4867-4870
| Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists
James M. Samanen,
Fadia E. Ali,
Linda S. Barton,
William E. Bondinell,
Joelle L. Burgess,
James F. Callahan,
Raul R. Calvo,
Wenting Chen,
Lichong Chen,
Karl Erhard,
Giora Feuerstein,
Richard Heys,
Shing-Mei Hwang,
Dalia R. Jakas,
Richard M. Keenan,
Thomas W. Ku,
Chet Kwon,
Chao-Pin Lee,
William H. Miller,
Kenneth A. Newlander,
Andrew Nichols,
Michael Parker,
Catherine E. Peishoff,
Gerald Rhodes,
Steven Ross,
Arthur Shu,
Richard Simpson,
Dennis Takata,
Tobias O. Yellin,
Irene Uzsinskas,
Joseph W. Venslavsky,
Chuan-Kui Yuan, and
William F. Huffman
[Full Article -
PDF] |
4871-4878
| (Carboxyalkyl)benzyl Propargyl Ethers as Selective Inhibitors of Leukocyte-Type 12-Lipoxygenases
Gilles Gorins,
Lethea Kuhnert,
Carl R. Johnson, and
Lawrence J. Marnett
[Full Article -
PDF] |
4879-4887
| Development of Potent Thrombin Receptor Antagonist Peptides
Michael S. Bernatowicz,
Clifford E. Klimas,
Karen S. Hartl,
Marianne Peluso,
Nick J. Allegretto, and
Steven M. Seiler
[Full Article -
PDF] |
4888-4896
| Anti-inflammatory 17 -Thioalkyl-16 ,17-ketal and -acetal Androstanes: A New Class of Airway Selective Steroids for the Treatment of Asthma
Michael J. Ashton,
Christopher Lawrence,
Jan-Anders Karlsson,
Keith A. J. Stuttle,
Christopher G. Newton,
Bernard Y. J. Vacher,
Stephen Webber, and
Michael J. Withnall
[Full Article -
PDF] |
4897-4904
| Bisphenolic Compounds That Enhance Cell Cation Transport Are Found in Commercial Phenol Red
Philip R. Kym,
Kim L. Hummert,
Anna G. Nilsson,
Martin Lubin, and
John A. Katzenellenbogen
[Full Article -
PDF] |
4905-4911
| Tyrphostins. 6. Dimeric Benzylidenemalononitrile Tyrphostins: Potent Inhibitors of EGF Receptor Tyrosine Kinase in Vitro
Aviv Gazit,
Nir Osherov,
Chaim Gilon, and
Alexander Levitzki
[Full Article -
PDF] |
4912-4919
| Conformationally Constrained Analogues of Diacylglycerol. 13. Protein Kinase C Ligands Based on Templates Derived from 2,3-Dideoxy-L-erythro(threo)-hexono-1,4-lactone and 2-Deoxyapiolactone
Jeewoo Lee,
Nancy E. Lewin,
Peter Acs,
Peter M. Blumberg, and
Victor E. Marquez
[Full Article -
PDF] |
4920-4927
| Serotonin Dimers: Application of the Bivalent Ligand Approach to the Design of New Potent and Selective 5-HT1B/1D Agonists
Serge Halazy,
Michel Perez,
Catherine Fourrier,
Isabelle Pallard,
Petrus J. Pauwels,
Christiane Palmier,
Gareth W. John,
Jean-Pierre Valentin,
Régine Bonnafous, and
Jean Martinez
[Full Article -
PDF] |
4928-4934
| Structure-Activity Relationship Studies on the 5-HT1A Receptor Affinity of 1-Phenyl-4-[ -(- or -tetralinyl)alkyl]piperazines. 4
Roberto Perrone,
Francesco Berardi,
Nicola A. Colabufo,
Marcello Leopoldo, and
Vincenzo Tortorella
, Maria Gioia Fornaretto,
Carla Caccia, and
Robert A. McArthur
[Full Article -
PDF] |
4935-4941
| Halogenated Mazindol Analogs as Potential Inhibitors of the Cocaine Binding Site at the Dopamine Transporter
William J. Houlihan,
John W. Boja,
Vincent A. Parrino,
Theresa A. Kopajtic, and
Michael J. Kuhar
[Full Article -
PDF] |
4942-4951
| Analogues of Capsaicin with Agonist Activity as Novel Analgesic Agents: Structure-Activity Studies. 4. Potent, Orally Active Analgesics
Roger Wrigglesworth,
Christopher S. J. Walpole,
Stuart Bevan,
Elizabeth A. Campbell,
Andy Dray,
Glyn A. Hughes,
Iain James,
Kay J. Masdin, and
Janet Winter
[Full Article -
PDF] |
4952-4957
| Potent 6-Desfluoro-8-methylquinolones as New Lead Compounds in Antibacterial Chemotherapy
Violetta Cecchetti,
Arnaldo Fravolini,
Manlio Palumbo,
Claudia Sissi,
Oriana Tabarrini,
Patrizia Terni, and
Tao Xin
[Full Article -
PDF] |
4958-4965
| Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Bis(S-acyl-2-thioethyl) Ester Derivatives of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as Potential PMEA Prodrugs with Improved Oral Bioavailability
Samira Benzaria,
Hélène Pélicano,
Richard Johnson,
Georges Maury,
Jean-Louis Imbach,
Anne-Marie Aubertin,
Georges Obert, and
Gilles Gosselin
[Full Article -
PDF] |
4966-4977
| Synthesis, Biological Activity, and Molecular Modeling Studies of Selective 5-HT2C/2B Receptor Antagonists
Ian T. Forbes,
Steven Dabbs,
D. Malcolm Duckworth,
Peter Ham,
Graham E. Jones,
Frank D. King,
Damian V. Saunders,
Frank E. Blaney,
Christopher B. Naylor,
Gordon S. Baxter,
Thomas P. Blackburn,
Guy A. Kennett, and
Martyn D. Wood
[Full Article -
PDF] |
4978-4987
| 2-[2'-(Dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones with Substituents at Positions 4, 8, 9, 10, and 11. Synthesis, Antitumor Activity, and Quantitative Structure-Activity Relationships
Salah M. Sami,
Robert T. Dorr,
David S. Alberts,
Anikó M. Sólyom, and
William A. Remers
[Full Article -
PDF] |
4988-4996
| Design, Synthesis, and in Vitro Evaluation of Cyclic Nitrones as Free Radical Traps for the Treatment of Stroke
Thomas L. Fevig,
S. Marc Bowen,
David A. Janowick,
Bryan K. Jones,
H. Randall Munson,
David F. Ohlweiler, and
Craig E. Thomas
[Full Article -
PDF] |
4997-5004
| Cyclic Nitrone Free Radical Traps: Isolation, Identification, and Synthesis of 3,3-Dimethyl-3,4-dihydroisoquinolin-4-ol N-Oxide, a Metabolite with Reduced Side Effects
Craig E. Thomas,
Patrick Bernardelli,
S. Marc Bowen,
Stephen F. Chaney,
Dirk Friedrich,
David A. Janowick,
Bryan K. Jones,
Frederick J. Keeley,
John H. Kehne,
Bert Ketteler,
David F. Ohlweiler,
Leo A. Paquette,
David J. Robke, and
Thomas L. Fevig
[Full Article -
PDF] |
5005-5011
| Nucleosides and Nucleotides. 158. 1-(3-C-Ethynyl--D-ribo-pentofuranosyl)- cytosine, 1-(3-C-Ethynyl--D-ribo-pentofuranosyl)uracil, and Their Nucleobase Analogues as New Potential Multifunctional Antitumor Nucleosides with a Broad Spectrum of Activity
Hideshi Hattori,
Motohiro Tanaka,
Masakazu Fukushima,
Takuma Sasaki, and
Akira Matsuda
[Full Article -
PDF] |
5012-5016
| Organometallic Anticancer Agents. 2. Aqueous Chemistry and Interaction of Niobocene Dichloride with Nucleic Acid Constituents and Amino Acids
Margaret M. Harding,
Michael Prodigalidad, and
Mark J. Lynch
[Full Article -
PDF] |
5017-5020
| Quantitative Structure-Activity Relationship Study of Fibrinogen Inhibitors, [[4-(4-Amidinophenoxy)butanoyl]aspartyl]valine (FK633) Derivatives, Using a Novel Hydrophobic Descriptor
Akito Tanaka and
Hideaki Fujiwara
[Full Article -
PDF] |
5021-5024
| Synthesis and in Vitro Evaluation of New Wortmannin Esters: Potent Inhibitors of Phosphatidylinositol 3-Kinase
Lawrence C. Creemer,
Herbert A. Kirst,
Chris J. Vlahos, and
Richard M. Schultz
[Full Article -
PDF] |
5025-5025
| Chemical Aspects of Drug Delivery Systems Edited by D. R. Karsa and R. A. Stephenson. The Royal Society of Chemistry, London. 1996. viii + 162 pp. 15 × 23 cm. ISBN 0-85404-706-9. $89.00.
Nicholas S. Bodor
[Full Article -
PDF] |
5025-5026
| Annual Review of Pharmacology and Toxicology, Volume 36 Edited by A. K. Cho. Annual Review, Inc., Palo Alto, CA. 1996. vii + 719 pp. 16 × 23 cm. ISBN 0-8243-0436-5. $52.00.
J. Paul Hieble
[Full Article -
PDF] |
5026-5026
| Methods of Organic Chemistry. (Houben-Weyl). Additional and Supplementary Volumes to the 4th Edition. Stereoselective Synthesis. Volume E21a. Nomenclature, Principles, Analytic, Axially Chiral Compounds, Bond Disconnection, Alkylation Reactions, and Insertion into C-H Bonds. Volume E21b. C-C Bond Formation by Addition to =O, =N, =--X, =-=O, =-=N, =-N=X, and =-S=X. Volume E21c. C-C Bond Formation by Addition to C=C, Cycloaddition Reactions, and Ene Reaction. Volume E21d. C-C Bond Formation by Sigmatropic Rearrangements, Electrocyclic Reactions, C-H, and C-Hal Bond Formation. Volume E21e. Bond Formation: C-N, C-O, C-P, C-S, C-Se, C-Si, C-Sn, and C-Te. Volume E21f. Survey of Chiral Auxiliaries, Solvents, Reagents, and Catalysts Edited by Gunter Helmchen, Reinhard W. Hoffmann, Johann Mulzer, and Ernst Schumann. Georg Thieme Verlag, Stuttgart, Germany. Volume E21a: 1995. xix + 1168 pp. 17.5 × 25.5 cm. ISBN 3-13-219504-9. DM 2840.00. Volume E21b: 1995. xviii + 1051 pp. 17.5 × 25.5 cm. ISBN 3-13-219504-9. DM 2480.00. Volume E21c: 1995. xv + 1096 pp. 17.5 × 25.5 cm. ISBN 3-13-798004-6. DM 2550.00. Volume E21d: 1995. xiv + 1020 pp. 17.5 × 25.5 cm. ISBN 3-13-100114-3. DM 2770. Volume E21e: 1995. xxi + 1261 pp. 17.5 × 25.5 cm. ISBN 3-13-100124-0. DM 2980.00. Volume E21f: 1996. xlii + 1230 pp. 17.5 × 25.5 cm. ISBN 3-13-102794-0. DM 1930.00. Volume Set: approximately DM 13900.00. Workbench Edition (10 Volume Set). ISBN 3-13-106124-3. DM 3600.
Staff
[Full Article -
PDF] |