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PERSPECTIVE
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5119-5143
| Immunophilins: Beyond Immunosuppression
G. S. Hamilton and
J. P. Steiner
[Full Article -
PDF] |
COMMUNICATIONS TO THE EDITOR
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5144-5147
| Nitrogen-Carbon-Linked (Azolylphenyl)oxazolidinones with Potent Antibacterial Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis
Michael J. Genin,
Douglas K. Hutchinson,
Debra A. Allwine,
Jackson B. Hester,
D. Edward Emmert,
Stuart A. Garmon,
Charles W. Ford,
Gary E. Zurenko,
Judith C. Hamel,
Ronda D. Schaadt,
Douglas Stapert,
Betty H. Yagi,
Janice M. Friis,
Eric M. Shobe, and
Wade J. Adams
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5148-5149
| A Novel (Benzodifuranyl)aminoalkane with Extremely Potent Activity at the 5-HT2A Receptor
Matthew A. Parker,
Danuta Marona-Lewicka,
Virginia L. Lucaites,
David L. Nelson, and
David E. Nichols
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EXPEDITED ARTICLES
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5150-5157
| Discovery and Structure-Activity Relationship of the First Non-Peptide Competitive Human Glucagon Receptor Antagonists
Peter Madsen,
Lotte B. Knudsen,
Finn C. Wiberg, and
Richard D. Carr
[Full Article -
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ARTICLES
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5158-5166
| Enantiospecific Semisynthesis of (+)-Almuheptolide-A, a Novel Natural Heptolide Inhibitor of the Mammalian Mitochondrial Respiratory Chain
Almudena Bermejo,
José R. Tormo,
Nuria Cabedo,
Ernesto Estornell,
Bruno Figadère, and
Diego Cortes
[Full Article -
PDF] |
5167-5176
| Side Chain Methyl Substitution in the  -Opioid Receptor Antagonist TIPP Has an Important Effect on the Activity Profile
Dirk Tourwé,
Els Mannekens,
Trang Nguyen Thi Diem,
Patricia Verheyden,
Hendrika Jaspers,
Géza Tóth,
Antal Péter,
István Kertész,
Gabriella Török,
Nga N. Chung, and
Peter W. Schiller
[Full Article -
PDF] |
5177-5187
| The Bioactive Conformation of Aminoalkylindoles at the Cannabinoid CB1 and CB2 Receptors: Insights Gained from (E)- and (Z)-Naphthylidene Indenes
Patricia H. Reggio,
Sharmista Basu-Dutt,
Judy Barnett-Norris,
Marie T. Castro,
Dow P. Hurst,
Herbert H. Seltzman,
Michael J. Roche,
Anne F. Gilliam,
Brian F. Thomas,
L. A. Stevenson,
Roger G. Pertwee, and
Mary E. Abood
[Full Article -
PDF] |
5188-5197
| Identification of an Opioid  Receptor Subtype-Selective N-Substituent for (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl)piperidine
James B. Thomas,
Michael J. Fall,
Julie B. Cooper,
Richard B. Rothman,
S. Wayne Mascarella,
Heng Xu,
John S. Partilla,
Christina M. Dersch,
Karen B. McCullough,
Buddy E. Cantrell,
Dennis M. Zimmerman, and
F. Ivy Carroll
[Full Article -
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5198-5218
| Biphenylsulfonamide Endothelin Antagonists: Structure-Activity Relationships of a Series of Mono- and Disubstituted Analogues and Pharmacology of the Orally Active Endothelin Antagonist 2'-Amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1,1'-biphenyl]-2-sulfonamide (BMS-187308)
Natesan Murugesan,
Zhengxiang Gu,
Philip D. Stein,
Sharon Bisaha,
Steve Spergel,
Ravi Girotra,
Ving G. Lee,
John Lloyd,
Raj N. Misra,
Joan Schmidt,
Arvind Mathur,
Leslie Stratton,
Yolanda F. Kelly,
Eileen Bird,
Tom Waldron,
Eddie C.-K. Liu,
Rongan Zhang,
Helen Lee,
Randy Serafino,
Benoni Abboa-Offei,
Parker Mathers,
Mary Giancarli,
Andrea Ann Seymour,
Maria L. Webb,
Suzanne Moreland,
Joel C. Barrish, and
John T. Hunt
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5219-5246
| Repaglinide and Related Hypoglycemic Benzoic Acid Derivatives
Wolfgang Grell,
Rudolf Hurnaus,
Gerhart Griss,
Robert Sauter,
Eckhard Rupprecht,
Michael Mark,
Peter Luger,
Herbert Nar,
Helmut Wittneben, and
Peter Müller
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5247-5256
| Resistance-Modifying Agents. 5. Synthesis and Biological Properties of Quinazolinone Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase (PARP)
Roger J. Griffin,
Sheila Srinivasan,
Karen Bowman,
A. Hilary Calvert,
Nicola J. Curtin,
David R. Newell,
Louise C. Pemberton, and
Bernard T. Golding
[Full Article -
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5257-5264
| (R)-(-)- and (S)-(+)-Synadenol: Synthesis, Absolute Configuration, and Enantioselectivity of Antiviral Effect
Yao-Ling Qiu,
Andrew Hempel,
Norman Camerman,
Arthur Camerman,
Fiona Geiser,
Roger G. Ptak,
Julie M. Breitenbach,
Toshiko Kira,
Ling Li,
Elizabeth Gullen,
Yung-Chi Cheng,
John C. Drach, and
Jiri Zemlicka
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5265-5271
| Inactivation of O6-Alkylguanine-DNA Alkyltransferase. 1. Novel O6-(Hetarylmethyl)guanines Having Basic Rings in the Side Chain
R. Stanley McElhinney,
Dorothy J. Donnelly,
Joan E. McCormick,
Jane Kelly,
Amanda J. Watson,
Joseph A. Rafferty,
Rhoderick H. Elder,
Mark R. Middleton,
Mark A. Willington,
T. Brian H. McMurry,
and
Geoffrey P. Margison
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5272-5286
| Prediction of Binding Affinities for TIBO Inhibitors of HIV-1 Reverse Transcriptase Using Monte Carlo Simulations in a Linear Response Method
Richard H. Smith, Jr.,
William L. Jorgensen,
Julian Tirado-Rives,
Michelle L. Lamb,
Paul A. J. Janssen,
Christopher J. Michejda, and
Marilyn B. Kroeger Smith
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5287-5296
| Chemoprotective Properties of Phenylpropenoids, Bis(benzylidene)cycloalkanones, and Related Michael Reaction Acceptors: Correlation of Potencies as Phase 2 Enzyme Inducers and Radical Scavengers
Albena T. Dinkova-Kostova,
Chitrananda Abeygunawardana, and
Paul Talalay
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5297-5309
| Self-Immolative Nitrogen Mustard Prodrugs for Suicide Gene Therapy
Dan Niculescu-Duvaz,
Ion Niculescu-Duvaz,
Frank Friedlos,
Janet Martin,
Robert Spooner,
Lawrence Davies,
Richard Marais, and
Caroline J. Springer
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5310-5319
| Synthesis and Potent Antifolate Activity and Cytotoxicity of B-Ring Deaza Analogues of the Nonpolyglutamatable Dihydrofolate Reductase Inhibitor N -(4-Amino-4-deoxypteroyl)-N-hemiphthaloyl-L-ornithine (PT523)
Andre Rosowsky,
Joel E. Wright,
Chitra M. Vaidya,
Henry Bader,
Ronald A. Forsch,
Clara E. Mota,
Jorge Pardo,
Cindy S. Chen, and
Ying-Nan Chen
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PDF] |
5320-5333
| Design and Synthesis of Novel 1a Adrenoceptor-Selective Dihydropyridine Antagonists for the Treatment of Benign Prostatic Hyperplasia
Dhanapalan Nagarathnam,
John M. Wetzel,
Shou Wu Miao,
Mohammad R. Marzabadi,
George Chiu,
Wai C. Wong,
Xingfang Hong,
James Fang,
Carlos Forray,
Theresa A. Branchek,
William E. Heydorn,
Raymond S. L. Chang,
Theodore Broten,
Terry W. Schorn, and
Charles Gluchowski
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BOOK REVIEWS
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5334-5334
| Annual Review of Pharmacology and Toxicology. Volume 38 Edited by Arthur K. Cho. Annual Reviews, Palo Alto, CA. 1998. vi + 581 pp. 16 × 23 cm. ISBN 0-8243-0438-1. $60.00.
J. Paul Hieble
[Full Article - PDF] |
5334-5335
| Mass Spectrometry of Biological Materials. Second Edition, Revised and Expanded Edited by B. S. Larsen and C. N. McEwen. Marcel Dekker, Inc., New York, NY. 1998. xiii + 469 pp. 15.5 x 23 cm. ISBN 0-8247-0157-7. $195.00.
James A. McCloskey
[Full Article - PDF] |
5335-5336
| The Antidepressant Era By David Healy. Harvard University Press, Cambridge, MA. 1998. x + 317 pp. 16 x 24.5 cm. ISBN 0674039572. $39.95.
John L. Neumeyer
[Full Article - PDF] |
5336-5336
| The Chemistry, Biology, and Medical Applications of Hyaluronan and Its Derivatives Edited by T. C. Laurent. Portland Press, London, U.K. 1998. xvi + 341 pp. 17 × 25 cm. ISBN 1-85578-119-0. $127.50.
Kevin G. Rice
[Full Article - PDF] |
5336-5336
| The Alkaloids. Volume 51. Chemistry and Biology Edited by Geoffrey A. Cordell. Academic Press, San Diego, CA. 1998. x + 439 pp. 15.5 × 23.5 cm. ISBN 0-12-469551-5. $135.
Ryan J. Huxtable
[Full Article - PDF] |