Journal of Medicinal Chemistry
Volume 41, Issue 27 (December 31, 1998)
Copyright © 1998 American Chemical Society

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PERSPECTIVE

5337-5352

Leptin, a Pleiotropic Hormone: Physiology, Pharmacology, and Strategies for Discovery of Leptin Modulators Jean Dallongeville, Jean-Charles Fruchart, and Johan Auwerx [Full Article - PDF]

ARTICLES

5353-5361

Novel Analogues of Arachidonylethanolamide (Anandamide): Affinities for the CB1 and CB2 Cannabinoid Receptors and Metabolic Stability Sonyuan Lin, Atmaram D. Khanolkar, Pusheng Fan, Andreas Goutopoulos, Ce Qin, Demetris Papahadjis, and Alexandros Makriyannis [Full Article - PDF]

5362-5374

Development of Dual-Acting Agents for Thromboxane Receptor Antagonism and Thromboxane Synthase Inhibition. 3. Synthesis and Biological Activities of Oxazolecarboxamide-Substituted -Phenyl--(3-pyridyl)alkenoic Acid Derivatives and Related Compounds Kumiko Takeuchi, Todd J. Kohn, Timothy A. True, Dale E. Mais, James H. Wikel, Barbara G. Utterback, Virginia L. Wyss, and Joseph A. Jakubowski [Full Article - PDF]

5375-5381

The 16,17-Double Bond Is Needed for Irreversible Inhibition of Human Cytochrome P45017 by Abiraterone (17-(3-Pyridyl)androsta-5,16-dien-3-ol) and Related Steroidal Inhibitors Michael Jarman, S. Elaine Barrie, and Jose M. Llera [Full Article - PDF]

5382-5392

Evaluation of Dynamic Polar Molecular Surface Area as Predictor of Drug Absorption: Comparison with Other Computational and Experimental Predictors Katrin Palm, Kristina Luthman, Anna-Lena Ungell, Gert Strandlund, Farideh Beigi, Per Lundahl, and Per Artursson [Full Article - PDF]

5393-5401

New 1,4-Dihydropyridines Conjugated to Furoxanyl Moieties, Endowed with Both Nitric Oxide-like and Calcium Channel Antagonist Vasodilator Activities Antonella Di Stilo, Sonja Visentin, Clara Cena, Andrea Marcello Gasco, Giuseppe Ermondi, and Alberto Gasco [Full Article - PDF]

5402-5409

7-[3-(1-Piperidinyl)propoxy]chromenones as Potential Atypical Antipsychotics. 2. Pharmacological Profile of 7-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymethyl)chromen-4-one (Abaperidone, FI-8602) Jordi Bolós, Lluís Anglada, Santiago Gubert, Josep M. Planas, Julián Agut, Marta Príncep, Àngels De la Fuente, Aurelio Sacristán, and José A. Ortiz [Full Article - PDF]

5410-5419

Homocamptothecins: Synthesis and Antitumor Activity of Novel E-Ring-Modified Camptothecin Analogues Olivier Lavergne, Laurence Lesueur-Ginot, Francesc Pla Rodas, Philip G. Kasprzyk, Jacques Pommier, Danièle Demarquay, Grégoire Prévost, Gérard Ulibarri, Alain Rolland, Anne-Marie Schiano-Liberatore, Jeremiah Harnett, Dominique Pons, José Camara, and Dennis C. H. Bigg [Full Article - PDF]

5420-5428

4-(trans-4-Methylcyclohexyl)-4-Oxobutyric Acid (JTT-608). A New Class of Antidiabetic Agent Hisashi Shinkai, Hidekazu Ozeki, Takahisa Motomura, Takeshi Ohta, Noboru Furukawa, and Itsuo Uchida [Full Article - PDF]

5429-5444

Synthesis and Antitumor Evaluation of 2,5-Disubstituted- Indazolo[4,3-gh]isoquinolin-6(2H)-ones (9-Aza-anthrapyrazoles) A. Paul Krapcho, Ernesto Menta, Ambrogio Oliva, Roberto Di Domenico, Luigi Fiocchi, Martin E. Maresch, Cynthia E. Gallagher, Miles P. Hacker, Gino Beggiolin, Fernando C. Giuliani, Gabriella Pezzoni, and Silvano Spinelli [Full Article - PDF]

5445-5456

Structural and Functional Analyses of Benzamidine-Based Inhibitors in Complex with Trypsin: Implications for the Inhibition of Factor Xa, tPA, and Urokinase Martin Renatus, Wolfram Bode, Robert Huber, Jörg Stürzebecher, and Milton T. Stubbs [Full Article - PDF]

5457-5465

Structure-Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor Brian D. Palmer, Jeff B. Smaill, Maruta Boyd, Diane H. Boschelli, Annette M. Doherty, James M. Hamby, Sonya S. Khatana, James B. Kramer, Alan J. Kraker, Robert L. Panek, Gina H. Lu, Tawny K. Dahring, R. Thomas Winters, H. D. Hollis Showalter, and William A. Denny [Full Article - PDF]