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COMMUNICATIONS TO THE EDITOR
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2663-2666
| D-Amino Acid Containing, High-Affinity Inhibitors of Recombinant Human Calpain I
Sankar Chatterjee,
Zi-Qiang Gu,
Derek Dunn,
Ming Tao,
Kurt Josef,
Rabindranath Tripathy,
Ron Bihovsky,
Shobha E. Senadhi,
Teresa M. O'Kane,
Beth Ann McKenna,
Satish Mallya,
Mark A. Ator,
Donna Bozyczko-Coyne,
Robert Siman, and
John P. Mallamo
[Full Article -
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2667-2670
| Enhancement of Oral Absorption in Selective 5-HT1D Receptor Agonists: Fluorinated 3-[3-(Piperidin-1-yl)propyl]indoles
José L. Castro,
Ian Collins,
Michael G. N. Russell,
Alan P. Watt,
Bindi Sohal,
Denise Rathbone,
Margaret S. Beer, and
Josephine A. Stanton
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PDF] |
2671-2675
| Novel and Specific Respiratory Syncytial Virus Inhibitors That Target Virus Fusion
Wei-dong Ding,
Boris Mitsner,
Girija Krishnamurthy,
Ann Aulabaugh,
Cynthia D. Hess,
Joe Zaccardi,
Mark Cutler,
Boris Feld,
Anna Gazumyan,
Yuri Raifeld,
Antonia Nikitenko,
Stanley A. Lang,
Yakov Gluzman,
Bryan O'Hara, and
George A. Ellestad
[Full Article -
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2676-2678
| Nucleosides and Nucleotides. 177. 9-(6,7-Dideoxy- -D-allo-hept-5- ynofuranosyl)adenine: A Selective and Potent Ligand for P3 Purinoceptor-like Protein
Akira Matsuda,
Haruyo Kosaki,
Yoshiko Saitoh,
Yuichi Yoshimura,
Noriaki Minakawa, and
Hiroyasu Nakata
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ARTICLES
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2679-2685
| Design, Synthesis, and Biological Activities of Potent and Selective Somatostatin Analogues Incorporating Novel Peptoid Residues
Thuy-Anh Tran,
Ralph-Heiko Mattern,
Michel Afargan,
Oved Amitay,
Ofer Ziv,
Barry A. Morgan,
John E. Taylor,
Daniel Hoyer, and
Murray Goodman
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2686-2692
| Conformational Analyses of Somatostatin-Related Cyclic Hexapeptides Containing Peptoid Residues
Ralph-Heiko Mattern,
Thuy-Anh Tran, and
Murray Goodman
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2693-2700
| Structure-Function Studies on Positions 17, 18, and 21 Replacement Analogues of Glucagon: The Importance of Charged Residues and Salt Bridges in Glucagon Biological Activity
Noel S. Sturm,
Ying Lin,
Stephen K. Burley,
John L. Krstenansky,
Jung-Mo Ahn,
Bassem Y. Azizeh,
Dev Trivedi, and
Victor J. Hruby
[Full Article -
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2701-2708
| Synthesis and in Vitro Efficacy of Transferrin Conjugates of the Anticancer Drug Chlorambucil
Ulrich Beyer,
Thomas Roth,
Peter Schumacher,
Gerhard Maier,
Anuschka Unold,
August W. Frahm,
Heinz H. Fiebig,
Clemens Unger, and
Felix Kratz
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2709-2719
| Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists
Hamideh Zarrinmayeh,
Anne M. Nunes,
Paul L. Ornstein,
Dennis M. Zimmerman,
M. Brian Arnold,
Douglas A. Schober,
Susan L. Gackenheimer,
Robert F. Bruns,
Philip A. Hipskind,
Thomas C. Britton,
Buddy E. Cantrell, and
Donald R. Gehlert
[Full Article -
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2720-2731
| Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro
Matthew A. Naylor,
Elizabeth Swann,
Steven A. Everett,
Mohammed Jaffar,
John Nolan,
Naomi Robertson,
Stacey D. Lockyer,
Kantilal B. Patel,
Madeleine F. Dennis,
Michael R. L. Stratford,
Peter Wardman,
Gerald E. Adams,
Christopher J. Moody, and
Ian J. Stratford
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2732-2744
| Selective Endothelin A Receptor Antagonists. 3. Discovery and Structure-Activity Relationships of a Series of 4-Phenoxybutanoic Acid Derivatives
Peter C. Astles,
Clive Brealey,
Thomas J. Brown,
Vincenzo Facchini,
Caroline Handscombe,
Neil V. Harris,
Clive McCarthy,
Iain M. McLay,
Barry Porter,
Alan G. Roach,
Carol Sargent,
Christopher Smith, and
Roger J. A. Walsh
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2745-2753
| Selective Endothelin A Receptor Antagonists. 4. Discovery and Structure-Activity Relationships of Stilbene Acid and Alcohol Derivatives
Peter C. Astles,
Thomas J. Brown,
Frank Halley,
Caroline M. Handscombe,
Neil V. Harris,
Clive McCarthy,
Iain M. McLay,
Peter Lockey,
Tahir Majid,
Barry Porter,
Alan G. Roach,
Christopher Smith, and
Roger Walsh
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2754-2764
| Antihyperglycemic Activities of Cryptolepine Analogues: An Ethnobotanical Lead Structure Isolated from Cryptolepis sanguinolenta
Donald E. Bierer,
Larisa G. Dubenko,
Pingsheng Zhang,
Qing Lu,
Patricia A. Imbach,
Albert W. Garofalo,
Puay-Wah Phuan,
Diana M. Fort,
Joane Litvak,
R. Eric Gerber,
Barbara Sloan,
Jian Luo,
Raymond Cooper, and
Gerald M. Reaven
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2765-2778
| Synthesis and Pharmacological Characterization of Novel 6-Fluorochroman Derivatives as Potential 5-HT1A Receptor Antagonists
Tomoyuki Yasunaga,
Takenori Kimura,
Ryo Naito,
Toru Kontani,
Fumikazu Wanibuchi,
Hiroshi Yamashita,
Tamako Nomura,
Shin-ichi Tsukamoto,
Tokio Yamaguchi, and
Toshiyasu Mase
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2779-2785
| Preparation, Resolution, and Biological Evaluation of 5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines: Potent, Orally Active, Nonsteroidal Progesterone Receptor Agonists
James P. Edwards,
Lin Zhi,
Charlotte L. F. Pooley,
Christopher M. Tegley,
Sarah J. West,
Ming-Wei Wang,
Marco M. Gottardis,
Charles Pathirana,
William T. Schrader, and
Todd K. Jones
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2786-2805
| Tripeptide Aldehyde Inhibitors of Human Rhinovirus 3C Protease: Design, Synthesis, Biological Evaluation, and Cocrystal Structure Solution of P1 Glutamine Isosteric Replacements
Stephen E. Webber,
Koji Okano,
Thomas L. Little,
Siegfried H. Reich,
Yue Xin,
Shella A. Fuhrman,
David A. Matthews,
Robert A. Love,
Thomas F. Hendrickson,
Amy K. Patick,
James W. Meador, III,
Rose Ann Ferre,
Edward L. Brown,
Clifford E. Ford,
Susan L. Binford, and
Stephen T. Worland
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2806-2818
| Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 1. Michael Acceptor Structure-Activity Studies
Peter S. Dragovich,
Stephen E. Webber,
Robert E. Babine,
Shella A. Fuhrman,
Amy K. Patick,
David A. Matthews,
Caroline A. Lee,
Siegfried H. Reich,
Thomas J. Prins,
Joseph T. Marakovits,
Ethel S. Littlefield,
Ru Zhou,
Jayashree Tikhe,
Clifford E. Ford,
Michael B. Wallace,
James W. Meador, III,
Rose Ann Ferre,
Edward L. Brown,
Susan L. Binford,
James E. V. Harr,
Dorothy M. DeLisle, and
Stephen T. Worland
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2819-2834
| Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 2. Peptide Structure-Activity Studies
Peter S. Dragovich,
Stephen E. Webber,
Robert E. Babine,
Shella A. Fuhrman,
Amy K. Patick,
David A. Matthews,
Siegfried H. Reich,
Joseph T. Marakovits,
Thomas J. Prins,
Ru Zhou,
Jayashree Tikhe,
Ethel S. Littlefield,
Ted M. Bleckman,
Michael B. Wallace,
Thomas L. Little,
Clifford E. Ford,
James W. Meador, III,
Rose Ann Ferre,
Edward L. Brown,
Susan L. Binford,
Dorothy M. DeLisle, and
Stephen T. Worland
[Full Article - PDF] |
2835-2845
| Derivatives of the Triazoloquinazoline Adenosine Antagonist (CGS 15943) Having High Potency at the Human A2B and A3 Receptor Subtypes
Yong-Chul Kim,
Maarten de Zwart,
Louis Chang,
Stefano Moro,
Jacobien K. von Frijtag Drabbe Künzel,
Neli Melman,
Ad P. IJzerman, and
Kenneth A. Jacobson
[Full Article - PDF] |
2846-2857
| Styrylquinoline Derivatives: A New Class of Potent HIV-1 Integrase Inhibitors That Block HIV-1 Replication in CEM Cells
Khalid Mekouar,
Jean-François Mouscadet,
Didier Desmaële,
Frédéric Subra,
Hervé Leh,
Delphine Savouré,
Christian Auclair, and
Jean d'Angelo
[Full Article - PDF] |
2858-2871
| N-Phenylamidines as Selective Inhibitors of Human Neuronal Nitric Oxide Synthase: Structure-Activity Studies and Demonstration of in Vivo Activity
Jon L. Collins,
Barry G. Shearer,
Jeffrey A. Oplinger,
Shuliang Lee,
Edward P. Garvey,
Mark Salter,
Claire Duffy,
Thimysta C. Burnette, and
Eric S. Furfine
[Full Article - PDF] |
2872-2881
| Synthesis, Opioid Receptor Binding, and Bioassay of Naltrindole Analogues Substituted in the Indolic Benzene Moiety
Subramaniam Ananthan,
Cheryl A. Johnson,
Ronald L. Carter,
Sarah D. Clayton,
Kenner C. Rice,
Heng Xu,
Peg Davis,
Frank Porreca, and
Richard B. Rothman
[Full Article - PDF] |
2882-2891
| -Lactam Derivatives as Inhibitors of Human Cytomegalovirus Protease
Christiane Yoakim,
William W. Ogilvie,
Dale R. Cameron,
Catherine Chabot,
Ingrid Guse,
Bruno Haché,
Julie Naud,
Jeff A. O'Meara,
Raymond Plante, and
Robert Déziel
[Full Article - PDF] |
2892-2902
| Nucleosides and Nucleotides. 175. Structural Requirements of the Sugar Moiety for the Antitumor Activities of New Nucleoside Antimetabolites, 1-(3-C-Ethynyl--D-ribo-pentofuranosyl)cytosine and -uracil
Hideshi Hattori,
Eisuke Nozawa,
Tomoharu Iino,
Yuichi Yoshimura,
Satoshi Shuto,
Yuji Shimamoto,
Makoto Nomura,
Masakazu Fukushima,
Motohiro Tanaka,
Takuma Sasaki, and
Akira Matsuda
[Full Article - PDF] |
2903-2909
| Prodrugs of Nitroxyl and Nitrosobenzene as Cascade Latentiated Inhibitors of Aldehyde Dehydrogenase
Terry T. Conway,
Eugene G. DeMaster,
Melinda J. C. Lee, and
Herbert T. Nagasawa
[Full Article - PDF] |
BOOK REVIEWS
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2910-2910
| Frontiers in Neurobiology 3. Amino Acid Neurotransmission Edited by F. Anne Stephenson and Anthony J. Turner. Portland Press, London. 1998. xiv + 247 pp. 16 × 23.5 cm. ISBN 1-85578-0801. $127.50.
S. J. Enna
[Full Article - PDF] |
2910-2910
| The P2 Nucleotide Receptors Edited by John T. Turner, Gary A. Weisman, and Jeffrey S. Fedan. Humana Press, Totowa, NJ. 1997. xi + 440 pp. 16 × 23.5 cm. ISBN 0-89603-425-9. $139.00.
Shripad S. Bhagwat
[Full Article - PDF] |