ALFRED BURGER AWARD ADDRESS
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2259-2269
| From Models to Molecules: Opioid Receptor Dimers, Bivalent Ligands, and Selective Opioid Receptor Probes
Philip S. Portoghese
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2270-2275
Isomerization of (Z,Z) to (E,E)1-Bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in Strong Base: Probes for Amyloid Plaques in the Brain
Chi-Wan Lee,
Zhi-Ping Zhuang,
Mei-Ping Kung,
Karl Plössl,
Daniel Skovronsky,
Tamar Gur,
Catherine Hou,
John Q. Trojanowski,
Virginia M.-Y. Lee, and
Hank F. Kung
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2276-2285
Utilization of an Intramolecular Hydrogen Bond To Increase the CNS Penetration of an NK1 Receptor Antagonist
Valerie A. Ashwood,
Mark J. Field,
David C. Horwell,
Christine Julien-Larose,
Russell A. Lewthwaite,
Scott McCleary,
Martyn C. Pritchard,
Jenny Raphy, and
Lakhbir Singh
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2286-2297
Novel N-(Arylalkyl)indol-3-ylglyoxylylamides Targeted as Ligands of the Benzodiazepine Receptor: Synthesis, Biological Evaluation, and Molecular Modeling Analysis of the Structure-Activity Relationships
Giampaolo Primofiore,
Federico Da Settimo,
Sabrina Taliani,
Anna Maria Marini,
Ettore Novellino,
Giovanni Greco,
Antonio Lavecchia,
François Besnard,
Letizia Trincavelli,
Barbara Costa, and
Claudia Martini
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2298-2303
Enantioselective Syntheses of Potent Retinoid X Receptor Ligands: Differential Biological Activities of Individual Antipodes
Vidyasagar Vuligonda,
Scott M. Thacher, and
Roshantha A. S. Chandraratna
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2304-2307
Discovery of Novel Mesangial Cell Proliferation Inhibitors Using a Three-Dimensional Database Searching Method
Yasuhisa Kurogi,
Kazuyoshi Miyata,
Takashi Okamura,
Kinji Hashimoto,
Kazuhiko Tsutsumi,
Masahiro Nasu, and
Matsuko Moriyasu
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2308-2318
Heterocycle-Containing Retinoids. Discovery of a Novel Isoxazole Arotinoid Possessing Potent Apoptotic Activity in Multidrug and Drug-Induced Apoptosis-Resistant Cells
Daniele Simoni,
Marinella Roberti,
Francesco Paolo Invidiata,
Riccardo Rondanin,
Riccardo Baruchello,
Cinzia Malagutti,
Angelica Mazzali,
Marcello Rossi,
Stefania Grimaudo,
Francesca Capone,
Luisa Dusonchet,
Maria Meli,
Maria Valeria Raimondi,
Marilena Landino,
Natale D'Alessandro,
Manlio Tolomeo,
Dhar Arindam,
Shennan Lu, and
Doris M. Benbrook
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2319-2332
4-Hydroxy-5,6-dihydropyrones as Inhibitors of HIV Protease: The Effect of Heterocyclic Substituents at C-6 on Antiviral Potency and Pharmacokinetic Parameters
Susan E. Hagen,
John Domagala,
Christopher Gajda,
Michael Lovdahl,
Bradley D. Tait,
Eric Wise,
Tod Holler,
Donald Hupe,
Carolyn Nouhan,
Andrej Urumov,
Greg Zeikus,
Eric Zeikus,
Elizabeth A. Lunney,
Alexander Pavlovsky,
Stephen J. Gracheck,
James Saunders,
Steve VanderRoest, and
Joanne Brodfuehrer
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2333-2343
A New Concept for Multidimensional Selection of Ligand Conformations (MultiSelect) and Multidimensional Scoring (MultiScore) of Protein-Ligand Binding Affinities
Gitte Elgaard Terp,
Bent Nagstrup Johansen,
Inge Th ger Christensen, and
Flemming Steen Jrgensen
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2344-2356
Synthesis and Structure-Activity Relationships of Trisubstituted Phenyl Urea Derivatives as Neuropeptide Y5 Receptor Antagonists
Christopher Fotsch,
Jennifer D. Sonnenberg,
Ning Chen,
Clarence Hale,
William Karbon, and
Mark H. Norman
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2357-2361
Synthesis and Antimalarial Activity of Novel Medium-Sized 1,2,4,5-Tetraoxacycloalkanes
Hye-Sook Kim,
Yukiko Nagai,
Kanako Ono,
Khurshida Begum,
Yusuke Wataya,
Yoshiaki Hamada,
Kaoru Tsuchiya,
Araki Masuyama,
Masatomo Nojima, and
Kevin J. McCullough
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2362-2365
Novel Inhibitors of Mitochondrial Respiratory Chain: Endoperoxides from the Marine Tunicate Stolonica socialis
Angelo Fontana,
Guido Cimino,
Margherita Gavagnin,
M. Carmen González, and
Ernesto Estornell
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2366-2369
Synthesis and Biological Activity of 7-Oxo Substituted Analogues of 5-Deaza-5,6,7,8-tetrahydrofolic Acid (5-DATHF) and 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid (DDATHF)
José I. Borrell,
Jordi Teixidó,
Josep Lluís Matallana,
Blanca Martínez-Teipel,
Carles Colominas,
Marta Costa,
Merche Balcells,
Elisabeth Schuler, and
María José Castillo
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2370-2373
Peptide Analogues of a Subdominant Epitope Expressed in EBV-Associated Tumors: Synthesis and Immunological Activity
Mauro Marastoni,
Martina Bazzaro,
Fabiola Micheletti,
Riccardo Gavioli, and
Roberto Tomatis
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2374-2377
Synthesis and Antibacterial Evaluation of Certain Quinolone Derivatives
Yeh-Long Chen,
Kuo-Chang Fang,
Jia-Yuh Sheu,
Shu-Lin Hsu, and
Cherng-Chyi Tzeng
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2378-2381
Conformational Analysis of a Glycosylated Human Myelin Oligodendrocyte Glycoprotein Peptide Epitope Able To Detect Antibody Response in Multiple Sclerosis
Alfonso Carotenuto,
Anna Maria D'Ursi,
Elena Nardi,
Anna Maria Papini, and
Paolo Rovero
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