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ARTICLES
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4733-4740
| Synthesis and in Vitro Anti-HIV Activity in Human Monocyte-Derived Macrophages of 2-Oxothiazolidine-4(R)-carboxylic Acid Derivatives
Joël Oiry,
Jean-Yves Puy,
Patricia Mialocq,
Pascal Clayette,
Philippe Fretier,
Philippe Jaccard,
Nathalie Dereuddre-Bosquet,
Dominique Dormont, and
Jean-Louis Imbach
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4741-4748
| Synthesis and Structure-Activity Relationships of Potential Anticancer Agents: Alkylcarbamates of 3-(9-Acridinylamino)-5-hydroxymethylaniline
Tsann-Long Su,
Ching-Huang Chen,
Lin-Fei Huang,
Chao-Hao Chen,
Manas K. Basu,
Xiu-Guo Zhang, and
Ting-Chao Chou
[Full Article -
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4749-4763
| Structure-Immunosuppressive Activity Relationships of New Analogues of 15-Deoxyspergualin. 2. Structural Modifications of the Spermidine Moiety
Luc Lebreton,
Eric Jost,
Bertrand Carboni,
Jocelyne Annat,
Michel Vaultier,
Patrick Dutartre, and
Patrice Renaut
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4764-4777
Design and Synthesis of Novel  1a Adrenoceptor-Selective Antagonists. 1. Structure-Activity Relationship in Dihydropyrimidinones
Dhanapalan Nagarathnam,
Shou Wu Miao,
Bharat Lagu,
George Chiu,
James Fang,
T. G. Murali Dhar,
Jack Zhang,
Sriram Tyagarajan,
Mohammad R. Marzabadi,
Fengqi Zhang,
Wai C. Wong,
Wanying Sun,
Dake Tian,
John M. Wetzel,
Carlos Forray,
Raymond S. L. Chang,
Theodore P. Broten,
Richard W. Ransom,
Terry W. Schorn,
Tsing B. Chen,
Stacey O'Malley,
Paul Kling,
Kathryn Schneck,
Robert Bendesky,
Charles M. Harrell,
Kamlesh P. Vyas, and
Charles Gluchowski
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4778-4793
| Design and Synthesis of Novel 1a Adrenoceptor-Selective Antagonists. 2. Approaches To Eliminate Opioid Agonist Metabolites via Modification of Linker and 4-Methoxycarbonyl-4-phenylpiperidine Moiety
T. G. Murali Dhar,
Dhanapalan Nagarathnam,
Mohammad R. Marzabadi,
Bharat Lagu,
Wai C. Wong,
George Chiu,
Sriram Tyagarajan,
Shou Wu Miao,
Fengqi Zhang,
Wanying Sun,
Dake Tian,
Quanrong Shen,
Jack Zhang,
John M. Wetzel,
Carlos Forray,
Raymond S. L. Chang,
Theodore P. Broten,
Terry W. Schorn,
Tsing Bao Chen,
Stacy O'Malley,
Richard Ransom,
Kathryn Schneck,
Robert Bendesky,
Charles M. Harrell,
Kamlesh P. Vyas,
Kanyin Zhang,
John Gilbert,
Douglas J. Pettibone,
Michael A. Patane,
Mark G. Bock,
Roger M. Freidinger, and
Charles Gluchowski
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4794-4803
| Design and Synthesis of Novel 1a Adrenoceptor-Selective Antagonists. 3. Approaches To Eliminate Opioid Agonist Metabolites by Using Substituted Phenylpiperazine Side Chains
Bharat Lagu,
Dake Tian,
Dhanapalan Nagarathnam,
Mohammad R. Marzabadi,
Wai C. Wong,
Shou W. Miao,
Fengqi Zhang,
Wanying Sun,
George Chiu,
James Fang,
Carlos Forray,
Raymond S. L. Chang,
Richard W. Ransom,
Tsing B. Chen,
Stacey O'Malley,
Kanyin Zhang,
Kamlesh P. Vyas, and
Charles Gluchowski
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4804-4813
| Design and Synthesis of Novel 1a Adrenoceptor-Selective Antagonists. 4. Structure-Activity Relationship in the Dihydropyrimidine Series
Wai C. Wong,
Wanying Sun,
Bharat Lagu,
Dake Tian,
Mohammad R. Marzabadi,
Fengqi Zhang,
Dhanapalan Nagarathnam,
Shou W. Miao,
John M. Wetzel,
Jian Peng,
Carlos Forray,
Raymond S. L. Chang,
Tsing B. Chen,
Richard Ransom,
Stacey O'Malley,
Theodore P. Broten,
Paul Kling,
Kamlesh P. Vyas,
Kanyin Zhang, and
Charles Gluchowski
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4814-4823
| Synthesis, Physicochemical Characterization, and Biological Evaluation of 2-(1'-Hydroxyalkyl)-3-hydroxypyridin-4-ones: Novel Iron Chelators with Enhanced pFe3+ Values
Zu D. Liu,
Hicham H. Khodr,
Ding Y. Liu,
Shu L. Lu, and
Robert C. Hider
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4824-4835
| Synthesis, Acid-Base Behavior, and Binding Properties of 6-Modified myo-Inositol 1,4,5-Tris(phosphate)s
Stéphanie Ballereau,
Philippe Guédat,
Stéphane N. Poirier,
Gaétan Guillemette,
Bernard Spiess, and
Gilbert Schlewer
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4836-4843
| Synthesis and Pharmacology of Site-Specific Cocaine Abuse Treatment Agents: 2-Substituted-6-amino-5-phenylbicyclo[2.2.2]octanes
Sahar Javanmard,
Howard M. Deutsch,
David M. Collard,
Michael J. Kuhar, and
Margaret M. Schweri
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4844-4852
| Discovery of a Series of Cyclohexylethylamine-Containing Protein Farnesyltransferase Inhibitors Exhibiting Potent Cellular Activity
Kenneth J. Henry, Jr.,
James Wasicak,
Andrew S. Tasker,
Jerome Cohen,
Patricia Ewing,
Michael Mitten,
John J. Larsen,
Douglas M. Kalvin,
Rolf Swenson,
Shi-Chung Ng,
Badr Saeed,
Sajeev Cherian,
Hing Sham, and
Saul H. Rosenberg
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4853-4860
| Structure-Based Design of Selective Inhibitors of Dihydrofolate Reductase: Synthesis and Antiparasitic Activity of 2,4-Diaminopteridine Analogues with a Bridged Diarylamine Side Chain
Andre Rosowsky,
Vivian Cody,
Nikolai Galitsky,
Hongning Fu,
Andrew T. Papoulis, and
Sherry F. Queener
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4861-4874
| Novel Modifications in the Alkenyldiarylmethane (ADAM) Series of Non-Nucleoside Reverse Transcriptase Inhibitors
Agustin Casimiro-Garcia,
Mark Micklatcher,
Jim A. Turpin,
Tracy L. Stup,
Karen Watson,
Robert W. Buckheit, and
Mark Cushman
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4875-4889
Fused Bicyclic Gly-Asp  -Turn Mimics with Specific Affinity for GPIIb-IIIa
Matthew J. Fisher,
Ann E. Arfstan,
Ulrich Giese,
Bruce P. Gunn,
Cathy S. Harms,
Vien Khau,
Michael D. Kinnick,
Terry D. Lindstrom,
Michael J. Martinelli,
Hans-Jürgen Mest,
Michael Mohr,
John M. Morin, Jr.,
Jeffrey T. Mullaney,
Anne Nunes,
Michael Paal,
Achim Rapp,
Gerd Rühter,
Ken J. Ruterbories,
Daniel J. Sall,
Robert M. Scarborough,
Theo Schotten,
Birgit Sommer,
Wolfgang Stenzel,
Richard D. Towner,
Suzane L. Um,
Barbara G. Utterback,
Robert T. Vasileff,
Silke Vöelkers,
Virginia L. Wyss, and
Joseph A. Jakubowski
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4890-4908
| New -Substituted Succinate-Based Hydroxamic Acids as TNF Convertase Inhibitors
Bernard Barlaam,
T. Geoffrey Bird,
Christine Lambert-van der Brempt,
Douglas Campbell,
Steve J. Foster, and
Rose Maciewicz
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4909-4913
| Synthesis and Biological Evaluation of a Potent E-Selectin Antagonist
Gebhard Thoma,
Willy Kinzy,
Christian Bruns,
John T. Patton,
John L. Magnani, and
Rolf Bänteli
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BRIEF ARTICLES
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4914-4918
| Synthesis and Human Neurotensin Receptor Binding Activities of Neurotensin(8-13) Analogues Containing Position 8 -Azido-N-alkylated Derivatives of Ornithine, Lysine, and Homolysine
Joseph T. Lundquist, IV and
Thomas A. Dix
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4919-4924
| Paclitaxel Derivatives for Targeted Therapy of Cancer: Toward the Development of Smart Taxanes
Ahmad Safavy,
Kevin P. Raisch,
M. B. Khazaeli,
Donald J. Buchsbaum, and
James A. Bonner
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BOOK REVIEWS
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4925-4925
| Theilheimer's Synthetic Methods of Organic Chemistry, Volume 54 Edited by Alan Fitch. Karger, Basel. 1998. xxiv + 301 pp. 16 x 23 cm. ISBN 3-8055-6696-4. $391.50.
Thomas J. Caggiano
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4925-4926
Molecular Mechanics and Conformational Analysis in Drug Design By G. M. Keseru and I. Kolossvary. Blackwell Science, Oxford, U.K. 1999. viii + 168 pp. 18 × 25 cm. ISBN 0-632-05289-9.  49.50.
Mark G. Bures
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4926-4926
| Uses of Inorganic Chemistry in Medicine Nicholas P. Farrell, Editor. Royal Society of Chemistry, Cambridge, U.K. 1999. xi + 159 pp. 16 × 24 cm. ISBN 0-85404-444-2. $59.50.
J. A. Cowan
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4926-4926
| Progress in Medicinal Chemistry. Volume 36 Edited by F. D. King and A. W. Oxford. Elsevier Science BV, Amsterdam. 1999. viii + 309 pp. 14.5 × 21.5 cm. ISBN 0-444-50090-1. $177.50.
[Full Article - PDF] | |