-024-0. $35.00.
Dennis M. Ackerman
[Full Article - PDF] |
2626-2626
| Free Radicals in Organic Chemistry By Jacques Fossey, Daniel Lefort, and Janine Sorba. John Wiley & Sons, Inc., New York. 1995. xiv + 307 pp. 16 × 24 cm. ISBN 0-471-95496-9. $39.95 (pbk).
Staff
[Full Article - PDF] |
2626-2626
| Lithium Chemistry. A Theoretical and Experimental Overview Edited by Anne-Marie Sapse and Paul von Ragué Schleyer. John Wiley & Sons, Inc., New York. 1995. x + 595 pp. 16 × 24 cm. ISBN 0-471-54930-4. $69.95.
Staff
[Full Article - PDF] |
2626-2626
| Antisense Therapeutics Edited by Sudhir Agrawal. Humana Press, Totowa, NJ. 1996. xiv + 276 pp. 16 × 23.5 cm. ISBN 0-89603-305-8. $99.50.
Staff
[Full Article - PDF] |
2626-2627
| Studies in Natural Products Chemistry. Volume 16. Stereoselective Synthesis (Part J) Edited by Atta-ur-Rahman. Elsevier, Amsterdam. 1995. xiv + 757 pp. ISBN 0-444-82264-X. $435.00.
Maurice Shamma
[Full Article - PDF] |
2627-2627
| Peptides: Synthesis, Structures and Applications Edited by Bernd Gutte. Academic Press, San Diego, CA. 1995. xiv + 511 pp. 16 × 23.5 cm. ISBN 0-12-310920-5. $69.95.
Ram Dharanipragada
[Full Article - PDF] |
2627-2628
| Technology Transfer. Making the most of your intellectual property By Neil F. Sullivan. Cambridge University Press, Cambridge, England. 1995. 15 × 23 cm. xiv + 221 pp. ISBN 0-521-46616-4. $24.95 (pbk).
Staff
[Full Article - PDF] |
2628-2628
| Books of Interest
[Full Article - PDF] |
2628-2628
| [Full Article - PDF] |