4135-4138
| Alkylation of DNA by the Anthracycline, Antitumor Drugs Adriamycin and Daunomycin
Dylan J. Taatjes,
Giorgio Gaudiano,
Katheryn Resing, and
Tad H. Koch
[Full Article -
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4139-4141
| 3 -(4'-Substituted phenyl)tropane- 2 -carboxylic Acid Methyl Esters: Novel Ligands with High Affinity and Selectivity at the Dopamine Transporter
Christopher R. Holmquist,
Kathryn I. Keverline-Frantz,
Philip Abraham,
John W. Boja,
Michael J. Kuhar, and
F. Ivy Carroll
[Full Article -
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4142-4148
| Derivatives of the Triazoloquinazoline Adenosine Antagonist (CGS15943) Are Selective for the Human A3 Receptor Subtype
Yong-Chul Kim,
Xiao-duo Ji, and
Kenneth A. Jacobson
[Full Article -
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4149-4155
| Structure-Activity Relationships of the Antimalarial Agent Artemisinin. 5. Analogs of 10-Deoxoartemisinin Substituted at C-3 and C-9
Mitchell A. Avery,
Sanjiv Mehrotra,
Theresa L. Johnson,
Jason D. Bonk,
Jeffrey A. Vroman, and
Robert Miller
[Full Article -
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4156-4161
| Synthesis and Structure-Activity Relationship of Pyrazolo[3,4-d]pyrimidines: Potent and Selective Adenosine A1 Receptor Antagonists
Sally-Ann Poulsen and
Ronald J. Quinn
[Full Article -
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4162-4166
| Inactivation of S-Adenosyl-L-homocysteine Hydrolase by Amide and Ester Derivatives of Adenosine-5'-carboxylic Acid
Stanislaw F. Wnuk,
Siming Liu,
Chong-Sheng Yuan,
Ronald T. Borchardt, and
Morris J. Robins
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4167-4172
| Understanding the Mechanism of Sweet Taste: Synthesis of Ultrapotent Guanidinoacetic Acid Photoaffinity Labeling Reagents
Srinivasan Nagarajan,
Michael S. Kellogg, and
Grant E. DuBois
, Göran Hellekant
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4173-4180
| Peptidomimetic Inhibitors of Herpes Simplex Virus Ribonucleotide Reductase with Improved in Vivo Antiviral Activity
Neil Moss,
Pierre Beaulieu,
Jean-Simon Duceppe,
Jean-Marie Ferland,
Michel Garneau,
Jean Gauthier,
Elise Ghiro,
Sylvie Goulet,
Ingrid Guse,
Jorge Jaramillo,
Montse Llinas-Brunet,
Éric Malenfant,
Raymond Plante,
Martin Poirier,
Francois Soucy,
Dominik Wernic,
Christiane Yoakim, and
Robert Déziel
[Full Article -
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4181-4196
| Structure-Activity Relationships for Inhibition of Inosine Monophosphate Dehydrogenase by Nuclear Variants of Mycophenolic Acid
Peter H. Nelson,
Stephen F. Carr,
Bruce H. Devens,
Elsie M. Eugui,
Fidencio Franco,
Carlos Gonzalez,
Ronald C. Hawley,
David G. Loughhead,
David J. Milan,
Eva Papp,
John W. Patterson,
Sussan Rouhafza,
Eric B. Sjogren,
David B. Smith,
Rebecca A. Stephenson,
Francisco X. Talamas,
Ann-Marie Waltos,
Robert J. Weikert, and
John C. Wu
[Full Article -
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4197-4210
| Hydroxamic Acid-Based Bisubstrate Analog Inhibitors of Ras Farnesyl Protein Transferase
Dinesh V. Patel,
Marian G. Young,
Simon P. Robinson,
Lisa Hunihan,
Brenda J. Dean, and
Eric M. Gordon
[Full Article -
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4211-4217
| 2-Alkenyl and 2-Alkyl Derivatives of Adenosine and Adenosine-5'-N-Ethyluronamide: Different Affinity and Selectivity of E- and Z-Diastereomers at A2A Adenosine Receptors
Sauro Vittori,
Emidio Camaioni,
Emanuela Di Francesco,
Rosaria Volpini,
Angela Monopoli,
Silvio Dionisotti,
Ennio Ongini, and
Gloria Cristalli
[Full Article -
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4218-4232
| Neurosteroid Analogues. 4. The Effect of Methyl Substitution at the C-5 and C-10 Positions of Neurosteroids on Electrophysiological Activity at GABAA Receptors
Mingcheng Han,
Charles F. Zorumski, and
Douglas F. Covey
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4233-4237
| Affinity for Dopamine D2, D3, and D4 Receptors of 2-Aminotetralins. Relevance of D2 Agonist Binding for Determination of Receptor Subtype Selectivity
L. Alexander van Vliet,
Pieter G. Tepper,
Durk Dijkstra,
Geert Damsma,
Håkan Wikström,
Thomas A. Pugsley,
Hyacinth C. Akunne,
Thomas G. Heffner,
Shelly A. Glase, and
Lawrence D. Wise
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4238-4246
| Synthesis, Resolution, and Preliminary Evaluation of trans-2-Amino-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes and Related Derivatives as Dopamine Receptors Ligands
Francesco Claudi,
Gian Mario Cingolani,
Antonio Di Stefano,
Gianfabio Giorgioni,
Francesco Amenta,
Paolo Barili,
Francesca Ferrari, and
Daniela Giuliani
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4247-4254
| Synthesis, Molecular Modeling, and K+ Channel-Blocking Activity of Dequalinium Analogues Having Semirigid Linkers
Joaquin Campos Rosa,
Dimitrios Galanakis,
C. Robin Ganellin, and
Philip M. Dunn
[Full Article -
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4255-4260
| Novel Potent  1 Ligands: N-[ -(Tetralin-1-yl)alkyl]piperidine Derivatives
Francesco Berardi,
Giuseppe Giudice,
Roberto Perrone,
Vincenzo Tortorella,
Stefano Govoni, and
Laura Lucchi
[Full Article -
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4261-4274
| Phenethylthiazolylthiourea (PETT) Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 2. Synthesis and Further Structure-Activity Relationship Studies of PETT Analogs
Amanda S. Cantrell,
Per Engelhardt,
Marita Högberg,
S. Richard Jaskunas,
Nils Gunnar Johansson,
Christopher L. Jordan,
Jussi Kangasmetsä,
Michael D. Kinnick,
Peter Lind,
John M. Morin, Jr.,
M. A. Muesing,
Rolf Noreén,
Bo Öberg,
Paul Pranc,
Christer Sahlberg,
Robert J. Ternansky,
Robert T. Vasileff,
Lotta Vrang,
Sarah J. West, and
Hong Zhang
[Full Article -
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4275-4284
| Molecular Basis of Peripheral vs Central Benzodiazepine Receptor Selectivity in a New Class of Peripheral Benzodiazepine Receptor Ligands Related to Alpidem
Maurizio Anzini,
Andrea Cappelli,
Salvatore Vomero,
Gianluca Giorgi,
Thierry Langer,
Giancarlo Bruni,
Maria R. Romeo, and
Anthony S. Basile
[Full Article -
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4285-4298
| 3-Amino-3,4-dihydro-2H-1-benzopyran Derivatives as 5-HT1A Receptor Ligands and Potential Anxiolytic Agents. 2. Synthesis and Quantitative Structure-Activity Relationship Studies of Spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans]
Corinne Comoy,
Christophe Marot,
Tchao Podona,
Marie-Laure Baudin,
Luc Morin-Allory,
Gérald Guillaumet,
Bruno Pfeiffer,
Daniel-Henry Caignard,
Pierre Renard,
Marie-Claire Rettori,
Gérard Adam, and
Béatrice Guardiola-Lemaître
[Full Article -
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4299-4312
| HIV Protease Inhibitory Bis-benzamide Cyclic Ureas: A Quantitative Structure-Activity Relationship Analysis
Wendell W. Wilkerson,
Emeka Akamike,
Walter W. Cheatham,
Andrea Y. Hollis,
R. Dale Collins,
Indawati DeLucca,
Patrick Y. S. Lam, and
Yu Ru
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4313-4320
| Biophysical Characterization of Zinc Ejection from HIV Nucleocapsid Protein by Anti-HIV 2,2'-Dithiobis[benzamides] and Benzisothiazolones
Joseph A. Loo,
Tod P. Holler,
Joseph Sanchez,
Rocco Gogliotti,
Lisa Maloney, and
Michael D. Reily
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4321-4331
| Chemistry of the Pyrrolo[1,2-a]benzimidazole Antitumor Agents: Influence of the 7-Substituent on the Ability To Alkylate DNA and Inhibit Topoisomerase II
Ru Zhou and
Edward B. Skibo
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4332-4334
| Molecular Modeling Studies of "Flap Up" Mannosyl Cation Mimics
David A. Winkler
[Full Article -
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4335-4339
| Synthesis and Evaluation of Pregnane Derivatives as Inhibitors of Human Testicular 17-Hydroxylase/C17,20-Lyase
Ji-song Li,
Yan Li,
Chong Son, and
Angela M. H. Brodie
[Full Article -
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4340-4344
| Design and Synthesis of Histidine Analogues of Folic Acid and Methotrexate as Potential Folylpolyglutamate Synthetase Inhibitors
Zhenmin Mao,
Jianping Pan, and
Thomas I. Kalman
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4345-4345
| Encyclopedia of Molecular Biology and Molecular Medicine. Volume 1 Edited by Robert A. Myers. VCH Verlagsgesellschaft mbH, Weinheim, Germany. 1996. xiii + 462 pp. 22.5 × 28.5 cm. ISBN 3-527-28471-0. DM 490.00.
Staff
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4345-4345
| Ocular Therapeutics and Drug Delivery: A Multidisciplinary Approach Edited by Indra K. Reddy. Technomic Publishing Co., Inc., Lancaster, PA. 1996. xxv + 585 pp. 16 × 23.5 cm. ISBN 1-56676-213-8. $89.00.
Manfred E. Wolff
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4345-4346
| Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. 2 Edited by H. M. Pinedo and J. H. Schornagel. Plenum Press, New York. 1996. x + 357 pp. 17 × 26.5 cm. ISBN 0-306-45287-1. $85.00.
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4346-4346
| Metal Ions in Biological Systems. Volume 32. Interactions of metal ions with nucleotides, nucleic acids, and their constituents A. Sigel and H. Sigel, Eds. Marcel Dekker Inc., New York. 1996. xxxix + 814 pp. 16 × 23.5 cm. ISBN 0-8247-99549-0. $225.00. Metal Ions in Biological Systems. Volume 33. Probing of nucleic acids by metal ion complexes of small molecules. A. Sigel and H. Sigel, Eds. Marcel Dekker Inc., New York. 1996. xli + 678 pp. 16 × 23.5 cm. ISBN 0-8247-9688-8. $195.00.
J. A. Cowan
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4346-4347
| TOXICOLOGY: Principles and Applications Edited by Raymond J. M. Niesink, John de Vries, and Mannfred A. Hollinger. CRC Press Inc., New York. 1996. 1284 pp. 22.5 × 28.5 cm. ISBN 0-8493-9232-2. $125.00.
Peter J. Wirth
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4347-4347
| Books of Interest
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4348-4348
| Mapping the Aspartic Acid Binding Site of Escherichia coli Asparagine Synthetase B Using Substrate Analogs
Ian B. Parr,
Susan K. Boehlein,
Anthony B.
Dribben,
Sheldon M. Schuster, and
Nigel G. J. Richards
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