3707-3711
| Synthesis of 5,6-Dihydro-4-hydroxy-2- pyrones as HIV-1 Protease Inhibitors: The Profound Effect of Polarity on Antiviral Activity
Susan E. Hagen,
J. V. N. Vara Prasad,
Frederick E. Boyer,
John M. Domagala,
Edmund L. Ellsworth,
Christopher Gajda,
Harriet W. Hamilton,
Larry J. Markoski,
Bruce A. Steinbaugh,
Bradley D. Tait,
Elizabeth A. Lunney,
Peter J. Tummino,
Donna Ferguson,
Donald Hupe,
Carolyn Nouhan,
Stephen J. Gracheck,
James M. Saunders, and
Steven VanderRoest
[Full Article -
PDF] |
3712-3714
| Potent and Selective 1,2,3-Trisubstituted Indole NPY Y-1 Antagonists
Philip A. Hipskind,
Karen L. Lobb,
James A. Nixon,
Thomas C. Britton,
Robert F. Bruns,
John Catlow,
Donna K. Dieckman-McGinty,
Susan L. Gackenheimer,
Bruce D. Gitter,
Smriti Iyengar,
Douglas A. Schober,
Rosa M. A. Simmons,
Steve Swanson,
Hamideh Zarrinmayeh,
Dennis M. Zimmerman, and
Donald R. Gehlert
[Full Article -
PDF] |
3715-3718
| Synthesis and Antimalarial Activity in Vitro and in Vivo of a New Ferrocene-Chloroquine Analogue
Christophe Biot,
Guillaume Glorian,
Lucien A. Maciejewski, and
Jacques S. Brocard
, Olivier Domarle,
Georgette Blampain,
Pascal Millet, and
Alain J. Georges
, Huguette Abessolo and
Daniel Dive
, Jacques Lebibi
[Full Article -
PDF] |
3719-3725
| Design, Synthesis, and Cocrystal Structure of a Nonpeptide Src SH2 Domain Ligand
Mark S. Plummer,
Debra R. Holland,
Aurash Shahripour,
Elizabeth A. Lunney,
James H. Fergus,
James S. Marks,
Patrick McConnell,
W. Thomas Mueller, and
Tomi K. Sawyer
[Full Article -
PDF] |
3726-3733
| Discovery of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors Incorporating Aminopyridyl Moieties at the P1 Position
Dong-Mei Feng,
Stephen J. Gardell,
S. Dale Lewis,
Mark G. Bock,
Zhongguo Chen,
Roger M. Freidinger,
Adel M. Naylor-Olsen,
Harri G. Ramjit,
Richard Woltmann,
Elizabeth P. Baskin,
Joseph J. Lynch,
Robert Lucas,
Jules A. Shafer,
Kimberley B. Dancheck,
I-Wu Chen,
Shi-Shan Mao,
Julie A. Krueger,
Timothy R. Hare,
Anne M. Mulichak, and
Joseph P. Vacca
[Full Article -
PDF] |
3734-3738
| 1,4-Disubstituted Anthracene Antitumor Agents
Bhashyam S. Iyengar,
Robert T. Dorr,
David S. Alberts,
Anikó M. Sólyom,
Mary Krutzsch, and
William A. Remers
[Full Article -
PDF] |
3739-3748
| Betidamino Acid Scan of the GnRH Antagonist Acyline
Guangcheng Jiang,
Charleen Miller,
Steven C. Koerber,
John Porter,
A. Grey Craig,
Sheela Bhattacharjee,
Patricia Kraft,
Thomas P. Burris,
Carolyn A. Campen,
Catherine L. Rivier, and
Jean E. Rivier
[Full Article -
PDF] |
3749-3755
| 1-[( -Aminoalkyl)amino]-4-[N-(-aminoalkyl)carbamoyl]-9-oxo-9,10-dihydro- acridines as Intercalating Cytotoxic Agents: Synthesis, DNA Binding, and Biological Evaluation
Ippolito Antonini,
Paolo Polucci,
Terence C. Jenkins,
Lloyd R. Kelland,
Ernesto Menta,
Nicoletta Pescalli,
Barbara Stefanska,
Jan Mazerski, and
Sante Martelli
[Full Article -
PDF] |
3756-3764
| Synthesis and Biological Evaluation of 4-(Hydroxyalkyl)estradiols and Related Compounds
Carl J. Lovely,
Abhijit S. Bhat,
Holly D. Coughenour,
Nancy E. Gilbert, and
Robert W. Brueggemeier
[Full Article -
PDF] |
3765-3772
| N6-Cyclopentyl-3'-substituted-xylofuranosyladenosines: A New Class of Non-Xanthine Adenosine A1 Receptor Antagonists
Serge Van Calenbergh,
Jacobien K. von Frijtag Drabbe Künzel,
Norbert M. Blaton,
Oswald M. Peeters,
Jef Rozenski,
Arthur Van Aerschot,
Andre De Bruyn,
Denis De Keukeleire,
Adriaan P. IJzerman, and
Piet Herdewijn
[Full Article -
PDF] |
3773-3780
| Simple Analogues of Anthralin: Unusual Specificity of Structure and Antiproliferative Activity
Klaus Müller,
Helge Prinz,
Ingo Gawlik,
Klaus Ziereis, and
Hsu-Shan Huang
[Full Article -
PDF] |
3781-3792
| 4-Hydroxy-5,6-dihydropyrones. 2. Potent Non-Peptide Inhibitors of HIV Protease
Bradley D. Tait,
Susan Hagen,
John Domagala,
Edmund L. Ellsworth,
Christopher Gajda,
Harriet W. Hamilton,
J. V. N. Vara Prasad,
Donna Ferguson,
Neil Graham,
Donald Hupe,
Carolyn Nouhan,
Peter J. Tummino,
Christine Humblet,
Elizabeth A. Lunney,
Alexander Pavlovsky,
John Rubin,
Stephen J. Gracheck,
Eric T. Baldwin,
T. N. Bhat,
John W. Erickson,
Sergei V. Gulnik, and
Beishan Liu
[Full Article -
PDF] |
3793-3803
| Design and Synthesis of Imidazoline Derivatives Active on Glucose Homeostasis in a Rat Model of Type II Diabetes. 1. Synthesis and Biological Activities of N-Benzyl-N '-(arylalkyl)-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines
Frédéric Rondu,
Gaëlle Le Bihan,
Xuan Wang,
Aazdine Lamouri,
Estera Touboul,
Georges Dive,
Tounès Bellahsene,
Bruno Pfeiffer,
Pierre Renard,
Béatrice Guardiola-Lemaitre,
Dominique Manechez,
Luc Penicaud,
Alain Ktorza, and
Jean-Jacques Godfroid
[Full Article -
PDF] |
3804-3819
| Antimuscarinic 3-(2-Furanyl)quinuclidin-2-ene Derivatives: Synthesis and Structure-Activity Relationships
Gary Johansson,
Staffan Sundquist,
Gunnar Nordvall,
Björn M. Nilsson,
Magnus Brisander,
Lisbeth Nilvebrant, and
Uli Hacksell
[Full Article -
PDF] |
3820-3828
| Synthesis and Biological Activity of a Series of Potent Fluoromethyl Ketone Inhibitors of Recombinant Human Calpain I
Sankar Chatterjee,
Mark A. Ator,
Donna Bozyczko-Coyne,
Kurt Josef,
Gregory Wells,
Rabindranath Tripathy,
Mohamed Iqbal,
Ron Bihovsky,
Shobha E. Senadhi,
Satish Mallya,
Teresa M. O'Kane,
Beth Ann McKenna,
Robert Siman, and
John P. Mallamo
[Full Article - PDF] |
3829-3835
| Synthesis and Evaluation of (S)-4-(3-(2'-[11C]Isopropylamino)-2-hydroxypropoxy)-2H-benzimidazol-2-one ((S)-[11C]CGP 12388) and (S)-4-(3-((1'-[18F]Fluoroisopropyl)amino)-2-hydroxypropoxy)-2H-benzimidazol-2-one ((S)-[18F]Fluoro-CGP 12388) for Visualization of  -Adrenoceptors with Positron Emission Tomography
Philip H. Elsinga,
Aren van Waarde,
Knut A. Jaeggi,
Gérard Schreiber,
Marco Heldoorn, and
Willem Vaalburg
[Full Article - PDF] |
3836-3841
| Synthesis and Structure-Activity Profiles of A-Homoestranes, the Estratropones
Thomas A. Miller,
Amanda L. Bulman,
Charles D. Thompson,
Michael E. Garst, and
Timothy L. Macdonald
[Full Article -
PDF] |
3842-3850
| Design, Synthesis, and Biochemical Evaluation of Phosphonate and Phosphonamidate Analogs of Glutathionylspermidine as Inhibitors of Glutathionylspermidine Synthetase/Amidase from Escherichia coli
Shoujun Chen,
Chun-Hung Lin,
David S. Kwon,
Christopher T. Walsh, and
James K. Coward
[Full Article -
PDF] |
3851-3857
| Retinoic Acid Conjugates as Potential Antitumor Agents: Synthesis and Biological Activity of Conjugates with Ara-A, Ara-C, 3(2H)-Furanone, and Aniline Mustard Moieties
Stefano Manfredini,
Daniele Simoni,
Roberto Ferroni,
Rita Bazzanini,
Silvia Vertuani,
Sigrid Hatse,
Jan Balzarini, and
Erik De Clercq
[Full Article - PDF] |
3858-3859
| Combinatorial Chemistry. Synthesis and Application Edited by Stephen R. Wilson and Anthony W. Czarnik. John Wiley & Sons. 1997. ix + 269 pp. 16 × 24 cm. ISBN 0-471-12687-X. $69.95.
Michael R. Pavia
[Full Article - PDF] |
3859-3859
| The Chemistry of Mind-Altering Drugs. History, Pharmacology, and Cultural Context By Daniel M. Perrine. American Chemical Society, Washington, D.C. 1996. x + 480 pp. 17.5 × 25 cm. ISBN 0-8412-3253-9. $39.95.
David E. Nichols
[Full Article - PDF] |
3859-3860
| Studies in Medicinal Chemistry. Volume 2. Biological Inhibitors Edited by M. Iqbal Choudhary. Harwood Academic Publishers GmbH, Amsterdam. 1996. xiv + 378 pp. 17.5 × 25.3 cm. ISBN 3-7186-5879-8. $150.00.
Joseph Weinstock
[Full Article - PDF] |
3860-3860
| Burgers' Medicinal Chemistry and Drug Discovery. Volume 4 Edited by M. E. Wolff. John Wiley & Sons, New York. 1997. viii + 656 pp. 18.5 × 26 cm. ISBN 0-471-57559-3. $225.00.
Lemont B. Kier
[Full Article - PDF] |