|
ARTICLES
|
1997-2009
| Orally Active Benzamide Antipsychotic Agents with Affinity for Dopamine D2, Serotonin 5-HT1A, and Adrenergic  1 Receptors
Allen B. Reitz,
Ellen W. Baxter,
Ellen E. Codd,
Coralie B. Davis,
Alfonzo D. Jordan,
Bruce E. Maryanoff,
Cynthia A. Maryanoff,
Mark E. McDonnell,
Eugene T. Powell,
Michael J. Renzi,
Mary R. Schott,
Malcolm K. Scott,
Richard P. Shank, and
Jeffry L. Vaught
[Full Article -
PDF] |
2010-2018
| Novel Benzothiazolin-2-one and Benzoxazin-3-one Arylpiperazine Derivatives with Mixed 5HT1A/D2 Affinity as Potential Atypical Antipsychotics
Thierry Taverne,
Ousmane Diouf,
Patrick Depreux,
Jacques H. Poupaert,
Daniel Lesieur,
Béatrice Guardiola-Lemaître,
Pierre Renard,
Marie-Claire Rettori,
Daniel-Henri Caignard, and
Bruno Pfeiffer
[Full Article -
PDF] |
2019-2028
| Cyclic HIV Protease Inhibitors: Design and Synthesis of Orally Bioavailable, Pyrazole P2/P2' Cyclic Ureas with Improved Potency
Qi Han,
Chong-Hwan Chang,
Renhua Li,
Yu Ru,
Prabhakar K. Jadhav, and
Patrick Y. S. Lam
[Full Article -
PDF] |
2029-2039
| Arylpiperazines with Serotonin-3 Antagonist Activity: A Comparative Molecular Field Analysis
Antonio Morreale,
Enrique Gálvez-Ruano,
Isabel Iriepa-Canalda, and
Donald B. Boyd
[Full Article -
PDF] |
2040-2046
| Newly Synthesized L-Enantiomers of 3'-Fluoro-Modified  -2'-Deoxyribonucleoside 5'-Triphosphates Inhibit Hepatitis B DNA Polymerases But Not the Five Cellular DNA Polymerases , ,  ,  , and eps Nor HIV-1 Reverse Transcriptase
Martin von Janta-Lipinski,
Burkhardt Costisella,
Hansueli Ochs,
Ulrich Hübscher,
Peter Hafkemeyer, and
Eckart Matthes
[Full Article -
PDF] |
2047-2055
| 6-Acetoxynortropane: A Potent Muscarinic Agonist with Apparent Selectivity toward M2-Receptors
Xue-Feng Pei,
Tara H. Gupta,
Barbara Badio,
W. L. Padgett, and
John W. Daly
[Full Article -
PDF] |
2056-2067
| Structure-Activity Relationships of the 7-Substituents of 5,4'-Diamino-6,8,3'-trifluoroflavone, a Potent Antitumor Agent
Tsutomu Akama,
Hiroyuki Ishida,
Uichiro Kimura,
Katsushige Gomi, and
Hiromitsu Saito
[Full Article -
PDF] |
2068-2075
| Structural Analysis of Thrombin Complexed with Potent Inhibitors Incorporating a Phenyl Group as a Peptide Mimetic and Aminopyridines as Guanidine Substitutes
Roger Bone,
Tianbao Lu,
Carl R. Illig,
Richard M. Soll, and
John C. Spurlino
[Full Article -
PDF] |
2076-2089
| New Alkenyldiarylmethanes with Enhanced Potencies as Anti-HIV Agents Which Act as Non-Nucleoside Reverse Transcriptase Inhibitors
Mark Cushman,
Agustin Casimiro-Garcia,
Elzbieta Hejchman,
Jeffrey A. Ruell,
Mingjun Huang,
Catherine A. Schaeffer,
Karen Williamson,
William G. Rice, and
Robert W. Buckheit, Jr.
[Full Article -
PDF] |
2090-2099
| Vancomycin: Conformational Consequences of the Sugar Substituent
Simona Golic Grdadolnik,
Primoz Pristov ek, and
Dale F. Mierke
[Full Article -
PDF] |
2100-2110
| Specific and Irreversible Cyclopeptide Inhibitors of Dipeptidyl Peptidase IV Activity of the T-Cell Activation Antigen CD26
Coralie Nguyen,
Julià Blanco,
Jean-Paul Mazaleyrat,
Bernard Krust,
Christian Callebaut,
Etienne Jacotot,
Ara G. Hovanessian, and
Michel Wakselman
[Full Article -
PDF] |
2111-2117
| [125I/127I/131I]Iodorhodamine: Synthesis, Cellular Localization, and Biodistribution in Athymic Mice Bearing Human Tumor Xenografts and Comparison with [99mTc]Hexakis(2-methoxyisobutylisonitrile)
Ravi S. Harapanhalli,
Aloka M. Roy,
S. James Adelstein, and
Amin I. Kassis
[Full Article -
PDF] |
2118-2125
| Selective Inhibitors of Monoamine Oxidase (MAO). 5. 1-Substituted Phenoxathiin Inhibitors Containing No Nitrogen That Inhibit MAO A by Binding It to a Hydrophobic Site
Morton Harfenist,
Daniel P. C. McGee,
Mark D. Reeves, and
Helen L. White
[Full Article -
PDF] |
2126-2133
| Design, Synthesis, and Biological Evaluation of a Second Generation of Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as Potent and Selective A2A Adenosine Receptor Antagonists
Pier Giovanni Baraldi,
Barbara Cacciari,
Giampiero Spalluto,
Manuela Bergonzoni,
Silvio Dionisotti,
Ennio Ongini,
Katia Varani, and
P. A. Borea
[Full Article -
PDF] |
2134-2145
| Substituted Naphthofurans as Hallucinogenic Phenethylamine-Ergoline Hybrid Molecules with Unexpected Muscarinic Antagonist Activity
Aaron P. Monte,
Danuta Marona-Lewicka,
Mechelle M. Lewis,
Richard B. Mailman,
David B. Wainscott,
David L. Nelson, and
David E. Nichols
[Full Article -
PDF] |
2146-2163
| Development of Orally Active Oxytocin Antagonists: Studies on 1-(1-{4-[1-(2-Methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and Related Pyridines
Ian M. Bell,
Jill M. Erb,
Roger M. Freidinger,
Steven N. Gallicchio,
James P. Guare,
Maribeth T. Guidotti,
Rita A. Halpin,
Doug W. Hobbs,
Carl F. Homnick,
Michelle S. Kuo,
Edward V. Lis,
David J. Mathre,
Stuart R. Michelson,
Joseph M. Pawluczyk,
Douglas J. Pettibone,
Duane R. Reiss,
Stanley Vickers,
Peter D. Williams, and
Carla J. Woyden
[Full Article -
PDF] |
2164-2167
| Antimalarial Cyclic Peroxy Ketals
Gary H. Posner,
Hardwin O'Dowd,
Poonsakdi Ploypradith,
Jared N. Cumming,
Suji Xie, and
Theresa A. Shapiro
[Full Article -
PDF] |
NOTES
|
2168-2170
| Does the Anti-Hepatitis B Virus Activity of (+)-5'-Noraristeromycin Exist in Its 4'-Epimer and 4'-Deoxygenated Derivatives?
Katherine L. Seley and
Stewart W. Schneller
, Brent Korba
[Full Article -
PDF] |
BOOK REVIEWS
|
2171-2171
| Supramolecular Chemistry of Anions Edited by Antonio Bianchi, Kristin Bowman-James, and Enrique Garcia-Espana. Wiley-VCH, New York, NY. 1997. xiv + 461 pp. ISBN 0-471-18622-8. $79.95.
J. A. Cowan
[Full Article -
PDF] |
2171-2171
| Emerging Therapeutic Targets. Volume 1 Edited by R. Anand, P. Smith, and P. Warne. Ashley Publications Ltd., London. 1997, ix + 281 pp. 21 × 29.5 cm. ISSN 1460-0412. $865.00.
Manfred E. Wolff
[Full Article -
PDF] |
2171-2172
| Highly Selective Neurotoxins. Basic and Clinical Applications Edited by R. M. Kostrzewa. Humana Press, Towota, NJ. 1998. xii + 404 pp. 16 × 23.5 cm. ISBN 0-89603-465-8. $125.00.
David E. Nichols
[Full Article -
PDF] |
2172-2172
| Pharmacologic Analysis of Drug-Receptor Interaction By Terry Kenakin. Lippincott-Raven Publishers, Philadelphia. 1997. xii + 491 pp. 16 × 24 cm. ISBN 0-397-51815-3. $99.00.
Duane D. Miller
[Full Article -
PDF] |
2172-2173
| Combinatorial Chemistry, Synthesis and Application Edited by S. R. Wilson and A. W. Czarnik. John Wiley & Sons, Inc., New York. 1997. ix + 269 pp. 16 × 24 cm. ISBN 0-471-12687. $69.95.
Donald J. Kyle, Ph.D.
[Full Article -
PDF] |
2173-2173
| Second Supplements to the Second Edition of Rodd's Chemistry of Carbon Compounds. Volume IV: Heterocyclic Compounds. Part A: Three-, Four- and Five-Membered Monoheterocyclic Compounds Edited by M. Sainsbury. Elsevier, Amsterdam. 1997. xxvi + 704 pp. 15.5 × 23 cm. ISBN-0-444-827366. $457.00.
Arnold Martin
[Full Article -
PDF] |
2173-2174
| Second Supplements to the Second Edition of Rodd's Chemistry of Carbon Compounds. Volume IV: Heterocyclic Compounds. Parb B: Five-Membered Monoheterocyclic Compounds: Alkaloids, Dyes, Pigments Edited by M. Sainsbury. Elsevier, Amsterdam. 1997. xvi + 509 pp. 15.5 × 23 cm. ISBN-0-444-827587. $324.25.
Arnold Martin
[Full Article -
PDF] |
2174-2174
| Second Supplements to the Second Edition of Rodd's Chemistry of Carbon Compounds. Volume IV: Heterocyclic Compounds. Part E: Six-Membered Monoheterocyclic Compounds with a Hetero Atom from Groups IV, VI or VII of the Periodic Table Edited by M. Sainsbury. Elsevier, Amsterdam. 1997. xiv + 692 pp. 15.5 × 23 cm. ISBN-0-444-827536. $447.75.
Arnold Martin
[Full Article -
PDF] |