3853-3874
| New Directions in Antibacterial Research
Daniel T. W. Chu,
Jacob J. Plattner, and
Leonard Katz
[Full Article -
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3875-3877
| Synthesis and Pharmacology of a Very Potent Cannabinoid Lacking a Phenolic Hydroxyl with High Affinity for the CB2 Receptor
John W. Huffman,
Shu Yu,
Vincent Showalter,
Mary E. Abood,
Jenny L. Wiley,
David R. Compton,
Billy R. Martin,
R. Daniel Bramblett, and
Patricia H. Reggio
[Full Article -
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3878-3881
| High-Resolution X-ray Crystallography Reveals Precise Binding Interactions between Human Nonpancreatic Secreted Phospholipase A2 and a Highly Potent Inhibitor (FPL67047XX)
Sun-Shin Cha,
Dennis Lee,
Jerry Adams,
Jeffrey T. Kurdyla,
Christopher S. Jones,
Lisa A. Marshall,
Brian Bolognese,
Sherin S. Abdel-Meguid, and
Byung-Ha Oh
[Full Article -
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3882-3888
| Comparative Molecular Field Analysis of Haptens Docked to the Multispecific Antibody IgE(Lb4)
Armin M. Gamper,
Rudolf H. Winger,
Klaus R. Liedl,
Christoph A. Sotriffer,
Janos M. Varga,
Romano T. Kroemer, and
Bernd M. Rode
[Full Article -
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3889-3896
| Syntheses and Structure-Activity Relationships of the Second-Generation Antitumor Taxoids: Exceptional Activity against Drug-Resistant Cancer Cells
Iwao Ojima,
John C. Slater,
Evelyne Michaud,
Scott D. Kuduk,
Pierre-Yves Bounaud,
Patricia Vrignaud,
Marie-Christine Bissery,
Jean M. Veith,
Paula Pera, and
Ralph J. Bernacki
[Full Article -
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3897-3907
| Hypoglycemic Activity of a Series of  -Alkylthio and -Alkoxy Carboxylic Acids Related to Ciglitazone
Bernard Hulin,
Linda S. Newton,
Diana M. Lewis,
Paul E. Genereux,
E. Michael Gibbs, and
David A. Clark
[Full Article -
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3908-3919
| Heterocyclic Amides: Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase with Hypocholesterolemic Activity in Several Species and Antiatherosclerotic Activity in the Rabbit
Andrew D. White,
Claude F. Purchase, II,
Joseph A. Picard,
Maureen K. Anderson,
Sandra Bak Mueller,
Thomas M. A. Bocan,
Richard F. Bousley,
Katherine L. Hamelehle,
Brian R. Krause,
Peter Lee,
Richard L. Stanfield, and
James F. Reindel
[Full Article -
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3920-3928
| New Potent Antihyperglycemic Agents in db/db Mice: Synthesis and Structure-Activity Relationship Studies of (4-Substituted benzyl)(trifluoromethyl)pyrazoles and -pyrazolones
Kenneth L. Kees,
John J. Fitzgerald, Jr.,
Kurt E. Steiner,
James F. Mattes,
Brenda Mihan,
Theresa Tosi,
Diane Mondoro, and
Michael L. McCaleb
[Full Article -
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3929-3937
| 1-Substituted 4-Aryl-5-pyridinylimidazoles: A New Class of Cytokine Suppressive Drugs with Low 5-Lipoxygenase and Cyclooxygenase Inhibitory Potency
Jeffrey C. Boehm,
Juanita M. Smietana,
Margaret E. Sorenson,
Ravi S. Garigipati,
Timothy F. Gallagher,
Peter L. Sheldrake,
Jeremy Bradbeer,
Alison M. Badger,
Jeffrey T. Laydon,
John C. Lee,
Leonard M. Hillegass,
Donald E. Griswold,
John J. Breton,
Marie C. Chabot-Fletcher, and
Jerry L. Adams
[Full Article -
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3938-3950
| 5-Lipoxygenase Inhibitors: Synthesis and Structure-Activity Relationships of a Series of 1-Aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones
Pramila A. Bhatia,
Clint D. W. Brooks,
Anwer Basha,
James D. Ratajczyk,
Bruce P. Gunn,
Jennifer B. Bouska,
Carmine Lanni,
Patrick R. Young,
Randy L. Bell, and
George W. Carter
[Full Article -
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3951-3970
| Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5-Lipoxygenase Inhibitors: Structure-Activity Relationship Study Directed toward the Improvement of Metabolic Stability
Daniel Delorme,
Yves Ducharme,
Christine Brideau,
Chi-Chung Chan,
Nathalie Chauret,
Sylvie Desmarais,
Daniel Dubé,
Jean-Pierre Falgueyret,
Réjean Fortin,
Jocelyne Guay,
Pierre Hamel,
Tom R. Jones,
Carole Lépine,
Chun Li,
Malia McAuliffe,
Cyril S. McFarlane,
Deborah A. Nicoll-Griffith,
Denis Riendeau,
James A. Yergey, and
Yves Girard
[Full Article -
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3971-3979
| Novel AMPA Receptor Antagonists: Synthesis and Structure-Activity Relationships of 1-Hydroxy-7-(1H-imidazol-1-yl)-6-nitro-2,3(1H,4H)- quinoxalinedione and Related Compounds
Junya Ohmori,
Masao Shimizu-Sasamata,
Masamichi Okada, and
Shuichi Sakamoto
[Full Article -
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3980-3983
| Synthesis and Structure-DNA Binding Relationship Analysis of DNA Triple-Helix Specific Intercalators
Lucjan Strekowski,
Yuri Gulevich,
Timothy C. Baranowski,
Alesia N. Parker,
Alexander S. Kiselyov,
Shou-Yuan Lin,
Farial A. Tanious, and
W. David Wilson
[Full Article -
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3984-3997
| (Aryloxy)aryl Semicarbazones and Related Compounds: A Novel Class of Anticonvulsant Agents Possessing High Activity in the Maximal Electroshock Screen
Jonathan R. Dimmock,
Ramanan N. Puthucode,
Jennifer M. Smith,
Mark Hetherington,
J. Wilson Quail,
Uma Pugazhenthi,
Terry Lechler, and
James P. Stables
[Full Article -
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3998-4006
| Homology Modeling of Metabotropic Glutamate Receptors. (mGluRs) Structural Motifs Affecting Binding Modes and Pharmacological Profile of mGluR1 Agonists and Competitive Antagonists
Gabriele Costantino and
Roberto Pellicciari
[Full Article -
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4007-4016
| H and 13C NMR Relaxation Studies of Molecular Dynamics of the Thyroid Hormones Thyroxine, 3,5,3'-Triiodothyronine, and 3,5-Diiodothyronine
Brendan M. Duggan and
David J. Craik
[Full Article -
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4017-4026
| Structure-Activity Relationships for the Binding of Arylpiperazines and Arylbiguanides at 5-HT3 Serotonin Receptors
Ma gorzata Dukat,
Ashraf A. Abdel-Rahman,
Abd M. Ismaiel,
Stacy Ingher,
Milt Teitler,
Laszlo Gyermek, and
Richard A. Glennon
[Full Article -
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4027-4035
| Synthesis and Transporter Binding Properties of 3 -(4'-Alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2-carboxylic Acid Methyl Esters: Serotonin Transporter Selective Analogs
Bruce E. Blough,
Philip Abraham,
Anita H. Lewin,
Michael J. Kuhar,
John W. Boja, and
F. Ivy Carroll
[Full Article -
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4036-4043
| Derivatives of (R)- and (S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin: Synthesis and Interactions with 5-HT1A Receptors
Berit Backlund Höök,
Lourdes Cortizo,
Anette M. Johansson,
Anita Westlind-Danielsson,
Nina Mohell, and
Uli Hacksell
[Full Article -
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4044-4057
| Structure-Activity Relationships of a Series of Novel (Piperazinylbutyl)thiazolidinone Antipsychotic Agents Related to 3-[4-[4-(6-Fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5-trimethyl-4- thiazolidinone Maleate
Nicholas J. Hrib,
John G. Jurcak,
Deborah E. Bregna,
Kendra L. Burgher,
Harold B. Hartman,
Sharon Kafka,
Lisa L. Kerman,
Sam Kongsamut,
Joachim E. Roehr,
Mark R. Szewczak,
Ann T. Woods-Kettelberger, and
Roy Corbett
[Full Article -
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4058-4064
| On the Bioisosteric Potential of Diazines: Diazine Analogues of the Combined Thromboxane A2 Receptor Antagonist and Synthetase Inhibitor Ridogrel
Gottfried Heinisch,
Wolfgang Holzer,
Friedbert Kunz,
Thierry Langer,
Peter Lukavsky,
Christoph Pechlaner, and
Hans Weissenberger
[Full Article -
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4065-4072
| Principal Components Describing Biological Activities and Molecular Diversity of Heterocyclic Aromatic Ring Fragments
Samuel Gibson,
Ross McGuire, and
David C. Rees
[Full Article -
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4073-4088
| Acyclic Nucleotide Analogs Derived from 8-Azapurines: Synthesis and Antiviral Activity
Antonín Hol,
Hana Dvoáková,
Jindich Jindich,
Milena Masojídková,
Milo Budínsk,
Jan Balzarini,
Graciella Andrei, and
Erik De Clercq
[Full Article -
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4089-4098
| Novel Peptidyl -Keto Amide Inhibitors of Calpains and Other Cysteine Proteases
Zhaozhao Li,
Anne-Cécile Ortega-Vilain,
Girish S. Patil,
Der-Lun Chu,
J. E. Foreman,
David D. Eveleth, and
James C. Powers
[Full Article -
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4099-4108
| New Purines and Purine Analogs as Modulators of Multidrug Resistance
Alain Dhainaut,
Gilbert Regnier,
Andre Tizot,
Alain Pierre,
Stephane Leonce,
Nicolas Guilbaud,
Laurence Kraus-Berthier, and
Ghanem Atassi
[Full Article -
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4109-4115
| Neighboring Group Catalysis in the Design of Nucleotide Prodrugs
Shahrzad Khamnei and
Paul F. Torrence
[Full Article -
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4116-4119
| Synthesis and in Vitro Characterization of N-[5-(4,5-Dihydro-1H-imidazol-2-yl)- 2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and Its Enantiomers: A Novel Selective 1A Receptor Agonist
Michael D. Meyer,
Robert J. Altenbach,
Arthur A. Hancock,
Steven A. Buckner,
Sheila M. Knepper, and
James F. Kerwin, Jr.
[Full Article -
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4120-4124
| The Use of Topographical Constraints In Receptor Mapping: Investigation of the Topographical Requirements of the Tryptophan 30 Residue for Receptor Binding of Asp-Tyr-D-Phe-Gly-Trp-(N-Me)Nle-Asp-Phe-NH2 (SNF 9007), a Cholecystokinin (26-33) Analogue That Binds to both CCK-B and  -Opioid Receptors
Lakmal W. Boteju,
Gregory V. Nikiforovich,
Carrie Haskell-Luevano,
Su-Nan Fang,
Teresa Zalewska,
Dagmar Stropova,
Henry I. Yamamura, and
Victor J. Hruby
[Full Article -
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4125-4130
| Cycloalkylpyranones and Cycloalkyldihydropyrones as HIV Protease Inhibitors: Exploring the Impact of Ring Size on Structure-Activity Relationships
Karen R. Romines,
Jeanette K. Morris,
W. Jeffrey Howe,
Paul K. Tomich,
Miao-Miao Horng,
Kong-Teck Chong,
Roger R. Hinshaw,
David J. Anderson,
Joseph W. Strohbach,
Steve R. Turner, and
Steve A. Mizsak
[Full Article -
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4131-4131
| Taxane Anticancer Agents: Basic Science and Current Status Edited by Gunda I. Georg, Thomas T. Chen, Iwao Ojima, and Dolatrai M. Vyas. ACS Symposium Series 583. American Chemical Society, Washington, D.C. 1995. xiii + 353 pp. 15.5 × 23.5 cm. ISBN 0-8412-3073-0. $99.95.
Samit K. Bhattacharya
[Full Article -
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4131-4132
| An Introduction to Medicinal Chemistry By Graham L. Patrick. Oxford University Press, New York. 1995. xiv + 336 pp. 19.5 × 25 cm. ISBN 0-19-855872-4. $59.00.
Joseph G. Cannon
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4132-4132
| Fluorine-containing Amino Acids. Synthesis and Properties Edited by V. P. Kukhar' and V. A. Soloshonok. John Wiley & Sons, Inc., New York. 1995. x + 411 pp. 15.5 × 23.5 cm. ISBN 0-471-95203-6. $140.00.
Kenneth A. Jacobson
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4132-4133
| The Biology of Nitric Oxide. Part 5 Edited by S. Moncada, J. Stamler, S. Gross, and E. A. Higgs. Portland Press Ltd., London. 1996. xxx + 353 pp. 21 × 29 cm. ISBN 1-85578-102-6. $160.00.
Staff
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4133-4133
| Chemometric Methods in Molecular Design Edited by Han van de Waterbeemd. VCH, Weinheim. 1995. xix + 359 pp. 17.5 × 24.5 cm. ISBN 3-527-30044-9. DM 188.00.
Alan H. Katz
[Full Article -
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4134-4134
| Synthesis and Biological Evaluation of DL-4,4-Difluoroglutamic Acid and DL- ,-Difluoromethotrexate
Takashi Tsukamoto,
Tomoya Kitazume,
John
J. McGuire, and
James K. Coward
[Full Article -
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4134-4134
| Synthesis and Biological Activity of Folic Acid and Methotrexate Analogues Containing L-threo-(2S,4S)-4-Fluoroglutamic Acid and DL-3,3-Difluoroglutamic Acid
Barry P. Hart,
William H. Haile,
Nicholas J. Licato,
Wanda E. Bolanowska,
John J. McGuire, and
James K. Coward
[Full Article -
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