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COMMUNICATIONS TO THE EDITOR
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1007-1010
| Physicochemical High Throughput Screening: Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes
Manfred Kansy,
Frank Senner, and
Klaus Gubernator
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EXPEDITED ARTICLES
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1011-1013
| Design of Novel, Potent, Noncovalent Inhibitors of Thrombin with Nonbasic P-1 Substructures: Rapid Structure-Activity Studies by Solid-Phase Synthesis
William C. Lumma, Jr.,
Keith M. Witherup,
Thomas J. Tucker,
Steven F. Brady,
John T. Sisko,
Adel M. Naylor-Olsen,
S. Dale Lewis,
Bobby J. Lucas, and
Joseph P. Vacca
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ARTICLES
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1014-1026
| Cytotoxic Activities of Mannich Bases of Chalcones and Related Compounds
Jonathan R. Dimmock,
N. Murthi Kandepu,
Mark Hetherington,
J. Wilson Quail,
Uma Pugazhenthi,
Athena M. Sudom,
Mahmood Chamankhah,
Patricia Rose,
Eric Pass,
Theresa M. Allen,
Sarah Halleran,
Jen Szydlowski,
Bulent Mutus,
Marie Tannous,
Elias K. Manavathu,
Timothy G. Myers,
Erik De Clercq,O and
Jan BalzariniO
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1027-1033
| Thiol-Induced Nitric Oxide Release from 3-Halogeno-3,4-dihydrodiazete 1,2-Dioxides
Igor A. Kirilyuk,
Darkhan I. Utepbergenov,
Dmitrii G. Mazhukin,
Klaus Fechner,
Katharina Mertsch,
Valery V. Khramtsov,
Ingolf E. Blasig, and
Reiner F. Haseloff
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1034-1041
| Design and Synthesis of Enantiomers of 3,5-Dinitro-o-tyrosine:  -Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic Acid (AMPA) Receptor Antagonists
Guoping Sun,
Meri Slavica,
Norman J. Uretsky,
Lane J. Wallace,
Gamal Shams,
David M. Weinstein,
John C. Miller, and
Duane D. Miller
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1042-1049
| Novel Nonpeptide CCK-B Antagonists: Design and Development of Quinazolinone Derivatives as Potent, Selective, and Orally Active CCK-B Antagonists
Janak K. Padia,
Mark Field,
Joanna Hinton,
Ken Meecham,
Julius Pablo,
Rob Pinnock,
Bruce D. Roth,
Lakhbir Singh,
Nirmala Suman-Chauhan,
Bharat K. Trivedi, and
Louise Webdale
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1050-1059
| Inhibition of Fc-eps-RI-Mediated Activation of Mast Cells by 2,3,4-Trihydropyrimidino[2,1-a]isoquinolines
Dieter Scholz,
Hannelore Schmidt,
Eva E. Prieschl,
Robert Csonga,
Winfried Scheirer,
Virginia Weber,
Anna Lembachner,
Gunther Seidl,
Gudrun Werner,
Peter Mayer, and
Thomas Baumruker
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1060-1067
| 2-Amino-4H-3,1-benzoxazin-4-ones as Inhibitors of C1r Serine Protease
Sheryl J. Hays,
Bradley W. Caprathe,
John L. Gilmore,
Nilam Amin,
Mark R. Emmerling,
Walter Michael,
Ravi Nadimpalli,
Rathna Nath,
Kadee J. Raser,
Daniel Stafford,
Desiree Watson,
Kevin Wang, and
Juan C. Jaen
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1068-1083
| Steroidal and Nonsteroidal Sulfamates as Potent Inhibitors of Steroid Sulfatase
L. W. Lawrence Woo,
Nicola M. Howarth,
Atul Purohit,
Hatem A. M. Hejaz,
Michael J. Reed, and
Barry V. L. Potter
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1084-1091
| Novel 5-(3-Aryl-2-propynyl)-5-(arylsulfonyl)thiazolidine-2,4-diones as Antihyperglycemic Agents
Jay Wrobel,
Zenan Li,
Arlene Dietrich,
Michael McCaleb,
Brenda Mihan,
Janet Sredy, and
Donald Sullivan
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1092-1098
| Synthesis and Endectocidal Activity of Novel 1-(Arylsulfonyl)-1-[(trifluoromethyl)sulfonyl]methane Derivatives
David I. Wickiser,
Sharon A. Wilson,
Daniel E. Snyder,
Karl R. Dahnke,
Charles K. Smith II, and
Paul J. McDermott
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1099-1111
| Novel Synthetic Inhibitors of Selectin-Mediated Cell Adhesion: Synthesis of 1,6-Bis[3-(3-carboxymethylphenyl)-4-(2--D-mannopyranosyloxy)phenyl]hexane (TBC1269)
Timothy P. Kogan,
Brian Dupré,
Huong Bui,
Kathy L. McAbee,
Jamal M. Kassir,
Ian L. Scott,
Xin Hu,
Peter Vanderslice,
Pamela J. Beck, and
Richard A. F. Dixon
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1112-1123
| New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 1. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents: Discovery and Variation of the 5-Keto Substituent
John M. Janusz,
Patricia A. Young,
James M. Ridgeway,
Michael W. Scherz,
Kevin Enzweiler,
Laurence I. Wu,
Lixian Gan,
Renuka Darolia,
Randall S. Matthews,
Duane Hennes,
David E. Kellstein,
Shelley A. Green,
Jennifer L. Tulich,
Theresa Rosario-Jansen,
I. Jack Magrisso,
Kenneth R. Wehmeyer,
Deborah L. Kuhlenbeck,
Thomas H. Eichhold,
Roy L. M. Dobson,
Steven P. Sirko, and
Ralph W. Farmer
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1124-1137
| New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 2. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents: Variations of the Dihydrobenzofuran Ring
John M. Janusz,
Patricia A. Young,
Michael W. Scherz,
Kevin Enzweiler,
Laurence I. Wu,
Lixian Gan,
Stanislaw Pikul,
Kelly L. McDow-Dunham,
Carl R. Johnson,
C. B. Senanayake,
David E. Kellstein,
Shelley A. Green,
Julie L. Tulich,
Theresa Rosario-Jansen,
I. Jack Magrisso,
Kenneth R. Wehmeyer,
Deborah L. Kuhlenbeck,
Thomas H. Eichhold, and
Roy L. M. Dobson
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1138-1145
| Synthesis and Anticonvulsant Activity of 2(3H)-Benzoxazolone and 2(3H)-Benzothiazolone Derivatives
Huseyin Ucar,
Kim Van derpoorten,
Silvia Cacciaguerra,
Santi Spampinato,
James P. Stables,
Paul Depovere,
Majed Isa,
Bernard Masereel,
Jacques Delarge, and
Jacques H. Poupaert
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1146-1154
| Potent Antagonists of Somatostatin: Synthesis and Biology
Simon J. Hocart,
Rahul Jain,
William A. Murphy,
John E. Taylor,
Barry Morgan, and
David H. Coy
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1155-1162
| Antitumor Agents. 181. Synthesis and Biological Evaluation of 6,7,2',3',4'-Substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a New Class of Antimitotic Antitumor Agents
Yi Xia,
Zheng-Yu Yang,
Peng Xia,
Kenneth F. Bastow,
Yoko Tachibana,
Sheng-Chu Kuo,
Ernest Hamel,
Torben Hackl, and
Kuo-Hsiung Lee
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1163-1171
| Synthesis and Evaluation of Compounds That Facilitate the Gastrointestinal Absorption of Heparin
Andrea Leone-Bay,
Duncan R. Paton,
John Freeman,
Christine Lercara,
Doris O'Toole,
David Gschneidner,
Eric Wang,
Elizabeth Harris,
Connie Rosado,
Theresa Rivera,
Aldonna DeVincent,
Monica Tai,
Frank Mercogliano,
Rajesh Agarwal,
Harry Leipold, and
Robert A. Baughman
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1172-1184
| (3R,4S)-3-[4-(4-Fluorophenyl)-4-hydroxypiperidin-1-yl]chroman-4,7-diol: A Conformationally Restricted Analogue of the NR2B Subtype-Selective NMDA Antagonist (1S,2S)-1-(4-Hydroxyphenyl)-2- (4-hydroxy-4-phenylpiperidino)-1-propanol
Todd W. Butler,
James F. Blake,
Jon Bordner,
Paul Butler,
Bertrand L. Chenard,
Mary A. Collins,
Debra DeCosta,
Mary J. Ducat,
Michael E. Eisenhard,
Frank S. Menniti,
Martin J. Pagnozzi,
Steven B. Sands,
Barbara E. Segelstein,
Walter Volberg,
W. Frost White, and
Dayao Zhao
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1185-1194
| Role of the C(6)-Hydroxy Group in Bicyclomycin: Synthesis, Structure, and Chemical, Biochemical, and Biological Properties
Alejandro Santillán, Jr.,
Xiangdong Zhang,
Jon Hardesty,
William R. Widger, and
Harold Kohn
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NOTES
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1195-1200
| Pharmacophoric Requirements for Cannabinoid Side Chains: Multiple Bond and C1'-Substituted  8-Tetrahydrocannabinols
Demetris P. Papahatjis,
Therapia Kourouli,
Vasiliki Abadji,
Andreas Goutopoulos, and
Alexandros Makriyannis
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1201-1204
| Simultaneous Measurement of Nineteen Binding Constants of Peptides to Vancomycin Using Affinity Capillary Electrophoresis-Mass Spectrometry
Yuriy M. Dunayevskiy,
Yelena V. Lyubarskaya,
Yen-Ho Chu,
Paul Vouros, and
Barry L. Karger
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