633-638
| Correlation of Antimalarial Activity of Artemisinin Derivatives with Binding Affinity with Ferroprotoporphyrin IX
Sumpan Paitayatat,
Bongkoch Tarnchompoo,
Yodhathai Thebtaranonth, and
Yongyuth Yuthavong
[Full Article -
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639-646
| Synthesis and Biological Activities of (R)-5,6-Dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and Its Metabolites
Richard F. Heier,
Lester A. Dolak,
J. Neil Duncan,
Deborah K. Hyslop,
Michael F. Lipton,
Iain J. Martin,
Michael A. Mauragis,
Montford F. Piercey,
Nanette F. Nichols,
Peggy J. K. D. Schreur,
Martin W. Smith, and
Malcolm W. Moon
[Full Article -
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647-658
| Structure-Based Design of New Constrained Cyclic Agonists of the Cholecystokinin CCK-B Receptor
Armand G. S. Blommaert,
Hélène Dhôtel,
Bertrand Ducos,
Christiane Durieux,
Nathalie Goudreau,
André Bado,
Christiane Garbay, and
Bernard P. Roques
[Full Article -
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659-667
| Structural Requirements for Binding of Anandamide-Type Compounds to the Brain Cannabinoid Receptor
Tzviel Sheskin,
Lumir Hanu,
Joram Slager,
Zvi Vogel, and
Raphael Mechoulam
[Full Article -
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668-676
| Synthesis and Antitumor Evaluation of New Thiazolo[5,4-b]quinoline Derivatives
Carlos Alvarez-Ibarra,
Rocío Fernández-Granda,
María L. Quiroga,
Angélica Carbonell,
Francisco Cárdenas, and
Ernest Giralt
[Full Article -
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677-683
| Structure-Based Design of Substituted Diphenyl Sulfones and Sulfoxides as Lipophilic Inhibitors of Thymidylate Synthase
Terence R. Jones,
Stephen E. Webber,
Michael D. Varney,
M. Rami Reddy,
Kathleen K. Lewis,
Vinit Kathardekar,
Hormoz Mazdiyasni,
Judith Deal,
Dzuy Nguyen,
Katharine M. Welsh,
Stephanie Webber,
Amanda Johnston,
David A. Matthews,
Ward W. Smith,
Cheryl A. Janson,
Russell J. Bacquet,
Eleanor F. Howland,
Carol L. J. Booth,
Steven M. Herrmann,
Robert W. Ward,
Jennifer White,
Charlotte A. Bartlett, and
Cathy A. Morse
[Full Article -
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684-694
| Highly Selective Aldose Reductase Inhibitors. 3. Structural Diversity of 3-(Arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic Acids
Takayuki Kotani,
Yasuhiro Nagaki,
Akira Ishii,
Yukari Konishi,
Hisashi Yago,
Seishi Suehiro,
Nobuhisa Okukado, and
Kaoru Okamoto
[Full Article -
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695-704
| Probes for Narcotic Receptor Mediated Phenomena. 23. Synthesis, Opioid Receptor Binding, and Bioassay of the Highly Selective  Agonist (+)-4-[( R)--((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and Related Novel Nonpeptide Opioid Receptor Ligands
Silvia N. Calderon,
Kenner C. Rice,
Richard B. Rothman,
Frank Porreca,
Judith L. Flippen-Anderson,
Hiroshi Kayakiri,
Heng Xu,
Karen Becketts,
Larren E. Smith,
Edward J. Bilsky,
Peg Davis, and
Robert Horvath
[Full Article -
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705-716
| Heteroaromatic Analogs of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as High-Affinity Dopamine Reuptake Inhibitors
Dorota Matecka,
David Lewis,
Richard B. Rothman,
Christina M. Dersch,
Francis H. E. Wojnicki,
John R. Glowa,
A. Courtney DeVries,
Agu Pert, and
Kenner C. Rice
[Full Article -
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717-729
| From Peptide to Non-Peptide. 3. Atropisomeric GPIIbIIIa Antagonists Containing the 3,4-Dihydro-1H-1,4-benzodiazepine-2,5-dione Nucleus
Brent K. Blackburn,
Arthur Lee,
Mark Baier,
Benjamin Kohl,
Alan G. Olivero,
Regina Matamoros,
Kirk D. Robarge, and
Robert S. McDowell
[Full Article -
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730-738
| Structure-Activity Relationships of Alkyl- and Alkoxy-Substituted 1,4-Dihydroquinoxaline-2,3-diones: Potent and Systemically Active Antagonists for the Glycine Site of the NMDA Receptor
Sui Xiong Cai,
Sunil M. Kher,
Zhang-Lin Zhou,
Victor Ilyin,
Stephen A. Espitia,
Minhtam Tran,
Jon E. Hawkinson,
Richard M. Woodward,
Eckard Weber, and
John F. W. Keana
[Full Article -
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739-748
| Three-Dimensional Quantitative Structure-Activity Relationship of Melatonin Receptor Ligands: A Comparative Molecular Field Analysis Study
Sames Sicsic,
Isabelle Serraz,
Jean Andrieux,
Béatrice Brémont,
Monique Mathé-Allainmat,
Annie Poncet,
Shuren Shen, and
Michel Langlois
[Full Article -
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749-753
| (E)- and (Z)-7-Arylidenenaltrexones: Synthesis and Opioid Receptor Radioligand Displacement Assays
Robert B. Palmer,
Alana L. Upthagrove, and
Wendel L. Nelson
[Full Article -
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754-765
| 4-Substituted-3-phenylquinolin-2(1H)-ones: Acidic and Nonacidic Glycine Site N-Methyl-D-aspartate Antagonists with in Vivo Activity
Robert W. Carling,
Paul D. Leeson,
Kevin W. Moore,
Christopher R. Moyes,
Matthew Duncton,
Martin L. Hudson,
Raymond Baker,
Alan C. Foster,
Sarah Grimwood,
John A. Kemp,
George R. Marshall,
Mark D. Tricklebank, and
Kay L. Saywell
[Full Article -
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766-770
| Synthesis and Evaluation of 6-(Dibromomethyl)-5-nitropyrimidines as Potential Antitumor Agents
M. Daniel Thompson,
Thomas L. Cupps,
Dean S. Wise,
Linda L. Wotring, and
Leroy B. Townsend
[Full Article -
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771-784
| Synthesis, Antiproliferative and Antiviral Activity of Imidazo[4,5-d]isothiazole Nucleosides as 5:5 Fused Analogs of Nebularine and 6-Methylpurine Ribonucleoside
Eric E. Swayze,
John C. Drach,
Linda L. Wotring, and
Leroy B. Townsend
[Full Article -
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785-793
| Synthesis and Antiviral Activity of Certain 5'-Modified Analogs of 2,5,6-Trichloro-1-( -D-ribofuranosyl)benzimidazole
Kristjan S. Gudmundsson,
John C. Drach,
Linda L. Wotring, and
Leroy B. Townsend
[Full Article -
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794-801
| Synthesis and Antiproliferative and Antiviral Activity of Carbohydrate-Modified Pyrrolo[2,3-d]pyridazin-7-one Nucleosides
Eric A. Meade,
Linda L. Wotring,
John C. Drach, and
Leroy B. Townsend
[Full Article -
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802-810
| Design, Synthesis, and Antiviral Evaluation of 2-Substituted 4,5-Dichloro- and 4,6-Dichloro-1--D-ribofuranosylbenzimidazoles as Potential Agents for Human Cytomegalovirus Infections
Ruiming Zou,
John C. Drach, and
Leroy B. Townsend
[Full Article -
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811-818
| Design, Synthesis, and Antiviral Evaluation of 2-Chloro-5,6-dihalo-1--D-ribofuranosylbenzimidazoles as Potential Agents for Human Cytomegalovirus Infections
Ruiming Zou,
John C. Drach, and
Leroy B. Townsend
[Full Article -
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819-824
| Nonsteroidal Anti-Inflammatory Drugs as Scaffolds for the Design of 5-Lipoxygenase Inhibitors
Teodozyj Kolasa,
Clint D. W. Brooks,
Karen E. Rodriques,
James B. Summers,
Joseph F. Dellaria,
Keren I. Hulkower,
Jennifer Bouska,
Randy L. Bell, and
George W. Carter
[Full Article -
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825-825
| Progress in Medicinal Chemistry. Volume 1. Studies in Medicinal Chemistry Edited by M. Iqbal Choudhary. Harwood Academic Publishers, Newark, NJ. 1996. xiv + 390 pp. 18 × 25.5 cm. ISBN 3-7186-5795-3. $150.00.
Richard L. Elliott
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825-825
| Books of Interest
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826-826
| 6-(1H-Imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione (YM90K) and Related Compounds: Structure-Activity Relationships for the AMPA-Type Non-NMDA Receptor
Junya Ohmori,
Shuichi Sakamoto,
Hirokazu
Kubota,
Masao Shimizu-Sasamata,
Masamichi
Okada,
Sachiko Kawasaki,
Kazuyuki Hidaka,
Junzi Togami,
Toshio Furuya, and
Kiyoshi Murase
[Full Article -
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