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COMMUNICATIONS TO THE EDITOR
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1741-1744
| Potent Antagonists of the SH2 Domain of Grb2: Optimization of the X+1 Position of 3-Amino-Z-Tyr(PO3H2)-X+1-Asn-NH2
Carlos García-Echeverría,
Pascal Furet,
Brigitte Gay,
Heinz Fretz,
Joseph Rahuel,
Joseph Schoepfer, and
Giorgio Caravatti
[Full Article -
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1745-1748
| Design and Synthesis of Cyclic Inhibitors of Matrix Metalloproteinases and TNF- Production
Chu-Biao Xue,
Xiaohua He,
John Roderick,
William F. DeGrado,2
Robert J. Cherney,
Karl D. Hardman,
David J. Nelson,
Robert A. Copeland,
Bruce D. Jaffee, and
Carl P. Decicco,3
[Full Article -
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1749-1751
| Macrocyclic Amino Carboxylates as Selective MMP-8 Inhibitors
Robert J. Cherney,
Li Wang,
Dayton T. Meyer,
Chu-Baio Xue,
Zelda R. Wasserman,
Karl D. Hardman,
Patty K. Welch,
Maryanne B. Covington,
Robert A. Copeland,
Elizabeth C. Arner,
William F. DeGrado, and
Carl P. Decicco
[Full Article -
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ARTICLES
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1752-1763
| Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3-d]pyrimidine Inhibitors
Susanne Trumpp-Kallmeyer,
J. Ronald Rubin,
Christine Humblet,
James M. Hamby, and
H. D. Hollis Showalter
[Full Article -
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1764-1776
| 32-Ascomycinyloxyacetic Acid Derived Immunosuppressants. Independence of Immunophilin Binding and Immunosuppressive Potency
Rolf Wagner,
Teresa A. Rhoades,
Yat Sun Or,
Benjamin C. Lane,
Gin Hsieh,
Karl W. Mollison, and
Jay R. Luly
[Full Article -
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1777-1788
| Structure-Activity Relationship of 2-[[(2-Pyridyl)methyl]thio]-1H- benzimidazoles as Anti Helicobacter pylori Agents in Vitro and Evaluation of their in Vivo Efficacy
Thomas C. Kühler,
Marianne Swanson,
Vladimir Shcherbuchin,
Håkan Larsson,
Björn Mellgård, and
Jan-Eric Sjöström
[Full Article -
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1789-1802
| Hydroxyphthalocyanines as Potential Photodynamic Agents for Cancer Therapy
Mougang Hu,
Nicole Brasseur,
S. Zeki Yildiz,
Johan E. van Lier, and
Clifford C. Leznoff
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1803-1814
| Three-Dimensional Models of Estrogen Receptor Ligand Binding Domain Complexes, Based on Related Crystal Structures and Mutational and Structure-Activity Relationship Data
Jean-Marie Wurtz,
Ursula Egner,
Nikolaus Heinrich,
Dino Moras, and
Anke Mueller-Fahrnow
[Full Article -
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1815-1826
| Molecular Modeling of Phenothiazines and Related Drugs As Multidrug Resistance Modifiers: A Comparative Molecular Field Analysis Study
Ilza Pajeva and
Michael Wiese
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1827-1837
| Synthesis, Rotamer Orientation, and Calcium Channel Modulation Activities of Alkyl and 2-Phenethyl 1,4-Dihydro-2,6-dimethyl-3-nitro-4-(3- or 6-substituted-2-pyridyl)-5-pyridinecarboxylates
Nadeem Iqbal,
Murthy R. Akula,
Dean Vo,
Wandikayi C. Matowe,
Carol-Anne McEwen,
Michael W. Wolowyk, and
Edward E. Knaus
[Full Article -
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1838-1845
| Identification of Novel Ligands for the Gabapentin Binding Site on the 2 Subunit of a Calcium Channel and Their Evaluation as Anticonvulsant Agents
Justin S. Bryans,
Natasha Davies,
Nicolas S. Gee,
Visaka U. K. Dissanayake,
Giles S. Ratcliffe,
David C. Horwell,
Clare O. Kneen,
Andrew I. Morrell,
Ryszard J. Oles,
John C. O'Toole,
Gemma M. Perkins,
Lakhbir Singh,
Nirmala Suman-Chauhan, and
Jacqueline A. O'Neill
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1846-1854
| Propofol Analogues. Synthesis, Relationships between Structure and Affinity at GABAA Receptor in Rat Brain, and Differential Electrophysiological Profile at Recombinant Human GABAA Receptors
Giuseppe Trapani,
Andrea Latrofa,
Massimo Franco,
Cosimo Altomare,
Enrico Sanna,
Marcello Usala,
Giovanni Biggio, and
Gaetano Liso
[Full Article -
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1855-1868
| New Azole Antifungals. 2. Synthesis and Antifungal Activity of Heterocyclecarboxamide Derivatives of 3-Amino-2-aryl-1-azolyl-2-butanol
Javier Bartroli,
Enric Turmo,
Mònica Algueró,
Eulàlia Boncompte,
Maria L. Vericat,
Lourdes Conte,
Joaquim Ramis,
Manuel Merlos,
Julián García-Rafanell, and
Javier Forn
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1869-1882
| New Azole Antifungals. 3. Synthesis and Antifungal Activity of 3-Substituted-4(3H)-quinazolinones
Javier Bartroli,
Enric Turmo,
Mònica Algueró,
Eulàlia Boncompte,
Maria L. Vericat,
Lourdes Conte,
Joaquim Ramis,
Manuel Merlos,
Julián García-Rafanell, and
Javier Forn
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1883-1893
| Synthesis and Structure-Activity Relationships of Bafilomycin A1 Derivatives as Inhibitors of Vacuolar H+-ATPase
Stefania Gagliardi,
P. Andrea Gatti,
Pietro Belfiore,
Andrea Zocchetti,
Geoffrey D. Clarke, and
Carlo Farina
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1894-1908
| Potent Dipeptide Inhibitors of the pp60c-src SH2 Domain
Gregory J. Pacofsky,
Karen Lackey,
Krystal J. Alligood,
Judd Berman,
Paul S. Charifson,,1
Renae M. Crosby,
George F. Dorsey, Jr.,
Paul L. Feldman,
Tona M. Gilmer,
Conrad W. Hummel,,1
Steven R. Jordan,,1
Christopher Mohr,
Lisa M. Shewchuk,
Daniel D. Sternbach, and
Marc Rodriguez,1
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1909-1926
| Synthesis and Activity of Dipeptides, Linked to Targeting Ligands, as Specific NK Cell Enhancers
Shaun D. Abbott,
Lyne Gagnon,
Mouna Lagraoui,
Salam Kadhim,
Giorgio Attardo,
Boulos Zacharie, and
Christopher L. Penney
[Full Article - PDF] |
1927-1933
| Isoxazolidine-3,5-dione and Noncyclic 1,3-Dicarbonyl Compounds as Hypoglycemic Agents
Hisashi Shinkai,
Syoji Onogi,
Masahiro Tanaka,
Tsutomu Shibata,
Megumi Iwao,
Korekiyo Wakitani, and
Itsuo Uchida
[Full Article - PDF] |
1934-1942
| (R)-(+)-2-[[[3-(Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl]morpholine Methanesulfonate: A New Selective Rat 5-Hydroxytryptamine1B Receptor Antagonist
Stefan Berg,
Lars-Gunnar Larsson,
Lucy Rényi,
Svante B. Ross,
Seth-Olof Thorberg, and
Gun Thorell-Svantesson
[Full Article - PDF] |
1943-1955
| Synthesis and Structure-Activity Relationships of Potent and Orally Active 5-HT4 Receptor Antagonists: Indazole and Benzimidazolone Derivatives
John M. Schaus,
Dennis C. Thompson,
William E. Bloomquist,
Alice D. Susemichel,
David O. Calligaro, and
Marlene L. Cohen
[Full Article - PDF] |
1956-1961
| Antitumor Agents. 185. Synthesis and Biological Evaluation of Tridemethylthiocolchicine Analogues as Novel Topoisomerase II Inhibitors
Jian Guan,
Xiao-Kang Zhu,
Yoko Tachibana,
Kenneth F. Bastow,
Arnold Brossi,
Ernest Hamel, and
Kuo-Hsiung Lee
[Full Article - PDF] |
1962-1969
| Chemistry and Pharmacology of the Piperidine-Based Analogues of Cocaine. Identification of Potent DAT Inhibitors Lacking the Tropane Skeleton
Alan P. Kozikowski,
Gian Luca Araldi,
John Boja,
William M. Meil,
Kenneth M. Johnson,
Judith L. Flippen-Anderson,
Clifford George, and
Eddine Saiah
[Full Article - PDF] |
1970-1979
| (±)-trans-2-[3-Methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a Potent Dual 5-Lipoxygenase Inhibitor and Platelet-Activating Factor Receptor Antagonist
Xiong Cai,
Ralph T. Scannell,
David Yaeger,
Md. Sajjat Hussoin,
David B. Killian,
Changgeng Qian,
Joseph Eckman,
San-Bao Hwang,
Lynn Libertine-Garahan,
C. Grace Yeh,
Stephen H. Ip, and
T. Y. Shen
[Full Article - PDF] |
1980-1990
| Investigation of the N-Substituent Conformation Governing Potency and  Receptor Subtype-Selectivity in (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl)- piperidine Opioid Antagonists
James B. Thomas,
S. Wayne Mascarella,
Richard B. Rothman,
John S. Partilla,
Heng Xu,
Karen B. McCullough,
Christina M. Dersch,
Buddy E. Cantrell,
Dennis M. Zimmerman, and
F. Ivy Carroll
[Full Article - PDF] |
BOOK REVIEWS
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1991-1991
| Structure-Based Drug Design Edited by Pandi Veerapandian. Marcel Dekker, Inc., New York. 1997. xiii + 647 pp. 16 × 23.5 cm. ISBN 0-8247-9869-4. $175.00.
James F. Kerwin, Jr.
[Full Article - PDF] |
1991-1992
| Asymmetric Synthesis By Gary Proctor. Oxford University Press, Oxford, UK. 1997. 237 pp. 16 × 24 cm. ISBN 0-19-855726-3. $85.00.
Thomas J. Caggiano
[Full Article - PDF] |
1992-1992
| Monosaccharide Sugars By Zoltán Györgydeák and István F. Pelyvás. Academic Press, San Diego, CA. 1998. xviii-508 pp. 15.5 × 23.5 cm. ISBN 0-12-550360-1. $89.95.
Hélène G. Bazin and
Robert J. Linhardt
[Full Article - PDF] |
1992-1994
| Reviews in Computational Chemistry, Volume 11 Edited by Kenney B. Lipkowitz and Donald B. Boyd. Wiley-VCH, Inc., New York, NY. 1997. xxiv + 431 pp. 16 x 24 cm. ISBN 0-471-19248-1. $120.00.
Emile M. Bellott
[Full Article - PDF] |
1994-1995
| From Chemical Topology to Three Dimensional Geometry Edited by Alexandru T. Balaban. Plenum Press, New York, NY. 1997. xviii + 420 pp. 16 × 23 cm. ISBN 0-30645462. $125.00.
Emile M. Bellott
[Full Article - PDF] |
1995-1995
| Books of Interest
[Full Article - PDF] |
ADDITIONS AND CORRECTIONS
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1996-1996
| Synthesis of Gonadotropin-Releasing Hormone III Analogs. Structure-Antitumor Activity Relationships
Imre Mezö,
Sándor Lovas,
István Pályi,
Borbála Vincze,
Adrien Kálnay,
Gizella Turi,
Zsolt Vadász,
János Seprödi,
Miklós Idei,Géza Tóth,
Eva Gulyás,
Ferenc Ötvös,
Mariann Mák,
Judit E. Horváth,
István Teplán, and
Richard F. Murphy
[Full Article - PDF] |