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COMMUNICATIONS TO THE EDITOR
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1357-1360
| (-)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor
Donn G. Wishka,
David R. Graber,
Laurice A. Kopta,
Robert A. Olmsted,
Janice M. Friis,
John D. Hosley,
Wade J. Adams,
Eric P. Seest,
Thomas M. Castle,
Lester A. Dolak,
Barbara J. Keiser,
Yoshihiko Yagi,
Azhwarsamy Jeganathan,
Stephen T. Schlachter,
Michael J. Murphy,
Gary J. Cleek,
Richard A. Nugent,
Susan M. Poppe,
Steven M. Swaney,
Fusen Han,
William Watt,
Wendy L. White,
Toni-Jo Poel,
Richard C. Thomas,
Richard L. Voorman,
Kevin J. Stefanski,
Randall G. Stehle,
W. Gary Tarpley, and
Joel Morris
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EXPEDITED ARTICLES
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1361-1366
| 2-Iminohomopiperidinium Salts as Selective Inhibitors of Inducible Nitric Oxide Synthase (iNOS)
Donald W. Hansen, Jr.,
Karen B. Peterson,
Mahima Trivedi,
Steven W. Kramer,
Ronald K. Webber,
Foe S. Tjoeng,
William M. Moore,
Gina M. Jerome,
Christine M. Kornmeier,
Pamela T. Manning,
Jane R. Connor,
Thomas P. Misko,
Mark G. Currie, and
Barnett S. Pitzele
[Full Article -
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1367-1370
| Rational Drug Design Approach for Overcoming Drug Resistance: Application to Pyrimethamine Resistance in Malaria
James H. McKie,
Kenneth T. Douglas,
Cecil Chan,
Simon A. Roser,
Robert Yates,
Martin Read,
John E. Hyde,
Michael J. Dascombe,
Yongyuth Yuthavong, and
Worachart Sirawaraporn
[Full Article -
PDF] |
1371-1381
| Anti-HIV Agents That Selectively Target Retroviral Nucleocapsid Protein Zinc Fingers without Affecting Cellular Zinc Finger Proteins
Mingjun Huang,
Andrew Maynard,
Jim A. Turpin,
Lisa Graham,
George M. Janini,
David G. Covell, and
William G. Rice
[Full Article -
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1382-1391
| Modulation of Receptor and Receptor Subtype Affinities Using Diastereomeric and Enantiomeric Monosaccharide Scaffolds as a Means to Structural and Biological Diversity. A New Route to Ether Synthesis
Ralph Hirschmann,
John Hynes, Jr.,
Maria A. Cichy-Knight,
Rachel D. van Rijn,
Paul A. Sprengeler,
P. Grant Spoors,
William C. Shakespeare,
Sherrie Pietranico-Cole,
Joseph Barbosa,
Josephine Liu,
Wenqing Yao,
Susan Rohrer, and
Amos B. Smith, III
[Full Article -
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ARTICLES
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1392-1398
| Effect of Steroids on DNA Synthesis in an in Vitro Replication System: Initial Quantitative Structure-Activity Relationship Studies and Construction of a Non-Estrogen Receptor Pharmacophore
Kamal Azzaoui,
Maria J. Diaz-Perez,
Maria Zannis-Hadjoupoulos,
Gerry B. Price, and
Irving W. Wainer
[Full Article -
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1399-1408
| Novel Tetranuclear Orthometalated Complexes of Pd(II) and Pt(II) Derived from p-Isopropylbenzaldehyde Thiosemicarbazone with Cytotoxic Activity in cis-DDP Resistant Tumor Cell Lines. Interaction of These Complexes with DNA
Adoración G. Quiroga,
José M. Pérez,
Isabel López-Solera,
José R. Masaguer,
Antonio Luque,
Pascual Román,
Andy Edwards,
Carlos Alonso, and
Carmen Navarro-Ranninger
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1409-1416
| Synthesis and Biological Activities of Tricyclic Conformationally Restricted Tetrahydropyrido Annulated Furo[2,3-d]pyrimidines as Inhibitors of Dihydrofolate Reductases
Aleem Gangjee,
Elfatih Elzein,
Sherry F. Queener, and
John J. McGuire
[Full Article -
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1417-1427
| cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine Monophosphate (cycloSal-d4TMP): Synthesis and Antiviral Evaluation of a New d4TMP Delivery System
Chris Meier,
Martina Lorey,
Erik De Clercq, and
Jan Balzarini
[Full Article -
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1428-1438
| Synthesis and Structure-Activity Relationships of Carboxyflavones as Structurally Rigid CysLT1 (LTD4) Receptor Antagonists
Mariël E. Zwaagstra,
Henk Timmerman,
Andrea C. van de Stolpe,
Frans J. J. de Kanter,
Masahiro Tamura,
Yasushi Wada, and
Ming-Qiang Zhang
[Full Article -
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1439-1445
| Development of a Three-Dimensional CysLT1 (LTD4) Antagonist Model with an Incorporated Amino Acid Residue from the Receptor
Mariël E. Zwaagstra,
Saskia H. H. F. Schoenmakers,
Paul H. J. Nederkoorn,
Edith Gelens,
Henk Timmerman, and
Ming-Qiang Zhang
[Full Article -
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1446-1455
| Nonpeptide Cyclic Cyanoguanidines as HIV-1 Protease Inhibitors: Synthesis, Structure-Activity Relationships, and X-ray Crystal Structure Studies
Prabhakar K. Jadhav,
Francis J. Woerner,
Patrick Y. S. Lam,
C. Nicholas Hodge,
Charles J. Eyermann,
Hon-Wah Man,
Wayne F. Daneker,
Lee T. Bacheler,
Marlene M. Rayner,
James L. Meek,
Susan Erickson-Viitanen,
David A. Jackson,
Joseph C. Calabrese,
Margaret Schadt, and
Chong-Hwan Chang
[Full Article -
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1456-1466
| Human P2Y1 Receptor: Molecular Modeling and Site-Directed Mutagenesis as Tools To Identify Agonist and Antagonist Recognition Sites
Stefano Moro,
Danping Guo,
Emidio Camaioni,
José L. Boyer,
T. Kendall Harden, and
Kenneth A. Jacobson
[Full Article -
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1467-1475
| Conformation-Function Relationship of Vitamin D: Conformational Analysis Predicts Potential Side-Chain Structure
Sachiko Yamada,
Keiko Yamamoto,
Hiroyuki Masuno, and
Masateru Ohta
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1476-1496
| Clarification of the Binding Mode of Teleocidin and Benzolactams to the Cys2 Domain of Protein Kinase C by Synthesis of Hydrophobically Modified, Teleocidin-Mimicking Benzolactams and Computational Docking Simulation
Yasuyuki Endo,
Shunji Takehana,
Michihiro Ohno,
Paul E. Driedger,
Silvia Stabel,
Miho Y. Mizutani,
Nobuo Tomioka,
Akiko Itai, and
Koichi Shudo
[Full Article -
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1497-1506
| Membrane-Induced Secondary Structures of Neuropeptides: A Comparison of the Solution Conformations Adopted by Agonists and Antagonists of the Mammalian Tachykinin NK1 Receptor
Tracy L. Whitehead,
Sharon D. McNair,
Chad E. Hadden,
John K. Young, and
Rickey P. Hicks
[Full Article -
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1507-1512
| Therapeutic Effects of Monoclonal Antibody- -Lactamase Conjugates in Combination with a Nitrogen Mustard Anticancer Prodrug in Models of Human Renal Cell Carcinoma
Håkan P. Svensson,
Ian S. Frank,
Karen K. Berry, and
Peter D. Senter
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1513-1523
| Design and Synthesis of Potent, Selective Inhibitors of Endothelin-Converting Enzyme
Eli M. Wallace,
John A. Moliterni,
Michael A. Moskal,
Alan D. Neubert,
Nicholas Marcopulos,
Lisa B. Stamford,
Angelo J. Trapani,
Paula Savage,
Mary Chou, and
Arco Y. Jeng
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1524-1530
| Synthesis and Biological Activity of Chimeric Structures Derived from the Cytotoxic Natural Compounds Dolastatin 10 and Dolastatin 15
Joël Poncet,
Magali Busquet,
Florence Roux,
Alain Pierré,
Ghanem Atassi, and
Patrick Jouin
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1531-1539
| Nuclease-Resistant Composite 2',5'-Oligoadenylate-3',5'-Oligonucleotides for the Targeted Destruction of RNA: 2-5A-Iso-antisense
Wei Xiao,
Guiying Li,
Mark R. Player,
Ratan K. Maitra,
Cornelius F. Waller,
Robert H. Silverman, and
Paul F. Torrence
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1540-1554
| Structure-Activity Relationship of New Growth Inhibitors of Trypanosoma cruzi
Güendalina M. Cinque,
Sergio H. Szajnman,
Li Zhong,
Roberto Docampo,
Andrea J. Schvartzapel,
Juan B. Rodriguez, and
Eduardo G. Gros
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BOOK REVIEWS
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1555-1556
| Reviews in Computational Chemistry, Volume 10 Edited by Kenny B. Lipkowitz and Donald B. Boyd. VCH Publishers, Inc., New York. 1997. xxiii + 334 pp. 16 × 24 cm. ISBN 1-56081-957-X. $120.00.
M. Katharine Holloway
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1556-1556
| The Impact of Stereochemistry on Drug Development and Use. Volume 142 in Chemical Analysis. Edited by H. Y. Aboul-Enein and I. W. Wainer. John Wiley & Sons, New York. 1997. xxvii + 695 pp. 16 × 23.5 cm. ISBN 0-471-59644-2. $99.00
David E. Nichols
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