Table of Contents
October 23, 2003
Volume 46, Issue 22
Pages 4625-4804
About the Cover: CConnolly surface map of the X-ray structure of the α-thrombin-cyclopentenedicarboxylic acid derivative complex (yellow) at 1.9 Å resolution superimposed on the X-ray structure of the α-thrombin-PPACK complex (magenta) (Thorstensson, F.; et al. J. Med. Chem. 2003, 46, 1165-1179).
Miniperspective
Human β-Secretase (BACE) and BACE Inhibitors
Varghese John, James P. Beck, Michael J. Bienkowski, Sukanto Sinha, and Robert L. Heinrikson
pp 4625–4630Publication Date (Web): September 24, 2003 (Perspective)
DOI: 10.1021/jm030247h
Hi-Res PDFThienyl and Phenyl α-Halomethyl Ketones: New Inhibitors of Glycogen Synthase Kinase (GSK-3β) from a Library of Compound Searching
Santiago Conde, Daniel I. Pérez, Ana Martínez, Concepción Perez, and Francisco J. Moreno
pp 4631–4633Publication Date (Web): September 20, 2003 (Letter)
DOI: 10.1021/jm034108b
Inclusion Complexation and Solubilization of Paclitaxel by Bridged Bis(β-cyclodextrin)s Containing a Tetraethylenepentaamino Spacer
Yu Liu, Guo-Song Chen, Li Li, Heng-Yi Zhang, Dong-Xu Cao, and Ying-Jin Yuan
pp 4634–4637Publication Date (Web): September 23, 2003 (Letter)
DOI: 10.1021/jm034148f
Articles
Kinases, Homology Models, and High Throughput Docking
David J. Diller and Rixin Li
pp 4638–4647Publication Date (Web): September 20, 2003 (Article)
DOI: 10.1021/jm020503a
Development of Potent Inhibitors of Botulinum Neurotoxin Type B
Christine Anne, Serge Turcaud, Jean Quancard, Franck Teffo, Hervé Meudal, Marie-Claude Fournié-Zaluski, and Bernard P. Roques
pp 4648–4656Publication Date (Web): September 19, 2003 (Article)
DOI: 10.1021/jm0300680
Receptor-Guided Alignment-Based Comparative 3D-QSAR Studies of Benzylidene Malonitrile Tyrphostins as EGFR and HER-2 Kinase Inhibitors
Shantaram Kamath and John K. Buolamwini
pp 4657–4668Publication Date (Web): September 25, 2003 (Article)
DOI: 10.1021/jm030065n
Thermal Denaturation: A Method to Rank Slow Binding, High-Affinity P38α MAP Kinase Inhibitors
Rachel R. Kroe, John Regan, Al Proto, Gregory W. Peet, Tapon Roy, Laura D. Landro, Natalie G. Fuschetto, Christopher A. Pargellis, and Richard H. Ingraham
pp 4669–4675Publication Date (Web): September 20, 2003 (Article)
DOI: 10.1021/jm030120s
Structure−Activity Relationships of the p38α MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796)
John Regan, Alison Capolino, Pier F. Cirillo, Thomas Gilmore, Anne G. Graham, Eugene Hickey, Rachel R. Kroe, Jeffrey Madwed, Monica Moriak, Richard Nelson, Christopher A. Pargellis, Alan Swinamer, Carol Torcellini, Michele Tsang, and Neil Moss
pp 4676–4686Publication Date (Web): September 20, 2003 (Article)
DOI: 10.1021/jm030121k
Molecular Determinants of Steroid Inhibition for the Mouse Constitutive Androstane Receptor
Johanna Jyrkkärinne, Janne Mäkinen, Jukka Gynther, Heidi Savolainen, Antti Poso, and Paavo Honkakoski
pp 4687–4695Publication Date (Web): September 27, 2003 (Article)
DOI: 10.1021/jm030861t
Design, Synthesis, and Crystal Structure of Selective 2-Pyridone Tissue Factor VIIa Inhibitors
John J. Parlow, Ravi G. Kurumbail, Roderick A. Stegeman, Anna M. Stevens, William C. Stallings, and Michael S. South
pp 4696–4701Publication Date (Web): September 13, 2003 (Article)
DOI: 10.1021/jm0301686
Design and Synthesis of 4-Azaindoles as Inhibitors of p38 MAP Kinase
Alejandra Trejo, Humberto Arzeno, Michelle Browner, Sushmita Chanda, Soan Cheng, Daniel D. Comer, Stacie A. Dalrymple, Pete Dunten, JoAnn Lafargue, Brett Lovejoy, Jose Freire-Moar, Julie Lim, Joel Mcintosh, Jennifer Miller, Eva Papp, Deborah Reuter, Rick Roberts, Florentino Sanpablo, John Saunders, Kyung Song, Armando Villasenor, Stephen D. Warren, Mary Welch, Paul Weller, Phyllis E. Whiteley, Lu Zeng, and David M. Goldstein
pp 4702–4713Publication Date (Web): September 19, 2003 (Article)
DOI: 10.1021/jm0301787
Azasterols as Inhibitors of Sterol 24-Methyltransferase in Leishmania Species and Trypanosoma cruzi
Filippo Magaraci, Carmen Jimenez Jimenez, Carlos Rodrigues, Juliany C. F. Rodrigues, Marina Vianna Braga, Vanessa Yardley, Kate de Luca-Fradley, Simon L. Croft, Wanderley de Souza, Luis M. Ruiz-Perez, Julio Urbina, Dolores Gonzalez Pacanowska, and Ian H. Gilbert
pp 4714–4727Publication Date (Web): September 20, 2003 (Article)
DOI: 10.1021/jm021114j
Synthesis and Pharmacological Evaluation of 1-Oxo-2-(3-piperidyl)-1,2,3,4- tetrahydroisoquinolines and Related Analogues as a New Class of Specific Bradycardic Agents Possessing If Channel Inhibitory Activity
Hideki Kubota, Akio Kakefuda, Toshihiro Watanabe, Noe Ishii, Koichi Wada, Noriyuki Masuda, Shuichi Sakamoto, and Shin-ichi Tsukamoto
pp 4728–4740Publication Date (Web): September 27, 2003 (Article)
DOI: 10.1021/jm0301742
Convergent Synthesis and Unexpected Ca2+-Mobilizing Activity of 8-Substituted Analogues of Cyclic ADP-Carbocyclic-Ribose, a Stable Mimic of the Ca2+-Mobilizing Second Messenger Cyclic ADP-Ribose
Satoshi Shuto, Masayoshi Fukuoka, Takashi Kudoh, Clive Garnham, Antony Galione, Barry V. L. Potter, and Akira Matsuda
pp 4741–4749Publication Date (Web): September 23, 2003 (Article)
DOI: 10.1021/jm030227f
Adenosine Kinase Inhibitors. 3. Synthesis, SAR, and Antiinflammatory Activity of a Series of l-Lyxofuranosyl Nucleosides
Bheemarao G. Ugarkar, Angelo J. Castellino, Jay S. DaRe, Michele Ramirez-Weinhouse, Joseph J. Kopcho, Sanna Rosengren, and Mark D. Erion
pp 4750–4760Publication Date (Web): September 23, 2003 (Article)
DOI: 10.1021/jm030230z
Synthesis and Antiprotozoal Activity of Aza-Analogues of Furamidine
Mohamed A. Ismail, Reto Brun, Judy D. Easterbrook, Farial A. Tanious, W. David Wilson, and David W. Boykin
pp 4761–4769Publication Date (Web): September 27, 2003 (Article)
DOI: 10.1021/jm0302602
Finding Discriminating Structural Features by Reassembling Common Building Blocks
Kevin P. Cross, Glenn Myatt, Chihae Yang, Michael A. Fligner, Joseph S. Verducci, and Paul E. Blower, Jr.
pp 4770–4775Publication Date (Web): September 25, 2003 (Article)
DOI: 10.1021/jm0302703
Potent Inhibition of NTPase/Helicase of the West Nile Virus by Ring-Expanded (“Fat”) Nucleoside Analogues
Ning Zhang, Huan-Ming Chen, Verena Koch, Herbert Schmitz, Michal Minczuk, Piotr Stepien, Ali I. Fattom, Robert B. Naso, Kishna Kalicharran, Peter Borowski, and Ramachandra S. Hosmane
pp 4776–4789Publication Date (Web): September 23, 2003 (Article)
DOI: 10.1021/jm030277k
Nonpeptide αvβ3 Antagonists. 8. In Vitro and in Vivo Evaluation of a Potent αvβ3 Antagonist for the Prevention and Treatment of Osteoporosis
John H. Hutchinson, Wasyl Halczenko, Karen M. Brashear, Michael J. Breslin, Paul J. Coleman, Le T. Duong, Carmen Fernandez-Metzler, Michael A. Gentile, John E. Fisher, George D. Hartman, Joel R. Huff, Donald B. Kimmel, Chih-Tai Leu, Robert S. Meissner, Kara Merkle, Rose Nagy, Brenda Pennypacker, James J. Perkins, Thomayant Prueksaritanont, Gideon A. Rodan, Sandor L. Varga, Greg A. Wesolowski, Amy E. Zartman, Sevgi B. Rodan, and Mark E. Duggan
pp 4790–4798Publication Date (Web): September 27, 2003 (Article)
DOI: 10.1021/jm030306r
Brief Articles
Inhibition of Human Immunodeficiency Virus Reverse Transcriptase by Synadenol Triphosphate and Its E-Isomer
Ruifang Wang, Shigeyoshi Harada, Hiroaki Mitsuya, and Jiri Zemlicka
pp 4799–4802Publication Date (Web): September 24, 2003 (Brief Article)
DOI: 10.1021/jm030048y
Book Reviews
Burger's Medicinal Chemistry and Drug Discovery. Sixth Edition. Volumes 1−6. Edited by D. J. Abraham. Wiley-Interscience, Hoboken, NJ. 2003. 18 × 26 cm. Vol. 1: xv + 932 pp; ISBN 0-471-27090-3. Vol. 2: xv + 808 pp; ISBN 0-471-37028-2. Vol. 3: xv + 880 pp; ISBN 0- 471-37029-0. Vol. 4: xiv + 702 pp; ISBN 0-471-37030-4. Vol. 5: xv + 1084 pp; ISBN 0-471-37031-2. Vol. 6: xiv + 1084 pp; ISBN 0471-27401-1. $2100.00.
Kennerly S. Patrick
p 4803Publication Date (Web): September 27, 2003 (Book Review)
DOI: 10.1021/jm0303960
Taxus: The Genus Taxus. Medicinal and Aromatic Plants
Industrial Profiles. Volume 32 Edited by Hideji Itokawa and Kuo-Hsiung Lee. Taylor & Francis, London and New York. 2003. xiii + 456 pp. 18 × 25.5 cm. ISBN 0-415-29837-7. $145.00.
A. Douglas Kinghorn
p 4804Publication Date (Web): September 18, 2003 (Book Review)
DOI: 10.1021/jm0303958