|
|
1313-1333
| Property-Based Design: Optimization of Drug Absorption and Pharmacokinetics
Han van de Waterbeemd,
Dennis A. Smith,
Kevin Beaumont, and
Don K. Walker
[Full Article -
PDF] | |
1334-1336
Indenopyrazoles as Novel Cyclin Dependent Kinase (CDK) Inhibitors
David A. Nugiel,*
Ana-Marie Etzkorn,
Anup Vidwans,
Pamela A. Benfield,
Michael Boisclair,
Catherine R. Burton,
Sarah Cox,
Phillip M. Czerniak,
Deborah Doleniak, and
Steven P. Seitz
[Full Article -
PDF]
| |
1337-1340
Atropisomeric Derivatives of 2',6'-Disubstituted (R)-11-Phenylaporphine: Selective Serotonin 5-HT7 Receptor Antagonists
Tero Linnanen,
Magnus Brisander,
Lena Unelius,
Susanne Rosqvist,
Gunnar Nordvall,
Uli Hacksell, and
Anette M. Johansson
[Full Article -
PDF]
| |
|
1341-1348
Novel Peptide Conjugates for Tumor-Specific Chemotherapy
Michael Langer,
Felix Kratz,
Barbara Rothen-Rutishauser,
Heidi Wunderli-Allenspach, and
Annette G. Beck-Sickinger
[Full Article -
PDF]
| |
1349-1355
Structure-Based Approach for the Discovery of Bis-benzamidines as Novel Inhibitors of Matriptase
Istvan J. Enyedy,
Sheau-Ling Lee,
Angera H. Kuo,
Robert B. Dickson,
Chen-Yong Lin, and
Shaomeng Wang
[Full Article -
PDF]
| |
1356-1363
Short Peptides with Induced  -Turn Inhibit the Interaction between HIV-1 gp120 and CD4
Yo Han Choi,
Won Sang Rho,
Nam Doo Kim,
Sang Jin Park,
Dong Hyuk Shin,
Jong Woo Kim,
Sung Hyuk Im,
Ho Sik Won,
Chang Woo Lee,
Chi Bom Chae, and
Young Chul Sung
[Full Article -
PDF]
| |
1364-1371
Bisubstrate Analogue Inhibitors of 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase: Synthesis and Biochemical and Crystallographic Studies
Genbin Shi,
Jaroslaw Blaszczyk,
Xinhua Ji, and
Honggao Yan
[Full Article -
PDF]
| |
1372-1379
Development of Potent Truncated Glucagon Antagonists
Jung-Mo Ahn,
Matthew Medeiros,
Dev Trivedi, and
Victor J. Hruby
[Full Article -
PDF]
| |
1380-1395
Azepanone-Based Inhibitors of Human and Rat Cathepsin K
Robert W. Marquis,
Yu Ru,
Steven M. LoCastro,
Jin Zeng,
Dennis S. Yamashita,
Hye-Ja Oh,
Karl F. Erhard,
Larry D. Davis,
Thaddeus A. Tomaszek,
David Tew,
Kevin Salyers,
Joel Proksch,
Keith Ward,
Brian Smith,
Mark Levy,
Maxwell D. Cummings,,1
R. Curtis Haltiwanger,
Gudrun Trescher,
Bing Wang,
Mark E. Hemling,
Chad J. Quinn,
H-Y. Cheng,
Fan Lin,
Ward W. Smith,
Cheryl A. Janson,
Baoguang Zhao,
Michael S. McQueney,
Karla D'Alessio,
Chao-Pin Lee,
Antonia Marzulli,
Robert A. Dodds,,2
Simon Blake,
Shing-Mei Hwang,
Ian E. James,
Catherine J. Gress,
Brian R. Bradley,
Michael W. Lark,
Maxine Gowen, and
Daniel F. Veber
[Full Article -
PDF]
| |
1396-1406
Novel Seco Cyclopropa[c]pyrrolo[3,2-e]indole Bisalkylators Bearing a 3,3'-Arylenebisacryloyl Group as a Linker
Yasumichi Fukuda,
Shigeki Seto,
Hirosuke Furuta,
Hiroyuki Ebisu,
Yasuo Oomori, and
Shiro Terashima
[Full Article -
PDF]
| |
1407-1415
Dicationic Bis(9-methylphenazine-1-carboxamides): Relationships between Biological Activity and Linker Chain Structure for a Series of Potent Topoisomerase Targeted Anticancer Drugs
Swarna A. Gamage,
Julie A. Spicer,
Graeme J. Finlay,
Alistair J. Stewart,
Peter Charlton,
Bruce C. Baguley, and
William A. Denny
[Full Article -
PDF]
| |
1416-1421
N-Methyl Scan of Somatostatin Octapeptide Agonists Produces Interesting Effects on Receptor Subtype Specificity
W. G. Rajeswaran,
Simon J. Hocart,
William A. Murphy,
John E. Taylor, and
David H. Coy
[Full Article -
PDF]
| |
1422-1428
Antitumor Agents. 207. Design, Synthesis, and Biological Testing of 4-Anilino-2-fluoro-4'-demethylpodophyllotoxin Analogues as Cytotoxic and Antiviral Agents
David S. VanVliet,
Yoko Tachibana,
Kenneth F. Bastow,
Eng-Shang Huang, and
Kuo-Hsiung Lee
[Full Article -
PDF]
| |
1429-1435
Design, Synthesis, and Discovery of a Novel CCR1 Antagonist
Akira Naya,
Yufu Sagara,
Kenji Ohwaki,
Toshihiko Saeki,
Daisuke Ichikawa,
Yoshikazu Iwasawa,
Kazuhito Noguchi, and
Norikazu Ohtake
[Full Article -
PDF]
| |
1436-1445
Discovery of Novel N-Phenylglycine Derivatives as Potent and Selective 3-Adrenoceptor Agonists for the Treatment of Frequent Urination and Urinary Incontinence
Nobuyuki Tanaka,
Tetsuro Tamai,
Harunobu Mukaiyama,
Akihito Hirabayashi,
Hideyuki Muranaka,
Satoshi Akahane,
Hiroshi Miyata, and
Masuo Akahane
[Full Article -
PDF]
| |
1446-1455
Antitumor Benzothiazoles. 14. Synthesis and in Vitro Biological Properties of Fluorinated 2-(4-Aminophenyl)benzothiazoles
Ian Hutchinson,
Mei-Sze Chua,
Helen L. Browne,
Valentina Trapani,
Tracey D. Bradshaw,
Andrew D. Westwell, and
Malcolm F. G. Stevens
[Full Article -
PDF]
| |
1456-1466
(4-Piperidin-1-yl)phenyl Amides: Potent and Selective Human 3 Agonists
Baihua Hu,
John Ellingboe,
Stella Han,
Elwood Largis,
Ruth Mulvey,
Alexander Oliphant,
Fuk-Wah Sum, and
Jeff Tillett
[Full Article -
PDF]
| |
|
1467-1470
Efficient Preparations of the -Glucuronides of Dihydroartemisinin and Structural Confirmation of the Human Glucuronide Metabolite
Paul M. O'Neill,
Feodor Scheinmann,
Andrew V. Stachulski,
James L. Maggs, and
B. Kevin Park
[Full Article -
PDF]
| |
1471-1474
Effect of N-Alkyl and N-Alkenyl Substituents in Noroxymorphindole, 17-Substituted-6,7-dehydro-4,5 -epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on Opioid Receptor Affinity, Selectivity, and Efficacy
Sherita McLamore,
Thomas Ullrich,
Richard B. Rothman,
Heng Xu,
Christina Dersch,
Andrew Coop,
Peg Davis,
Frank Porreca,
Arthur E. Jacobson, and
Kenner C. Rice
[Full Article -
PDF]
| |
1475-1478
Synthesis and Structural Studies of Aza Analogues of Functionalized Amino Acids: New Anticonvulsant Agents
Shridhar V. Andurkar,
Cécile Béguin,
J. P. Stables, and
Harold Kohn
[Full Article -
PDF]
| |