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COMMUNICATIONS TO THE EDITOR
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4677-4680
| Novel CDC25A Phosphatase Inhibitors from Pyrolysis of 3- -Azido-B-homo-6-oxa-4-cholesten-7-one on Silica Gel
Hairuo Peng and
Leon H. Zalkow
, Robert T. Abraham
, Garth Powis
[Full Article -
PDF] |
EXPEDITED ARTICLES
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4681-4685
| Syntheses of New Isodethiaazacephems as Potent Antibacterial Agents
Jih Ru Hwu,
Shwu-Chen Tsay, and
Shahram Hakimelahi
[Full Article -
PDF] |
ARTICLES
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4686-4692
| Synthesis and Evaluation of 11 -Substituted 21-Chloro/Iodo-(17,20E/Z)-19-norpregna-1,3,5(10),20-tetraene-3,17-diols: High-Affinity Ligands for the Estrogen Receptor
Robert N. Hanson,
Elio Napolitano, and
Rita Fiaschi
[Full Article -
PDF] |
4693-4705
| Nonpeptide Somatostatin Agonists with sst4 Selectivity: Synthesis and Structure-Activity Relationships of Thioureas
Shenquan Liu,
Cheng Tang,
Bin Ho,
Michael Ankersen,
Carsten E. Stidsen, and
A. Michael Crider
[Full Article -
PDF] |
4706-4715
| Synthesis, Activity, and Molecular Modeling of New 2,4-Dioxo-5-(naphthylmethylene)-3-thiazolidineacetic Acids and 2-Thioxo Analogues as Potent Aldose Reductase Inhibitors
Patrick Fresneau,
Max Cussac,
Jean-Marc Morand,
Barbara Szymonski,
Duc Tranqui, and
Gérard Leclerc
[Full Article -
PDF] |
4716-4722
| Synthesis and Cytotoxicity of 2-Methyl-4,9-dihydro-1-substituted-1H-imidazo[4,5-g]quinoxaline-4,9-diones and 2,3-Disubstituted-5,10-pyrazino[2,3-g]quinoxalinediones
Hee-Won Yoo,
Myung-Eun Suh, and
Sang Woo Park
[Full Article -
PDF] |
4723-4732
| Conformationally Restricted Analogues of 1N,12N-Bisethylspermine: Synthesis and Growth Inhibitory Effects on Human Tumor Cell Lines
Venodhar K. Reddy,
Aldonia Valasinas,
Aparajita Sarkar,
Hirak S. Basu,
Laurence J. Marton, and
Benjamin Frydman
[Full Article -
PDF] |
4733-4743
| Synthesis of 7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and Novel Derivatives Free of Positional Isomers. Potent Inhibitors of cAMP-Specific Phosphodiesterase and of Malignant Tumor Cell Growth
Karl-Heinz Merz,
Doris Marko,
Thomas Regiert,
Guido Reiss,
Walter Frank, and
Gerhard Eisenbrand
[Full Article -
PDF] |
4744-4754
| DNA-Directed Alkylating Agents. 7. Synthesis, DNA Interaction, and Antitumor Activity of Bis(hydroxymethyl)- and Bis(carbamate)-Substituted Pyrrolizines and Imidazoles
Graham J. Atwell,
Jun-Yao Fan,
Karin Tan, and
William A. Denny
[Full Article -
PDF] |
4755-4766
| Indolequinone Antitumor Agents: Correlation between Quinone Structure, Rate of Metabolism by Recombinant Human NAD(P)H:Quinone Oxidoreductase, and in Vitro Cytotoxicity
Howard D. Beall,
Shannon Winski,
Elizabeth Swann,
Anna R. Hudnott,
Ann S. Cotterill,
Noeleen O'Sullivan,
Stephen J. Green,
Richard Bien,
David Siegel,
David Ross, and
Christopher J. Moody
[Full Article -
PDF] |
4767-4776
| De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the  -Opioid Receptor
Subo Liao,
Josue Alfaro-Lopez,
Mark D. Shenderovich,
Keiko Hosohata,
Jun Lin,
Xiaoping Li,
Dagmar Stropova,
Peg Davis,
Kevin A. Jernigan,
Frank Porreca,
Henry I. Yamamura, and
Victor J. Hruby
[Full Article -
PDF] |
4777-4789
| Conformational Analysis and Automated Receptor Docking of Selective Arylacetamide-Based  -Opioid Agonists
Govindan Subramanian,
M. Germana Paterlini,
Dennis L. Larson,
Philip S. Portoghese, and
David M. Ferguson
[Full Article -
PDF] |
4790-4799
| Selective Tight Binding Inhibitors of Trypanosomal Glyceraldehyde-3-phosphate Dehydrogenase via Structure-Based Drug Design
Alex M. Aronov,
Christophe L. M. J. Verlinde,
Wim G. J. Hol, and
Michael H. Gelb
[Full Article -
PDF] |
4800-4818
| Covalent Modification of Cyclooxygenase-2 (COX-2) by 2-Acetoxyphenyl Alkyl Sulfides, a New Class of Selective COX-2 Inactivators
Amit S. Kalgutkar,
Kevin R. Kozak,
Brenda C. Crews,
G. Phillip Hochgesang, Jr., and
Lawrence J. Marnett
[Full Article -
PDF] |
4819-4832
| Antileishmanial Chalcones: Statistical Design, Synthesis, and Three-Dimensional Quantitative Structure-Activity Relationship Analysis
Simon Feldbæk Nielsen,
S ren Brgger Christensen,
Gabriele Cruciani,
Arsalan Kharazmi, and
Tommy Liljefors
[Full Article -
PDF] |
4833-4843
| Design and Synthesis of Hydrazinopeptides and Their Evaluation as Human Leukocyte Elastase Inhibitors
Laure Guy,
Joëlle Vidal, and
André Collet
, Augustin Amour and
Michèle Reboud-Ravaux
[Full Article -
PDF] |
4844-4853
| Design, Synthesis, and Biological Activity of Prazosin-Related Antagonists. Role of the Piperazine and Furan Units of Prazosin on the Selectivity for 1-Adrenoreceptor Subtypes
Maria L. Bolognesi,
Roberta Budriesi,
Alberto Chiarini,
Elena Poggesi,
Amedeo Leonardi, and
Carlo Melchiorre
[Full Article -
PDF] |
4854-4860
| 1,2-Benzisothiazol-3-one 1,1-Dioxide Inhibitors of Human Mast Cell Tryptase
Keith D. Combrink,
H. Belgin Gülgeze,
Nicholas A. Meanwell,
Bradley C. Pearce,
Pi Zulan,
Gregory S. Bisacchi,
Daniel G. M. Roberts,
Paul Stanley, and
Steven M. Seiler
[Full Article -
PDF] |
4861-4872
| Exploration of Biologically Relevant Conformations of Anandamide, 2-Arachidonylglycerol, and Their Analogues Using Conformational Memories
Judy Barnett-Norris,
Frank Guarnieri,
Dow P. Hurst, and
Patricia H. Reggio
[Full Article -
PDF] |
4873-4884
| Human Telomerase Inhibition by Regioisomeric Disubstituted Amidoanthracene-9,10-diones
Philip J. Perry,
Anthony P. Reszka,
Alexis A. Wood,
Martin A. Read,
Sharon M. Gowan,
Harvinder S. Dosanjh,
John O. Trent,
Terence C. Jenkins,
Lloyd R. Kelland, and
Stephen Neidle
[Full Article - PDF] |
4885-4889
| Synthesis and Biological Evaluation of 4-Chloro-3,5-dinitrobenzotrifluoride Analogues as Antileishmanial Agents
Kevin K. Pitzer,
Karl A. Werbovetz,
James J. Brendle, and
John P. Scovill
[Full Article - PDF] |
4890-4902
| (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336): A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor Agent
F. George Njoroge,
Arthur G. Taveras,
Joseph Kelly,
Stacy Remiszewski,
Alan K. Mallams,
Ronald Wolin,
Adriano Afonso,
Alan B. Cooper,
Dinananth F. Rane,
Yi-Tsung Liu,
Jesse Wong,
Bancha Vibulbhan,
Patrick Pinto,
Jeffrey Deskus,
Carmen S. Alvarez,
Joycelyn del Rosario,
Michael Connolly,
James Wang,
Jagdish Desai,
Randall R. Rossman,
W. Robert Bishop,
Robert Patton,
Lynn Wang,
Paul Kirschmeier,
Mathew S. Bryant,
Amin A. Nomeir,
C.-C. Lin,
Ming Liu,
Andrew T. McPhail,
Ronald J. Doll,
Viyyoor M. Girijavallabhan, and
Ashit K. Ganguly
[Full Article - PDF] |
NOTES
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4903-4909
| N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: A Potent and Selective Dopamine D4 Ligand
Roberto Perrone,
Francesco Berardi,
Nicola A. Colabufo,
Marcello Leopoldo, and
Vincenzo Tortorella
[Full Article - PDF] |
ADDITIONS AND CORRECTIONS
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4910-4910
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Cecil Chan,
Hong Yin,
Jacqui Garforth,
James H. McKie,
Rabih Jaouhari,
Peter Speers,
Kenneth T. Douglas,
Peter J. Rock,
Vanessa
Yardley,
Simon L. Croft, and
Alan H. Fairlamb
Phenothiazine Inhibitors of Trypanothione Reductase
as Potential Antitrypanosomal and Antileishmanial
Drugs
[Full Article - PDF] |