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COMMUNICATIONS TO THE EDITOR
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3303-3306
| 3-Deoxy-D-myo-inositol 1-Phosphate, 1-Phosphonate, and Ether Lipid Analogues as Inhibitors of Phosphatidylinositol-3-kinase Signaling and Cancer Cell Growth
Lixin Qiao,
Fajun Nan,
Mark Kunkel,
Alfred Gallegos,
Garth Powis, and
Alan P. Kozikowski
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ARTICLES
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3307-3313
| Anticonvulsant Activity and Interactions with Neuronal Voltage-Dependent Sodium Channel of Analogues of Ameltolide
Joseph Vamecq,
Didier Lambert,
Jacques H. Poupaert,
Bernard Masereel, and
James P. Stables
[Full Article -
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3314-3324
| Can We Learn To Distinguish between "Drug-like" and "Nondrug-like" Molecules?
Ajay,
W. Patrick Walters, and
Mark A. Murcko
[Full Article -
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3325-3329
| A Scoring Scheme for Discriminating between Drugs and Nondrugs
Jens Sadowski and
Hugo Kubinyi
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3330-3336
| Synthesis and Antiallergic Activity of Dimethyl-2-(phenylcarbamoyl)ethylsulfonium p-Toluenesulfonate Derivatives
Yukio Tada,
Ichiro Yamawaki,
Shuichi Ueda,
Hiroshi Matsumoto,
Naosuke Matsuura,
Mitsugi Yasumoto,
Akihide Koda, and
Mikio Hori
[Full Article -
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3337-3346
| Design and Synthesis of Brefeldin A Sulfide Derivatives as Prodrug Candidates with Enhanced Aqueous Solubilities
Ankush B. Argade,
Rajesh Devraj,
Jeffrey A. Vroman,
Rudiger D. Haugwitz,
Melinda Hollingshead, and
Mark Cushman
[Full Article -
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3347-3359
| Synthesis, Physicochemical Properties, and Evaluation of N-Substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones
Bijaya L. Rai,
Lotfollah S. Dekhordi,
Hicham Khodr,
Yi Jin,
Zudong Liu, and
Robert C. Hider
[Full Article -
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3360-3366
| Structure-Activity Study of the Nociceptin(1-13)-NH2 N-Terminal Tetrapeptide and Discovery of a Nociceptin Receptor Antagonist
Girolamo Calo',
Remo Guerrini,
Raffaella Bigoni,
Anna Rizzi,
Clementina Bianchi,
Domenico Regoli, and
Severo Salvadori
[Full Article -
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3367-3372
| 4-Benzylamino-1-chloro-6-substituted Phthalazines: Synthesis and Inhibitory Activity toward Phosphodiesterase 5
Nobuhisa Watanabe,
Yasuhiro Kabasawa,
Yasutaka Takase,
Masayuki Matsukura,
Kazuki Miyazaki,
Hiroki Ishihara,
Kohtarou Kodama, and
Hideyuki Adachi
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3373-3386
| Conformational Analysis of Ketolide, Conformations of RU 004 in Solution and Bound to Bacterial Ribosomes
Gildas Bertho,
Josyane Gharbi-Benarous,
Marcel Delaforge,
Catherine Lang,
Annick Parent, and
Jean-Pierre Girault
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3387-3401
| New Aza-Dipeptide Analogues as Potent and Orally Absorbed HIV-1 Protease Inhibitors: Candidates for Clinical Development
Guido Bold,
Alexander Fässler,
Hans-Georg Capraro,
Robert Cozens,
Thomas Klimkait,
Janis Lazdins,
Jürgen Mestan,
Bernard Poncioni,
Johannes Rösel,
David Stover,
Marina Tintelnot-Blomley,
Figan Acemoglu,
Werner Beck,
Eugen Boss,
Martin Eschbach,
Thomas Hürlimann,
Elvira Masso,
Serge Roussel,
Katharina Ucci-Stoll,
Dominique Wyss, and
Marc Lang
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3402-3408
| Synthesis of 9-Deoxo-4''-deoxy-6,9-epoxyerythromycin Derivatives: Novel and Acid-Stable Motilides
Ramin Faghih,
Paul A. Lartey,
Hugh N. Nellans,
Louis Seif,
Cynthia Burnell-Curty,
Larry L. Klein,
Paul Thomas,
Albert Petersen,
Anthony Borre,
Thomas Pagano,
Ki Hwan Kim,
Matthew Heindel,
Youssef L. Bennani, and
Jacob J. Plattner
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3409-3416
| 3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: A New Class of AMPA Receptor Antagonists
Alba Chimirri,
Giovambattista De Sarro,
Angela De Sarro,
Rosaria Gitto,
Silvana Quartarone,
Maria Zappalà,
Andrew Constanti, and
Vincenzo Libri
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3417-3425
| Small Molecular Probes for G-Protein-Coupled C5a Receptors: Conformationally Constrained Antagonists Derived from the C Terminus of the Human Plasma Protein C5a
Allan K. Wong,
Angela M. Finch,
Gregory K. Pierens,
David J. Craik,
Stephen M. Taylor, and
David P. Fairlie
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3426-3434
| Structure-Based Design and Synthesis of Lipophilic 2,4-Diamino-6-Substituted Quinazolines and Their Evaluation as Inhibitors of Dihydrofolate Reductases and Potential Antitumor Agents
Aleem Gangjee,
Anup P. Vidwans,
Anil Vasudevan,
Sherry F. Queener,
Roy L. Kisliuk,
Vivian Cody,
Ruming Li,
Nikolai Galitsky,
Joe R. Luft, and
Walter Pangborn
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3435-3441
| Synthesis and Evaluation of 2-Amino-9-(3-hydroxymethyl-4-alkoxycarbonyloxybut-1-yl)purines as Potential Prodrugs of Penciclovir
Dae-Kee Kim,
Namkyu Lee,
Young-Woo Kim,
Kieyoung Chang,
Jae-Sun Kim,
Guang-Jin Im,
Won-Son Choi,
Inho Jung,
Taek-Soo Kim,
Yong-Youn Hwang,
Dong-Sun Min,
Key An Um,
Yong-Baik Cho, and
Key H. Kim
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3442-3449
| Structure-Based Design and Synthesis of High Affinity Tripeptide Ligands of the Grb2-SH2 Domain
Pascal Furet,
Brigitte Gay,
Giorgio Caravatti,
Carlos García-Echeverría,
Joseph Rahuel,
Joseph Schoepfer, and
Heinz Fretz
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3450-3460
|  -Amino-thiols Inhibit the Zinc Metallopeptidase Activity of Tetanus Toxin Light Chain
Loïc Martin,
Fabrice Cornille,
Pascale Coric,
Bernard P. Roques, and
Marie-Claude Fournié-Zaluski
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3461-3466
| Discovery and Preliminary SAR Studies of a Novel, Nonsteroidal Progesterone Receptor Antagonist Pharmacophore
Charlotte L. F. Pooley,
James P. Edwards,
Mark E. Goldman,
Ming-Wei Wang,
Keith B. Marschke,
Diane L. Crombie, and
Todd K. Jones
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3467-3476
| Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class
Steve R. Turner,
Joseph W. Strohbach,
Ruben A. Tommasi,
Paul A. Aristoff,
Paul D. Johnson,
Harvey I. Skulnick,
Lester A. Dolak,
Eric P. Seest,
Paul K. Tomich,
Michael J. Bohanon,
Miao-Miao Horng,
Janet C. Lynn,
Kong-Teck Chong,
Roger R. Hinshaw,
Keith D. Watenpaugh,
Musiri N. Janakiraman, and
Suvit Thaisrivongs
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3477-3492
| Studies of Structure-Activity Relationship of Nitroxide Free Radicals and Their Precursors as Modifiers Against Oxidative Damage
Murali C. Krishna,
William DeGraff,
Olga H. Hankovszky,
Cecília P. Sár,
Tamás Kálai,
József Jeko,
Angelo Russo,
James B. Mitchell, and
Kálmán Hideg
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3493-3498
| 3-Alkyl Ethers of Clocinnamox: Delayed Long-Term  -Antagonists with Variable Efficacy
Stephen M. Husbands,
John Sadd,
Jillian H. Broadbear,
James H. Woods,
Jason Martin,
John R. Traynor,
Mario D. Aceto,
Edward R. Bowman,
Louis S. Harris, and
John W. Lewis
[Full Article - PDF] |
3499-3506
| Structure-Activity Relationships for a Series of Bis(phenylalkyl)amines: Potent Subtype-Selective Inhibitors of N-Methyl-D-aspartate Receptors
Amir P. Tamiz,
Edward R. Whittemore,
Zhang-Lin Zhou,
Jin-Cheng Huang,
John A. Drewe,
Jie-Cheng Chen,
Sui-Xiong Cai,
Eckard Weber,
Richard M. Woodward, and
John F. W. Keana
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3507-3514
| Synthesis and Biological Activity of Conformationally Restricted Analogues of Milnacipran: (1S,2R)-1-Phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide Is a Novel Class of NMDA Receptor Channel Blocker
Satoshi Shuto,
Shizuka Ono,
Hiroaki Imoto,
Kiyonori Yoshii, and
Akira Matsuda
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3515-3529
| New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 3. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents: Variations at the 5 Position
John M. Janusz,
Patricia A. Young,
James M. Ridgeway,
Michael W. Scherz,
Kevin Enzweiler,
Laurence I. Wu,
Lixian Gan,
Julian Chen,
David E. Kellstein,
Shelley A. Green,
Jennifer L. Tulich,
Theresa Rosario-Jansen,
I. Jack Magrisso,
Kenneth R. Wehmeyer,
Deborah L. Kuhlenbeck,
Thomas H. Eichhold, and
Roy L. M. Dobson
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3530-3538
| Pyrazole Bioisosteres of Leflunomide as B-Cell Immunosuppressants for Xenotransplantation and Chronic Rejection: Scope and Limitations
Christos Papageorgiou,
Rainer Albert,
Philipp Floersheim,
Michel Lemaire,
Francis Bitch,
Hans-Peter Weber,
Elsebeth Andersen,
Valerie Hungerford, and
Max H. Schreier
[Full Article - PDF] |
NOTES
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3539-3545
| Synthesis and Biological Activity of 4-Amino-7-oxo-Substituted Analogues of 5-Deaza-5,6,7,8-tetrahydrofolic Acid and 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid
José I. Borrell,
Jordi Teixidó,
Blanca Martínez-Teipel,
Josep Lluís Matallana,
M. Teresa Copete,
Ana Llimargas, and
Eva García
[Full Article - PDF] |
3546-3549
| Physical Parameters and Biological Stability of Yttrium(III) Diethylenetriaminepentaacetic Acid Derivative Conjugates
Thomas J. McMurry,
C. Greg Pippin,
Chuanchu Wu,
Kim A. Deal,
Martin W. Brechbiel,
Saed Mirzadeh, and
Otto A. Gansow
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BOOK REVIEWS
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3550-3550
| Methods in Molecular Biology, Volume 87. Combinatorial Peptide Library Protocols Edited by Shmuel Cabilly. Humana Press, Totowa, NJ. 1998. xiii + 313 pp. 15.5 × 23.5 cm. ISBN 0-89603-392-9. $74.50.
Bruce A. Beutel
[Full Article - PDF] |
3550-3550
| The P2 Nucleotide Receptors Edited by John T. Turner, Gary A. Weisman, and Jeffrey S. Fedan. Humana Press, Totowa, NJ. 1997. xi + 440 pp. 16 × 23.5 cm. ISBN 0-89603-425-9. $139.00.
Shripad S. Bhagwat
[Full Article - PDF] |