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COMMUNICATIONS TO THE EDITOR
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775-777
| Acetamidine Lysine Derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide Dihydrochloride: A Highly Selective Inhibitor of Human Inducible Nitric Oxide Synthase
E. Ann Hallinan,
Sofya Tsymbalov,
Patricia M. Finnegan,
William M. Moore,
Gina M. Jerome,
Mark G. Currie, and
Barnett S. Pitzele
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ARTICLES
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778-786
| High-Affinity Aptamers Selectively Inhibit Human Nonpancreatic Secretory Phospholipase A2 (hnps-PLA2)
Philippe Bridonneau,
Ying-Fon Chang,
Dan O'Connell,
Stanley C. Gill,
David W. Snyder,
Lea Johnson,
Theodore Goodson, Jr.,
David K. Herron, and
David H. Parma
[Full Article -
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787-797
| Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 1. Discovery, Synthesis, Biological Activity, and Structure-Activity Relationships of 4-Guanidino- and 4-Amino-4H-pyran-6-carboxamides
Paul W. Smith,
Steven L. Sollis,
Peter D. Howes,
Peter C. Cherry,
Ian D. Starkey,
Kevin N. Cobley,
Helen Weston,
Jan Scicinski,
Andrew Merritt,
Andrew Whittington,
Paul Wyatt,
Neil Taylor,
Darren Green,
Richard Bethell,
Safia Madar,
Robert J. Fenton,
Peter J. Morley,
Tony Pateman, and
Alan Beresford
[Full Article -
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798-807
| Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 2. Crystallographic and Molecular Modeling Study of Complexes of 4-Amino-4H-pyran-6-carboxamides and Sialidase from Influenza Virus Types A and B
Neil R. Taylor,
Anne Cleasby,
Onkar Singh,
Tadeusz Skarzynski,
Alan J. Wonacott,
Paul W. Smith,
Steven L. Sollis,
Peter D. Howes,
Peter C. Cherry,
Richard Bethell,
Peter Colman, and
Jose Varghese
[Full Article -
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808-820
| (E)-3-(2-(N-Phenylcarbamoyl)vinyl)pyrrole-2-carboxylic Acid Derivatives. A Novel Class of Glycine Site Antagonists
Cesarino Balsamini,
Annalida Bedini,
Giuseppe Diamantini,
Gilberto Spadoni,
Andrea Tontini, and
Giorgio Tarzia
, Romano Di Fabio,
Aldo Feriani,
Angelo Reggiani,
Giovanna Tedesco, and
Roberta Valigi
[Full Article -
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821-835
| 1,4-Cyclohexanecarboxylates: Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma
Siegfried B. Christensen,
Aimee Guider,
Cornelia J. Forster,
John G. Gleason,
Paul E. Bender,
Joseph M. Karpinski,
Walter E. DeWolf, Jr.,
Mary S. Barnette,
David C. Underwood,
Don E. Griswold,
Lenora B. Cieslinski,
Miriam Burman,
Steven Bochnowicz,
Ruth R. Osborn,
Carol D. Manning,
Marilyn Grous,
Leonard M. Hillegas,
Joan O'Leary Bartus,
M. Dominic Ryan,
Drake S. Eggleston,
R. Curtis Haltiwanger, and
Theodore J. Torphy
[Full Article -
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836-852
| Comparative Binding Energy Analysis of HIV-1 Protease Inhibitors: Incorporation of Solvent Effects and Validation as a Powerful Tool in Receptor-Based Drug Design
Carlos Pérez,
Manuel Pastor,
Angel R. Ortiz, and
Federico Gago
[Full Article -
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853-863
| Molecular Properties and Pharmacokinetic Behavior of Cetirizine, a Zwitterionic H1-Receptor Antagonist
Alessandra Pagliara,
Bernard Testa,
Pierre-Alain Carrupt,
Pascale Jolliet,
Christophe Morin,
Didier Morin,
Saïk Urien,
Jean-Paul Tillement, and
Jean-Pierre Rihoux
[Full Article -
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864-876
| (-)-3 -Substituted Ecgonine Methyl Esters as Inhibitors for Cocaine Binding and Dopamine Uptake
Spencer F. Lieske,
Biao Yang,
Mohyee E. Eldefrawi,
Alexander D. MacKerell, Jr., and
Jeremy Wright
[Full Article -
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877-893
| Inhibitors of Farnesyl Protein Transferase. 4-Amido, 4-Carbamoyl, and 4-Carboxamido Derivatives of 1-(8-Chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-Bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine
Alan K. Mallams,
Randall R. Rossman,
Ronald J. Doll,
Viyyoor M. Girijavallabhan,
Ashit K. Ganguly,
Joanne Petrin,
Lynn Wang,
Robert Patton,
W. Robert Bishop,
Donna M. Carr,
Paul Kirschmeier,
Joseph J. Catino,
Matthew S. Bryant,
Kwang-Jong Chen,
Walter A. Korfmacher,
Cymbelene Nardo,
Shiyong Wang,
Amin A. Nomeir,
Chin-Chung Lin,
Zujun Li,
Jianping Chen,
Suining Lee,
Janet Dell,
Philip Lipari,
Michael Malkowski,
Bodan Yaremko,
Ivan King, and
Ming Liu
[Full Article -
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894-901
| Ethnobotanical-Directed Discovery of the Antihyperglycemic Properties of Cryptolepine: Its Isolation from Cryptolepis sanguinolenta, Synthesis, and in Vitro and in Vivo Activities
Donald E. Bierer,
Diana M. Fort,
Christopher D. Mendez,
Jian Luo,
Patricia A. Imbach,
Larisa G. Dubenko,
Shivanand D. Jolad,
R. Eric Gerber,
Joane Litvak,
Qing Lu,
Pingsheng Zhang,
Michael J. Reed,
Nancy Waldeck,
Reimar C. Bruening,
Ben K. Noamesi,
Richard F. Hector,
Thomas J. Carlson, and
Steven R. King
[Full Article -
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902-912
| Novel 17-Azolyl Steroids, Potent Inhibitors of Human Cytochrome 17 -Hydroxylase-C17,20-lyase (P45017): Potential Agents for the Treatment of Prostate Cancer
Vincent C. O. Njar,
Katsuya Kato,
Ivo P. Nnane,
Dmitry N. Grigoryev,
Brian J. Long, and
Angela M. H. Brodie
[Full Article -
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913-918
| 2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine Analogues of Trimethoprim as Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase
Andre Rosowsky,
Andrew T. Papoulis, and
Sherry F. Queener
[Full Article -
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919-929
| A Backbone-Cyclic, Receptor 5-Selective Somatostatin Analogue: Synthesis, Bioactivity, and Nuclear Magnetic Resonance Conformational Analysis
Chaim Gilon,
Martin Huenges,
Barbara Mathä,
Gary Gellerman,
Vered Hornik,
Michel Afargan,
Oved Amitay,
Ofer Ziv,
Etty Feller,
Asher Gamliel,
Dvira Shohat,
Mazal Wanger,
Oded Arad, and
Horst Kessler
[Full Article -
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930-939
| Excitatory Amino Acid Receptor Ligands: Resolution, Absolute Stereochemistry, and Enantiopharmacology of 2-Amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic Acid
Tommy N. Johansen,
Bjarke Ebert,
Hans Bräuner-Osborne,
Michael Didriksen,
Inge T. Christensen,
Karina K. S by,
Ulf Madsen,
Povl Krogsgaard-Larsen, and
Lotte Brehm
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940-951
| Orally Active Antimalarial 3-Substituted Trioxanes: New Synthetic Methodology and Biological Evaluation
Gary H. Posner,
Jared N. Cumming,
Soon-Hyung Woo,
Poonsakdi Ploypradith,
Suji Xie, and
Theresa A. Shapiro
[Full Article -
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952-964
| Design, Synthesis, Derivatization, and Structure-Activity Relationships of Simplified, Tricyclic, 1,2,4-Trioxane Alcohol Analogues of the Antimalarial Artemisinin
Jared N. Cumming,
Dasong Wang,
Sheldon B. Park,
Theresa A. Shapiro, and
Gary H. Posner
[Full Article -
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965-972
| Intensely Potent Doxorubicin Analogues: Structure-Activity Relationship
David Farquhar,
Abdallah Cherif,
Elena Bakina, and
J. Arly Nelson
[Full Article -
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973-980
| Discovery of 1-(4-Fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)- hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235): A Designed, Potent, Orally Active Inhibitor of Cholesterol Absorption
Stuart B. Rosenblum,
Tram Huynh,
Adriano Afonso,
Harry R. Davis, Jr.,
Nathan Yumibe,
John W. Clader, and
Duane A. Burnett
[Full Article -
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981-987
| Design, Synthesis, and Evaluation of the Multidrug Resistance-Reversing Activity of D-Glucose Mimetics of Hapalosin
Tam Q. Dinh,
Charles D. Smith,
Xiaohui Du, and
Robert W. Armstrong
[Full Article -
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988-995
| Molecular Features Associated with Polyamine Modulation of NMDA Receptors
Anita H. Lewin,
Guobin Sun,
Louise Fudala,
Hernan Navarro,
Li-Ming Zhou,
Piotr Popik,
Alexander Faynsteyn, and
Phil Skolnick
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NOTES
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996-1000
| Novel Biologically Active Nonpeptidic Inhibitors of MyristoylCoA:Protein N-Myristoyltransferase
Balekudru Devadas,
Sandra K. Freeman,
Charles A. McWherter,
Nandini S. Kishore,
Jennifer K. Lodge,
Emily Jackson-Machelski,
Jeffrey I. Gordon, and
James A. Sikorski
[Full Article -
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1001-1005
| Synthesis and Pharmacological Evaluation of Ring-Methylated Derivatives of 3,4-(Methylenedioxy)amphetamine (MDA)
Matthew A. Parker,
Danuta Marona-Lewicka,
Deborah Kurrasch,
Alexander T. Shulgin, and
David E. Nichols
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ADDITIONS AND CORRECTIONS
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1006-1006
| Synthesis and Pharmacological Evaluation of N-(2,5-Disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methylguanidines As N-Methyl-D-aspartate Receptor Ion-Channel Blockers
Lain-Yen Hu,
Junqing Guo,
Sharad S. Magar,
James B. Fischer,
Kathleen J. Burke-Howie, and
Graham J. Durant
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