3035-3038
| Identification of a Retinoic Acid Receptor  Subtype Specific Agonist
Min Teng,
Tien T. Duong,
Elliott S. Klein,
Mary E. Pino, and
Roshantha A. S. Chandraratna
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3039-3043
| Potent Thrombin Inhibitors That Probe the S1' Subsite: Tripeptide Transition State Analogues Based on a Heterocycle-Activated Carbonyl Group
Michael J. Costanzo,
Bruce E. Maryanoff,
Leonard R. Hecker,
Mary R. Schott,
Stephen C. Yabut,
Han-Cheng Zhang,
Patricia Andrade-Gordon,
Jack A. Kauffman,
Joan M. Lewis,
Raman Krishnan, and
Alexander Tulinsky
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3044-3045
| Potent Inhibition of Tumor Necrosis Factor- Production by Tetrafluorothalidomide and Tetrafluorophthalimides
Satomi Niwayama,
Benjamin E. Turk, and
Jun O. Liu
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3046-3048
| Mechanism-Based Inhibition of L-Pipecolate Oxidase by 4,5-Dehydro-L-Pipecolic Acid
T. Mark Zabriskie
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3049-3059
| Neighborhood Behavior: A Useful Concept for Validation of "Molecular Diversity" Descriptors
David E. Patterson,
Richard D. Cramer,
Allan M. Ferguson,
Robert D. Clark, and
Laurence E. Weinberger
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3060-3069
| Bioisosterism as a Molecular Diversity Descriptor: Steric Fields of Single "Topomeric" Conformers
Richard D. Cramer,
Robert D. Clark,
David E. Patterson, and
Allan M. Ferguson
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3070-3088
| Synthesis and Structure-Activity Relationships of 2-Pyridones: A Novel Series of Potent DNA Gyrase Inhibitors as Antibacterial Agents
Qun Li,
Daniel T. W. Chu,
Akiyo Claiborne,
Curt S. Cooper,
Cheuk M. Lee,
Kathleen Raye,
Kristine B. Berst,
Pamela Donner,
Weibo Wang,
Lisa Hasvold,
Anthony Fung,
Zhenkun Ma,
Michael Tufano,
Robert Flamm,
Linus L. Shen,
John Baranowski,
Angela Nilius,
Jeff Alder,
Jonathan Meulbroek,
Kennan Marsh,
DeAnne Crowell,
Yuhua Hui,
Louis Seif,
Laura M. Melcher,
Rodger Henry,
Steven Spanton,
Ramin Faghih,
Larry L. Klein,
S. Ken Tanaka, and
Jacob J. Plattner
[Full Article -
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3089-3095
| Synthesis of 2-Amido-2,3-dihydro-1H-phenalene Derivatives as New Conformationally Restricted Ligands for Melatonin Receptors
Monique Mathé-Allainmat,
Florence Gaudy,
Sames Sicsic,
Anne-Laure Dangy-Caye,
Shuren Shen,
Béatrice Brémont,
Zohra Benatalah,
Michel Langlois,
Pierre Renard, and
Philippe Delagrange
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3096-3106
| Evaluation of the Stability and Animal Biodistribution of Gadolinium(III) Benzylamine-Derivatized Diethylenetriaminepentaacetic Acid
Kim A. Deal,
Ramunas J. Motekaitis,
Arthur E. Martell, and
Michael J. Welch
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3107-3113
| De Novo Antimicrobial Peptides with Low Mammalian Cell Toxicity
Maryam M. Javadpour,
Martha M. Juban,
Wai-Chun J. Lo,
Steven M. Bishop,
J. Brannon Alberty,
Scott M. Cowell,
Calvin L. Becker, and
Mark L. McLaughlin
[Full Article -
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3114-3122
| Peptidyl Anthraquinones as Potential Antineoplastic Drugs: Synthesis, DNA Binding, Redox Cycling, and Biological Activity
Barbara Gatto,
Giuseppe Zagotto,
Claudia Sissi,
Cinzia Cera,
Eugenio Uriarte,
Giorgio Palù,
Giovanni Capranico, and
Manlio Palumbo
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3123-3131
| Synthesis and Evaluation of Phorboid 20-Homovanillates: Discovery of a Class of Ligands Binding to the Vanilloid (Capsaicin) Receptor with Different Degrees of Cooperativity
Giovanni Appendino,
Giancarlo Cravotto, and
Giovanni Palmisano
, Rita Annunziata
, Arpad Szallasi
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3132-3138
| Antipsoriatic Anthrones with Modulated Redox Properties. 3. 10-Thio-Substituted 1,8-Dihydroxy-9(10H)-anthracenones as Inhibitors of Keratinocyte Growth, 5-Lipoxygenase, and the Formation of 12(S)-HETE in Mouse Epidermis
Klaus Müller,
Hsu-Shan Huang, and
Wolfgang Wiegrebe
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3139-3147
| Orally Active Fibrinogen Receptor Antagonists. 2. Amidoximes as Prodrugs of Amidines
Thomas Weller,
Leo Alig,
Maureen Beresini,
Brent Blackburn,
Stuart Bunting,
Paul Hadváry,
Marianne Hürzeler Müller,
Dietmar Knopp,
Bernard Levet-Trafit,
M. Terry Lipari,
Nishit B. Modi,
Marcel Müller,
Canio J. Refino,
Monique Schmitt,
Peter Schönholzer,
Sabine Weiss, and
Beat Steiner
[Full Article -
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3148-3157
| Structure-Activity Relationships of (E)-3-(1,4-Benzoquinonyl)-2-[(3-pyridyl)- alkyl]-2-propenoic Acid Derivatives That Inhibit Both 5-Lipoxygenase and Thromboxane A2 Synthetase
Shigeki Hibi,
Yasushi Okamoto,
Katsuya Tagami,
Hirotoshi Numata,
Naoki Kobayashi,
Masanobu Shinoda,
Tetsuya Kawahara,
Koukichi Harada,
Kaname Miyamoto, and
Isao Yamatsu
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3158-3168
| Mercaptoacyl Dipeptides as Orally Active Dual Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase
Cynthia A. Fink,
J. Eric Carlson,
Patricia A. McTaggart,
Ying Qiao,
Randy Webb,
Ricardo Chatelain,
Arco Y. Jeng, and
Angelo J. Trapani
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3169-3173
| Synthesis and Characterization of Pseudopeptide Bradykinin B2 Receptor Antagonists Containing the 1,3,8-Triazaspiro[4.5]decan-4-one Ring System
Babu J. Mavunkel,
Zhijian Lu,
R. Richard Goehring,
Songfeng Lu,
Sarvajit Chakravarty,
John Perumattam,
Elizabeth A. Novotny,
Maureen Connolly,
Heather Valentine, and
Donald J. Kyle
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3174-3178
| Synthesis and Biological Activity of NK-1 Selective, N-Backbone Cyclic Analogs of the C-Terminal Hexapeptide of Substance P
Gerardo Byk,
David Halle,
Irena Zeltser,
Gal Bitan,
Zvi Selinger, and
Chaim Gilon
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3179-3187
| Aryl 1-But-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as Potential Antipsychotic Agents: Synthesis and Structure-Activity Relationships
Shelly A. Glase,
Hyacinth C. Akunne,
Thomas G. Heffner,
Juan C. Jaen,
Robert G. MacKenzie,
Leonard T. Meltzer,
Thomas A. Pugsley,
Sarah J. Smith, and
Lawrence D. Wise
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3188-3194
| A New Highly Selective Metabotropic Excitatory Amino Acid Agonist: 2-Amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric Acid
Hans Bräuner-Osborne,
Frank A. Sl k,
Niels Skjærbæk,
Bjarke Ebert,
Naohiro Sekiyama,
Shigetada Nakanishi, and
Povl Krogsgaard-Larsen
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3195-3202
| 1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: Alkylamido and Alkylamino Derivatives. Synthesis, 5-HT1A Receptor Affinity, and Selectivity. 3
Roberto Perrone,
Francesco Berardi,
Marcello Leopoldo, and
Vincenzo Tortorella
, Maria Gioia Fornaretto,
Carla Caccia, and
Robert A. McArthur
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3203-3216
| Aza-Peptide Analogs as Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors with Oral Bioavailability
Alexander Fässler,
Guido Bold,
Hans-Georg Capraro,
Robert Cozens,
Jürgen Mestan,
Bernard Poncioni,
Johannes Rösel,
Marina Tintelnot-Blomley, and
Marc Lang
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3217-3227
| Synthesis and Biological Evaluation of Certain Alkenyldiarylmethanes as Anti-HIV-1 Agents Which Act as Non-Nucleoside Reverse Transcriptase Inhibitors
Mark Cushman,
W. Marek Golebiewski,
Lisa Graham,
Jim A. Turpin,
William G. Rice,
Valerie Fliakas-Boltz, and
Robert W. Buckheit, Jr.
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3228-3228
| 2,4-Diamino-5-deaza-6-Substituted Pyrido[2,3-d]pyrimidine Antifolates as Potent and Selective Nonclassical Inhibitors of Dihydrofolate Reductases
Aleem Gangjee,
Anil Vasudevan,
Sherry F. Queener, and
Roy L. Kisliuk
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