Journal of Medicinal Chemistry
Volume 39, Issue 10 (May 10, 1996)
Copyright © 1996 American Chemical Society

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1935-1937

11-Ketotigogenin Cellobioside (Pamaqueside): A Potent Cholesterol Absorption Inhibitor in the Hamster Peter A. McCarthy, Michael P. DeNinno, Lee A. Morehouse, Charles E. Chandler, Faan Wen Bangerter, Theresa C. Wilson, Frank J. Urban, Stanley W. Walinsky, Patricia G. Cosgrove, Kimberly Duplantier, John B. Etienne, Michael A. Fowler, John F. Lambert, John P. O'Donnell, Susan L. Pezzullo, Harry A. Watson, Jr., Robert W. Wilkins, Lawrence M. Zaccaro, and Michael P. Zawistoski [Full Article - PDF]

1938-1940

Drug Delivery Systems. 2. Camptothecin 20-O-Poly(ethylene glycol) Ester Transport Forms Richard B. Greenwald, Annapurna Pendri, Charles Conover, Carl Gilbert, Ross Yang, and Jing Xia [Full Article - PDF]

1941-1942

3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: An Antagonist with High Affinity and Selectivity for the Human Dopamine D4 Receptor Janusz J. Kulagowski, Howard B. Broughton, Neil R. Curtis, Ian M. Mawer, Mark P. Ridgill, Raymond Baker, Frances Emms, Stephen B. Freedman, Rosemarie Marwood, Shil Patel, Smita Patel, C. Ian Ragan, and Paul D. Leeson [Full Article - PDF]

1943-1945

5-(4-Chlorophenyl)-4-methyl-3-(1-(2- phenylethyl)piperidin-4-yl)isoxazole: A Potent, Selective Antagonist at Human Cloned Dopamine D4 Receptors Michael Rowley, Howard B. Broughton, Ian Collins, Raymond Baker, Frances Emms, Rosemarie Marwood, Shil Patel, Smita Patel, C. Ian Ragan, Stephen B. Freedman, and Paul D. Leeson [Full Article - PDF]

1946-1948

Design and Synthesis of 2-Naphthoate Esters as Selective Dopamine D4 Antagonists Izzy Boyfield, Thomas H. Brown, Martyn C. Coldwell, David G. Cooper, Michael S. Hadley, Jim J. Hagan, Maureen A. Healy, Amanda Johns, Ron J. King, Derek N. Middlemiss, David J. Nash, Graham J. Riley, Emma E. Scott, Stephen A. Smith, and Geoffrey Stemp [Full Article - PDF]

1949-1955

Screening Derivatized Peptide Libraries for Tight Binding Inhibitors to Carbonic Anhydrase II by Electrospray Ionization-Mass Spectrometry Jinming Gao, Xueheng Cheng, Ruidan Chen, George B. Sigal, James E. Bruce, Brenda L. Schwartz, Steven A. Hofstadler, Gordon A. Anderson, Richard D. Smith, and George M. Whitesides [Full Article - PDF]

1956-1966

Asymmetric Syntheses, Opioid Receptor Affinities, and Antinociceptive Effects of 8-Amino-5,9-methanobenzocyclooctenes, a New Class of Structural Analogues of the Morphine Alkaloids Arthur G. Schultz,,1a Aihua Wang,1a Carlos Alva,1a Alice Sebastian,1a Stanley D. Glick,1b Darlene C. Deecher,1b and Jean M. Bidlack1c [Full Article - PDF]

1967-1974

(Aminoalkyl)indole Isothiocyanates as Potential Electrophilic Affinity Ligands for the Brain Cannabinoid Receptor Koichiro Yamada, Kenner C. Rice, Judith L. Flippen-Anderson, Michael A. Eissenstat, Susan J. Ward, M. Ross Johnson, and Allyn C. Howlett [Full Article - PDF]

1975-1980

Antitumor Agents. 166. Synthesis and Biological Evaluation of 5,6,7,8-Substituted-2-phenylthiochromen-4-ones Hui-Kang Wang, Kenneth F. Bastow, L. Mark Cosentino, and Kuo-Hsiung Lee [Full Article - PDF]

1981-1990

Decomposition Pathways and in Vitro HIV Inhibitory Effects of IsoddA Pronucleotides: Toward a Rational Approach for Intracellular Delivery of Nucleoside 5'-Monophosphates Gilles Valette, Alain Pompon, Jean-Luc Girardet, Loredana Cappellacci, Palmarisa Franchetti, Mario Grifantini, Paolo La Colla, Anna Giulia Loi, Christian Périgaud, Gilles Gosselin, and Jean-Louis Imbach [Full Article - PDF]

1991-2007

Aminodiol HIV Protease Inhibitors. Synthesis And Structure-Activity Relationships Of P1/P1' Compounds: Correlation between Lipophilicity and Cytotoxicity Ping Chen, Peter T. W. Cheng, Masud Alam, Barbara D. Beyer, Gregory S. Bisacchi, Tamara Dejneka, Adelaide J. Evans, Jill A. Greytok, Mark A. Hermsmeier, W. Griffith Humphreys, Glenn A. Jacobs, Octavian Kocy, Pin-Fang Lin, Karen A. Lis, Michael A. Marella, Denis E. Ryono, Amy K. Sheaffer, Steven H. Spergel, Chong-qing Sun, Joseph A. Tino, Gregory Vite, Richard J. Colonno, Robert Zahler, and Joel C. Barrish [Full Article - PDF]

2008-2017

Rational Design of True Hirudin Mimetics: Synthesis and Characterization of Multisite-Directed -Thrombin Inhibitors Angela Lombardi, Flavia Nastri, Rossella Della Morte, Armando Rossi, Alfredo De Rosa, Norma Staiano, Carlo Pedone, and Vincenzo Pavone [Full Article - PDF]

2018-2029

Oxidation Chemistry of (-)-Norepinephrine in the Presence of L-Cysteine Xue-Ming Shen and Glenn Dryhurst [Full Article - PDF]

2030-2039

Partially Modified Retro-Inverso Pseudopeptides as Non-natural Ligands for the Human Class I Histocompatibility Molecule HLA-A2 Gilles Guichard, Francine Connan, Roland Graff, Marina Ostankovitch, Sylviane Muller, Jean-Gérard Guillet, Jeannine Choppin, and Jean-Paul Briand [Full Article - PDF]

2040-2046

Synthesis of Novel Se-Substituted Selenocysteine Derivatives as Potential Kidney Selective Prodrugs of Biologically Active Selenol Compounds: Evaluation of Kinetics of -Elimination Reactions in Rat Renal Cytosol Ioanna Andreadou, Wiro M. P. B. Menge, Jan N. M. Commandeur, Eduard A. Worthington, and Nico P. E. Vermeulen [Full Article - PDF]

2047-2054

Discovery of Novel, Non-Peptide HIV-1 Protease Inhibitors by Pharmacophore Searching Shaomeng Wang, G. W. A. Milne, Xinjian Yan, Isadora J. Posey, Marc C. Nicklaus, Lisa Graham, and William G. Rice [Full Article - PDF]

2055-2059

Studies on Selectin Blockers. 2. Novel Selectin Blocker as Potential Therapeutics for Inflammatory Disorders Yukihisa Wada, Tadayuki Saito, Naomi Matsuda, Hiroshi Ohmoto, Kohichiro Yoshino, Masami Ohashi, and Hirosato Kondo , Hideharu Ishida, Makoto Kiso, and Akira Hasegawa [Full Article - PDF]

2060-2067

Inhibitors of Human Immunodeficiency Virus Type 1 Protease Containing 2-Aminobenzyl-Substituted 4-Amino-3-hydroxy-5-phenylpentanoic Acid: Synthesis, Activity, and Oral Bioavailability Philipp Lehr, Andreas Billich, Brigitte Charpiot, Peter Ettmayer, Dieter Scholz, Brigitte Rosenwirth, and Hubert Gstach [Full Article - PDF]

2068-2080

Novel Selective and Partial Agonists of 5-HT3 Receptors. Part 1. Synthesis and Biological Evaluation of Piperazinopyrrolothienopyrazines Sylvain Rault, Jean-Charles Lancelot, Hervé Prunier, Max Robba, Pierre Renard, Philippe Delagrange, Bruno Pfeiffer, Daniel-Henri Caignard, Béatrice Guardiola-Lemaitre, and Michel Hamon [Full Article - PDF]

2081-2086

Probes for Narcotic Receptor-Mediated Phenomena. 21. Novel Derivatives of 3-(1,2,3,4,5,11-Hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol-6-yl)- phenols with Improved Opioid Receptor Selectivity Craig M. Bertha, Matthew Ellis, Judith L. Flippen-Anderson, Frank Porreca, Richard B. Rothman, Peg Davis, Heng Xu, Karen Becketts, and Kenner C. Rice [Full Article - PDF]

2087-2094

Structure-Activity Relationships of Boronic Acid Inhibitors of Dipeptidyl Peptidase IV. 1. Variation of the P2 Position of Xaa-boroPro Dipeptides Simon J. Coutts, Terence A. Kelly, Roger J. Snow, Charles A. Kennedy, Randall W. Barton, Julian Adams, Dale A. Krolikowski, Dorothy M. Freeman, Scot J. Campbell, John F. Ksiazek, and William W. Bachovchin [Full Article - PDF]

2095-2101

Design and Synthesis of New Linear and Cyclic Bradykinin Antagonists Christophe Thurieau, Michel Félétou, Philippe Hennig, Eric Raimbaud, Emmanuel Canet, and Jean-Luc Fauchère [Full Article - PDF]

2102-2102

Synthesis of Substituted 1-Norbornylamines with Antiviral Activity A. García Martínez, E. Teso Vilar, A. García Fraile, S. de la Moya Cerero, M. E. Rodríguez Herrero, P. Martínez Ruiz, L. R. Subramanian, and A. García Gancedo [Full Article - PDF]