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PERSPECTIVE
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3103-3127
| Peptidomimetic Growth Hormone Secretagogues. Design Considerations and Therapeutic Potential
Ravi P. Nargund,
Arthur A. Patchett,
Mark A. Bach,
M. Gail Murphy, and
Roy G. Smith
[Full Article -
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ARTICLES
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3128-3141
| Studies on Quinazolines and 1,2,4-Benzothiadiazine 1,1-Dioxides. 8. Synthesis and Pharmacological Evaluation of Tricyclic Fused Quinazolines and 1,2,4-Benzothiadiazine 1,1-Dioxides as Potential  1-Adrenoceptor Antagonists
Ji-Wang Chern,
Pao-Luh Tao,
Kuang-Chao Wang,
Alexander Gutcait,
Shiou-Wen Liu,
Mao-Hsiung Yen,
Shu-Lan Chien, and
Jiann-Kuo Rong
[Full Article -
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3142-3158
| New Substituted 1,4-Benzoxazine Derivatives with Potential Intracellular Calcium Activity
Anne-Sophie Bourlot,
Isabel Sánchez,
Georges Dureng,
Gérald Guillaumet,
Roy Massingham,
André Monteil,
Eileen Winslow,
M. Dolors Pujol, and
Jean-Yves Mérour
[Full Article -
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3159-3173
| 2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N- methylamide (SDZ NKT 343), a Potent Human NK1 Tachykinin Receptor Antagonist with Good Oral Analgesic Activity in Chronic Pain Models
C. Walpole,
S. Y. Ko,
M. Brown,
D. Beattie,
E. Campbell,
F. Dickenson,
S. Ewan,
G. A. Hughes,
M. Lemaire,
J. Lerpiniere,
S. Patel, and
L. Urban
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3174-3185
| Synthesis and Biological Activity of a New Series of N6-Arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-Carboxamido Derivatives of Adenosine-5'-N-ethyluronamide as A1 and A3 Adenosine Receptor Agonists
Pier Giovanni Baraldi,
Barbara Cacciari,
Maria José Pineda de Las Infantas,
Romeo Romagnoli,
Giampiero Spalluto,
Rosaria Volpini,
Stefano Costanzi,
Sauro Vittori,
Gloria Cristalli,
Neli Melman,
Kyung-Sun Park,
Xiao-duo Ji, and
Kenneth A. Jacobson
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3186-3201
| Structure-Activity Relationships and Molecular Modeling of 3,5-Diacyl-2,4-dialkylpyridine Derivatives as Selective A3 Adenosine Receptor Antagonists
An-Hu Li,
Stefano Moro,
Neli Melman,
Xiao-duo Ji, and
Kenneth A. Jacobson
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3202-3209
| Salicylhydrazine-Containing Inhibitors of HIV-1 Integrase: Implication for a Selective Chelation in the Integrase Active Site
Nouri Neamati,
Huixiao Hong,
Joshua M. Owen,
Sanjay Sunder,
Heather E. Winslow,
John L. Christensen,
He Zhao,
Terrence R. Burke, Jr.,
George W. A. Milne, and
Yves Pommier
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3210-3219
| Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position
Thomas J. Tucker,
Stephen F. Brady,
William C. Lumma,
S. Dale Lewis,
Stephen J. Gardell,
Adel M. Naylor-Olsen,
Youwei Yan,
Jack T. Sisko,
Kenneth J. Stauffer,
Bobby J. Lucas,
Joseph J. Lynch,
Jacquelynn J. Cook,
Maria T. Stranieri,
Marie A. Holahan,
Elizabeth A. Lyle,
Elizabeth P. Baskin,
I-Wu Chen,
Kimberly B. Dancheck,
Julie A. Krueger,
Carolyn M. Cooper, and
Joseph P. Vacca
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3220-3231
| Synthesis and Pharmacological Characterization of O-Alkynyloximes of Tropinone and N-Methylpiperidinone as Muscarinic Agonists
Rong Xu,
Meng-Kwoon Sim, and
Mei-Lin Go
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3232-3238
| Synthesis and Comparison of the Antiinflammatory Activity of Manoalide and Cacospongionolide B Analogues
Margherita De Rosa,
Silvana Giordano,
Arrigo Scettri,
Guido Sodano,
Annunziata Soriente,
Pablo García Pastor,
Maria J. Alcaraz, and
Miguel Payá
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3239-3244
| Design, Synthesis, and Anticonvulsant Activity of 1-(Pyrid-3-ylsulfonamido)-2-nitroethylenes
Bernard Masereel,
Johan Wouters,
Lionel Pochet, and
Didier Lambert
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3245-3252
| Syntheses and Structure-Activity Relationships of Novel Retinoid X Receptor Agonists
Shigeki Hibi,
Kouichi Kikuchi,
Hiroyuki Yoshimura,
Mitsuo Nagai,
Kenji Tai, and
Takayuki Hida
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3253-3260
| 1,4- and 2,6-Disubstituted Amidoanthracene-9,10-dione Derivatives as Inhibitors of Human Telomerase
Philip J. Perry,
Sharon M. Gowan,
Anthony P. Reszka,
Paolo Polucci,
Terence C. Jenkins,
Lloyd R. Kelland, and
Stephen Neidle
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3261-3275
| Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 3. Discovery of a Potent, 2-Nonaryl, Highly Selective ETA Antagonist (A-216546)
Gang Liu,
Kenneth J. Henry, Jr.,
Bruce G. Szczepankiewicz,
Martin Winn,
Natasha S. Kozmina,
Steven A. Boyd,
James Wasicak,
Thomas W. von Geldern,
Jinshyun R. Wu-Wong,
William J. Chiou,
Douglas B. Dixon,
Bach Nguyen,
Kennan C. Marsh, and
Terry J. Opgenorth
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3276-3292
| 2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure-Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity
Sylvester R. Klutchko,
James M. Hamby,
Diane H. Boschelli,
Zhipei Wu,
Alan J. Kraker,
Aneesa M. Amar,
Brian G. Hartl,
Cynthia Shen,
Wayne D. Klohs,
Randall W. Steinkampf,
Denise L. Driscoll,
James M. Nelson,
William L. Elliott,
Billy J. Roberts,
Chad L. Stoner,
Patrick W. Vincent,
Donald J. Dykes,
Robert L. Panek,
Gina H. Lu,
Terry C. Major,
Tawny K. Dahring,
Hussein Hallak,
Laura A. Bradford,
H. D. Hollis Showalter, and
Annette M. Doherty
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NOTES
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3293-3297
| Tolerance in the Replacement of the Benzhydrylic O Atom in 4-[2-(Diphenylmethoxy)ethyl]-1-benzylpiperidine Derivatives by an N Atom: Development of New-Generation Potent and Selective N-Analogue Molecules for the Dopamine Transporter
Aloke K. Dutta,
Cen Xu, and
Maarten E. A. Reith
[Full Article - PDF] |
3298-3302
| Synthesis and Pharmacological Evaluation of N,N'-Diarylguanidines as Potent Sodium Channel Blockers and Anticonvulsant Agents
N. Laxma Reddy,
Wenhong Fan,
Sharad S. Magar,
Michael E. Perlman,
Elizabeth Yost,
Lu Zhang,
David Berlove,
James B. Fischer,
Kathy Burke-Howie,
Teresa Wolcott, and
Graham J. Durant
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