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EDITORIAL
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1-1
| Combinatorial Chemistry Editorial Policy
P. S. Portoghese
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COMMUNICATIONS TO THE EDITOR
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2-5
| Bis-Quinolinium Cyclophanes: 6,10-Diaza-3(1,3),8(1,4)-dibenzena-1,5(1,4)- diquinolinacyclodecaphane (UCL 1684), the First Nanomolar, Non-Peptidic Blocker of the Apamin-Sensitive Ca2+-Activated K+ Channel
Joaquin Campos Rosa,
Dimitrios Galanakis,
C. Robin Ganellin,
Philip M. Dunn, and
Donald H. Jenkinson
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6-9
| A Substrate-Based Difluoro Ketone Selectively Inhibits Alzheimer's  -Secretase Activity
Michael S. Wolfe,
Martin Citron,
Thekla S. Diehl,
Weiming Xia,
Isaac O. Donkor, and
Dennis J. Selkoe
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EXPEDITED ARTICLES
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10-23
| (Z)- and (E)-2-((Hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New Nucleoside Analogues with a Broad-Spectrum Antiviral Activity
Yao-Ling Qiu,
Mohamad B. Ksebati,
Roger G. Ptak,
Boreas Y. Fan,
Julie M. Breitenbach,
Ju-Sheng Lin,
Yung-Chi Cheng,
Earl R. Kern,
John C. Drach, and
Jiri Zemlicka
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ARTICLES
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24-30
| N-(Benzyloxycarbonyl)glycine Esters and Amides as New Anticonvulsants
Muriel Geurts,
Jacques H. Poupaert,
Gerhard K. E. Scriba, and
Didier M. Lambert
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31-37
| Alkyl Esters of Camptothecin and 9-Nitrocamptothecin: Synthesis, in Vitro Pharmacokinetics, Toxicity, and Antitumor Activity
Zhisong Cao,
Nick Harris,
Anthony Kozielski,
Dana Vardeman,
John S. Stehlin, and
Beppino Giovanella
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38-45
| Second Generation "Peptoid" CCK-B Receptor Antagonists: Identification and Development of N-(Adamantyloxycarbonyl)- -methyl-(R)-tryptophan Derivative (CI-1015) with an Improved Pharmacokinetic Profile
Bharat K. Trivedi,
Janak K. Padia,
Ann Holmes,
Steven Rose,
D. Scott Wright,
Joanna P. Hinton,
Martyn C. Pritchard,
Jon M. Eden,
Clare Kneen,
Louise Webdale,
Nirmala Suman-Chauhan,
Phil Boden,
Lakhbir Singh,
Mark J. Field, and
David Hill
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46-52
| Flavonoid Derivatives as Adenosine Receptor Antagonists: A Comparison of the Hypothetical Receptor Binding Site Based on a Comparative Molecular Field Analysis Model
Stefano Moro,
A. Michiel van Rhee,
Lawrence H. Sanders, and
Kenneth A. Jacobson
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53-62
| Rational Design and Synthesis of Novel, Potent Bis-phenylamidine Carboxylate Factor Xa Inhibitors
Thomas P. Maduskuie, Jr.,
Kevin J. McNamara,
Yu Ru,
Robert M. Knabb, and
Pieter F. W. Stouten
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63-73
| Synthesis, Anticonvulsant Activity, and Structure-Activity Relationships of Sodium Channel Blocking 3-Aminopyrroles
Klaus Unverferth,
Jürgen Engel,
Norbert Höfgen,
Angelika Rostock,
Ralf Günther,
Hans-Joachim Lankau,
Manfred Menzer,
Andreas Rolfs,
Jürgen Liebscher,
Birgit Müller, and
Hans-Jörg Hofmann
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74-95
| Discovery and Evaluation of a Series of 3-Acylindole Imidazopyridine Platelet-Activating Factor Antagonists
Michael L. Curtin,
Steven K. Davidsen,
H. Robin Heyman,
Robert B. Garland,
George S. Sheppard,
Alan S. Florjancic,
Lianhong Xu,
George M. Carrera, Jr.,
Douglas H. Steinman,
Jeff A. Trautmann,
Daniel H. Albert,
Terrance J. Magoc,
Paul Tapang,
David A. Rhein,
Richard G. Conway,
Gongjin Luo,
Jon F. Denissen,
Kennan C. Marsh,
Douglas W. Morgan, and
James B. Summers
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96-101
| Substituted 2-Iminopiperidines as Inhibitors of Human Nitric Oxide Synthase Isoforms
R. Keith Webber,
Suzanne Metz,
William M. Moore,
Jane R. Connor,
Mark G. Currie,
Kam F. Fok,
Timothy J. Hagen,
Donald W. Hansen, Jr.,
Gina M. Jerome,
Pamela T. Manning,
Barnett S. Pitzele,
Mihaly V. Toth,
Mahima Trivedi,
Mark E. Zupec, and
F. Siong Tjoeng
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102-108
| 5'-Substituted Adenosine Analogs as New High-Affinity Partial Agonists for the Adenosine A1 Receptor
Eleonora M. van der Wenden,
Marta Carnielli,
Harlof C. P. F. Roelen,
Anna Lorenzen,
Jacobien K. von Frijtag Drabbe Künzel, and
Adriaan P. IJzerman
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109-116
| Conformationally Constrained Analogues of the Muscarinic Agonist 3-(4-(Methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine. Synthesis, Receptor Affinity, and Antinociceptive Activity
Per Sauerberg,
Preben H. Olesen,
Malcolm J. Sheardown,
Karin Rimvall,
Henning Th gersen,
Harlan E. Shannon,
Barry D. Sawyer,
John S. Ward,
Frank P. Bymaster,
Neil W. DeLapp,
David O. Calligaro, and
Michael D. B. Swedberg
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117-123
| From Micromolar to Nanomolar Affinity: A Systematic Approach To Identify the Binding Site of CGRP at the Human Calcitonin Gene-Related Peptide 1 Receptor
Beate Rist,
Michael Entzeroth, and
Annette G. Beck-Sickinger
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124-129
| 2,5-Bis[4-(N-alkylamidino)phenyl]furans as Anti-Pneumocystis carinii Agents
David W. Boykin,
Arvind Kumar,
Ge Xiao,
W. David Wilson,
Brendan C. Bender,
Donald R. McCurdy,
James Edwin Hall, and
Richard R. Tidwell
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130-142
| Structure-Activity of Novel Rhodacyanine Dyes as Antitumor Agents
Masayuki Kawakami,
Keizo Koya,
Toshinao Ukai,
Noriaki Tatsuta,
Akihiko Ikegawa,
Keizo Ogawa,
Tadao Shishido, and
Lan Bo Chen
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