Table of Contents
January 30, 2003
Volume 46, Issue 3
Pages 319-444
Perspectives
5-HT4 Receptor Ligands: Applications and New Prospects
Michel Langlois and Rodolphe Fischmeister
pp 319–344Publication Date (Web): January 04, 2003 (Perspective)
DOI: 10.1021/jm020099f
Hi-Res PDFPhenethyl Amides as Novel Noncovalent Inhibitors of Hepatitis C Virus NS3/4A Protease: Discovery, Initial SAR, and Molecular Modeling
Stefania Colarusso, Uwe Koch, Benjamin Gerlach, Christian Steinkühler, Raffaele De Francesco, Sergio Altamura, Victor G. Matassa, and Frank Narjes
pp 345–348Publication Date (Web): December 21, 2002 (Letter)
DOI: 10.1021/jm025594q
Hybrid-Designed Inhibitors of p38 MAP Kinase Utilizing N-Arylpyridazinones
Steven L. Colletti, Jessica L. Frie, Elizabeth C. Dixon, Suresh B. Singh, Bernard K. Choi, Giovanna Scapin, Catherine E. Fitzgerald, Sanjeev Kumar, Elizabeth A. Nichols, Stephen J. O'Keefe, Edward A. O'Neill, Gene Porter, Koppara Samuel, Dennis M. Schmatz, Cheryl D. Schwartz, Wesley L. Shoop, Chris M. Thompson, James E. Thompson, Ruixiu Wang, Andrea Woods, Dennis M. Zaller, and James B. Doherty
pp 349–352Publication Date (Web): December 20, 2002 (Letter)
DOI: 10.1021/jm025585h
3‘-Aminoadenosine-5‘-uronamides: Discovery of the First Highly Selective Agonist at the Human Adenosine A3 Receptor
Michael P. DeNinno, Hiroko Masamune, Lois K. Chenard, Kenneth J. DiRico, Cynthia Eller, John B. Etienne, Jeanene E. Tickner, Scott P. Kennedy, Delvin R. Knight, Jimmy Kong, Joseph J. Oleynek, W. Ross Tracey, and Roger J. Hill
pp 353–355Publication Date (Web): December 20, 2002 (Letter)
DOI: 10.1021/jm0255724
Ketones as Building Blocks for Dynamic Combinatorial Libraries: Highly Active Neuraminidase Inhibitors Generated via Selection Pressure of the Biological Target
Matthias Hochgürtel, Ralf Biesinger, Heiko Kroth, Dorothea Piecha, Michael W. Hofmann, Sonja Krause, Otmar Schaaf, Claude Nicolau, and Alexey V. Eliseev
pp 356–358Publication Date (Web): January 03, 2003 (Letter)
DOI: 10.1021/jm025589m
Articles
Human Factor Xa Bound Amidine Inhibitor Conformation by Double Rotational-Echo Double Resonance Nuclear Magnetic Resonance and Molecular Dynamics Simulations
Lynda M. McDowell, Margaret A. McCarrick, Daniel R. Studelska, Robert D. O'Connor, David R. Light, William J. Guilford, Damian Arnaiz, Marc Adler, Jerry L. Dallas, Barbara Poliks, and Jacob Schaefer
pp 359–363Publication Date (Web): January 01, 2003 (Article)
DOI: 10.1021/jm0202324
New Amide-Bearing Benzolactam-Based Protein Kinase C Modulators Induce Enhanced Secretion of the Amyloid Precursor Protein Metabolite sAPPα
Alan P. Kozikowski, Ireneusz Nowak, Pavel A. Petukhov, Rene Etcheberrigaray, Ali Mohamed, Mathew Tan, Nancy Lewin, Henry Hennings, Larry L. Pearce, and Peter M. Blumberg
pp 364–373Publication Date (Web): December 13, 2002 (Article)
DOI: 10.1021/jm020350r
Topomer CoMFA: A Design Methodology for Rapid Lead Optimization
Richard D. Cramer
pp 374–388Publication Date (Web): January 01, 2003 (Article)
DOI: 10.1021/jm020194o
Synthesis, Anti-HIV Activity, and Molecular Mechanism of Drug Resistance of l-2‘,3‘-Didehydro-2‘,3‘-dideoxy-2‘-fluoro-4‘-thionucleosides
Hyunah Choo, Youhoon Chong, Yongseok Choi, Judy Mathew, Raymond F. Schinazi, and Chung K. Chu
pp 389–398Publication Date (Web): December 20, 2002 (Article)
DOI: 10.1021/jm020376i
Indanylidenes. 1. Design and Synthesis of (E)-2-(4,6-Difluoro-1-indanylidene)acetamide, a Potent, Centrally Acting Muscle Relaxant with Antiinflammatory and Analgesic Activity
David L. Musso, Felicia R. Cochran, James L. Kelley, Ed W. McLean, Jeffrey L. Selph, Greg C. Rigdon, G. Faye Orr, Ronda G. Davis, Barrett R. Cooper, Virgil L. Styles, James B. Thompson, and William R. Hall
pp 399–408Publication Date (Web): December 31, 2002 (Article)
DOI: 10.1021/jm020067s
Indanylidenes. 2. Design and Synthesis of (E)-2-(4-Chloro-6-fluoro-1-indanylidene)-N-methylacetamide, a Potent Antiinflammatory and Analgesic Agent without Centrally Acting Muscle Relaxant Activity
David L. Musso, G. Faye Orr, Felicia R. Cochran, James L. Kelley, Jeffrey L. Selph, Greg C. Rigdon, Barrett R. Cooper, and Michael L. Jones
pp 409–416Publication Date (Web): December 31, 2002 (Article)
DOI: 10.1021/jm020068k
Substituted Pyrrol-1-ylacetic Acids That Combine Aldose Reductase Enzyme Inhibitory Activity and Ability To Prevent the Nonenzymatic Irreversible Modification of Proteins from Monosaccharides
Ioannis Nicolaou and Vassilis J. Demopoulos
pp 417–426Publication Date (Web): December 21, 2002 (Article)
DOI: 10.1021/jm0209477
Synthesis and Biological Activity of Nitro Heterocycles Analogous to Megazol, a Trypanocidal Lead
Gérard Chauvière, Bernard Bouteille, Bertin Enanga, Cristina de Albuquerque, Simon L. Croft, Michel Dumas, and Jacques Périé
pp 427–440Publication Date (Web): January 04, 2003 (Article)
DOI: 10.1021/jm021030a
Brief Articles
Furoyl and Benzofuroyl Pyrroloquinolones as Potent and Selective PDE5 Inhibitors for Treatment of Erectile Dysfunction
Weiqin Jiang, Zhihua Sui, Mark J. Macielag, Shawn P. Walsh, James J. Fiordeliso, James C. Lanter, Jihua Guan, Yuhong Qiu, Patricia Kraft, Sheela Bhattacharjee, Elizabeth Craig, Donna Haynes-Johnson, T. Matthew John, and Joanna Clancy
pp 441–444Publication Date (Web): December 28, 2002 (Brief Article)
DOI: 10.1021/jm0202573