Journal of Medicinal Chemistry
Volume 41, Issue 2 (January 15, 1998)
Copyright © 1998 American Chemical Society

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COMMUNICATIONS TO THE EDITOR

143-147

A New Class of Highly Potent Farnesyl Diphosphate-Competitive Inhibitors of Farnesyltransferase Tetsuya Aoyama, Toshihiko Satoh, Mari Yonemoto, Jun Shibata, Katsumasa Nonoshita, Sachie Arai, Kumiko Kawakami, Yoshikazu Iwasawa, Hideki Sano, Kenji Tanaka, Yoshiaki Monden, Tsutomu Kodera, Hiroharu Arakawa, Ikuko Suzuki-Takahashi, Toshio Kamei, and Koji Tomimoto [Full Article - PDF]

ARTICLES

148-156

Phenothiazine Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal and Antileishmanial Drugs Cecil Chan, Hong Yin, Jacqui Garforth, James H. McKie, Rabih Jaouhari, Peter Speers, Kenneth T. Douglas, Peter J. Rock, Vanessa Yardley, Simon L. Croft, and Alan H. Fairlamb [Full Article - PDF]

157-166

Isoindol-1-one Analogues of 4-(2'-methoxyphenyl)-1-[2'-[N-(2''-pyridyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI) as 5-HT1A Receptor Ligands Zhi-Ping Zhuang, Mei-Ping Kung, Mu Mu, and Hank F. Kung [Full Article - PDF]

167-174

Conformational Studies on a Diastereoisomeric Pair of Tricyclic Nonclassical Cannabinoids by NMR Spectroscopy and Computer Molecular Modeling Xiang-Qun Xie, Spiro Pavlopoulos, C. M. DiMeglio, and Alexandros Makriyannis [Full Article - PDF]

175-182

Modeling RNA-Ligand Interactions: The Rev-Binding Element RNA-Aminoglycoside Complex Fabrice Leclerc and Robert Cedergren [Full Article - PDF]

183-190

Deoxyadenosine Bisphosphate Derivatives as Potent Antagonists at P2Y1 Receptors Emidio Camaioni, José L. Boyer, Arvind Mohanram, T. Kendall Harden, and Kenneth A. Jacobson [Full Article - PDF]

191-198

Synthesis and Anti-HIV-1 Activity of Novel 2,3-Dihydro-7H-thiazolo[3,2-a]pyrimidin-7-ones Krzysztof Danel, Erik B. Pedersen, and Claus Nielsen [Full Article - PDF]

199-223

Matrix Metalloproteinase Inhibitors: A Structure-Activity Study Daniel E. Levy, France Lapierre, Weisheng Liang, Wenqing Ye, Christopher W. Lange, Xiaoyuan Li, Damian Grobelny, Marie Casabonne, David Tyrrell, Kevin Holme, Alex Nadzan, and Richard E. Galardy [Full Article - PDF]

224-235

Synthesis, Activity, and Structure-Activity Relationship Studies of Novel Cationic Lipids for DNA Transfer Gerardo Byk, Catherine Dubertret, Virginie Escriou, Marc Frederic, Gabrielle Jaslin, Ravi Rangara, Bruno Pitard, Joel Crouzet, Pierre Wils, Bertrand Schwartz, and Daniel Scherman [Full Article - PDF]

236-246

Design and Synthesis of [2-(8,9-Dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)- ethyl]phosphonic Acid (EAA-090), a Potent N-Methyl-D-aspartate Antagonist, via the Use of 3-Cyclobutene-1,2-dione as an Achiral -Amino Acid Bioisostere William A. Kinney, Magid Abou-Gharbia, Deanna T. Garrison, Jean Schmid, Dianne M. Kowal, Donna R. Bramlett, Tracy L. Miller, Rene P. Tasse, Margaret M. Zaleska, and John A. Moyer [Full Article - PDF]

247-257

Synthesis and Ligand Binding of Tropane Ring Analogues of Paroxetine Kathryn I. Keverline-Frantz, John W. Boja, Michael J. Kuhar, Philip Abraham, Jason P. Burgess, Anita H. Lewin, and F. Ivy Carroll [Full Article - PDF]

BOOK REVIEWS

258-258

Annual Reports in Medicinal Chemistry. Volume 32 Editor-in-Chief: James A. Bristol. Academic Press, San Diego, CA. 1997. xi + 378 pp. 17 × 25 cm. ISBN 0-12-040532-6. $70.00. Staff [Full Article - PDF]

258-259

Anti-Infectives. Recent Advances in Chemistry and Structure-Activity Relationships Edited by P. H. Bentley and P. J. O'Hanlon. The Royal Society of Chemistry, Cambrige, U.K. 1997. xi + 338 pp. 16 × 24 cm. ISBN 0-85404-707-7. $174.00. Kenneth G. Holden [Full Article - PDF]

259-260

Modern Strategy for Preclinical Pharmaceutical R&D: Towards the Virtual Research Company By David Cavalla, with contributions from John Flack and Richard Jennings. John Wiley & Sons, Chichester, England. 1997. x + 218 pp. 15.5 × 23.5 cm. ISBN 0-471-97117-0. Price Unavailable: (hbk: alk. paper). Michael J. Sherrod [Full Article - PDF]

260-260

G Protein Methods and Protocols. Role of G Proteins in Psychiatric and Neurologic Disorders Edited by Ram K. Mishra, Glen B. Baker, and Alan A. Boulton. Humana Press, Totowa, NJ. 1997. xiv + 433 pp. 16 × 23.5 cm. ISBN 0-89603-490-9. $99.50. Allen M. Spiegel [Full Article - PDF]

260-261

Reductions in Organic Chemistry. Second Edition. ACS Monograph 188 By Milos Hudlicky. American Chemical Society, Washington, D.C. 1996. xxvi + 429 pp. 15.5 × 23.5 cm. ISBN 0-8412-3344-6. $109.95. Ciro J. Spagnuolo [Full Article - PDF]

ADDITIONS AND CORRECTIONS

262-262

Studies on Selection Blockers. 5. Design, Synthesis, and Biological Profile of Sialyl Lewis X Mimetics Based on Modified Serine-Glutamic Acid Dipeptides Takahiro Tsukida, Yasuyuki Hiramatsu, Hideki Tsujishita, Takao Kiyoi, Masahiro Yoshida, Kiriko Kurokawa, Hideki Moriyama, Hiroshi Ohmoto, Yukihisa Wada, Tadayuki Saito, and Hirosata Kondo [Full Article - PDF]