| Cover Picture: Evaluation of Novel Epothilone Analogues by means of a Common Pharmacophore and a QSAR Pseudoreceptor Model for Taxanes and Epothilones (ChemMedChem 1/2010) Stefano Forli, Fabrizio Manetti, Karl-Heinz Altmann, Maurizio Botta 1  |
| Full: PDF (944 K) |
| Inside Cover: Anticancer Therapeutics That Target Selenoenzymes: Synthesis, Characterization, in vitro Cytotoxicity, and Thioredoxin Reductase Inhibition of a Series of Gold(I) Complexes Containing Hydrophilic Phosphine Ligands (ChemMedChem 1/2010) Elena Vergara, Angela Casini, Francesca Sorrentino, Olivier Zava, Elena Cerrada, Maria Pia Rigobello, Alberto Bindoli, Mariano Laguna, Paul J. Dyson 2  |
| Full: PDF (524 K) |
| Editorial: High Five! Peter Gölitz, Natalia Ortúzar, Scott D. Williams 3-6 |
| Full: PDF (493 K) |
| Graphical Abstract: ChemMedChem 1/2010 8-13 |
| Full: PDF (1656 K) |
| Spotlights on our sister journals: ChemMedChem 1/2010 16-18 |
| Full: PDF (767 K) |
| Bisubstrate Inhibitors of Protein Kinases: from Principle to Practical Applications Darja Lavogina, Erki Enkvist, Asko Uri 23-34  |
| Full: PDF (908 K) |
| Evaluation of Novel Epothilone Analogues by means of a Common Pharmacophore and a QSAR Pseudoreceptor Model for Taxanes and Epothilones Stefano Forli, Fabrizio Manetti, Karl-Heinz Altmann, Maurizio Botta 35-40  |
| Full: PDF (566 K) |
| Optimisation of Conoidin A, a Peroxiredoxin Inhibitor Gu Liu, Catherine H. Botting, Kathryn M. Evans, Jeffrey A. G. Walton, Guogang Xu, Alexandra M. Z. Slawin, Nicholas J. Westwood 41-45  |
| Full: PDF (450 K) |
| Water-soluble Organometallic Analogues of Oxaliplatin with Cytotoxic and Anticlonogenic Activity Michele Benedetti, Daniela Antonucci, Danilo Migoni, Vita M. Vecchio, Cosimo Ducani, Francesco P. Fanizzi 46-51  |
| Full: PDF (326 K) |
| Synthesis and Evaluation of Hybrid Bis-cationic Salts as Antimalarial Drugs Stéphanie Ortial, Séverine Denoyelle, Sharon Wein, Olivier Berger, Thierry Durand, Roger Escale, Alain Pellet, Henri Vial, Yen Vo-Hoang 52-55  |
| Full: PDF (221 K) |
| Rational Design of Amyloid Binding Agents Based on the Molecular Rotor Motif Jeyanthy Sutharsan, Marianna Dakanali, Christina C. Capule, Mark A. Haidekker, Jerry Yang, Emmanuel A. Theodorakis 56-60  |
| Full: PDF (290 K) |
| Inhibitors of Cathepsins K and S Identified Using the DynaMAD Virtual Screening Algorithm Dagmar Stumpfe, Mihiret T. Sisay, Maxim Frizler, Ingo Vogt, Michael Gütschow, Jürgen Bajorath 61-64  |
| Full: PDF (336 K) |
| Modulation on C- and N-Terminal Moieties of a Series of Potent and Selective Linear Tachykinin NK2 Receptor Antagonists Martina Gensini, Maria Altamura, Tula Dimoulas, Valentina Fedi, Danilo Giannotti, Sandro Giuliani, Antonio Guidi, Nicholas J. S. Harmat, Stefania Meini, Rossano Nannicini, Franco Pasqui, Manuela Tramontana, Antonio Triolo, Carlo Alberto Maggi 65-78  |
| Full: PDF (410 K) |
| Neuroprotective Effects of N-Alkyl-1,2,4-oxadiazolidine-3,5-diones and Their Corresponding Synthetic Intermediates N-Alkylhydroxylamines and N-1-Alkyl-3-carbonyl-1-hydroxyureas against in vitro Cerebral Ischemia Alain Cesar Biraboneye, Sebastien Madonna, Pamela Maher, Jean-Louis Kraus 79-85  |
| Full: PDF (266 K) |
| New Antimicrobial Hexapeptides: Synthesis, Antimicrobial Activities, Cytotoxicity, and Mechanistic Studies Rohit K. Sharma, Sandeep Sundriyal, Nishima Wangoo, Werner Tegge, Rahul Jain 86-95  |
| Full: PDF (379 K) |
| Anticancer Therapeutics That Target Selenoenzymes: Synthesis, Characterization, in vitro Cytotoxicity, and Thioredoxin Reductase Inhibition of a Series of Gold(I) Complexes Containing Hydrophilic Phosphine Ligands Elena Vergara, Angela Casini, Francesca Sorrentino, Olivier Zava, Elena Cerrada, Maria Pia Rigobello, Alberto Bindoli, Mariano Laguna, Paul J. Dyson 96-102  |
| Full: PDF (511 K) |
| Synthesis, Enzymatic Evaluation, and Docking Studies of Fluorogenic Caspase 8 Tetrapeptide Substrates Przemyslaw Reszka, Riad Schulz, Karen Methling, Michael Lalk, Patrick J. Bednarski 103-117  |
| Full: PDF (930 K) |
| Discovery of Potent Vascular Endothelial Growth Factor Receptor-2 Inhibitors Athanasios Papakyriakou, Maria E. Katsarou, Maria Belimezi, Michael Karpusas, Dionisios Vourloumis 118-129  |
| Full: PDF (821 K) |
| Novel Imatinib Derivatives with Altered Specificity between Bcr-Abl and FMS, KIT, and PDGF Receptors Konstantinos Skobridis, Maria Kinigopoulou, Vassiliki Theodorou, Emilia Giannousi, Alison Russell, Rakhee Chauhan, Roberta Sala, Nicola Brownlow, Serafim Kiriakidis, Jan Domin, Andreas G. Tzakos, Nick J. Dibb 130-139  |
| Full: PDF (664 K) |
| Bisnaphthalimidopropyl Derivatives as Inhibitors of Leishmania SIR2 Related Protein 1 Joana Tavares, Ali Ouaissi, Paul Kong Thoo Lin, Inês Loureiro, Simranjeet Kaur, Nilanjan Roy, Anabela Cordeiro-da-Silva 140-147  |
| Full: PDF (724 K) |
| Comparison of Structure- and Ligand-Based Virtual Screening Protocols Considering Hit List Complementarity and Enrichment Factors Dennis M. Krüger, Andreas Evers 148-158  |
| Full: PDF (1472 K) |
| Post-translational Modification of Protein Biopharmaceuticals. Edited by Gary Walsh. Benjamin G. Davis 159 |
| Full: PDF (86 K) |
| Hyaluronan in Cancer Biology. Edited by Robert Stern. Mark Slevin 160 |
| Full: PDF (73 K) |
| Preview: ChemMedChem 2/2010 163 |
| Full: PDF (74 K) |