Journal of Medicinal Chemistry
Volume 40, Issue 8 (April 11, 1997)
Copyright © 1997 American Chemical Society

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1179-1185

Inhibition of Uridine Phosphorylase. Synthesis and Structure-Activity Relationships of Aryl-Substituted 1-((2-Hydroxyethoxy)methyl)-5-(3-phenoxybenzyl)uracil G. Faye Orr, David L. Musso, James L. Kelley, Suzanne S. Joyner, Stephen T. Davis, and David P. Baccanari [Full Article - PDF]

1186-1194

Arylamide Inhibitors of HIV-1 Integrase He Zhao, Nouri Neamati, Abhijit Mazumder, Sanjay Sunder, Yves Pommier, and Terrence R. Burke, Jr. [Full Article - PDF]

1195-1200

Correlation of Selective Modifications to a 2',5'-Oligoadenylate-3',5'-Deoxyribonucleotide Antisense Chimera with Affinity for the Target Nucleic Acid and with Ability To Activate RNase L Wei Xiao, Guiying Li, Ratan K. Maitra, Avudaiappan Maran, Robert H. Silverman, and Paul F. Torrence [Full Article - PDF]

1201-1210

Novel Indole-2-carboxamide and Cycloalkeno[1,2-b]indole Derivatives. Structure-Activity Relationships for High Inhibition of Human LDL Peroxidation Catherine Kuehm-Caubere, Paul Caubere, Brigitte Jamart-Gregoire, Anne Negre-Salvayre, Dominique Bonnefont-Rousselot, Jean-Guy Bizot-Espiard, Bruno Pfeiffer, Daniel-Henri Caignard, Béatrice Guardiola-Lemaitre, and Pierre Renard [Full Article - PDF]

1211-1218

Synthesis and Opioid Activity of Conformationally Constrained Dynorphin A Analogues. 2. Seksiri Arttamangkul, Jane E. Ishmael, Thomas F. Murray, David K. Grandy, Gary E. DeLander, Brigitte L. Kieffer, and Jane V. Aldrich [Full Article - PDF]

1219-1229

Selecting Optimally Diverse Compounds from Structure Databases: A Validation Study of Two-Dimensional and Three-Dimensional Molecular Descriptors Hans Matter [Full Article - PDF]

1230-1246

Synthesis and Biological Characterization of 1,4,5,6-Tetrahydropyrimidine and 2-Amino-3,4,5,6-tetrahydropyridine Derivatives as Selective m1 Agonists William S. Messer, Jr., Yahaya F. Abuh, Yang Liu, Sumudra Periyasamy, Dan O. Ngur, Michael A. N. Edgar, Afif A. El-Assadi, Sbeih Sbeih, Philip G. Dunbar, Scott Roknich, Taikyun Rho, Zheng Fang, Babatunde Ojo, Hao Zhang, James J. Huzl, III, and Peter I. Nagy [Full Article - PDF]

1247-1251

Synthesis and Transporter Binding Properties of 2,3-Diphenyltropane Stereoisomers. Comparison to 3-Phenyltropane-2-carboxylic Acid Esters An-Chih Chang, Jason P. Burgess, S. Wayne Mascarella, Philip Abraham, Michael J. Kuhar, and F. Ivy Carroll [Full Article - PDF]

1252-1257

N-[2-[(Substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines: Synthesis and Wide Range of Antagonism at the Human 5-HT1A Receptor Tomoyuki Yasunaga, Ryo Naito, Toru Kontani, Shin-ichi Tsukamoto, Tamako Nomura, Tokio Yamaguchi, and Toshiyasu Mase [Full Article - PDF]

1258-1269

1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: Novel AMPA Receptor Antagonists Alba Chimirri, Giovambattista De Sarro, Angela De Sarro, Rosaria Gitto, Silvana Grasso, Silvana Quartarone, Maria Zappalà, Piero Giusti, Vincenzo Libri, Andrew Constanti, and Astrid G. Chapman [Full Article - PDF]

1270-1275

Mustard Prodrugs for Activation by Escherichia coli Nitroreductase in Gene-Directed Enzyme Prodrug Therapy Frank Friedlos, William A. Denny, Brian D. Palmer, and Caroline J. Springer [Full Article - PDF]

1276-1286

Redox Pathway Leading to the Alkylation of DNA by the Anthracycline, Antitumor Drugs Adriamycin and Daunomycin Dylan J. Taatjes, Giorgio Gaudiano, Katheryn Resing, and Tad H. Koch [Full Article - PDF]

1287-1291

The Practical Synthesis of a Methylenebisphosphonate Analogue of Benzamide Adenine Dinucleotide: Inhibition of Human Inosine Monophosphate Dehydrogenase (Type I and II) Krzysztof W. Pankiewicz, Krystyna Lesiak, Andrzej Zatorski, Barry M. Goldstein, Stephen F. Carr, Marek Sochacki, Alokes Majumdar, Michael Seidman, and Kyoichi A. Watanabe [Full Article - PDF]

1292-1292

The Discovery of Potent Isoxazoline Glycoprotein IIb/IIIa Receptor Antagonists John Wityak, Thais M. Sielecki, Donald J. Pinto, George Emmett, Jean Y. Sze, Jie Liu, A. Ewa Tobin, Shuaige Wang, Biao Jiang, Philip Ma, Shaker A. Mousa, Richard E. Olson, and Ruth R. Wexler [Full Article - PDF]