Table of Contents
March 13, 2003
Volume 46, Issue 6
Pages 883-1080
Perspectives
Antiestrogens and Selective Estrogen Receptor Modulators as Multifunctional Medicines. 1. Receptor Interactions
V. Craig Jordan
pp 883–908Publication Date (Web): February 25, 2003 (Perspective)
DOI: 10.1021/jm020449y
Hi-Res PDF Letters
A Novel Atypical Retinoid Endowed with Proapoptotic and Antitumor Activity
Raffaella Cincinelli, Sabrina Dallavalle, Lucio Merlini, Sergio Penco, Claudio Pisano, Paolo Carminati, Giuseppe Giannini, Loredana Vesci, Carlo Gaetano, Barbara Illy, Valentina Zuco, Rosanna Supino, and Franco Zunino
pp 909–912Publication Date (Web): February 19, 2003 (Letter)
DOI: 10.1021/jm025593y
1,2-Dihydro-4-quinazolinamines: Potent, Highly Selective Inhibitors of Inducible Nitric Oxide Synthase Which Show Antiinflammatory Activity in Vivo
Alan C. Tinker, Haydn G. Beaton, Nigel Boughton-Smith, Tony R. Cook, Sally L. Cooper, Lynne Fraser-Rae, Kay Hallam, Peter Hamley, Tom McInally, David J. Nicholls, Austen D. Pimm, and Alan V. Wallace
pp 913–916Publication Date (Web): February 07, 2003 (Letter)
DOI: 10.1021/jm0255926
Simple, Potent, and Selective Pyrrole Inhibitors of Monoamine Oxidase Types A and B
Romano Silvestri, Giuseppe La Regina, Gabriella De Martino, Marino Artico, Olivia Befani, Marianna Palumbo, Enzo Agostinelli, and Paola Turini
pp 917–920Publication Date (Web): February 15, 2003 (Letter)
DOI: 10.1021/jm0256124
Synthesis, Nicotinic Acetylcholine Receptor Binding Affinities, and Molecular Modeling of Constrained Epibatidine Analogues
Zhi-Liang Wei, Pavel A. Petukhov, Yingxian Xiao, Werner Tückmantel, Clifford George, Kenneth J. Kellar, and Alan P. Kozikowski
pp 921–924Publication Date (Web): February 15, 2003 (Letter)
DOI: 10.1021/jm025613w
Articles
Synthesis and Characterization of Iodine-123 Labeled 2β-Carbomethoxy-3β-(4‘-((Z)-2-iodoethenyl)phenyl)nortropane. A Ligand for in Vivo Imaging of Serotonin Transporters by Single-Photon-Emission Tomography
Mark M. Goodman, Ping Chen, Christophe Plisson, Laurent Martarello, James Galt, John R. Votaw, Clinton D. Kilts, Gene Malveaux, Vernon M. Camp, Bing Shi, Timothy D. Ely, Leonard Howell, Jon McConathy, and Charles B. Nemeroff
pp 925–935Publication Date (Web): February 15, 2003 (Article)
DOI: 10.1021/jm0100180
Regioselective Covalent Modification of Hemoglobin in Search of Antisickling Agents
Soobong Park, Brittany L. Hayes, Fatima Marankan, Debbie C. Mulhearn, Linda Wanna, Andrew D. Mesecar, Bernard D. Santarsiero, Michael E. Johnson, and Duane L. Venton
pp 936–953Publication Date (Web): February 07, 2003 (Article)
DOI: 10.1021/jm020361k
Structure−Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 2. Role of the Substituents on the Phenyl Ring and Nitrogen Atoms of Caproctamine
Vincenzo Tumiatti, Michela Rosini, Manuela Bartolini, Andrea Cavalli, Gabriella Marucci, Vincenza Andrisano, Piero Angeli, Rita Banzi, Anna Minarini, Maurizio Recanatini, and Carlo Melchiorre
pp 954–966Publication Date (Web): February 14, 2003 (Article)
DOI: 10.1021/jm021055+
Full Text HTML4-Hydroxymethyl-3-aminoacridine Derivatives as a New Family of Anticancer Agents
Franck Charmantray, Martine Demeunynck, Danièle Carrez, Alain Croisy, Amélie Lansiaux, Christian Bailly, and Pierre Colson
pp 967–977Publication Date (Web): February 15, 2003 (Article)
DOI: 10.1021/jm020389w
Synthesis and Cytotoxic Activity of Conjugates of Muramyl and Normuramyl Dipeptides with Batracylin Derivatives
Krystyna Dzierzbicka, Piotr Trzonkowski, Przemysław Sewerynek, and Andrzej Myśliwski
pp 978–986Publication Date (Web): February 19, 2003 (Article)
DOI: 10.1021/jm021067v
Antitumor Activity of Novel Deoxoartemisinin Monomers, Dimers, and Trimer
Mankil Jung, Sangmin Lee, Jungyeob Ham, Kyunghoon Lee, Hanjo Kim, and Soo Kie Kim
pp 987–994Publication Date (Web): February 15, 2003 (Article)
DOI: 10.1021/jm020119d
Synthesis of 3‘- and 5‘-Nitrooxy Pyrimidine Nucleoside Nitrate Esters: “Nitric Oxide Donor” Agents for Evaluation as Anticancer and Antiviral Agents
Ebrahim Naimi, Aihua Zhou, Panteha Khalili, Leonard I. Wiebe, Jan Balzarini, Erik De Clercq, and Edward E. Knaus
pp 995–1004Publication Date (Web): February 12, 2003 (Article)
DOI: 10.1021/jm020299r
Synthesis and Structure−Activity Relationships of 5-Amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic Acid Antibacterials Having Fluorinated 7-[(3R)-3-(1-Aminocyclopropan-1-yl)pyrrolidin-1-yl] Substituents1
Hiroaki Inagaki, Satoru Miyauchi, Rie N. Miyauchi, Haruko C. Kawato, Hitoshi Ohki, Norikazu Matsuhashi, Katsuhiro Kawakami, Hisashi Takahashi, and Makoto Takemura
pp 1005–1015Publication Date (Web): February 07, 2003 (Article)
DOI: 10.1021/jm020328y
Nonsteroidal Selective Glucocorticoid Modulators: The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines
Philip R. Kym, Michael E. Kort, Michael J. Coghlan, Jimmie L. Moore, Rui Tang, James D. Ratajczyk, Daniel P. Larson, Steven W. Elmore, John K. Pratt, Michael A. Stashko, H. Douglass Falls, Chun W. Lin, Masake Nakane, Loan Miller, Curtis M. Tyree, Jeffery N. Miner, Peer B. Jacobson, Denise M. Wilcox, Phong Nguyen, and Benjamin C. Lane
pp 1016–1030Publication Date (Web): February 19, 2003 (Article)
DOI: 10.1021/jm020335m
Systematic Development of High Affinity Bis(ammonio)alkane-type Allosteric Enhancers of Muscarinic Ligand Binding
Mathias Muth, Wiebke Bender, Olaf Scharfenstein, Ulrike Holzgrabe, Edith Balatkova, Christian Tränkle, and Klaus Mohr
pp 1031–1040Publication Date (Web): February 07, 2003 (Article)
DOI: 10.1021/jm021017q
Trypanocidal Activity of Conformationally Restricted Pentamidine Congeners
Isaac O. Donkor, Tien L. Huang, Bin Tao, Donna Rattendi, Schennella Lane, Marc Vargas, Burt Goldberg, and Cyrus Bacchi
pp 1041–1048Publication Date (Web): February 13, 2003 (Article)
DOI: 10.1021/jm020375q
Synthesis and Cytotoxic Activity of Carboxamide Derivatives of Benzo[b][1,6]naphthyridines
Leslie W. Deady, Thomas Rodemann, Li Zhuang, Bruce C. Baguley, and William A. Denny
pp 1049–1054Publication Date (Web): February 05, 2003 (Article)
DOI: 10.1021/jm020420u
[(3-Chlorophenyl)piperazinylpropyl]pyridazinones and Analogues as Potent Antinociceptive Agents
Maria Paola Giovannoni, Claudia Vergelli, Carla Ghelardini, Nicoletta Galeotti, Alessandro Bartolini, and Vittorio Dal Piaz
pp 1055–1059Publication Date (Web): January 30, 2003 (Article)
DOI: 10.1021/jm021057u
Orally Active, Antimalarial, Anticancer, Artemisinin-Derived Trioxane Dimers with High Stability and Efficacy
Gary H. Posner, Ik-Hyeon Paik, Surojit Sur, Andrew J. McRiner, Kristina Borstnik, Suji Xie, and Theresa A. Shapiro
pp 1060–1065Publication Date (Web): February 15, 2003 (Article)
DOI: 10.1021/jm020461q
QSAR and Classification of Murine and Human Soluble Epoxide Hydrolase Inhibition by Urea-Like Compounds
Nathan R. McElroy and Peter C. JursChristophe Morisseau and Bruce D. Hammock
pp 1066–1080Publication Date (Web): February 20, 2003 (Article)
DOI: 10.1021/jm020269o