Journal of Medicinal Chemistry
Volume 41, Issue 5 (February 26, 1998)
Copyright © 1998 American Chemical Society

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COMMUNICATIONS TO THE EDITOR

655-657

(R)-3,N-Dimethyl-N-[1-methyl-3-(4-methylpiperidin-1-yl)propyl]benzenesulfonamide: The First Selective 5-HT7 Receptor Antagonist Ian T. Forbes, Steven Dabbs, D. Malcolm Duckworth, Andrew J. Jennings, Frank D. King, Peter J. Lovell, Anthony M. Brown, Lissa Collin, Jim J. Hagan, Derek N. Middlemiss, Graham J. Riley, David R. Thomas, and Neil Upton [Full Article - PDF]

ARTICLES

658-667

Novel Antipsychotic Agents with Dopamine Autoreceptor Agonist Properties: Synthesis and Pharmacology of 7-[4-(4-Phenyl-1-piperazinyl)butoxy]-3,4-dihydro-2(1H)-quinolinone Derivatives Yasuo Oshiro, Seiji Sato, Nobuyuki Kurahashi, Tatsuyoshi Tanaka, Tetsuro Kikuchi, Katsura Tottori, Yasufumi Uwahodo, and Takao Nishi [Full Article - PDF]

668-673

Novel 3-Aralkyl-7-(amino-substituted)-1,2,3-triazolo[4,5-d]pyrimidines with High Affinity toward A1 Adenosine Receptors Laura Betti, Giuliana Biagi, Gino Giannaccini, Irene Giorgi, Oreste Livi, Antonio Lucacchini, Clementina Manera, and Valerio Scartoni [Full Article - PDF]

674-681

Mono- and Disubstituted-3,8-diazabicyclo[3.2.1]octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling Daniela Barlocco, Giorgio Cignarella, Donatella Tondi, Paola Vianello, Stefania Villa, Alessandro Bartolini, Carla Ghelardini, Nicoletta Galeotti, David J. Anderson, Theresa A. Kuntzweiler, Diego Colombo, and Lucio Toma [Full Article - PDF]

682-690

-Substituted Malonester Amides: Tools To Define the Relationship between ACAT Inhibition and Adrenal Toxicity Drago R. Sliskovic, Joseph A. Picard, Patrick M. O'Brien, Peggy Liao, W. Howard Roark, Bruce D. Roth, Maureen A. Anderson, Sandra Bak Mueller, Thomas M. A. Bocan, Richard F. Bousley, Katherine L. Hamelehle, Reynold Homan, James F. Reindel, Richard L. Stanfield, Daniel Turluck, and Brian R. Krause [Full Article - PDF]

691-698

A New Method for Predicting the Alignment of Flexible Molecules and Orienting Them in a Receptor Cleft of Known Structure Maria Cristina De Rosa and Anders Berglund [Full Article - PDF]

699-705

Potent and Selective Ligands for the Dopamine Transporter (DAT): Structure-Activity Relationship Studies of Novel 4-[2-(Diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine Analogues Aloke K. Dutta, Lori L. Coffey, and Maarten E. A. Reith [Full Article - PDF]

706-716

Discovery of Novel Pyridinopolyamines with Potent Antimicrobial Activity: Deconvolution of Mixtures Synthesized by Solution-Phase Combinatorial Chemistry Haoyun An, Becky D. Haly, and P. Dan Cook [Full Article - PDF]

717-727

Human Growth Hormone-Releasing Hormone hGHRH(1-29)-NH2: Systematic Structure-Activity Relationship Studies Laura A. Cervini, Cynthia J. Donaldson, Steven C. Koerber, Wylie W. Vale, and Jean E. Rivier [Full Article - PDF]

728-741

Novel Potent and Selective Central 5-HT3 Receptor Ligands Provided with Different Intrinsic Efficacy. 1. Mapping the Central 5-HT3 Receptor Binding Site by Arylpiperazine Derivatives Andrea Cappelli, Maurizio Anzini, Salvatore Vomero, Laura Mennuni, Francesco Makovec, Edith Doucet, Michel Hamon, Giancarlo Bruni, Maria R. Romeo, M. Cristina Menziani, Pier G. De Benedetti, and Thierry Langer [Full Article - PDF]

742-751

Tyrosine Kinase Inhibitors. 14. Structure-Activity Relationships for Methyl- amino-Substituted Derivatives of 4-[(3-Bromophenyl)amino]-6-(methylamino)- pyrido[3,4-d]pyrimidine (PD 158780), a Potent and Specific Inhibitor of the Tyrosine Kinase Activity of Receptors for the EGF Family of Growth Factors Gordon W. Rewcastle, Donna K. Murray, William L. Elliott, David W. Fry, Curtis T. Howard, James M. Nelson, Billy J. Roberts, Patrick W. Vincent, H. D. Hollis Showalter, R. Thomas Winters, and William A. Denny, [Full Article - PDF]

752-759

Synthesis of C3 Heteroatom-Substituted Azetidinones That Display Potent Cholesterol Absorption Inhibitory Activity Brian A. McKittrick, Ke Ma, Keith Huie, Nathan Yumibe, Harry Davis, Jr., John W. Clader, and Michael Czarniecki , Andrew T. McPhail [Full Article - PDF]

760-771

Aminopyrimidines with High Affinity for Both Serotonin and Dopamine Receptors David Wustrow, Thomas Belliotti, Shelly Glase, Suzanne Ross Kesten, Don Johnson, Norman Colbry, Ronald Rubin, Anthony Blackburn, Hyacinth Akunne, Ann Corbin, M. Duff Davis, Lynn Georgic, Steven Whetzel, Kim Zoski, Thomas Heffner, Thomas Pugsley, and Lawrence Wise [Full Article - PDF]

BOOK REVIEWS

772-772

Computational Approaches to Biochemical Reactivity Edited by Gabor Naray-Szabo and Arieh Warshel. Kluwer Academic Publ., Dordrecht, The Netherlands. 1977. x + 379 pp. 16.5 × 24.5 cm. ISBN 0-7923-4512-6. $183.00. Lemont B. Kier [Full Article - PDF]

772-773

Burger's Medicinal Chemistry and Drug Discovery. Fifth Edition. Volume 5: Therapeutic Agents Edited by Manfred E. Wolff. John Wiley and Sons, New York. 1997. viii + 879 pp. ISBN 0-4711-57560-7. $225.00. Lemont B. Kier [Full Article - PDF]

773-773

Protein NMR Techniques, Volume 60 Methods in Molecular Biology Edited by David G. Reid. Humana Press, Totowa, NJ. 1997. x + 418 pp. 16 x 23.5 cm. ISBN 0-89603-309-0. $79.50. Rickey P. Hicks [Full Article - PDF]

773-774

Reviews in Computational Chemistry, Volume 9 Edited by Kenny B. Lipkowitz and Donald B. Boyd (Indiana University-Purdue University at Indianapolis). Wiley/VCH, New York. 1996. xxxiii + 282 pp. ISBN 1-56081-930-8. $110.00. Vivian Cody [Full Article - PDF]

774-774

From Ion Channels to Cell-to-Cell Conversations Edited by R. Latorre and J. C. Saez. Plenum Press, New York and London. 1997. 16 × 23.5 cm. xxvii + 504 pp. ISBN 0-306-45605-2. $135.00. David J. Triggle [Full Article - PDF]