3603-3605
| Antimicrobial  ,-Dialkylated Amino Acid Rich Peptides with in-Vivo Activity against an Intracellular Pathogen
T. Scott Yokum,
Philip H. Elzer, and
Mark L. McLaughlin
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3606-3616
| Evaluation of Selected Chemotypes in Coupled Cellular and Molecular Target-Based Screens Identifies Novel HIV-1 Zinc Finger Inhibitors
William G. Rice,
Jim A. Turpin,
Catherine A. Schaeffer,
Lisa Graham,
David Clanton,
Robert W. Buckheit, Jr.,
Daniel Zaharevitz,
Michael F. Summers,
Anders Wallqvist, and
David G. Covell
[Full Article -
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3617-3624
| Synthesis of a Series of Aryl Kainic Acid Analogs and Evaluation in Cells Stably Expressing the Kainate Receptor humGluR6
Buddy E. Cantrell,
Dennis M. Zimmerman,
James A. Monn,
Rajender K. Kamboj,
Ken H. Hoo,
Joseph P. Tizzano,
Ian A. Pullar,
Louise N. Farrell, and
David Bleakman
[Full Article -
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3625-3635
| Conformationally Defined 6-s-trans-Retinoic Acid Analogs. 3. Structure-Activity Relationships for Nuclear Receptor Binding, Transcriptional Activity, and Cancer Chemopreventive Activity
Donald D. Muccio,
Wayne J. Brouillette,
Muzaffar Alam,
Michael F. Vaezi,
Brahma P. Sani,
Pratap Venepally,
Lakshmi Reddy,
Ellen Li,
Andrew W. Norris,
Linda Simpson-Herren, and
Donald L. Hill
[Full Article -
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3636-3658
| Potent Inhibitors of Secretory Phospholipase A2: Synthesis and Inhibitory Activities of Indolizine and Indene Derivatives
Sanji Hagishita,
Masaaki Yamada,
Kazuhiro Shirahase,
Toshihiko Okada,
Yasushi Murakami,
Yuji Ito,
Takaharu Matsuura,
Masaaki Wada,
Toshiyuki Kato,
Masahiko Ueno,
Yukiko Chikazawa,
Katsutoshi Yamada,
Takashi Ono,
Isao Teshirogi, and
Mitsuaki Ohtani
[Full Article -
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3659-3670
| Synthesis, Physicochemical Properties, and Biological Evaluation of Hydroxypyranones and Hydroxypyridinones: Novel Bidentate Ligands for Cell-Labeling
Beverley L. Ellis,
Anne K. Duhme,
Robert C. Hider,
M. Bilayet Hossain,
Safia Rizvi, and
Dick van der Helm
[Full Article -
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3671-3683
| Synthesis and Cardiotonic Activity of Novel Pyrimidine Derivatives: Crystallographic and Quantum Chemical Studies
Paola Dorigo,
Daniela Fraccarollo,
Giovanni Santostasi,
Ildebrando Maragno,
Maura Floreani,
Pier Andrea Borea,
Luisa Mosti,
Laura Sansebastiano,
Paola Fossa,
Fulvia Orsini,
Franco Benetollo, and
Gabriella Bombieri
[Full Article -
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3684-3693
| 2-Azetidinone Cholesterol Absorption Inhibitors: Structure-Activity Relationships on the Heterocyclic Nucleus
John W. Clader,
Duane A. Burnett,
Mary Ann Caplen,
Martin S. Domalski,
Sundeep Dugar,
Wayne Vaccaro,
Rosy Sher,
Margaret E. Browne,
Hongrong Zhao,
Robert E. Burrier,
Brian Salisbury, and
Harry R. Davis, Jr.
[Full Article -
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3694-3700
| Assessment of Structural Requirements for the Monoamine Oxidase-B-Catalyzed Oxidation of 1,4-Disubstituted-1,2,3,6-tetrahydropyridine Derivatives Related to the Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Stéphane Mabic and
Neal Castagnoli, Jr.
[Full Article -
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3701-3711
| Iodinated Analogs of Trimetoquinol as Highly Potent and Selective  2-Adrenoceptor Ligands
Joseph E. De Los Angeles,
Victor I. Nikulin,
Gamal Shams,
Anish A. Konkar,
Ratna Mehta,
Dennis R. Feller, and
Duane D. Miller
[Full Article -
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3712-3722
| Design, Synthesis, and Evaluation of 2-Alkenyl Penam Sulfone Acids as Inhibitors of -Lactamases
Hans G. F. Richter,
Peter Angehrn,
Christian Hubschwerlen,
Malgosia Kania,
Malcolm G. P. Page,
Jean-Luc Specklin, and
Fritz K. Winkler
[Full Article -
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3723-3738
| Serotonin 5-HT2 Receptor, Dopamine D2 Receptor, and 1 Adrenoceptor Antagonists. Conformationally Flexible Analogues of the Atypical Antipsychotic Sertindole
Kim Andersen,
Tommy Liljefors,
John Hyttel,and
Jens Perregaard
[Full Article -
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3739-3747
| Nucleosides with a Twist. Can Fixed Forms of Sugar Ring Pucker Influence Biological Activity in Nucleosides and Oligonucleotides?
Victor E. Marquez,
Maqbool A. Siddiqui,
Abdallah Ezzitouni,
Pamela Russ,
Jianying Wang,
Richard W. Wagner, and
Mark D. Matteucci
[Full Article -
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3748-3755
| A Novel Series of [2-[Methyl(2-phenethyl)amino]-2-oxoethyl]benzene-Containing Leukotriene B4 Antagonists: Initial Structure-Activity Relationships
Fu-Chih Huang,
Wan-Kit Chan,
Kevin J. Moriarty,
Gregory Poli,
Matthew M. Morrissette,
Robert A. Galemmo,
James D. Warus,
William P. Dankulich, and
Charles A. Sutherland
[Full Article -
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3756-3768
| Structure-Activity Relationships Study of Two Series of Leukotriene B4 Antagonists: Novel Indolyl and Naphthyl Compounds Substituted with a 2-[Methyl(2-phenethyl)amino]-2-oxoethyl Side Chain
Wan K. Chan,
Fu-Chih Huang,
Matthew M. Morrissette,
James D. Warus,
Kevin J. Moriarty,
Robert A. Galemmo,
William D. Dankulich,
Gregory Poli, and
Charles A. Sutherland
[Full Article -
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3769-3789
| Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors
Donna L. Romero,
Robert A. Olmsted,
Toni Jo Poel,
Raymond A. Morge,
Carolyn Biles,
Barbara J. Keiser,
Laurice A. Kopta,
Jan M. Friis,
John D. Hosley,
Kevin J. Stefanski,
Donn G. Wishka,
David B. Evans,
Joel Morris,
Randy G. Stehle,
Satish K. Sharma,
Yoshihiko Yagi,
Richard L. Voorman,
Wade J. Adams,
W. Gary Tarpley, and
Richard C. Thomas
[Full Article -
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3790-3796
| Unsaturated Side Chain -11-Hydroxyhexahydrocannabinol Analogs
Jakob Busch-Petersen,
W. Adam Hill,
Pusheng Fan,
Atmaram Khanolkar,
Xuang-Qun Xie,
Marcus A. Tius, and
Alexandros Makriyannis
[Full Article -
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3797-3805
| Synthesis and Selective Coronary Vasodilatory Activity of 3,4-Dihydro-2,2-bis(methoxymethyl)-2H-1-benzopyran-3-ol Derivatives: Novel Potassium Channel Openers
Hidetsura Cho,
Susumu Katoh,
Shinsuke Sayama,
Kengo Murakami,
Hiroyuki Nakanishi,
Yasuyuki Kajimoto,
Hiroshi Ueno,
Hisashi Kawasaki,
Kazuo Aisaka, and
Itsuo Uchida
[Full Article -
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3806-3813
| A Novel Series of (Phenoxyalkyl)imidazoles as Potent H3-Receptor Histamine Antagonists
C. Robin Ganellin,
Abdellatif Fkyerat,
Benny Bang-Andersen,
Salah Athmani,
Wasyl Tertiuk,
Monique Garbarg,
Xavier Ligneau, and
Jean-Charles Schwartz
[Full Article -
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3814-3819
| Structure-Activity Relationships of Novel Hematoregulatory Peptides
Pradip K. Bhatnagar,
Erik K. Agner,
Doreen Alberts,
Bente E. Arbo,
James F. Callahan,
Allan S. Cuthbertson,
Steinar J. Engelsen,
Hege Fjerdingstad,
Michael Hartmann,
Dirk Heerding,
Johann Hiebl,
William F. Huffman,
Mette Hysben,
Andrew G. King,
Peter Kremminger,
Chet Kwon,
Steve LoCastro,
Dagfinn L vhaug,
Louis M. Pelus,
Steve Petteway, and
Joanne S. Takata
[Full Article -
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3820-3836
| 3-Phenyl-Substituted Imidazo[1,5-a]quinoxalin-4-ones and Imidazo[1,5-a]quinoxaline Ureas That Have High Affinity at the GABAA/Benzodiazepine Receptor Complex
E. Jon Jacobsen,
Lindsay S. Stelzer,
Kenneth L. Belonga,
Donald B. Carter,
Wha Bin Im,
Vimala H. Sethy,
Andrew H. Tang,
Philip F. VonVoigtlander, and
James D. Petke
[Full Article - PDF] |
3837-3841
| (E)-3-[6-[[(2,6-Dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2-pyridinyl]-2- propenoic Acid: A High-Affinity Leukotriene B4 Receptor Antagonist with Oral Antiinflammatory Activity
Robert A. Daines,
Pamela A. Chambers,
James J. Foley,
Don E. Griswold,
William D. Kingsbury,
Lenox D. Martin,
Dulcie B. Schmidt,
Kelvin K. C. Sham, and
Henry M. Sarau
[Full Article - PDF] |
3842-3846
| Rediscovering an Endothelin Antagonist (BQ-123): A Self-Deconvoluting Cyclic Pentapeptide Library
Arno F. Spatola and
Yvon Crozet
, Damiane deWit and
Masashi Yanagisawa
[Full Article -
PDF] |
3847-3852
| New Neplanocin Analogues. 7. Synthesis and Antiviral Activity of 2-Halo Derivatives of Neplanocin A
Takumi Obara,
Satoshi Shuto,
Yasuyoshi Saito,
Robert Snoeck,
Graciela Andrei,
Jan Balzarini,
Erik De Clercq, and
Akira Matsuda
[Full Article - PDF] |