Journal of Medicinal Chemistry
Volume 41, Issue 20 (September 24, 1998)
Copyright © 1998 American Chemical Society

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COMMUNICATIONS TO THE EDITOR

3759-3762

Synthesis and Pharmacology of a New AMPA-Kainate Receptor Agonist with Potent Convulsant Activity Paola Conti, Marco De Amici, Giovambattista De Sarro, Tine Bryan Stensbl, Hans Bräuner-Osborne, Ulf Madsen, and Carlo De Micheli [Full Article - PDF]

ARTICLES

3763-3772

New Antipsychotic Agents with Serotonin and Dopamine Antagonist Properties Based on a Pyrrolo[2,1-b][1,3]benzothiazepine Structure Giuseppe Campiani, Vito Nacci, Susanna Bechelli, Silvia M. Ciani, Antonio Garofalo, Isabella Fiorini, Håkan Wikström, Peter de Boer, Yi Liao, Pieter G. Tepper, Alfredo Cagnotto, and Tiziana Mennini [Full Article - PDF]

3773-3781

Strategies To Target Kyotorphin Analogues to the Brain Pei Chen, Nicholas Bodor, Whei-Mei Wu, and Laszlo Prokai [Full Article - PDF]

3782-3792

Design and Synthesis of New Potent C2-Symmetric HIV-1 Protease Inhibitors. Use of L-Mannaric Acid as a Peptidomimetic Scaffold Mathias Alterman, Magnus Björsne, Anna Mühlman, Björn Classon, Ingemar Kvarnström, Helena Danielson, Per-Olof Markgren, Ulrika Nillroth, Torsten Unge, Anders Hallberg, and Bertil Samuelsson [Full Article - PDF]

3793-3803

Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV Richard A. Nugent, Stephen T. Schlachter, Michael J. Murphy, Gary J. Cleek, Toni J. Poel, Donn G. Wishka, David R. Graber, Yoshihiko Yagi, Barbara J. Keiser, Robert A. Olmsted, Laurie A. Kopta, Steven M. Swaney, Susan M. Poppe, Joel Morris, W. Gary Tarpley, and Richard C. Thomas [Full Article - PDF]

3804-3811

Design of Self-Coded Combinatorial Libraries To Facilitate Direct Analysis of Ligands by Mass Spectrometry Ian Hughes [Full Article - PDF]

3812-3820

Inhibition of Monoamine Oxidase-B by Condensed Pyridazines and Pyrimidines: Effects of Lipophilicity and Structure-Activity Relationships Cosimo Altomare, Saverio Cellamare, Luciana Summo, Marco Catto, and Angelo Carotti , Ulrike Thull, Pierre-Alain Carrupt, and Bernard Testa , Helen Stoeckli-Evans [Full Article - PDF]

3821-3830

N'-Phenylindol-3-ylglyoxylohydrazide Derivatives: Synthesis, Structure-Activity Relationships, Molecular Modeling Studies, and Pharmacological Action on Brain Benzodiazepine Receptors Antonio Da Settimo, Giampaolo Primofiore, Federico Da Settimo, Anna Maria Marini, Ettore Novellino, Giovanni Greco, Marco Gesi, Claudia Martini, Gino Giannaccini, and Antonio Lucacchini [Full Article - PDF]

3831-3844

Melatonin Receptor Ligands: Synthesis of New Melatonin Derivatives and Comprehensive Comparative Molecular Field Analysis (CoMFA) Study Marco Mor, Silvia Rivara, Claudia Silva, Fabrizio Bordi, and Pier Vincenzo Plazzi , Gilberto Spadoni, Giuseppe Diamantini, Cesarino Balsamini, and Giorgio Tarzia , Franco Fraschini, Valeria Lucini, Romolo Nonno, and Bojidar Michaylov Stankov [Full Article - PDF]

3845-3856

The Frontier Orbital Phase Angles: Novel QSAR Descriptors for Benzene Derivatives, Applied to Phenylalkylamine Hallucinogens Brian W. Clare [Full Article - PDF]

3857-3864

Inactivation of S-Adenosyl-L-homocysteine Hydrolase and Antiviral Activity with 5',5',6',6'-Tetradehydro-6'-deoxy-6'-halohomoadenosine Analogues (4'-Haloacetylene Analogues Derived from Adenosine) Morris J. Robins, Stanislaw F. Wnuk, Xiaoda Yang, Chong-Sheng Yuan, Ronald T. Borchardt, Jan Balzarini, and Erik De Clercq [Full Article - PDF]

3865-3871

Synthesis and Biological Activity of Certain 4'-Thio-D-arabinofuranosylpurine Nucleosides John A. Secrist III, Kamal N. Tiwari, Anita T. Shortnacy-Fowler, Lea Messini, James M. Riordan, and John A. Montgomery , Scott C. Meyers and Steven E. Ealick [Full Article - PDF]

3872-3878

Extended Aromatic Furan Amidino Derivatives as Anti-Pneumocystis carinii Agents Katherine T. Hopkins, W. David Wilson, Brendan C. Bender, Donald R. McCurdy, James Edwin Hall, Richard R. Tidwell, Arvind Kumar, Miro Bajic, and David W. Boykin [Full Article - PDF]

3879-3887

Selective Inhibitors of Human Lactate Dehydrogenases and Lactate Dehydrogenase from the Malarial Parasite Plasmodium falciparum Lorraine M. Deck, Robert E. Royer, Brian B. Chamblee, Valerie M. Hernandez, Richard R. Malone, Jose E. Torres, Lucy A. Hunsaker, Robert C. Piper, Michael T. Makler, and David L. Vander Jagt [Full Article - PDF]

3888-3900

Synthesis of Reagents for the Construction of Hypusine and Deoxyhypusine Peptides and Their Application as Peptidic Antigens Raymond J. Bergeron, William R. Weimar, Ralf Müller, Curt O. Zimmerman, Bruce H. McCosar, Hua Yao, and Richard E. Smith [Full Article - PDF]

3901-3908

Effect of Polyamine Analogues on Hypusine Content in JURKAT T-Cells Raymond J. Bergeron, William R. Weimar, Ralf Müller, Curt O. Zimmerman, Bruce H. McCosar, Hua Yao, and Richard E. Smith [Full Article - PDF]

NOTES

3909-3911

Naamidine A Is an Antagonist of the Epidermal Growth Factor Receptor and an in Vivo Active Antitumor Agent Brent R. Copp, Craig R. Fairchild, Laurie Cornell, Ana Maria Casazza, Simon Robinson, and Chris M. Ireland [Full Article - PDF]

3912-3916

Novel Peptidyl Phosphorus Derivatives as Inhibitors of Human Calpain I Ming Tao, Ron Bihovsky, Gregory J. Wells, and John P. Mallamo [Full Article - PDF]

BOOK REVIEWS

3917-3917

Phytochemical Diversity: A Source of New Industrial Products Edited by Stephen Wrigley, Martin Hayes, Robert Thomas, and Ewan Chrystal. The Royal Society of Chemistry, Cambridge, U.K. 1997. xi + 254 pp. 16 × 24 cm. ISBN 0-85404-717-4. $135.00. Lester A. Mitscher [Full Article - PDF]

3917-3918

Serotonin Receptors and Their Ligands Edited by B. Olivier, I. Van Wijngaarden, and W. Soudin. Elsevier, Amsterdam. 1997. × + 367 pp. 17 × 24.5 cm. ISBN 0-444-82041-8. $297.00. Richard A. Glennon [Full Article - PDF]