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COMMUNICATIONS TO THE EDITOR
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4429-4432
| TROTEC-1: A New High-Affinity Ligand for Labeling of the Dopamine Transporter
Alexander Hoepping,
Martina Reisgys,
Peter Brust,
Sepp Seifert,
Hartmut Spies,
Roger Alberto, and
Bernd Johannsen
[Full Article -
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ARTICLES
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4433-4438
| Structure-Activity Relationships of a Series of Analogues of the Octadecaneuropeptide ODN on Calcium Mobilization in Rat Astrocytes
Jérôme Leprince,
Pierrick Gandolfo,
Jean-Louis Thoumas,
Christine Patte,
Jean-Luc Fauchère,
Hubert Vaudry, and
Marie-Christine Tonon
[Full Article -
PDF] |
4439-4452
| Highly Potent Bisphosphonate Ligands for Phosphoglycerate Kinase
David L. Jakeman,
Andrew J. Ivory,
Michael P. Williamson, and
G. Michael Blackburn
[Full Article -
PDF] |
4453-4465
| Pharmacophoric Search and 3D-QSAR Comparative Molecular Field Analysis Studies on Agonists of Melatonin Sheep Receptors
Christophe Marot,
Philippe Chavatte,
Luc Morin-Allory,
Marie Claude Viaud,
Gérald Guillaumet,
Pierre Renard,
Daniel Lesieur, and
André Michel
[Full Article -
PDF] |
4466-4474
| Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates
Philip E. J. Sanderson,
Terry A. Lyle,
Kellie J. Cutrona,
Dona L. Dyer,
Bruce D. Dorsey,
Colleen M. McDonough,
Adel M. Naylor-Olsen,
I-Wu Chen,
Zhongguo Chen,
Jacquelynn J. Cook,
Carolyn M. Cooper,
Stephen J. Gardell,
Timothy R. Hare,
Julie A. Krueger,
S. Dale Lewis,
Jiunn H. Lin,
Bobby J. Lucas, Jr.,
Elizabeth A. Lyle,
Joseph J. Lynch, Jr.,
Maria T. Stranieri,
Kari Vastag,
Youwei Yan,
Jules A. Shafer, and
Joseph P. Vacca
[Full Article -
PDF] |
4475-4485
| Synthesis and Antitumor Activity of New Glycosides of Epipodophyllotoxin, Analogues of Etoposide, and NK 611
Laurent Daley,
Yves Guminski,
Pierre Demerseman,
Anna Kruczynski,
Chantal Etiévant,
Thierry Imbert,
Bridget T. Hill, and
Claude Monneret
[Full Article -
PDF] |
4486-4491
| Modified Ibogaine Fragments: Synthesis and Preliminary Pharmacological Characterization of 3-Ethyl-5-phenyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]benzothiophenes
Simon M. N. Efange,
Deborah C. Mash,
Anil B. Khare, and
Quinjie Ouyang
[Full Article -
PDF] |
4492-4501
| Clavaric Acid and Steroidal Analogues as Ras- and FPP-Directed Inhibitors of Human Farnesyl-Protein Transferase
Russell B. Lingham,
Keith C. Silverman,
Hiranthi Jayasuriya,
B. Moon Kim,
Suzanne E. Amo,
Francine R. Wilson,
Deborah J. Rew,
Michael D. Schaber,
James D. Bergstrom,
Kenneth S. Koblan,
Samuel L. Graham,
Nancy E. Kohl,
Jackson B. Gibbs, and
Sheo B. Singh
[Full Article -
PDF] |
4502-4520
| FLEXS: A Method for Fast Flexible Ligand Superposition
Christian Lemmen,
Thomas Lengauer, and
Gerhard Klebe
[Full Article -
PDF] |
4521-4532
| Three-Dimensional Quantitative Structure-Activity Relationship Study of the Cannabimimetic (Aminoalkyl)indoles Using Comparative Molecular Field Analysis
Joong-Youn Shim,
Elizabeth R. Collantes, and
William J. Welsh
, Babu Subramaniam and
Allyn C. Howlett
, Michael A. Eissenstat and
Susan J. Ward
[Full Article -
PDF] |
4533-4541
| 6-Substituted 2,4-Diaminopyrido[3,2-d]pyrimidine Analogues of Piritrexim as Inhibitors of Dihydrofolate Reductase from Rat Liver, Pneumocystis carinii, and Toxoplasma gondii and as Antitumor Agents
Aleem Gangjee,
Yuanming Zhu, and
Sherry F. Queener
[Full Article -
PDF] |
4542-4549
| Alkoxypsoralens, Novel Nonpeptide Blockers of Shaker-Type K+ Channels: Synthesis and Photoreactivity
Heike Wulff,
Heiko Rauer,
Tim Düring,
Christine Hanselmann,
Katharina Ruff,
Anja Wrisch,
Stephan Grissmer, and
Wolfram Hänsel
[Full Article -
PDF] |
4550-4555
| Synthesis and Enzymic Evaluation of 4-Mercapto-6-oxo-1,4-azaphosphinane-2-carboxylic Acid 4-Oxide as an Inhibitor of Mammalian Dihydroorotase
Michael K. Manthey,
Danny T. C. Huang,
William A. Bubb, and
Richard I. Christopherson
[Full Article - PDF] |
4556-4566
| Substituted Tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and Tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones as Hypoglycemic Agents
Thomas D. Aicher,
Bork Balkan,
Philip A. Bell,
Leonard J. Brand,
S. H. Cheon,
Rhonda O. Deems,
Jay B. Fell,
William S. Fillers,
James D. Fraser,
Jiaping Gao,
Douglas C. Knorr,
Gerald G. Kahle,
Christina L. Leone,
Jeffrey Nadelson,
Ronald Simpson, and
Howard C. Smith
[Full Article -
PDF] |
4567-4576
| Use of Papain as a Model for the Structure-Based Design of Cathepsin K Inhibitors: Crystal Structures of Two Papain-Inhibitor Complexes Demonstrate Binding to S'-Subsites
Judith M. LaLonde,
Baoguang Zhao,
Ward W. Smith,
Cheryl A. Janson,
Renee L. DesJarlais,
Thaddeus A. Tomaszek,
Thomas J. Carr,
Scott K. Thompson,
Hye-Ja Oh,
Dennis S. Yamashita,
Daniel F. Veber, and
Sherin S. Abdel-Meguid
[Full Article - PDF] |
4577-4586
| Structure-Based Enhancement of Boronic Acid-Based Inhibitors of AmpC  -Lactamase
G. Scott Weston,
Jesús Blázquez,
Fernando Baquero, and
Brian K. Shoichet
[Full Article - PDF] |
4587-4598
| A Novel Class of Orally Active Non-Peptide Bradykinin B2 Receptor Antagonists. 4. Discovery of Novel Frameworks Mimicking the Active Conformation
Yoshito Abe,
Hiroshi Kayakiri,
Shigeki Satoh,
Takayuki Inoue,
Yuki Sawada,
Noriaki Inamura,
Masayuki Asano,
Ichiro Aramori,
Chie Hatori,
Hiroe Sawai,
Teruo Oku, and
Hirokazu Tanaka
[Full Article - PDF] |
4599-4606
| Novel Disaccharide Inhibitors of Human Glioma Cell Division
Begoña Aguilera,
Lorenzo Romero-Ramírez,
José Abad-Rodríguez,
Guillermo Corrales,
Manuel Nieto-Sampedro, and
Alfonso Fernández-Mayoralas
[Full Article - PDF] |
4607-4614
| Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist
Jeffrey J. Hale,
Sander G. Mills,
Malcolm MacCoss,
Paul E. Finke,
Margaret A. Cascieri,
Sharon Sadowski,
Elzbieta Ber,
Gary G. Chicchi,
Marc Kurtz,
Joseph Metzger,
George Eiermann,
Nancy N. Tsou,
F. David Tattersall,
Nadia M. J. Rupniak,
Angela R. Williams,
Wayne Rycroft,
Richard Hargreaves, and
D. Euan MacIntyre
[Full Article - PDF] |
4615-4622
| 2-Fluoro-4-pyridinylmethyl Analogues of Linopirdine as Orally Active Acetylcholine Release-Enhancing Agents with Good Efficacy and Duration of Action
Richard A. Earl,
Robert Zaczek,
Christopher A. Teleha,
Barbara N. Fisher,
Carla M. Maciag,
Maria E. Marynowski,
Andrew R. Logue,
S. William Tam,
William J. Tinker,
Shiew-Mei Huang, and
Robert J. Chorvat
[Full Article - PDF] |
4623-4635
| 4,4-Disubstituted Piperidine High-Affinity NK1 Antagonists: Structure-Activity Relationships and in Vivo Activity
Graeme I. Stevenson,
Ian Huscroft,
Angus M. MacLeod,
Christopher J. Swain,
Margaret A. Cascieri,
Gary G. Chicchi,
Michael I. Graham,
Timothy Harrison,
Fintan J. Kelleher,
Marc Kurtz,
Tamara Ladduwahetty,
Kevin J. Merchant,
Joseph M. Metzger,
D. E. MacIntyre,
Sharon Sadowski,
Balbinder Sohal, and
Andrew P. Owens
[Full Article - PDF] |
4636-4647
| Abasic Analogues of TSAO-T as the First Sugar Derivatives That Specifically Inhibit HIV-1 Reverse Transcriptase
Sonsoles Velázquez,
Cristina Chamorro,
María-Jesús Pérez-Pérez,
Rosa Alvarez,
María-Luisa Jimeno,
Angel Martín-Domenech,
Carlos Pérez,
Federico Gago,
Erik De Clercq,
Jan Balzarini,
Ana San-Félix, and
María-José Camarasa
[Full Article - PDF] |
4648-4657
| Anti-AIDS Agents. 34. Synthesis and Structure-Activity Relationships of Betulin Derivatives as Anti-HIV Agents
I-Chen Sun,
Hui-Kang Wang,
Yoshiki Kashiwada,
Jing-Kang Shen,
L. Mark Cosentino,
Chin-Ho Chen,
Li-Ming Yang, and
Kuo-Hsiung Lee
[Full Article - PDF] |
4658-4661
| Synthesis and Cytotoxicity of 2-Acetyl-4,8-dihydrobenzodithiophene-4,8-dione Derivatives
Yu-Hua Chao,
Sheng-Chu Kuo,
Chun-Hsiung Wu,
Chun-Yann Lee,
Anthony Mauger,
I-Chen Sun,
Susan L. Morris-Natschke, and
Kuo-Hsiung Lee
[Full Article - PDF] |
4662-4674
| New 1 ,25-Dihydroxy-19-norvitamin D3 Compounds of High Biological Activity: Synthesis and Biological Evaluation of 2-Hydroxymethyl, 2-Methyl, and 2-Methylene Analogues
Rafal R. Sicinski,
Jean M. Prahl,
Connie M. Smith, and
Hector F. DeLuca
[Full Article - PDF] |
BOOK REVIEWS
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4675-4675
| Computer Modeling of Chemical Reactions in Enzymes and Solutions By Arieh Warshel. John Wiley & Sons, Inc., New York, NY. 1997. xiv + 236 pp. 15.5 × 23.5 cm. ISBN 0-471-18440-3. $49.95.
Emile M. Bellott
[Full Article - PDF] |
4675-4676
| The Merck Index. Twelfth Edition on CD-ROM and User Guide By Janet E. Ash. Chapman-Hall, London, 1996. ISBN 0-412-75650-1. $299.95.
Emile M. Bellott
[Full Article - PDF] |