Journal of Medicinal Chemistry
Volume 42, Issue 1 (January 14, 1999)
Copyright © 1999
American Chemical Society
| PERSPECTIVE | |
1-24 | Emerging Therapies for the Prevention or Treatment of Postmenopausal Osteoporosis
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ARTICLES | |
25-35 | Potent Inhibition of Grb2 SH2 Domain Binding by Non-Phosphate-Containing Ligands
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36-49 | Synthesis and Structure-Activity Relationships of a New Model of Arylpiperazines. 4. 1-[ -(4-Arylpiperazin-1-yl)alkyl]-3-(diphenylmethylene)- 2,5-pyrrolidinediones and -3-(9H-fluoren-9-ylidene)-2,5-pyrrolidinediones: Study of the Steric Requirements of the Terminal Amide Fragment on 5-HT1A Affinity/Selectivity
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50-59 | 2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imidazo[1,2-a]pyridines as a Novel Class of Inhibitors of Human Rhinovirus: Stereospecific Synthesis and Antiviral Activity
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60-66 | IcePick: A Flexible Surface-Based System for Molecular Diversity
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67-86 | Synthesis and Biological Properties of Novel Pyridinioalkanoyl Thiolesters (PATE) as Anti-HIV-1 Agents That Target the Viral Nucleocapsid Protein Zinc Fingers
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87-94 | Design and Synthesis of Phosphinamide-Based Hydroxamic Acids as Inhibitors of Matrix Metalloproteinases
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95-108 | Desazadesmethyldesferrithiocin Analogues as Orally Effective Iron Chelators
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109-117 | Calculation of the pKa Values for the Ligands and Side Chains of Escherichia coli D-Alanine:D-Alanine Ligase
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118-134 | Synthesis, Biochemical Evaluation, and Classical and Three-Dimensional Quantitative Structure-Activity Relationship Studies of 7-Substituted-1,2,3,4-tetrahydroisoquinolines and Their Relative Affinities toward Phenylethanolamine N-Methyltransferase and the  2-Adrenoceptor,1
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135-152 | Stereospecific Synthesis, Structure-Activity Relationship, and Oral Bioavailability of Tetrahydropyrimidin-2-one HIV Protease Inhibitors
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153-163 | Hypoglycemic Prodrugs of 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid
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164-172 | Carboxy-Substituted Cinnamides: A Novel Series of Potent, Orally Active LTB4 Receptor Antagonists
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BRIEF ARTICLES | |
173-177 | Novel Adrenoceptor Antagonists with a Tricyclic Pyrrolodipyridazine Skeleton
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BOOK REVIEWS | |
178-178 | Bioorganic Chemistry: Peptides and Proteins Edited by Sidney M. Hecht. Oxford University Press, New York. 1998. x + 532 pp. 17 × 24.5 cm. ISBN 0-19-508468-3. $75.00.
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178-179 | Metal Ions in Biological Systems. Volume 25. Iron Transport in Microorganisms, Plants, and Animals Edited by A. Sigel and H. Sigel. Marcel Dekker, Inc., New York. 1998. xlii + 775 pp. 16 × 23.5 cm. ISBN 0-8247-9984-4. $250.00.
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179-179 | Progress in Medicinal Chemistry. Volume 35 Edited by G. P. Ellis, D. K. Luscombe, and A. W. Oxford. Elsevier Science B.V., Amsterdam, The Netherlands. 1998. vii + 270 pp. 14.5 × 21 cm. ISBN 0-444-82909-1. $198.50.
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179-180 | Integration of Pharmaceutical Discovery and Development: Case Histories Edited by Ronald T. Borchardt, Roger M. Freidinger, Tomi K. Sawyer, and Philip L. Smith. Plenum Press, New York. 1998. xxix + 607 pp. 16 × 23 cm. ISBN 0-306-45743-1. $125.00.
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