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PERSPECTIVE
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2911-2927
| G-Protein Coupled Receptors: Models, Mutagenesis, and Drug Design
Jack Andrew Bikker,
Susanne Trumpp-Kallmeyer, and
Christine Humblet
[Full Article -
PDF] |
COMMUNICATIONS TO THE EDITOR
|
2928-2931
| Discovery and Preclinical Pharmacology of a Novel, Potent, Nonsteroidal Estrogen Receptor Agonist/Antagonist, CP-336156, a Diaryltetrahydronaphthalene
Robert L. Rosati,
Paul Da Silva Jardine,
Kimberly O. Cameron,
David D. Thompson,
Hua Zhu Ke,
Steven M. Toler,
Thomas A. Brown,
Lydia C. Pan,
Charles F. Ebbinghaus,
Anthony R. Reinhold,
Nancy C. Elliott,
Bradley N. Newhouse,
Christina M. Tjoa,
Paul M. Sweetnam,
Mark J. Cole,
Mark W. Arriola,
Jeffrey W. Gauthier,
D. Todd Crawford,
David F. Nickerson,
Christine M. Pirie,
Hong Qi,
Hollis A. Simmons, and
George T. Tkalcevic
[Full Article -
PDF] |
2932-2933
| 3,6-Diamino-10-methylacridan: Uncharged Precursor of Acriflavine and Its Unique Antimicrobial Activity
Jan Adamus,
Jerzy G bicki,
Ireneusz Ciebiada,
Ewa Korczak, and
Andrzej Denys
[Full Article -
PDF] |
2934-2938
| Indole-2-carboxamide Inhibitors of Human Liver Glycogen Phosphorylase
Dennis J. Hoover,
Sheri Lefkowitz-Snow,
Jana L. Burgess-Henry,
William H. Martin,
Sandra J. Armento,
Ingrid A. Stock,
R. Kirk McPherson,
Paul E. Genereux,
E. Michael Gibbs, and
Judith L. Treadway
[Full Article -
PDF] |
EXPEDITED ARTICLES
|
2939-2945
| Substituted Salicylanilides as Inhibitors of Two-Component Regulatory Systems in Bacteria
Mark J. Macielag,
James P. Demers,
Stephanie A. Fraga-Spano,
Dennis J. Hlasta,
Sigmond G. Johnson,
Ramesh M. Kanojia,
Ronald K. Russell,
Zhihua Sui,
Michele A. Weidner-Wells,
Harvey Werblood,
Barbara D. Foleno,
Raul M. Goldschmidt,
Michael J. Loeloff,
Glenda C. Webb, and
John F. Barrett
[Full Article -
PDF] |
ARTICLES
|
2946-2959
| 4H-1,2,4-Pyridothiadiazine 1,1-Dioxides and 2,3-Dihydro-4H-1,2,4-pyridothiadiazine 1,1-Dioxides Chemically Related to Diazoxide and Cyclothiazide as Powerful Positive Allosteric Modulators of (R/S)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors: Design, Synthesis, Pharmacology, and Structure-Activity Relationships
Bernard Pirotte,
Tchao Podona,
Ousmane Diouf,
Pascal de Tullio,
Philippe Lebrun,
Léon Dupont,
Fabian Somers,
Jacques Delarge,
Philippe Morain,
Pierre Lestage,
Jean Lepagnol, and
Michael Spedding
[Full Article -
PDF] |
2960-2971
| Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 7. 8-Arylethyldipyridodiazepinones as Potent Broad-Spectrum Inhibitors of Wild-Type and Mutant Enzymes
Janice M. Klunder,
MaryAnn Hoermann,
Charles L. Cywin,
Eva David,
Janice R. Brickwood,
Racheline Schwartz,
Kevin J. Barringer,
Daniel Pauletti,
Cheng-Kon Shih,
David A. Erickson,
Christopher L. Sorge,
David P. Joseph,
Susan E. Hattox,
Julian Adams, and
Peter M. Grob
[Full Article -
PDF] |
2972-2984
| Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 8. 8-Aryloxymethyl- and 8-Arylthiomethyldipyridodiazepinones
Charles L. Cywin,
Janice M. Klunder,,2
MaryAnn Hoermann,
Janice R. Brickwood,
Eva David,,3
Peter M. Grob,
Racheline Schwartz,
Daniel Pauletti,
Kevin J. Barringer,
Cheng-Kon Shih,
Christopher L. Sorge,
David A. Erickson,
David P. Joseph, and
Susan E. Hattox
[Full Article -
PDF] |
2985-2993
| Synthesis and Pharmacological Activity of Triazolo[1,5-a]triazine Derivatives Inhibiting Eosinophilia
Fumihiko Akahoshi,
Shinji Takeda,
Takehiro Okada,
Masahiko Kajii,
Hiroko Nishimura,
Masanori Sugiura,
Yoshihisa Inoue,
Chikara Fukaya,
Youichiro Naito,
Takashi Imagawa, and
Norifumi Nakamura
[Full Article -
PDF] |
2994-3000
| Antiviral Activities of Methylated Nordihydroguaiaretic Acids. 1. Synthesis, Structure Identification, and Inhibition of Tat-Regulated HIV Transactivation
Jih Ru Hwu,
Wen Nan Tseng,
John Gnabre,
Paul Giza, and
Ru Chih C. Huang
[Full Article -
PDF] |
3001-3007
| Antiviral Activities of Methylated Nordihydroguaiaretic Acids. 2. Targeting Herpes Simplex Virus Replication by the Mutation Insensitive Transcription Inhibitor Tetra-O-methyl-NDGA
Hongshan Chen,
Li Teng,
Jian-Nong Li,
Richard Park,
David E. Mold,
John Gnabre,
Jih Ru Hwu,
Wen Nan Tseng, and
Ru Chih C. Huang
[Full Article -
PDF] |
3008-3014
| Noncalcemic, Antiproliferative, Transcriptionally Active, 24-Fluorinated Hybrid Analogues of the Hormone 1 ,25-Dihydroxyvitamin D3. Synthesis and Preliminary Biological Evaluation
Gary H. Posner,
Jae Kyoo Lee,
Qiang Wang,
Sara Peleg,
Martin Burke,
Henry Brem,
Patrick Dolan, and
Thomas W. Kensler
[Full Article -
PDF] |
3015-3021
| Benzoxazole Derivatives as Novel 5-HT3 Receptor Partial Agonists in the Gut
Yasuo Sato,
Megumi Yamada,
Satoshi Yoshida,
Tomoko Soneda,
Midori Ishikawa,
Tetsutaro Nizato,
Kokichi Suzuki, and
Fukio Konno
[Full Article - PDF] |
3022-3032
| Novel Combretastatin Analogues Effective against Murine Solid Tumors: Design and Structure-Activity Relationships
Koji Ohsumi,
Ryusuke Nakagawa,
Yumiko Fukuda,
Toshihiro Hatanaka,
Yoshihiro Morinaga,
Yukio Nihei,
Kazuo Ohishi,
Yasuyo Suga,
Yukio Akiyama, and
Takashi Tsuji
[Full Article - PDF] |
3033-3040
| A New Approach to the Design of Novel Inhibitors of Na+,K+-ATPase: 17-Substituted Seco-D 5 -Androstane as Cassaine Analogues
Sergio De Munari,
Paolo Barassi,
Alberto Cerri,
Giorgio Fedrizzi,
Mauro Gobbini,
Massimo Mabilia, and
Piero Melloni
[Full Article - PDF] |
3041-3047
| Bis-Substituted Malonic Acid Hydroxamate Derivatives as Inhibitors of Human Neutrophil Collagenase (MMP8)
Erich Graf von Roedern,
Hans Brandstetter,
Richard A. Engh,
Wolfram Bode,
Frank Grams, and
Luis Moroder
[Full Article - PDF] |
3048-3061
| Design, Synthesis, and Pharmacological Evaluation of Conformationally Constrained Analogues of N,N'-Diaryl- and N-Aryl-N-aralkylguanidines as Potent Inhibitors of Neuronal Na+ Channels
Michel C. Maillard,
Michael E. Perlman,
Oved Amitay,
Deborah Baxter,
David Berlove,
Sonia Connaughton,
James B. Fischer,
Jun Qing Guo,
Lain-Yen Hu,
Robert N. McBurney,
Peter I. Nagy,
Katragadda Subbarao,
Elizabeth A. Yost,
Lu Zhang, and
Graham J. Durant
[Full Article - PDF] |
3062-3077
| Synthesis and Structure-Activity Relationships of 2-Pyrazinylcarboxamido- benzoates and -Ionylideneacetamidobenzoates with Retinoidal Activity
Paul Jones,
Gérald B. Villeneuve,
Chengpei Fei,
Josie DeMarte,
Allison J. Haggarty,
Khin Than Nwe,
Deborah A. Martin,
Anne-Marie Lebuis,
Joshua M. Finkelstein,
Barbara J. Gour-Salin,
Tak Hang Chan, and
Brian R. Leyland-Jones
[Full Article - PDF] |
3078-3083
| Discovery of Type II (Covalent) Inactivation of S-Adenosyl-L-homocysteine Hydrolase Involving Its "Hydrolytic Activity": Synthesis and Evaluation of Dihalohomovinyl Nucleoside Analogues Derived from Adenosine
Stanislaw F. Wnuk,
Yue Mao,
Chong-Sheng Yuan,
Ronald T. Borchardt,
Graciela Andrei,
Jan Balzarini,
Erik De Clercq, and
Morris J. Robins
[Full Article - PDF] |
3084-3090
| Rational Design of Antitumor Prostaglandins with High Biological Stability
Masaaki Suzuki,
Toshihiro Kiho,
Keiichiro Tomokiyo,
Kyoji Furuta,
Shoji Fukushima,
Yoshikazu Takeuchi,
Makoto Nakanishi, and
Ryoji Noyori
[Full Article - PDF] |
3091-3098
| Synthesis of 7-Arylmorphinans. Probing the "Address" Requirements for Selectivity at Opioid  Receptors
Peng Gao,
Dennis L. Larson, and
Philip S. Portoghese
[Full Article - PDF] |
BOOK REVIEWS
|
3099-3099
| Principles of Process Research and Chemical Development in the Pharmaceutical Industry By Oljan Repic. John Wiley & Sons, New York. 1998. xvi + 213 pp. 16 × 24 cm. ISBN 0-471-16516-6. $74.95.
Pat N. Confalone
[Full Article - PDF] |
3099-3100
| Glycoanalysis Protocols Edited by Elizabeth F. Hounsell. Humana Press, Totowa, NJ. 1997. x + 262 pp. 15.5 × 23.5 cm. ISBN 0-896-0335-4. $64.50.
Robert J. Linhardt
[Full Article - PDF] |
3100-3100
| Pharmacology of Antimuscarinic Agents By Laszlo Gyermek. CRC Press, Boca Raton, FL. 1997. xx + 501 pp. 16 × 24 cm. ISBN 0-8493-8559-8. $129.95.
B. V. Rama Sastry
[Full Article - PDF] |
3100-3101
| Approaches to Design and Synthesis of Antiparasitic Drugs By Satyavan Sharma. Edited by Nitya Anand. Elsevier Science B.V., Amsterdam. 1997. xi + 511 pp. 17 × 25 cm. ISBN 0-444-89476-4. $265.75.
Jonathan L. Vennerstrom
[Full Article - PDF] |
ADDITIONS AND CORRECTIONS
|
3102-3102
| Synthesis and Anticonvulsant Activity of 2(3H)-Benzoxazolone and 2(3H)-Benzothiazolone Derivatives
Huseyin Ucar,
Kim Van derpoorten,
Silvia Cacciaguerra,
Santi Spampinato,
James P. Stables,
Paul Depovere,
Majed Isa,
Bernard Masereel,
Jacques Delarge, and
Jacques H. Poupaert
[Full Article - PDF] |
3102-3102
| New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 2. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents: Variations of the Dihydrobenzofuran Ring
John M. Janusz,
Patricia A. Young,
Michael W.
Scherz,
Kevin Enzweiler,
Laurence I. Wu,
Lixian Gan,
Stanislaw Pikul,
Kelly L. McDow-Dunham,
Carl R. Johnson,
C. B. Senanayake,
David E. Kellstein,
Shelley A. Green,
Jennifer L.
Tulich,
Theresa Rosario-Jansen,
I. Jack Magrisso,
Kenneth R. Wehmeyer,
Deborah L. Kuhlenbeck,
Thomas H. Eichhold, and
Roy L. M. Dobson
[Full Article - PDF] |