Table of Contents
July 17, 2003
Volume 46, Issue 15
Pages 3181-3424
About the Cover: Connolly surface map of the X-ray structure of the α-thrombin-cyclopentenedicarboxylic acid derivative complex (yellow) at 1.9 Å resolution superimposed on the X-ray structure of the α-thrombin-PPACK complex (magenta) (Thorstensson, F.; et al. J. Med. Chem. 2003, 46, 1165-1179).
Letters
An Orally Bioavailable Oxime Ether Capsid Binder with Potent Activity against Human Rhinovirus
Keith G. Watson, Renee N. Brown, Rachel Cameron, David K. Chalmers, Stephanie Hamilton, Betty Jin, Guy Y. Krippner, Angela Luttick, Darryl B. McConnell, Phillip A. Reece, Jane Ryan, Pauline C. Stanislawski, Simon P. Tucker, Wen-Yang Wu, Dale L. Barnard, and Robert W. Sidwell
pp 3181–3184Publication Date (Web): June 18, 2003 (Letter)
DOI: 10.1021/jm0202876
Hi-Res PDFAcetogenins as Selective Inhibitors of the Human Ovarian 1A9 Tumor Cell Line1
Yuka Nakanishi, Fang-Rong Chang, Chih-Chuang Liaw, Yang-Chang Wu, Kenneth F. Bastow, and Kuo-Hsiung Lee
pp 3185–3188Publication Date (Web): June 21, 2003 (Letter)
DOI: 10.1021/jm020548b
Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor: Synthesis and Subtype Selectivity of N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine
Michael P. Johnson, Melvyn Baez, G. Erik Jagdmann, Jr., Thomas C. Britton, Thomas H. Large, David O. Callagaro, Joseph P. Tizzano, James A. Monn, and Darryle D. Schoepp
pp 3189–3192Publication Date (Web): June 12, 2003 (Letter)
DOI: 10.1021/jm034015u
First Dual Aromatase-Steroid Sulfatase Inhibitors
L. W. Lawrence Woo, Oliver B. Sutcliffe, Christian Bubert, Anna Grasso, Surinder K. Chander, Atul Purohit, Michael J. Reed, and Barry V. L. Potter
pp 3193–3196Publication Date (Web): June 13, 2003 (Letter)
DOI: 10.1021/jm034033b
(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: An Orally Bioavailable KCNQ2 Opener with Significant Activity in a Cortical Spreading Depression Model of Migraine
Yong-Jin Wu, Christopher G. Boissard, Corinne Greco, Valentin K. Gribkoff, David G. Harden, Huan He, Alexandre L'Heureux, Shing Hong Kang, Gene G. Kinney, Ronald J. Knox, Joanne Natale, Amy E. Newton, Sanna Lehtinen-Oboma, Michael W. Sinz, Digavalli V. Sivarao, John E. Starrett, Jr., Li-Qiang Sun, Svetlana Tertyshnikova, Mark W. Thompson, David Weaver, Henry S. Wong, Lei Zhang, and Steven I. Dworetzky
pp 3197–3200Publication Date (Web): June 12, 2003 (Letter)
DOI: 10.1021/jm034073f
Articles
Unique High-Affinity Synthetic μ-Opioid Receptor Agonists with Central- and Systemic-Mediated Analgesia
Yoshio Okada, Yuko Tsuda, Yoshio Fujita, Toshio Yokoi, Yusuke Sasaki, Akihiro Ambo, Ryoji Konishi, Mitsuhiro Nagata, Severo Salvadori, Yunden Jinsmaa, Sharon D. Bryant, and Lawrence H. Lazarus
pp 3201–3209Publication Date (Web): June 17, 2003 (Article)
DOI: 10.1021/jm020459z
QSAR and the Rational Design of Long-Acting Dual D2-Receptor/β2-Adrenoceptor Agonists
Rupert P. Austin, Patrick Barton, Roger V. Bonnert, Roger C. Brown, Peter A. Cage, David R. Cheshire, Andrew M. Davis, Iain G. Dougall, Francis Ince, Garry Pairaudeau, and Alan Young
pp 3210–3220Publication Date (Web): June 20, 2003 (Article)
DOI: 10.1021/jm020886c
Pharmacophoric Requirements for the Cannabinoid Side Chain. Probing the Cannabinoid Receptor Subsite at C1‘
Demetris P. Papahatjis, Spyros P. Nikas, Therapia Kourouli, Ravi Chari, Wei Xu, Roger G. Pertwee, and Alexandros Makriyannis
pp 3221–3229Publication Date (Web): June 21, 2003 (Article)
DOI: 10.1021/jm020558c
Novel Substituted Pyridinyl Imidazoles as Potent Anticytokine Agents with Low Activity against Hepatic Cytochrome P450 Enzymes
Stefan A. Laufer, Gerd K. Wagner, Dunja A. Kotschenreuther, and W. Albrecht
pp 3230–3244Publication Date (Web): June 24, 2003 (Article)
DOI: 10.1021/jm030766k
l-2‘,3‘-Didehydro-2‘,3‘-dideoxy-3‘-fluoronucleosides: Synthesis, Anti-HIV Activity, Chemical and Enzymatic Stability, and Mechanism of Resistance
Youhoon Chong, Giuseppe Gumina, Judy S. Mathew, Raymond F. Schinazi, and Chung K. Chu
pp 3245–3256Publication Date (Web): June 24, 2003 (Article)
DOI: 10.1021/jm0300274
Drug Rings Database with Web Interface. A Tool for Identifying Alternative Chemical Rings in Lead Discovery Programs
Xiao Qing Lewell, Andrew C. Jones, Craig L. Bruce, Gavin Harper, Matthew M. Jones, Iain M. Mclay, and John Bradshaw
pp 3257–3274Publication Date (Web): June 13, 2003 (Article)
DOI: 10.1021/jm0300429
Design, Synthesis, and Biological Evaluation of Cytotoxic 11-Alkenylindenoisoquinoline Topoisomerase I Inhibitors and Indenoisoquinoline−Camptothecin Hybrids
Brian M. Fox, Xiangshu Xiao, Smitha Antony, Glenda Kohlhagen, Yves Pommier, Bart L. Staker, Lance Stewart, and Mark Cushman
pp 3275–3282Publication Date (Web): June 17, 2003 (Article)
DOI: 10.1021/jm0300476
Isolation, Structure, Synthesis, and Bioactivity of a Novel Putative Insulin Mediator. A Galactosamine chiro-Inositol Pseudo-Disaccharide Mn2+ Chelate with Insulin-like Activity
Joseph Larner, John D. Price, Douglas Heimark, Leigh Smith, Gordon Rule, Thomas Piccariello, Manasses C. Fonteles, Carla Pontes, Daniele Vale, and Laura Huang
pp 3283–3291Publication Date (Web): June 21, 2003 (Article)
DOI: 10.1021/jm030071j
A Conformationally Locked Analogue of the Anti-HIV Agent Stavudine. An Important Correlation between Pseudorotation and Maximum Amplitude
Yongseok Choi, Clifford George, Maria J. Comin, Joseph J. Barchi, Jr., Hak Sung Kim, Kenneth A. Jacobson, Jan Balzarini, Hiroaki Mitsuya, Paul L. Boyer, Stephen H. Hughes, and Victor E. Marquez
pp 3292–3299Publication Date (Web): June 20, 2003 (Article)
DOI: 10.1021/jm030116g
Activation of Human Telomerase Reverse Transcriptase Expression by Some New Symmetrical Bis-Substituted Derivatives of the Anthraquinone
Hsu-Shan Huang, Jeng-Fong Chiou, Yaou Fong, Ching-Cheng Hou, Yu-Cheng Lu, Jen-Yi Wang, Jing-Wen Shih, Yen-Ru Pan, and Jing-Jer Lin
pp 3300–3307Publication Date (Web): June 13, 2003 (Article)
DOI: 10.1021/jm020492l
Characteristics of Selenazolidine Prodrugs of Selenocysteine: Toxicity and Glutathione Peroxidase Induction in V79 Cells
Megan D. Short, Yang Xie, Liang Li, Pamela B. Cassidy, and Jeanette C. Roberts
pp 3308–3313Publication Date (Web): June 17, 2003 (Article)
DOI: 10.1021/jm020496q
A Computational Model of Binding Thermodynamics: The Design of Cyclin-dependent Kinase 2 Inhibitors
Peter A. Sims, Chung F. Wong, and J. Andrew McCammon
pp 3314–3325Publication Date (Web): June 12, 2003 (Article)
DOI: 10.1021/jm0205043
Computer-Aided Selection of Potential Antihypertensive Compounds with Dual Mechanism of Action
Alexey A. Lagunin, Oleg A. Gomazkov, Dmitrii A. Filimonov, Tatyana A. Gureeva, Elvira A. Dilakyan, Elena V. Kugaevskaya, Yulia E. Elisseeva, Nina I. Solovyeva, and Vladimir V. Poroikov
pp 3326–3332Publication Date (Web): June 24, 2003 (Article)
DOI: 10.1021/jm021089h
Synthesis and in Vitro Characterization of 1-(4-Aminofurazan-3-yl)-5-dialkylaminomethyl-1H-[1,2,3]triazole-4-carboxylic Acid Derivatives. A New Class of Selective GSK-3 Inhibitors
Preben H. Olesen, Anders R. Sørensen, Birgitte Ursø, Peter Kurtzhals, Andrew N. Bowler, Ulrich Ehrbar, and Bo F. Hansen
pp 3333–3341Publication Date (Web): June 10, 2003 (Article)
DOI: 10.1021/jm021095d
Toward Tissue-Selective Pancreatic B-Cells KATP Channel Openers Belonging to 3-Alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-Dioxides
Pascal de Tullio, Bénédicte Becker, Stéphane Boverie, Michael Dabrowski, Philip Wahl, Marie-Hélène Antoine, Fabian Somers, Sophie Sebille, Raogo Ouedraogo, John Bondo Hansen, Philippe Lebrun, and Bernard Pirotte
pp 3342–3353Publication Date (Web): June 19, 2003 (Article)
DOI: 10.1021/jm021117w
Synthesis and Structure−Activity Studies of Novel Orally Active Non-Terpenoic 2,3-Oxidosqualene Cyclase Inhibitors
Henrietta Dehmlow, Johannes D. Aebi, Synèse Jolidon, Yu-Hua Ji, Elisabeth M. von der Mark, Jacques Himber, and Olivier H. Morand
pp 3354–3370Publication Date (Web): June 18, 2003 (Article)
DOI: 10.1021/jm021120f
Tethered Dimers as NAD Synthetase Inhibitors with Antibacterial Activity
Sadanandan E. Velu, Walter A. Cristofoli, Gabriel J. Garcia, Christie G. Brouillette, Milton C. Pierson, Chi-Hao Luan, Lawrence J. DeLucas, and Wayne J. Brouillette
pp 3371–3381Publication Date (Web): June 17, 2003 (Article)
DOI: 10.1021/jm030003x
Novel Benzylidene-9(10H)-anthracenones as Highly Active Antimicrotubule Agents. Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization
Helge Prinz, Yukihito Ishii, Takeo Hirano, Thomas Stoiber, Juan A. Camacho Gomez, Peter Schmidt, Heiko Düssmann, Angelika M. Burger, Jochen H. M. Prehn, Eckhard G. Günther, Eberhard Unger, and Kazuo Umezawa
pp 3382–3394Publication Date (Web): June 21, 2003 (Article)
DOI: 10.1021/jm0307685
Jatrophane Diterpenes as P-Glycoprotein Inhibitors. First Insights of Structure−Activity Relationships and Discovery of a New, Powerful Lead
Gabriella Corea, Ernesto Fattorusso, Virginia Lanzotti, Orazio Taglialatela-Scafati, Giovanni Appendino, Mauro Ballero, Pierre-Noël Simon, Charles Dumontet, and Attilio Di Pietro
pp 3395–3402Publication Date (Web): June 17, 2003 (Article)
DOI: 10.1021/jm030787e
Novel Bioactive and Stable Neurotensin Peptide Analogues Capable of Delivering Radiopharmaceuticals and Molecular Beacons to Tumors
Samuel Achilefu, Ananthacari Srinivasan, Michelle A. Schmidt, Hermo N. Jimenez, Joseph E. Bugaj, and Jack L. Erion
pp 3403–3411Publication Date (Web): June 20, 2003 (Article)
DOI: 10.1021/jm030081k
Exploring Structure−Activity Relationships of Transition State Analogues of Human Purine Nucleoside Phosphorylase
Gary B. Evans, Richard H. Furneaux, Andrzej Lewandowicz, Vern L. Schramm, and Peter C. Tyler
pp 3412–3423Publication Date (Web): June 20, 2003 (Article)
DOI: 10.1021/jm030145r
Additions and Corrections
2,4-Diaminothieno[2,3-d]pyrimidine Lipophilic Antifolates as Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase.
Andre Rosowsky, Andrew T. Papoulis, and Sherry F. Queener:
p 3424Publication Date (Web): June 17, 2003 (Addition/Correction)
DOI: 10.1021/jm030231r