|
PERSPECTIVES
|
477-501
| Current and Novel Approaches to the Drug Treatment of Schizophrenia
Michael Rowley,
Linda J. Bristow, and
Peter H. Hutson
[Full Article -
PDF] | |
502-511
Improved Scoring of Ligand-Protein Interactions Using OWFEG Free Energy Grids
David A. Pearlman and
Paul S. Charifson
[Full Article -
PDF]
| |
ARTICLES
|
512-523
Reduction in Glucose Levels in STZ Diabetic Rats by 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid: A Prodrug Approach for Targeting the Liver
Gregory R. Bebernitz,
Jeremy G. Dain,
Rhonda O. Deems,
Dario A. Otero,
W. Ronald Simpson, and
Robert J. Strohschein
[Full Article -
PDF]
| |
524-530
Crystal Structure of Human Cyclin-Dependent Kinase 2 in Complex with the Adenine-Derived Inhibitor H717
Matthias K. Dreyer,
David R. Borcherding,
Jennifer A. Dumont,
Norton P. Peet,
Joseph T. Tsay,
Paul S. Wright,
Alan J. Bitonti,
Jian Shen, and
Sung-Hou Kim
[Full Article -
PDF]
| |
531-539
Design, Synthesis, and Evaluation of Novel A2A Adenosine Receptor Agonists
Jayson M. Rieger,
Milton L. Brown,
Gail W. Sullivan,
Joel Linden, and
Timothy L. Macdonald
[Full Article -
PDF]
| |
540-547
Coumarin and Chromen-4-one Analogues as Tautomerase Inhibitors of Macrophage Migration Inhibitory Factor: Discovery and X-ray Crystallography
Masaya Orita,
Satoshi Yamamoto,
Naoko Katayama,
Motonori Aoki,
Kazuhisa Takayama,
Yoko Yamagiwa,
Norio Seki,
Hiroshi Suzuki,
Hiroyuki Kurihara,
Hitoshi Sakashita,
Makoto Takeuchi,
Shigeo Fujita,
Toshimitsu Yamada, and
Akihiro Tanaka
[Full Article -
PDF]
| |
548-565
2- and 3-Substituted 1,4-Naphthoquinone Derivatives as Subversive Substrates of Trypanothione Reductase and Lipoamide Dehydrogenase from Trypanosoma cruzi: Synthesis and Correlation between Redox Cycling Activities and in Vitro Cytotoxicity
Laurence Salmon-Chemin,
Eric Buisine,
Vanessa Yardley,
Sven Kohler,
Marie-Ange Debreu,
Valérie Landry,
Christian Sergheraert,
Simon L. Croft,
R. Luise Krauth-Siegel, and
Elisabeth Davioud-Charvet
[Full Article -
PDF]
| |
566-578
Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)- [1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa
Donald J. P. Pinto,
Michael J. Orwat,
Shuaige Wang,
John M. Fevig,
Mimi L. Quan,
Eugene Amparo,
Joseph Cacciola,
Karen A. Rossi,
Richard S. Alexander,
Angela M. Smallwood,
Joseph M. Luettgen,
Li Liang,
Bruce J. Aungst,
Matthew R. Wright,
Robert M. Knabb,
Pancras C. Wong,
Ruth R. Wexler, and
Patrick Y. S. Lam
[Full Article -
PDF]
| |
579-585
Labeling and Evaluation of N-[11C]Methylated Quinoline-2-carboxamides as Potential Radioligands for Visualization of Peripheral Benzodiazepine Receptors
Mario Matarrese,
Rosa Maria Moresco,
Andrea Cappelli,
Maurizio Anzini,
Salvatore Vomero,
Pasquale Simonelli,
Elisa Verza,
Fulvio Magni,
Francesco Sudati,
Dmitri Soloviev,
Sergio Todde,
Assunta Carpinelli,
Marzia Galli Kienle, and
Ferruccio Fazio
[Full Article -
PDF]
| |
586-593
A Conformational and Structure-Activity Relationship Study of Cytotoxic 3,5-Bis(arylidene)-4-piperidones and Related N-Acryloyl Analogues
Jonathan R. Dimmock,
Maniyan P. Padmanilayam,
Ramanan N. Puthucode,
Adil J. Nazarali,
Narasimhan L. Motaganahalli,
Gordon A. Zello,
J. Wilson Quail,
Eliud O. Oloo,
Heinz-Bernhard Kraatz,
Jared S. Prisciak,
Theresa M. Allen,
Cheryl L. Santos,
Jan Balzarini,
Erik De Clercq, and
Elias K. Manavathu
[Full Article -
PDF]
| |
594-601
Structure-Activity Studies of Substituted Quinoxalinones as Multiple-Drug-Resistance Antagonists
David S. Lawrence,
Jean E. Copper, and
Charles D. Smith
[Full Article -
PDF]
| |
602-612
Novel Glucocorticoid Antedrugs Possessing a 17 -( -Lactone) Ring
Panayiotis A. Procopiou,
Keith Biggadike,
Alan F. English,
Rosanne M. Farrell,
Graham N. Hagger,
Ashley P. Hancock,
Michael V. Haase,
Wendy R. Irving,
Meenu Sareen,
Michael A. Snowden,
Yemisi E. Solanke,
Cathy J. Tralau-Stewart,
Sarah E. Walton, and
Jenny A. Wood
[Full Article -
PDF]
| |
613-618
AMP Deaminase Inhibitors. 5. Design, Synthesis, and SAR of a Highly Potent Inhibitor Series
Srinivas Rao Kasibhatla,
Brett C. Bookser,
Wei Xiao, and
Mark D. Erion
[Full Article -
PDF]
| |
619-626
seco-Cyclothialidines: New Concise Synthesis, Inhibitory Activity toward Bacterial and Human DNA Topoisomerases, and Antibacterial Properties
Joachim Rudolph,
Heidi Theis,
Roman Hanke,
Rainer Endermann,
Lars Johannsen, and
Frank-Ulrich Geschke
[Full Article -
PDF]
| |
627-632
Synthesis of New Cyclitol Compounds That Influence the Activity of Phosphatidylinositol 4-Kinase Isoform, PI4K230
István F. Pelyvás,
Zoltán G. Tóth,
György Vereb,
András Balla,
Elza Kovács,
András Gorzsás,
Ferenc Sztaricskai, and
Pál Gergely
[Full Article -
PDF]
| |
633-640
Structure-Activity Relationships at Monoamine Transporters and Muscarinic Receptors for N-Substituted-3 -(3'-chloro-, 4'-chloro-, and 4',4' '-dichloro-substituted-diphenyl)methoxytropanes
Amy Hauck Newman,
Michael J. Robarge,
Ileana M. Howard,
Sharine L. Wittkopp,
Clifford George,
Theresa Kopajtic,
Sari Izenwasser, and
Jonathan L. Katz
[Full Article -
PDF]
| |