5027-5030
| Identification of Retinoic Acid Receptor  Subtype Specific Agonists
Alan T. Johnson,
Elliott S. Klein,
Liming Wang,
Mary E. Pino, and
Roshantha A. S. Chandraratna
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5031-5034
| Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase (ACAT) as Hypocholesterolemic Agents. CI-1011: An Acyl Sulfamate with Unique Cholesterol-Lowering Activity in Animals Fed Noncholesterol-Supplemented Diets
Helen T. Lee,
Drago R. Sliskovic,
Joseph A. Picard,
Bruce D. Roth,
Wendell Wierenga,
James L. Hicks,
Richard F. Bousley,
Katherine L. Hamelehle,
Reynold Homan,
Cecilia Speyer,
Richard L. Stanfield, and
Brian R. Krause
[Full Article -
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5035-5046
| Bicyclic N-Hydroxyurea Inhibitors of 5-Lipoxygenase: Pharmacodynamic, Pharmacokinetic, and in Vitro Metabolic Studies Characterizing N-Hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea
Jerry L. Adams,
Ravi S. Garigipati,
Margaret Sorenson,
Stanley J. Schmidt,
William R. Brian,
John F. Newton,
Kathy A. Tyrrell,
Eric Garver,
Lee A. Yodis,
Marie Chabot-Fletcher,
Maritsa Tzimas,
Edward F. Webb,
John J. Breton, and
Don E. Griswold
[Full Article -
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5047-5052
| Indole Derivatives as a New Class of Steroid 5 -Reductase Inhibitors
Hitoshi Takami,
Hirokazu Koshimura,
Nobuyuki Kishibayashi,
Akio Ishii,
Hiromi Nonaka,
Shiro Aoyama,
Hiroshi Kase, and
Toshiaki Kumazawa
[Full Article -
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5053-5063
| Synthesis and Biological Activity of Metabolites of the Antidiabetic, Antihyperglycemic Agent Pioglitazone
Steven P. Tanis,
Timothy T. Parker,
Jerry R. Colca,
Roberta M. Fisher, and
Rolf F. Kletzein
[Full Article -
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5064-5071
| Structure-Based Alignment and Comparative Molecular Field Analysis of Acetylcholinesterase Inhibitors
Sung Jin Cho,
Maria Luisa Serrano Garsia,
Jim Bier, and
Alexander Tropsha
[Full Article -
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5072-5082
| Design, Synthesis, and Evaluation of Nonpeptidic Inhibitors of Human Rhinovirus 3C Protease
Stephen E. Webber,
Jayashree Tikhe,
Stephen T. Worland,
Shella A. Fuhrman,
Thomas F. Hendrickson,
David A. Matthews,
Robert A. Love,
Amy K. Patick,
James W. Meador,
Rose Ann Ferre,
Edward L. Brown,
Dorothy M. DeLisle,
Clifford E. Ford, and
Susan L. Binford
[Full Article -
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5083-5091
| Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies of N-(Indol-3-ylglyoxylyl)benzylamine Derivatives Acting at the Benzodiazepine Receptor
Antonio Da Settimo,
Giampaolo Primofiore,
Federico Da Settimo,
Anna Maria Marini,
Ettore Novellino,
Giovanni Greco,
Claudia Martini,
Gino Giannaccini, and
Antonio Lucacchini
[Full Article -
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5092-5099
| Synthesis and Bioevaluation of  7-5-Desaturase Inhibitors, an Enzyme Late in the Biosynthesis of the Fungal Sterol Ergosterol
Alex S. Goldstein
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5100-5109
| 2'-O-Aminopropyl Ribonucleotides: A Zwitterionic Modification That Enhances the Exonuclease Resistance and Biological Activity of Antisense Oligonucleotides
Richard H. Griffey,
Brett P. Monia,
Lendall L. Cummins,
Susan Freier,
Michael J. Greig,
Charles J. Guinosso,
Elena Lesnik,
Sherilynn M. Manalili,
Venkatraman Mohan,
Steven Owens,
Bruce R. Ross,
Henri Sasmor,
Ed Wancewicz,
Kurt Weiler,
Patrick D. Wheeler, and
P. Dan Cook
[Full Article -
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5110-5118
| Synthesis and Evaluation of Two Positron-Labeled Nitric Oxide Synthase Inhibitors, S-[11C]Methylisothiourea and S-(2-[18F]Fluoroethyl)isothiourea, as Potential Positron Emission Tomography Tracers
Jian Zhang,
Timothy J. McCarthy,
William M. Moore,
Mark G. Currie, and
Michael J. Welch
[Full Article -
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5119-5136
| Indole Inhibitors of Human Nonpancreatic Secretory Phospholipase A2. 1. Indole-3-acetamides
Robert D. Dillard,
Nicholas J. Bach,
Susan E. Draheim,
Dennis R. Berry,
Donald G. Carlson,
Nickolay Y. Chirgadze,
David K. Clawson,
Lawrence W. Hartley,
Lea M. Johnson,
Noel D. Jones,
Emma R. McKinney,
Edward D. Mihelich,
Jennifer L. Olkowski,
Richard W. Schevitz,
Amy C. Smith,
David W. Snyder,
Cynthia D. Sommers, and
Jean-Pierre Wery
[Full Article -
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5137-5158
| Indole Inhibitors of Human Nonpancreatic Secretory Phospholipase A2. 2. Indole-3-acetamides with Additional Functionality
Robert D. Dillard,
Nicholas J. Bach,
Susan E. Draheim,
Dennis R. Berry,
Donald G. Carlson,
Nickolay Y. Chirgadze,
David K. Clawson,
Lawrence W. Hartley,
Lea M. Johnson,
Noel D. Jones,
Emma R. McKinney,
Edward D. Mihelich,
Jennifer L. Olkowski,
Richard W. Schevitz,
Amy C. Smith,
David W. Snyder,
Cynthia D. Sommers, and
Jean-Pierre Wery
[Full Article -
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5159-5175
| Indole Inhibitors of Human Nonpancreatic Secretory Phospholipase A2. 3. Indole-3-glyoxamides
Susan E. Draheim,
Nicholas J. Bach,
Robert D. Dillard,
Dennis R. Berry,
Donald G. Carlson,
Nickolay Y. Chirgadze,
David K. Clawson,
Lawrence W. Hartley,
Lea M. Johnson,
Noel D. Jones,
Emma R. McKinney,
Edward D. Mihelich,
Jennifer L. Olkowski,
Richard W. Schevitz,
Amy C. Smith,
David W. Snyder,
Cynthia D. Sommers, and
Jean-Pierre Wery
[Full Article -
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5176-5182
| Studies on Disease-Modifying Antirheumatic Drugs: Synthesis of Novel Quinoline and Quinazoline Derivatives and Their Anti-inflammatory Effect
Atsuo Baba,
Noriaki Kawamura,
Haruhiko Makino,
Yoshikazu Ohta,
Shigehisa Taketomi, and
Takashi Sohda
[Full Article -
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5183-5191
| Synthesis and Phospholipase A2 Inhibitory Activity of Thielocin B3 Derivatives
Isao Teshirogi,
Shigeru Matsutani,
Kazuhiro Shirahase,
Yasuhiko Fujii,
Tadashi Yoshida,
Kazushige Tanaka, and
Mitsuaki Ohtani
[Full Article -
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5192-5201
| Mechanism of Selective Incorporation of the Melanoma Seeker 2-Thiouracil into Growing Melanin
Alessandra Napolitano,
Anna Palumbo,
Marco d'Ischia, and
Giuseppe Prota
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5202-5207
| Synthesis, Biotransformation, and Pharmacokinetic Studies of 9-(-D-Arabinofuranosyl)-6-azidopurine: A Prodrug for Ara-A Designed To Utilize the Azide Reduction Pathway
Lakshmi P. Kotra,
Konstantine K. Manouilov,
Erica Cretton-Scott,
Jean-Pierre Sommadossi,
F. Douglas Boudinot,
Raymond F. Schinazi, and
Chung K. Chu
[Full Article -
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5208-5214
| Antitumor Properties of Some 2-[(Dimethylamino)methyl]phenylgold(III) Complexes
Robert G. Buckley,
Amanda M. Elsome,
Simon P. Fricker,
Graham R. Henderson,
Brian R. C. Theobald,
Richard V. Parish,
Brian P. Howe, and
Lloyd R. Kelland
[Full Article -
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5215-5227
| Synthesis and Protein Kinase C Inhibitory Activities of Acyclic Balanol Analogs That Are Highly Selective for Protein Kinase C over Protein Kinase A
Jean M. Defauw,
Marcia M. Murphy,
G. Erik Jagdmann, Jr.,
Hong Hu,
John W. Lampe,
Sean P. Hollinshead,
Thomas J. Mitchell,
Heidi M. Crane,
Julia M. Heerding,
José S. Mendoza,
Jefferson E. Davis,
James W. Darges,
Frederick R. Hubbard, and
Steven E. Hall
[Full Article -
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5228-5235
| Synthesis and Angiotensin II Receptor Antagonistic Activities of Benzimidazole Derivatives Bearing Acidic Heterocycles as Novel Tetrazole Bioisosteres
Yasuhisa Kohara,
Keiji Kubo,
Eiko Imamiya,
Takeo Wada,
Yoshiyuki Inada, and
Takehiko Naka
[Full Article -
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5236-5245
| Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity (II): Optimization of the C3 Amino Substituent
Gavin C. Hirst,
Christopher Aquino,
Lawrence Birkemo,
Dallas K. Croom,
Milana Dezube,
Robert W. Dougherty, Jr.,
Gregory N. Ervin,
Mary K. Grizzle,
Brad Henke,
Michael K. James,
Michael F. Johnson,
Tanya Momtahen,
Kennedy L. Queen,
Ronald G. Sherrill,
Jerzy Szewczyk,
Timothy M. Willson, and
Elizabeth E. Sugg
[Full Article -
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5246-5256
| Genetic Neural Networks for Quantitative Structure-Activity Relationships: Improvements and Application of Benzodiazepine Affinity for Benzodiazepine/GABAA Receptors
Sung-Sau So and
Martin Karplus
[Full Article -
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5257-5266
| Polyamine Analogue Regulation of NMDA MK-801 Binding: A Structure-Activity Study
Raymond J. Bergeron,
William R. Weimar,
Qianhong Wu,
Yang Feng, and
James S. McManis
[Full Article -
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5267-5275
| Synthesis and Bioactivity of Novel Bis(heteroaryl)piperazine (BHAP) Reverse Transcriptase Inhibitors: Structure-Activity Relationships and Increased Metabolic Stability of Novel Substituted Pyridine Analogs
Michael J. Genin,
Toni J. Poel,
Yoshihiko Yagi,
Carolyn Biles,
Irene Althaus,
Barbara J. Keiser,
Laurice A. Kopta,
Jan M. Friis,
Fritz Reusser,
Wade J. Adams,
Robert A. Olmsted,
Richard L. Voorman,
Richard C. Thomas, and
Donna L. Romero
[Full Article -
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5276-5280
| Synthesis and HIV Inhibition Activity of 2',3'-Dideoxy-3'-C-hydroxymethyl Nucleosides
E. Lee-Ruff,,1a
Mario Ostrowski,1b
Azim Ladha,1b
Dennis V. Stynes,1a
Isaak Vernik,1a
Ji-Long Jiang,1a
Wei-Qin Wan,1c
Shi-Fa Ding,1b and
Sadhna Joshi,1b
[Full Article -
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5281-5284
| Structure-Activity Relationships of Phomactin Derivatives as Platelet Activating Factor Antagonists
Michihiro Sugano,
Aiya Sato,
Kazuko Saito,
Sachiko Takaishi,
Yoichi Matsushita, and
Yasuteru Iijima
[Full Article -
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5285-5285
| Ion Channels Volume 4 Edited by Toshio Narahashi. Plenum Press, New York and London. 1996. XVII + 457 pp. 17 × 25.5 cm. ISBN 0-306-45224-3. $110.00.
David J. Triggle
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5285-5285
| Reviews in Computational Chemistry. Volume 8 Edited by Kenny B. Lipkowitz and Donald B. Boyd.VCH Publishers, Inc., New York. 1996. xxi + 324 pp. 16 × 24 cm. ISBN 1-56081-929-4. $110.00.
Mark G. Bures
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5285-5286
| Circular Dichroism and the Conformational Analysis of Biomolecules Edited by Gerald D. Fasman. Plenum Press, New York and London. 1996. ix + 738 pp. 17 × 25.5 cm. ISBN 0-306-45152-5. $125.00.
R. Lee Webb
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5286-5286
| Indoles Richard J. Sundberg. Academic Press, London. 1996. xv + 175 pp. 15.5 × 23.5 cm. ISBN 0-12-676945-1. $45.00.
Richard A. Glennon
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5286-5287
| Emerging Drugs. The Prospect for Improved Medicines. Annual Executive Briefing. Volume One 1996 Edited by W. C. Bowman, J. D. Fitzgerald, and J. B. Taylor. Ashley Publications Ltd., London. 1996. 436 pp. 20.5 × 29 cm. ISSN 1361-9195. $495.00.
James A. Bristol
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5287-5287
| Chemical Synthesis. Gnosis to Prognosis NATO Advanced Science Institutes Series. Series E. Applied Sciences. Volume 320 Edited by Chryssostomos Chatgilialoglu and Victor Snieckus. Kluwer Academic Publishers, Dordrecht, The Netherlands. 1996. xi + 625 pp. 16.5 × 24.5 cm. ISBN 0-7923-4041-8. $299.00.
Staff
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5287-5288
| Lipophilicity in Drug Action and Toxicology Edited by V. Plika, B. Testa, and H. van de Waterbeemd. VCH, Weinheim, Germany. 1996. xxv + 438. 17.5 × 24.5 cm. ISBN 3-527-29383-3. DM 198.00.
John G. Topliss
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5288-5288
| Palladium Reagents and Catalysis. Innovations in Organic Synthesis By Jiro Tsuji. John Wiley and Sons, Inc., New York. 1996. xiv + 560 pp. 16 × 23.5 cm. ISBN 0-471-95483-7. $150.00.
James W. Herndon
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5288-5289
| The Chemistry of Heterocycles T. Eicher and S. Hauptmann. Translated by H. Suschitzky and J. Suschitzky. G. Thieme, Stuttgart, 1996. X + 504 pp. 17 × 24 cm. ISBN 3-13-100511-4. DM 84.00.
Raymond P. Panzica
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5289-5289
| Drug Prototypes and their Exploitation By Walter Sneader. John Wiley and Sons Ltd. Baffins Lane, Chichester, West Sussex PO19 1UD, England. 1996. xii + 788pp. 19.5 × 25 cm. ISBN 0-471-94847-0. $129.95.
Donald T. Witiak
[Full Article -
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5289-5290
| Neurotherapeutics Emerging Strategies Edited by Linda M. Pullan and Jitendra Patel. Humana Press, Totowa, NJ. 1995. x + 434 pp. 16 × 23.5 cm. ISBN 0-89603-306-6. $125.00.
John Wm. Ferkany
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5290-5290
| Biological Models in Radiopharmaceutical Development By R. M. Lambrecht. Kluwer Academic Publishers, Boston, MA. 1996. x + 269 pp. 16.5 × 24.5 cm. ISBN 0-7923-3836-7. $136.00.
Crist N. Filer
[Full Article -
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5290-5291
| Models for Assessing Drug Absorption and Metabolism Edited by Ronald T. Borchardt, Philip L. Smith, and Glynn Wilson. Plenum Press, New York. 1996. xxii + 444 pp. 15.5 × 28 cm. ISBN 0-306-45243-X. $95.00.
Staff
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5291-5291
| Analytical Profiles of Drug Substances and Excipients. Volume 24 Edited by Harry G. Brittain. Academic Press, Inc., San Diego, CA. 1996. xi + 619 pp. 15.5 × 23.5 cm. ISBN 0-12-260824-0. $99.00.
Staff
[Full Article -
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5291-5291
| Biological Reactive Intermediates V. Basic Mechanistic Research in Toxicology and Human Risk Assessment. Advances in Experimental Medicine and Biology. Volume 387 Edited by Robert Snyder, James J. Kocsis, I. Glenn Sipes, George F. Kalf, David J. Jollow, Helmut Greim, Terrence J. Monks, and Charlotte M. Witmer. Plenum Press, New York. 1996. xiv + 461 pp. 17 × 25.5 cm. ISBN 0-306-45197-2. $125.00.
Staff
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5291-5292
| The Drug Development Process. Increasing Efficiency and Cost-Effectiveness Edited by Peter G. Welling, Louis Lasagna, and Umesh V. Banakar. Marcel Dekker, Inc., New York. 1996. xviii + 447 pp. 16 × 23.5 cm. ISBN 0-8247-9727-2. $150.00.
Staff
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5292-5292
| Eicosanoids From Biotechnology to Therapeutic Applications. NATO ASI Series A: Life Sciences Vol. 283 Edited by G. C. Folco, B. Samuelsson, J. Maclouf, and G. P. Velo. Plenum Press, New York in cooperation with NATO Scientific Affairs Division. 1996. viii + 208 pp. 17 × 25.5 cm. ISBN 0-306-45286-3. $79.50.
Peter R. Bernstein
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5292-5292
| Books of Interest
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5292-5293
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5293-5293
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