2629-2654
| Modulators of Leukotriene Biosynthesis and Receptor Activation
Clint D. W. Brooks and
James B. Summers
[Full Article -
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2655-2658
| 3-(1H-Indazol-3-ylmethyl)-1,5-benzodiazepines: CCK-A Agonists That Demonstrate Oral Activity as Satiety Agents
Brad R. Henke,
Timothy M. Willson,
Elizabeth E. Sugg,
Dallas K. Croom,
Robert W. Dougherty, Jr.,
Kennedy L. Queen,
Larry S. Birkemo,
Gregory N. Ervin,
Mary K. Grizzle,
Michael F. Johnson, and
Michael K. James
[Full Article -
PDF] |
2659-2663
| Discovery of Novel Retinoic Acid Receptor Agonists Having Potent Antiproliferative Activity in Cervical Cancer Cells
Lin Zhang,
Alex M. Nadzan,
Richard A. Heyman,
Deborah L. Love,
Dale E. Mais,
Glenn Croston,
William W. Lamph, and
Marcus F. Boehm
[Full Article -
PDF] |
2664-2671
| (S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno- 1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and Related Analogues: Isozyme Selective Inhibitors of Protein Kinase C
Michael R. Jirousek,
James R. Gillig,
Cecile M. Gonzalez,
William F. Heath,
John H. McDonald III,
David A. Neel,
Christopher J. Rito,
Upinder Singh,
Lawrence E. Stramm,
Anita Melikian-Badalian,
Matthew Baevsky,
Lawrence M. Ballas,
Steven E. Hall,
Leonard L. Winneroski, and
Margaret M. Faul
[Full Article -
PDF] |
2672-2680
| Pyrrolobenzothiazepinones and Pyrrolobenzoxazepinones: Novel and Specific Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors with Antiviral Activity
Giuseppe Campiani,
Vito Nacci,
Isabella Fiorini,
Maria P. De Filippis,
Antonio Garofalo,
Giovanni Greco,
Ettore Novellino,
Sergio Altamura, and
Laura Di Renzo
[Full Article -
PDF] |
2681-2689
| Inhibitors of Human Immunodeficiency Virus Type 1 Derived from gp41 Transmembrane Protein: Structure-Activity Studies
Wieslaw M. Kazmierski,
Richard J. Hazen,
Ann Aulabaugh, and
Marty H. StClair
[Full Article -
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2690-2695
| Rational Design of Novel Immunosuppressive Drugs: Analogues of Azathioprine Lacking the 6-Mercaptopurine Substituent Retain or Have Enhanced Immunosuppressive Effects
Duncan J. K. Crawford,
John L. Maddocks,
D. Neville Jones, and
Paul Szawlowski
[Full Article -
PDF] |
2696-2704
| Novel Selective PDE IV Inhibitors as Antiasthmatic Agents. Synthesis and Biological Activities of a Series of 1-Aryl-2,3-bis(hydroxymethyl)naphthalene Lignans
Tameo Iwasaki,
Kazuhiko Kondo,
Tooru Kuroda,
Yasunori Moritani,
Shinsuke Yamagata,
Masaki Sugiura,
Hideo Kikkawa,
Osamu Kaminuma, and
Katsuo Ikezawa
[Full Article -
PDF] |
2705-2709
| Preparation of Phenolic Paclitaxel Metabolites
Haeil Park,
Michael Hepperle,
Thomas C. Boge,
Richard H. Himes, and
Gunda I. Georg
[Full Article -
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2710-2719
| Deconvolution of Combinatorial Libraries for Drug Discovery: Theoretical Comparison of Pooling Strategies
Danielle A. M. Konings,
Jacqueline R. Wyatt,
David J. Ecker, and
Susan M. Freier
[Full Article -
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2720-2726
| Deconvolution of Combinatorial Libraries for Drug Discovery: Experimental Comparison of Pooling Strategies
Laura Wilson-Lingardo,
Peter W. Davis,
David J. Ecker,
Normand Hébert,
Oscar Acevedo,
Kelly Sprankle,
Thomas Brennan,
Leslie Schwarcz,
Susan M. Freier, and
Jacqueline R. Wyatt
[Full Article -
PDF] |
2727-2737
| Conformationally Restricted Analogs of 1 ,25-Dihydroxyvitamin D3 and Its 20-Epimer: Compounds for Study of the Three-Dimensional Structure of Vitamin D Responsible for Binding to the Receptor
Keiko Yamamoto,
Wei Yan Sun,
Masateru Ohta,
Kazuhiro Hamada,
Hector F. DeLuca, and
Sachiko Yamada
[Full Article -
PDF] |
2738-2744
| Novel Cyclic Analogs of Angiotensin II with Cyclization between Positions 5 and 7: Conformational and Biological Implications
Wei-Jun Zhang,
Gregory V. Nikiforovich,
Jacqueline Pérodin,
Darren E. Richard,
Emanuel Escher, and
Garland R. Marshall
[Full Article -
PDF] |
2745-2752
| Forskolin Carbamates: Binding and Activation Studies with Type I Adenylyl Cyclase
Joan D. Robbins,
Daniel L. Boring,
Wei-Jen Tang,
Robin Shank, and
Kenneth B. Seamon
[Full Article -
PDF] |
2753-2763
| Synthesis, Ligand Binding, and Quantitative Structure-Activity Relationship Study of 3-(4'-Substituted phenyl)-2-heterocyclic Tropanes: Evidence for an Electrostatic Interaction at the 2-Position
Pravin Kotian,
S. Wayne Mascarella,
Philip Abraham,
Anita H. Lewin,
John W. Boja,
Michael J. Kuhar, and
F. Ivy Carroll
[Full Article -
PDF] |
2764-2772
| Dopamine D3 and D4 Receptor Antagonists: Synthesis and Structure-Activity Relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl)amino]-2-methoxybenzamide (YM-43611) and Related Compounds
Junya Ohmori,
Kyoichi Maeno,
Kazuyuki Hidaka,
Kazuhiro Nakato,
Mitsuyuki Matsumoto,
Shoko Tada,
Hanae Hattori,
Shuichi Sakamoto,
Shin-ichi Tsukamoto,
Shinji Usuda, and
Toshiyasu Mase
[Full Article -
PDF] |
2773-2780
| Potent, Selective Tetrahydro--carboline Antagonists of the Serotonin 2B (5HT2B) Contractile Receptor in the Rat Stomach Fundus
James E. Audia,
Deborah A. Evrard,
Gwyn R. Murdoch,
James J. Droste,
Jeffrey S. Nissen,
Kathy W. Schenck,
Pawel Fludzinski,
Virginia L. Lucaites,
David L. Nelson, and
Marlene L. Cohen
[Full Article -
PDF] |
2781-2794
| Structure-Based Design and Synthesis of Substituted 2-Butanols as Nonpeptidic Inhibitors of HIV Protease: Secondary Amide Series
Siegfried H. Reich,
Michael Melnick,
Mark J. Pino,
Mary Ann M. Fuhry,
Anthony J. Trippe,
Krzysztof Appelt,
Jay F. Davies II,
Bor-Wen Wu, and
Linda Musick
[Full Article - PDF] |
2795-2811
| Bis Tertiary Amide Inhibitors of the HIV-1 Protease Generated via Protein Structure-Based Iterative Design
Michael Melnick,
Siegfried H. Reich,
Kathy K. Lewis,
Lennert J. Mitchell, Jr.,
Dzuy Nguyen,
Anthony J. Trippe,
Heather Dawson,
Jay F. Davies II,
Krzysztof Appelt,
Bor-Wen Wu,
Linda Musick,
Dan K. Gehlhaar,
Stephanie Webber,
Bhasker Shetty,
Maha Kosa,
Deborah Kahil, and
Dominic Andrada
[Full Article - PDF] |
2812-2818
| Cyclopent[a]anthraquinones as DNA-Intercalating Agents with Covalent Bond Formation Potential: Synthesis and Biological Activity
Joong Young Kim,
Tsann-Long Su,
Ting-Chao Chou,
Bernd Koehler,
Alex Scarborough,
Ouathek Ouerfelli, and
Kyoichi A. Watanabe
[Full Article - PDF] |
2819-2834
| Structure-Activity Relationships of the Didemnins
Ryuichi Sakai,
Kenneth L. Rinehart,
Vimal Kishore,
Bijoy Kundu,
Glynn Faircloth,
James B. Gloer,
John R. Carney,
Michio Namikoshi,
Furong Sun,
Robert G. Hughes, Jr.,
Dolores García Grávalos,
Teresa García de Quesada,
George R. Wilson, and
Richard M. Heid
[Full Article - PDF] |
2835-2843
| Structure-Activity Relationships of 1-(2-Deoxy-2-fluoro--L-arabino- furanosyl)pyrimidine Nucleosides as Anti-Hepatitis B Virus Agents
Tianwei Ma,
S. Balakrishna Pai,
Yong Lian Zhu,
Ju Sheng Lin,
Kirupa Shanmuganathan,
Jinfa Du,
Chunguang Wang,
Hongbum Kim,
M. Gary Newton,
Yung Chi Cheng, and
Chung K. Chu
[Full Article -
PDF] |
2844-2851
| Synthesis and Structure-Activity Relationships of Fused Imidazopyridines: A New Series of Benzodiazepine Receptor Ligands
Susumu Takada,
Takashi Sasatani,
Nobuo Chomei,
Makoto Adachi,
Toshio Fujishita,
Masami Eigyo,
Shunji Murata,
Kazuo Kawasaki, and
Akira Matsushita
[Full Article - PDF] |
2852-2855
| Potential Antitumor Agents. 24. Synthesis and Pharmacological Behavior of Imidazo[2,1-b]thiazole Guanylhydrazones Bearing at Least One Chlorine
Aldo Andreani,
Mirella Rambaldi,
Alberto Leoni,
Alessandra Locatelli,
Rosaria Bossa,
Alessandra Fraccari,
Iraklis Galatulas, and
Gaetano Salvatore
[Full Article - PDF] |
2856-2859
| Synthesis of Acyclo-C-nucleosides in the Imidazo[1,2-a]pyridine and Pyrimidine Series as Antiviral Agents
Alain Gueiffier,
Mohammed Lhassani,
Ahmed Elhakmaoui,
Robert Snoeck,
Graciela Andrei,
Olivier Chavignon,
Jean-Claude Teulade,
Abdelali Kerbal,
El Mokhtar Essassi,
Jean-Claude Debouzy,
Myriam Witvrouw,
Yves Blache,
Jan Balzarini,
Erik De Clercq, and
Jean-Pierre Chapat
[Full Article - PDF] |
2860-2864
| New Steroidal Diazo Ketones as Potential Photoaffinity Labeling Reagents for the Mineralocorticoid Receptor: Synthesis and Biological Activities
Elisabeth Davioud,
Jérôme Fagart,
Anny Souque,
Marie-Edith Rafestin-Oblin, and
Andrée Marquet
[Full Article - PDF] |
2865-2868
| Immunosuppressive Cyclolignans
Marina Gordaliza,
Glynn T. Faircloth,
Ma Angeles Castro,
José M. Miguel del Corral,
Ma Luisa López-Vázquez, and
Arturo San Feliciano
[Full Article - PDF] |
2869-2869
| Classical and Three Dimensional QSAR in Agrochemistry Edited by C. Hansch and T. Fujita. American Chemical Society, Washington, D.C. 1995. x + 342 pp. 16 × 23.5 cm. ISBN 0-8412-3321-7. $88.95.
Lemont B. Kier
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2869-2869
| Handbook of Methods in Gastrointestinal Pharmacology Edited by Timothy S. Gaginella. CRC Press, Boca Raton, FL. 1996. 452 pp. 18 × 26 cm. ISBN 0-8493-8304-8. $129.95.
James F. Kachur
[Full Article - PDF] |
2870-2870
| Structure-Activity Relationship Studies of Novel 4-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine Analogs: Synthesis and Biological Evaluation at the Dopamine and Serotonin Transporter Sites
Aloke K. Dutta,
Cen Xu, and
Maarten E. A.
Reith
[Full Article - PDF] |